Article
Biochemistry & Molecular Biology
Min Hu, Brittany Bodnar, Yonggang Zhang, Fangxin Xie, Fang Li, Siying Li, Jin Zhao, Ruotong Zhao, Naveen Gedupoori, Yifan Mo, Lanyi Lin, Xue Li, Wentong Meng, Xiaofeng Yang, Hong Wang, Mary F. Barbe, Shanthi Srinivasan, John R. Bethea, Xianming Mo, Hong Xu, Wenhui Hu
Summary: Loss of function in the TRAPP complex is associated with a group of genetic disorders called TRAPPopathies. NIBP syndrome, one of these disorders, is characterized by microcephaly and intellectual disability and is caused by mutations in NIBP/TRAPPC9. Deficiency of Nibp/Trappc9 affects the stability of the TRAPPII complex and impairs neurite elongation and branching, providing key insights into the molecular mechanisms underlying microcephaly and intellectual disability. These findings highlight the potential of targeting the TRAPPII complex as a therapeutic approach for TRAPPopathies.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Endocrinology & Metabolism
Ana P. Huerta Guevara, Sara J. McGowan, Melissa Kazantzis, Tania Rozgaja Stallons, Tokio Sano, Niels L. Mulder, Angelika Jurdzinski, Theo H. van Dijk, Bart J. L. Eggen, Johan W. Jonker, Laura J. Niedernhofer, Janine K. Kruit
Summary: The study demonstrated that persistent endogenous DNA damage accumulation in Ercc1(d/-) mice affects energy metabolism, insulin sensitivity, and beta-cell function, leading to improved insulin sensitivity and decreased insulin secretion.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2021)
Article
Cell Biology
Wenbo Zhao, Philip Wiedemann, Eva Maria Woelfel, Mona Neven, Stephanie Peters, Thomas Imhof, Manuel Koch, Bjoern Busse, Michael Amling, Thorsten Schinke, Timur Alexander Yorgan
Summary: Col22a1, predominantly expressed in bone, deficiency may result in trabecular osteopenia and increased osteoclast numbers.
Article
Biochemistry & Molecular Biology
Sirikanda Jantaboon, Nithidol Sakunrangsit, Parichart Toejing, Asada Leelahavanichkul, Prapaporn Pisitkun, Matthew B. Greenblatt, Sutada Lotinun
Summary: Chronic inflammation in patients with SLE contributes to skeletal disorders by stimulating osteoclast activity and causing bone loss. This study found that the loss of FcγRIIB gene alleviates bone regeneration and that LPS induction impairs fracture healing and mineralization in mice. Both local and systemic LPS burden exacerbate bone regeneration impairment, delay mineralization and skeletal repair, and induce inflammation in SLE patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Hayato Sasaki, Madoka Imanishi, Daisuke Fujikura, Makoto Sugiyama, Kyosuke Tanimoto, Yohei Mochiji, Yuki Takahashi, Koki Hiura, Masaki Watanabe, Takashige Kashimoto, Kenta Nakano, Tadashi Okamura, Nobuya Sasaki
Summary: The study successfully achieved specific depletion of all populations of mast cells in vivo using the Mcpt5/Cma1(DTR/+) mouse model, without causing a marked reduction in other cells. This new mouse model helps to further understand the functions of mast cells in the body and their impact on the immune system.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Takujiro Homma, Yuji Takeda, Tomoyuki Nakano, Shinya Akatsuka, Daisuke Kinoshita, Toshihiro Kurahashi, Shinichi Saitoh, Ken-ichi Yamada, Satoshi Miyata, Hironobu Asao, Kaoru Goto, Tetsu Watanabe, Masafumi Watanabe, Shinya Toyokuni, Junichi Fujii
Summary: The study revealed that in double knockout mice lacking Sod1 and Akr1a, cessation of AsA supplementation resulted in oxidative damage in lung tissues, triggering immune responses and ultimately leading to death. These findings suggest that the pivotal role of AsA in combating ROS is primarily seen in pulmonary tissues exposed to a hyperoxygenic microenvironment.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Food Science & Technology
Xiaohui Yang, Dohyeon Lee, Hyun-Woo Kim, Byung-Hyun Park, Changjin Lim, Eun Ju Bae
Summary: The study investigates the effects of cannabidiol (CBD) on mast cell degranulation and passive cutaneous anaphylaxis in mice. CBD suppresses antigen-stimulated mast cell degranulation by inhibiting downstream signaling molecules and calcium mobilization. In addition, CBD inhibits the development of mast cells and suppresses passive cutaneous anaphylaxis in mice.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Medicine, Research & Experimental
Hyun-Woo Kim, Ga-Hee Ryoo, Hyun-Young Jang, So-Young Rah, Dong Hyun Lee, Do-Kyun Kim, Eun Ju Bae, Byung-Hyun Park
Summary: Research reveals that restoring cellular NAD+ concentration by supplementing NAD+ precursors can suppress mast cell activity in allergic reactions, thus alleviating the allergic response. This therapeutic strategy may hold significant importance for limiting mast cell-mediated anaphylactic responses.
Article
Biochemistry & Molecular Biology
Dragica Gajic, Ivan Koprivica, Ivana Stojanovic, Tamara Saksida
Summary: The absence of pro-inflammatory cytokine MIF in adipose tissue leads to obesity and inflammation, with an increase in Treg cell numbers but decreased functionality observed in VAT of MIF-/- mice.
Article
Endocrinology & Metabolism
Masanori Koide, Teruhito Yamashita, Keigo Nakamura, Hisataka Yasuda, Nobuyuki Udagawa, Yasuhiro Kobayashi
Summary: This study found that approximately two-thirds of bone formation is remodeling-based in Sost-deficient mice, while remodeling-based bone formation accounts for most of the bone formation in Sost(+/-) mice. Anti-RANKL antibody may be useful for detecting modeling-based bone formation on trabecular bone.
Article
Immunology
William Stohl, Ning Yu, Ying Wu
Summary: The interactions between TACI and/or BCMA and BAFF may modulate the expression of B cell subsets and Foxp3+ cells, which could help explain the contradictory observations of autoimmunity and autoimmune disease in mice without functional engagement of BR3 by BAFF.
JOURNAL OF IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Domenico Ribatti, Antonio d'Amati
Summary: Hematopoietic stem cells (HSCs) have the ability to self-renew and differentiate into all mature hematopoietic cell types. They are mainly found in the bone marrow and are regulated by a hierarchy of different types of cells. Mast cells, a type of innate immune cell, have a complex developmental process starting from the yolk sac and later originating from HSCs. This review article summarizes the knowledge on mast cell sources and the mechanisms involved in their development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Yuanyuan Wu, Lili Huang, Weili Sai, Fei Chen, Yu Liu, Cheng Han, Joanna M. Barker, Zinah D. Zwaini, Mark P. Lowe, Nigel J. Brunskill, Bin Yang
Summary: The regulation of neutrophil phagocytosis in renal ischemia-reperfusion (IR) injury by properdin and innate repair receptor is still unknown. A peptide derived from erythropoietin receptor (EPOR) and beta common receptor (beta cR) can improve functional and structural damage in both wild-type and properdin knockout mice. This study demonstrates that the peptide can enhance the phagocytic function of tubular epithelial cells and promote kidney repair through upregulation of EPOR/beta cR triggered by IR and properdin deficiency.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Muneera Waheed Alfarhan, Heba Al-Hussaini, Narayana Kilarkaje
Summary: Type 2 diabetes negatively affects testicular structure and function, increasing oxidative DNA damage and BER protein levels. PPAR-γ modulation has minimal impact on testicular structural changes, but affects oxidative DNA damage and BER proteins.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Agriculture, Multidisciplinary
Tingyang Ai, Lulu Hao, Longchen Shang, Ling Wang, Bin Li, Jing Li
Summary: The study found that konjac oligosaccharides (KOS) intervention improved calcium balance, promoted trabecular number and cortical thickness, and enhanced skeletal mechanical strength in calcium-deficient mice. Additionally, specific gut microbial genera and metabolites were significantly associated with increased bone mass, demonstrating a potential link between prebiotics and bone health.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Cardiac & Cardiovascular Systems
Hedi Zhao, Ana-Maria Misariu, Jose L. Ramirez-GarciaLuna, Tamar Nobel, Carmen Mueller, Jonathan Cools-Lartigue, Jonathan Spicer, Daniela Molena, Manjit Bains, Stephen Swisher, Wayne Hofstetter, Lorenzo Ferri
Summary: This study evaluated the safety and feasibility of combined resection for patients with synchronous pulmonary and esophageal cancer. The results showed that the complications associated with combined resection are not significantly different from esophagectomy alone in this highly selected group of patients.
ANNALS OF THORACIC SURGERY
(2022)
Article
Oncology
James Tankel, Alexander Calderone, Jose Luis Ramirez Garcia-Luna, Carmen L. Mueller, Sarah Najmeh, Jonathan Spicer, David Mulder, Lorenzo Ferri, Jonathan Cools-Lartigue
Summary: This study suggests that changes in PLR during the neoadjuvant and perioperative periods are associated with survival outcomes in patients with oesophageal adenocarcinoma. Higher positive lymph node ratio is positively correlated with PLR changes during the neoadjuvant period, while larger PLR changes are associated with major postoperative complications. Smaller PLR changes during the perioperative period are associated with better survival outcomes.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Editorial Material
Oncology
James Tankel, Alexander Calderone, Jose Luis Ramirez-Garcia-Luna, Carmen L. Mueller, Sarah Najmeh, Johnathan Spicer, David Mulder, Lorenzo Ferri, Jonathan Cools-Lartigue
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Aroub Alkaaki, Ali Abo Al-Saud, Elise Di Lena, Jose Luis Ramirez-GarciaLuna, Jonathan Spicer, Lorenzo Ferri, David Mulder, Christian Sirois, Jonathan Cools-Lartigue
Summary: This study analyzed the clinicopathological features, survival outcomes, and patterns of recurrence in patients with TEN who underwent resection. Complete resection, high-risk histology, and lymphovascular invasion were identified as risk factors for recurrence. The study highlights the importance of effective adjuvant modalities.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Review
Physiology
Jose L. Ramirez-GarciaLuna, Robert Bartlett, Jesus E. Arriaga-Caballero, Robert D. J. Fraser, Gennadi Saiko
Summary: The article discusses the advancements and clinical applications of thermal measurement technologies, particularly focusing on thermographic imaging in wound care, surgery, and sports medicine. The use of thermographic imaging for inflammation-based and perfusion-based scenarios, which rely on local temperature measurements, is identified. The adoption of thermography could be enhanced through larger studies supporting its clinical utility.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Health Care Sciences & Services
Dhanesh Ramachandram, Jose Luis Ramirez-GarciaLuna, Robert D. J. Fraser, Mario Aurelio Martinez-Jimenez, Jesus E. Arriaga-Caballero, Justin Allport
Summary: This study measures the variability in manual tissue segmentation and quantification among wound care clinicians and explores the use of deep neural networks for objective assessment of tissue types. The results show significant variability among clinicians in identifying tissue types, while the deep learning models perform well in wound and tissue segmentation. This technique can assist clinicians in accurately documenting wounds and have a significant impact on wound care.
JMIR MHEALTH AND UHEALTH
(2022)
Article
Oncology
Shufeng Zhou, Amani Hassan, Tenzin Kungyal, Sebastien Tabaries, Jose Luis Ramirez Garcia Luna, Peter M. Siegel, Anie Philip
Summary: The study reveals the crucial role of CD109 in the progression of vulvar squamous cell carcinoma, showing its regulation of stemness and epithelial morphology through a cell-surface interaction and signaling pathway.
