Article
Clinical Neurology
Tuan Van Nguyen, Tuan Anh Tran, Hinh Thi Vu
Summary: The study evaluated the role of electromyography and Awaji criteria for the early diagnosis of ALS, finding that Awaji criteria have higher sensitivity for early diagnosis of ALS.
NEUROLOGICAL SCIENCES
(2022)
Article
Clinical Neurology
Gordon Jewett, Shahin Khayambashi, Geoffrey S. Frost, Benjamin Beland, Angela Lee, Victoria Hodgkinson, Lawrence Korngut, Sameer Chhibber
Summary: The Gold Coast consensus criteria aim to simplify the diagnosis of ALS and refine clinical trial populations, potentially increasing eligibility rates and improving the external validity of clinical trial results.
Article
Neurosciences
Dongchao Shen, Xunzhe Yang, Yanying Wang, Di He, Xiaohan Sun, Zhengyi Cai, Jinyue Li, Mingsheng Liu, Liying Cui
Summary: The study showed that the Gold Coast criteria had greater diagnostic sensitivity for ALS than the rEEC and Awaji criteria in a Chinese population. The sensitivity remained robust across subgroups, especially in limb-onset ALS patients, indicating its potential for use in clinical practice and future therapeutic trials.
TRANSLATIONAL NEURODEGENERATION
(2021)
Editorial Material
Clinical Neurology
Lars Hendrik Mueschen, Susanne Petri, Sonja Korner
Summary: The diagnosis of amyotrophic lateral sclerosis (ALS) is challenging for clinicians due to the absence of a reliable biomarker. Clinical and electromyographic examination play a major role in diagnosing ALS. The well-established revised El-Escorial and Awaji criteria, mainly used for clinical trials, are complex and confusing, especially for patients. The newly proposed Gold Coast criteria provide a simplified synopsis of the previous diagnostic criteria.
KLINISCHE NEUROPHYSIOLOGIE
(2022)
Article
Clinical Neurology
Andrew Hannaford, Nathan Pavey, Mehdi van den Bos, Nimeshan Geevasinga, Parvathi Menon, Jeremy M. Shefner, Matthew C. Kiernan, Steve Vucic
Summary: The study found that the Gold Coast criteria had high sensitivity in the diagnosis of ALS, with consistent accuracy across different subgroups based on disease origin, duration, and functional impairments. In atypical ALS phenotypes, the Gold Coast criteria showed higher sensitivity and specificity.
ANNALS OF NEUROLOGY
(2021)
Article
Clinical Neurology
Kirsten Pugdahl, Jean-Philippe Camdessanche, Bulent Cengiz, Mamede de Carvalho, Rocco Liguori, Celine Rossatto, Miguel Oliveira Santos, Veria Vacchiano, Birger Johnsen
Summary: The study found that the "Gold Coast" diagnostic criteria for ALS had higher sensitivity compared to previous criteria, primarily due to considering PMA as a form of ALS. This simpler criteria can be used in clinical practice and may be included in clinical trials.
CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Clinical Neurology
A. Barp, V. Ada Sansone, C. Lunetta
Summary: ALS diagnosis is challenging as it often presents with overlapping clinical features with other rare diseases, necessitating comprehensive assessments for accurate diagnosis.
REVUE NEUROLOGIQUE
(2021)
Article
Clinical Neurology
Maria Claudia Torrieri, Matteo Monticelli, Rosario Vasta, Fabio Cofano, Marco Ajello, Antonio Canosa, Federica Penner, