Review
Oncology
Sarah Jenkins, Megan E. Kachur, Kamil Rechache, Justin M. Wells, Stanley Lipkowitz
Summary: Rare subtypes of breast cancer each have unique features with defined pathological and clinical characteristics that impact treatment recommendations. However, data is limited for optimal treatment approaches.
CURRENT ONCOLOGY REPORTS
(2021)
Article
Multidisciplinary Sciences
Qing Xia, Qibin Yan, Zehua Wang, Qinyuan Huang, Xinying Zheng, Jinze Shen, Lihua Du, Hanbing Li, Shiwei Duan
Summary: This study aimed to construct a prediction model for breast cancer subtypes based on disulfidptosis-related lncRNAs. The random forest algorithm was used to select important lncRNAs, and a prediction model was successfully established. The study also revealed that key lncRNAs were closely related to RNA methylation modification, angiogenesis, and immune infiltrating cells.
SCIENTIFIC REPORTS
(2023)
Review
Cell Biology
Kevin M. Turner, Syn Kok Yeo, Tammy M. Holm, Elizabeth Shaughnessy, Jun-Lin Guan
Summary: Breast cancer exemplifies how molecular characterization influences therapeutic decisions. The compartmentalization of breast cancer into diverse subtypes is well-documented, but intratumoral heterogeneity, driven by both intrinsic and extrinsic factors, complicates this model. Evidence suggests that intratumoral molecular subtypes are dynamic and interconversion between subtypes contributes to tumor progression, metastases, and treatment resistance. Therapeutic strategies need to address this heterogeneity to improve treatment outcomes.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Manuela Gago-Dominguez, Carmen M. Redondo, Manuel Calaza, Marcos Matabuena, Maria A. Bermudez, Roman Perez-Fernandez, Maria Torres-Espanol, Angel Carracedo, J. Esteban Castelao
Summary: The study revealed an association between LIPG and breast cancer, particularly in specific conditions including pre-menopausal breast cancer, Luminal A breast cancers, HER2-negative breast cancers, women with high total cholesterol levels, non-postpartum breast cancer, and grades II and III breast cancers.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Analytical
Mengjia Hu, Virginia Brown, Joshua M. Jackson, Harshani Wijerathne, Harsh Pathak, Devin C. Koestler, Emily Nissen, Mateusz L. Hupert, Rolf Muller, Andrew K. Godwin, Malgorzata A. Witek, Steven A. Soper
Summary: Extracellular vesicles (EVs) have the potential to be used as a minimally invasive liquid biopsy marker for precision medicine, as they carry RNA cargo associated with the cell-of-origin. Researchers have developed an EV microfluidic affinity purification (EV-MAP) chip, made from plastic for high-scale production, which can isolate EV subpopulations. They demonstrated the utility of this chip in molecular subtyping breast cancer patients, isolating two subpopulations of EVs that better recapitulate the tumor microenvironment. The EV-MAP provided high recovery and specificity based on exosomal mRNA and PCR results, and the EV subpopulations showed potential for prognostication using the PAM50 test.
ANALYTICAL CHEMISTRY
(2023)
Article
Cell Biology
Sagarika Banerjee, Zhi Wei, Tian Tian, Dipayan Bose, Natalie N. C. Shih, Michael D. Feldman, Thaer Khoury, Angela De Michele, Erle S. Robertson
Summary: Alterations to the natural microbiome are linked to different diseases, and the presence or absence of specific microbes is directly related to disease outcomes. The study found that different subtypes of breast cancer have specific viromes and microbiomes, with ER+ and TN tumors showing the most and least diverse microbiome, respectively. Specific microbial signatures allowed discrimination between different BC subtypes and correlated with clinical outcomes.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Animesh Kar, Nihal Medatwal, Kajal Rajput, Susmita Mandal, Trishna Pani, Ali Khan, Pankaj Sharma, Ajit Singh Oberoi, Gayatri Vishwakarma, S. V. S. Deo, Mohit Kumar Jolly, Avinash Bajaj, Ujjaini Dasgupta
Summary: This study identified sphingolipid profiles that can distinguish luminal and TNBC subtypes of breast cancer, as well as stratify tumor grades and lymphovascular invasion status. These findings provide valuable evidence for the development of sphingolipids as diagnostic markers and predictors of disease severity in breast cancer.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Review
Oncology
Miquel Ensenyat-Mendez, Pere Llinas-Arias, Javier I. J. Orozco, Sandra iniguez-Munoz, Matthew P. Salomon, Borja Sese, Maggie L. DiNome, Diego M. Marzese
Summary: TNBC is a highly heterogeneous disease lacking targeted treatment options, emphasizing the need for improved stratification systems. New methodologies such as microarray technology and high-throughput sequencing have allowed for the characterization of TNBC subtypes, but challenges remain in integrating diverse molecular data and implementing cost-effective classification methods. The application of artificial intelligence in translational oncology shows promise in identifying definitive TNBC subtypes.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Julieta Leone, Rachel A. Freedman, Nancy U. Lin, Sara M. Tolaney, Carlos T. Vallejo, Bernardo A. Leone, Eric P. Winer, Jose Pablo Leone
Summary: This study revealed significant differences in survival outcomes by tumor subtype among male breast cancer patients. Specifically, triple-negative tumor subtype had the worst survival outcomes. Stage, tumor subtype, and race were found to be significantly associated with overall survival and breast cancer-specific survival.
BREAST CANCER RESEARCH AND TREATMENT
(2021)
Article
Biochemical Research Methods
Yuanyuan Chen, Yu Gu, Zixi Hu, Xiao Sun
Summary: Breast cancer is highly heterogeneous, with various forms of categorization based on gene expression profiles. Biological networks are stable over time, in contrast to gene expression profiles. By using a gene interaction network, this study identified four subtypes of breast cancer based on individual-specific edge perturbations, showing strong heterogeneity in prognosis, somatic mutations, and enriched pathways. The network-based subtypes are closely related to existing subtypes and immunohistochemistry index, providing insights into breast cancer heterogeneity and mechanisms.
BRIEFINGS IN BIOINFORMATICS
(2021)
Article
Oncology
Joel S. Parker, Michael Mullins, Maggie C. U. Cheang, Samuel Leung, David Voduc, Tammi Vickery, Sherri Davies, Christiane Fauron, Xiaping He, Zhiyuan Hu, John F. Quackenbush, Inge J. Stijleman, Juan Palazzo, J. S. Marron, Andrew B. Nobel, Elaine Mardis, Torsten O. Nielsen, Matthew J. Ellis, Charles M. Perou, Philip S. Bernard
Summary: This study developed a risk model that incorporates gene expression-based intrinsic subtypes for breast cancer prognosis and prediction of chemotherapy benefit. The intrinsic subtypes showed significant prognostic significance and remained significant even when standard parameters were incorporated. The model can be used to predict prognosis for node-negative breast cancer and assess the likelihood of efficacy from neoadjuvant chemotherapy.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Review
Endocrinology & Metabolism
Fanxiu Xiong, Qichen Dai, Sihan Zhang, Stephen Bent, Peggy Tahir, Erin L. Van Blarigan, Stacey A. Kenfield, June M. M. Chan, Gabriela Schmajuk, Rebecca E. Graff
Summary: There is a positive association between diabetes mellitus and breast cancer risk, particularly in postmenopausal women and subtypes of breast cancer defined by receptor status. Further research is needed to understand the mechanisms underlying this association and the influence of diabetes mellitus on breast cancer receptor expression.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Article
Oncology
Zelalem Desalegn, Meron Yohannes, Martin Porsch, Kathrin Stueckrath, Endale Anberber, Pablo Santos, Marcus Bauer, Adamu Addissie, Yonas Bekuretsion, Mathewos Assefa, Yasin Worku, Lesley Taylor, Tamrat Abebe, Eva Johanna Kantelhardt, Martina Vetter
Summary: This study characterized PAM50-based intrinsic subtypes among Ethiopian breast cancer patients and found that different subtypes were associated with clinical and histopathological parameters. The results have implications for improving breast cancer care and providing personalized treatment for patients.