Review
Peripheral Vascular Disease
Karina Gasbarrino, Kashif Khan, Jose L. Ramirez-Garcialuna, Ibtisam Mahmoud, Stella S. Daskalopoulou
Summary: This study aims to compare the associated risk between various plaque features assessed through medical imaging of carotid/coronary arteries and cardiovascular/cerebrovascular events. It also evaluates the impact of combining high-risk plaque features with the degree of artery stenosis in predicting cardiovascular risk.
ITALIAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2022)
Article
Surgery
Mario A. Martinez-Jimenez, Samuel Kolosovas-Machuca, Francisco Alcocer, Luis Carlos Ortiz-Dosal, Mariana C. Gonzalez-Grijalva, Gibran A. Delsol-Revuelta, Francisco I. Gaitan-Gaona, Francisco J. Valadez-Castillo, Jose L. Ramirez-GarciaLuna
Summary: The topical administration of insulin glargine appears to be safe and promotes wound healing and tissue repair in nondiabetic patients with chronic venous ulcers.
JOURNAL OF SURGICAL RESEARCH
(2022)
Article
Orthopedics
Bardia Barimani, Fose L. Ramirez-Garcialuna, Karen Smith, Adam Hart, Michael Tanzer
Summary: This study investigated the impact of downsizing the femoral head size, performing a posterior capsular closure, and short external rotator repair on the dislocation rate after converting a failed hemiarthroplasty (HA) to a total hip arthroplasty (THA) through a posterior approach. The study reviewed 15 patients who underwent the conversion surgery and had a 2-year follow-up. The results showed that downsizing the femoral head and closing the posterior capsule can effectively reduce the risk of dislocation.
Review
Anesthesiology
Robert Harutyunyan, Sean D. Jeffries, Jose L. Ramirez-GarciaLuna, Thomas M. Hemmerling
Summary: DSSs have been shown to have a beneficial impact in critical care medicine, particularly in the fields of anesthesia and ICU. However, the effectiveness of DSS in emergency medicine is inconclusive and further research is needed. Overall, DSS integration has the potential to improve patient outcomes in critical care.
ANESTHESIA AND ANALGESIA
(2023)
Article
Surgery
Gertruda Evaristo, Amit Katz, Jose L. Ramirez-GarciaLuna, Marianne S. M. Issac, Veena Sangwan, Duc-Vinh Thai, Nicholas Bertos, Marie-Christine Guiot, Sophie Camilleri-Broet, Victoria Marcus, Carmen Mueller, Jonathan Cools-Lartigue, Pierre O. O. Fiset, Lorenzo E. E. Ferri
Summary: It has been reported that MMR and MSI status can predict outcomes in gastroesophageal carcinomas. In this study, Canadian surgical patients were characterized based on MMR status, clinicopathologic correlates, and tumor location. The results showed that dMMR status was associated with longer overall survival.
CANADIAN JOURNAL OF SURGERY
(2023)
Review
Medicine, General & Internal
Adrienn N. Bourkas, Natasha Barone, Matthew E. C. Bourkas, Matthew Mannarino, Robert D. J. Fraser, Amy Lorincz, Sheila C. Wang, Jose Luis Ramirez-GarciaLuna
Summary: A systematic review and meta-analysis of 44 studies found a high agreement rate between teledermatology and face-to-face dermatology diagnoses, with higher consistency when conducted by specialists. Training in image acquisition and the use of high-quality imaging technologies improved diagnostic agreement. Teledermatology can be a valuable option in resource-poor settings.
Article
Medicine, General & Internal
Jose L. Ramirez-GarciaLuna, Karla Rangel-Berridi, Robert Bartlett, Robert D. J. Fraser, Mario A. Martinez-Jimenez
Summary: Infrared thermal imaging is an objective tool that can aid clinicians in locating and documenting the extent of inflammation, as well as monitoring treatment response.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Meeting Abstract
Gastroenterology & Hepatology
Elyanne M. Ratcliffe, Parsa Karimi, Maria Sunil, Russell Leong, Jose Luis Ramirez-GarciaLuna, Gregorio Zuniga-Villanueva