BREAST CANCER RESEARCH AND TREATMENT
(2022)
Article
Oncology
Esther Cabanas Morafraile, Javier Perez-Pena, Jesus Fuentes-Antras, Aranzazu Manzano, Pedro Perez-Segura, Atanasio Pandiella, Eva M. Galan-Moya, Alberto Ocana
Summary: Breast cancer is the most common invasive tumor in women and identification of druggable targets to improve current therapies is a major goal. In this study, an in silico analysis of transcriptomic datasets in breast cancer revealed upregulated genes involved in DNA damage response pathways like ATM/ATR, BARD1, and Fanconi Anemia, which correlated with worse prognosis. Understanding these genetic vulnerabilities may help in developing improved therapeutic strategies for breast cancer.
Article
Oncology
Carolina Mathias, Joao Carlos Degraf Muzzi, Bruna Borba Antunes, Daniela F. Gradia, Mauro A. A. Castro, Jaqueline Carvalho de Oliveira
Summary: Breast cancer is the leading cause of cancer globally, with diverse molecular subtypes that can be classified using ncRNAs and lncRNAs. The composition of tumor microenvironment immune cells can directly impact patient prognosis and therapy response. By utilizing bioinformatics methods and RNA-seq data, the complexity of lncRNAs can be incorporated into BRCA molecular and immune subtype classifications.
FRONTIERS IN ONCOLOGY
(2021)
Article
Ophthalmology
Aapo Virtanen, Jari Haukka, Sirpa Loukovaara, Mika Harju
Summary: In this longitudinal population-based study, a modest decrease in the risk of open-angle glaucoma was found for individuals with diabetes mellitus after adjusting for confounding factors.
ACTA OPHTHALMOLOGICA
(2023)
Letter
Allergy
Anni Koskinen, Riikka Lemmetyinen, Annika Luukkainen, Hannu Kankaanranta, Pinja Ilmarinen, Jussi Karjalainen, Juha Pekkanen, Heini Huhtala, Jari Haukka, Anna But, Sanna Toppila-Salmi
Article
Pharmacology & Pharmacy
Konsta Teppo, Jussi Jaakkola, Fausto Biancari, Olli Halminen, Miika Linna, Jari Haukka, Jukka Putaala, Pirjo Mustonen, Janne Kinnunen, Juha Hartikainen, K. E. Juhani Airaksinen, Mika Lehto
Summary: AF patients with higher income or educational level are more frequently initiated with oral anticoagulant therapy for stroke prevention, highlighting potential missed opportunities in stroke prevention among AF patients with low income.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Endocrinology & Metabolism
Lars Christian Lund, Patricia Hjorslev Jensen, Anton Pottegard, Morten Andersen, Nicole Pratt, Jesper Hallas
Summary: Using Danish nationwide health registries, researchers identified 70 drug-diabetes associations, of which 27 were previously unknown. These findings are important for understanding the drugs that can cause diabetes.
DIABETES OBESITY & METABOLISM
(2023)
Article
Engineering, Biomedical
A. Weizel, T. Distler, R. Detsch, A. R. Boccaccini, H. Seitz, S. Budday
Summary: Numerical simulations using appropriate material models and parameters are valuable for understanding the effects of mechanical stimulation on hydrogels for cartilage replacement. In this study, hyperviscoelastic material parameters for human articular cartilage and two replacement materials were identified using COMSOL Multiphysics (R) v. 5.6. The results revealed that ADA-GEL and ChondroFiller(liquid) exhibit faster stress relaxation and lower relaxation time constants compared to cartilage. Additionally, ADA-GEL and ChondroFiller(liquid) have a predominant elastic response, while cartilage has a predominant viscoelastic response.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Abdullah Riaz, Christian Polley, Henrik Lund, Armin Springer, Hermann Seitz
Summary: By fabricating a composite scaffold of titanium alloy (Ti6Al4V) and barium titanate (BaTiO3), the biomechanical stability of Ti6Al4V is combined with the electrical activity of BaTiO3, offering potential for the treatment of critical-size bone defects in load-bearing areas.
MATERIALS & DESIGN
(2023)
Article
Biology
Olli Kurkela, Jaakko Nevalainen, Salla-Maaria Patsi, Katja Kojo, Olli Holmgren, Anssi Auvinen
Summary: This study estimated the number of lung cancer cases attributable to residential radon in Finland in 2017, considering factors such as age, sex, dwelling type, and smoking status. The results showed that at least 3% and at most 8% of all lung cancers were attributed to residential radon. Among smokers, the majority of radon-related cases were due to the joint effect of radon and smoking. Reducing radon exposure to specified action levels could significantly decrease the number of radon-attributable cases.
RADIATION AND ENVIRONMENTAL BIOPHYSICS
(2023)
Article
Genetics & Heredity
Stefanie H. Mueller, Alvina G. Lai, Maria Valkovskaya, Kyriaki Michailidou, Manjeet K. Bolla, Qin Wang, Joe Dennis, Michael Lush, Zomoruda Abu-Ful, Thomas U. Ahearn, Irene L. Andrulis, Hoda Anton-Culver, Natalia N. Antonenkova, Volker Arndt, Kristan J. Aronson, Annelie Augustinsson, Thais Baert, Laura E. Beane Freeman, Matthias W. Beckmann, Sabine Behrens, Javier Benitez, Marina Bermisheva, Carl Blomqvist, Natalia Bogdanova, Stig E. Bojesen, Bernardo Bonanni, Hermann Brenner, Sara Y. Brucker, Saundra S. Buys, Jose E. Castelao, Tsun L. Chan, Jenny Chang-Claude, Stephen J. Chanock, Ji-Yeob Choi, Wendy K. Chung, Sarah Colonna, Sten Cornelissen, Fergus J. Couch, Kamila Czene, Mary B. Daly, Peter Devilee, Thilo Dork, Laure Dossus, Miriam Dwek, Diana M. Eccles, Arif B. Ekici, A. Heather Eliassen, Christoph Engel, D. Gareth Evans, Peter A. Fasching, Olivia Fletcher, Henrik Flyger, Manuela Gago-Dominguez, Yu-Tang Gao, Montserrat Garcia-Closas, Jose A. Garcia-Saenz, Jeanine Genkinger, Aleksandra Gentry-Maharaj, Felix Grassmann, Pascal Guenel, Melanie Gundert, Lothar Haeberle, Eric Hahnen, Christopher A. Haiman, Niclas Hakansson, Per Hall, Elaine F. Harkness, Patricia A. Harrington, Jaana M. Hartikainen, Mikael Hartman, Alexander Hein, Weang-Kee Ho, Maartje J. Hooning, Reiner Hoppe, John L. Hopper, Richard S. Houlston, Anthony Howell, David J. Hunter, Dezheng Huo, Abctb Investigators, Hidemi Ito, Motoki Iwasaki, Anna Jakubowska, Wolfgang Janni, Esther M. John, Michael E. Jones, Audrey Jung, Rudolf Kaaks, Daehee Kang, Elza K. Khusnutdinova, Sung-Won Kim, Cari M. Kitahara, Stella Koutros, Peter Kraft, Vessela N. Kristensen, Katerina Kubelka-Sabit, Allison W. Kurian, Ava Kwong, James Lacey, Diether Lambrechts, Loic Le Marchand, Jingmei Li, Martha Linet, Wing-Yee Lo, Jirong Long, Artitaya Lophatananon, Arto Mannermaa, Mehdi Manoochehri, Sara Margolin, Keitaro Matsuo, Dimitrios Mavroudis, Usha Menon, Kenneth Muir, Rachel A. Murphy, Heli Nevanlinna, William G. Newman, Dieter Niederacher, Katie M. O'Brien, Nadia Obi, Kenneth Offit, Olufunmilayo Olopade, Andrew F. Olshan, Hakan Olsson, Sue K. Park, Alpa Patel, Achal Patel, Charles M. Perou, Julian Peto, Paul D. P. Pharoah, Dijana Plaseska-Karanfilska, Nadege Presneau, Brigitte Rack, Paolo Radice, Dhanya Ramachandran, Muhammad U. Rashid, Gad Rennert, Atocha Romero, Kathryn J. Ruddy, Matthias Ruebner, Emmanouil Saloustros, Dale P. Sandler, Elinor J. Sawyer, Marjanka K. Schmidt, Rita K. Schmutzler, Michael O. Schneider, Christopher Scott, Mitul Shah, Priyanka Sharma, Chen-Yang Shen, Xiao-Ou Shu, Jacques Simard, Harald Surowy, Rulla M. Tamimi, William J. Tapper, Jack A. Taylor, Soo Hwang Teo, Lauren R. Teras, Amanda E. Toland, Rob A. E. M. Tollenaar, Diana Torres, Gabriela Torres-Mejia, Melissa A. Troester, Therese Truong, Celine M. Vachon, Joseph Vijai, Clarice R. Weinberg, Camilla Wendt, Robert Winqvist, Alicja Wolk, Anna H. Wu, Taiki Yamaji, Xiaohong R. Yang, Jyh-Cherng Yu, Wei Zheng, Argyrios Ziogas, Elad Ziv, Alison M. Dunning, Douglas F. Easton, Harry Hemingway, Ute Hamann, Karoline B. Kuchenbaecker
Summary: This study identified 14 genes associated with breast cancer using gene-based aggregation analysis, including two newly discovered genes FMNL3 and AC058822.1. Furthermore, associations with established candidate genes like ESR1 were found through the collaboration of multi-ancestral cohorts, highlighting the importance of diversifying study cohorts. These findings provide new insights into the development of breast cancer.
Article
Medicine, General & Internal
V. Muroke, M. Jalanko, J. Haukka, J. Hartikainen, A. Tahvanainen, H. Ukkonen, K. Ylitalo, J. Pihkala, J. Sinisalo
Summary: This nationwide cohort evaluated the long-term outcome of transcatheter-closed ASDs. The study found that patients who underwent transcatheter closure of ASD are at higher risk of new-onset atrial fibrillation and migraine, as well as comorbidities such as ischemic heart disease, ventricular fibrillation/tachycardia, and AV conduction disorder. Major complications after the closure, including erosion and device embolization, are rare.
ANNALS OF MEDICINE
(2023)
Article
Chemistry, Physical
Hafiz Ahmed Waqas, Muhammad Waseem, Abdullah Riaz, Muhammad Ilyas, Muhammad Naveed, Hermann Seitz
Summary: The design and construction of precast reinforced box culverts need to be improved to meet contemporary demands of reliability and affordability. This research aims to develop an effective and affordable design improvement procedure for a precast box culvert using modern numerical tools. The study reveals that adjusting the haunch geometry and adding reinforcement significantly affect the load-carrying capacity of a culvert, with a potential 25% increase achievable.
Editorial Material
Medicine, General & Internal
Anssi Auvinen
BMJ-BRITISH MEDICAL JOURNAL
(2023)
Article
Ophthalmology
Sirpa Loukovaara, Ani Korhonen, Leo Niskanen, Jari Haukka
Summary: This study investigates the associations between systemic drugs and the incidence of DME, aiming to identify beneficial and/or deleterious associations.
ACTA OPHTHALMOLOGICA
(2023)
Article
Clinical Neurology
Tuomas Natukka, Joonas Haapasalo, Tomi Kivioja, Linnea Rajala, Jani Raitanen, Jaakko Nevalainen, Sirpa-Liisa Lahtela, Kristiina Nordfors, Minna Rauhala, Arja Jukkola, Juhana Frosen, Pauli Helen, Anssi Auvinen, Hannu Haapasalo
Summary: The study aimed to analyze the impact of time interval from referral to surgery and from surgery to adjuvant treatment on survival of adult isocitrate dehydrogenase-wild-type (IDH-wt) glioblastomas. The results showed that the time interval from referral to surgery within 4-10 weeks was not associated with decreased survivals in IDH-wt glioblastomas, while a delay exceeding 30 days from surgery to adjuvant treatment may decrease long-term survival.
WORLD NEUROSURGERY
(2023)
Article
Polymer Science
Timo Banko, Stefan Gruenwald, Rainer Kronberger, Hermann Seitz
Summary: This paper presents a novel approach to manufacturing components with integrated conductor paths using fused filament fabrication (FFF) and isotropic conductive adhesive (ICA). The approach involves embedding the ICA into a printed groove and sealing it with a wide extruded plastic strand. Through parameter studies, a consistent cavity for uniform formation of the ICA path was obtained.
Article
Multidisciplinary Sciences
Saeed Shakibfar, Morten Andersen, Maurizio Sessa
Summary: A disease risk score for CAP hospitalization among older individuals was developed using population-wide real-world data and AI. The score can help in clinical practice to identify individuals at higher risk of CAP hospitalization and intervene to minimize their risk of being hospitalized for CAP.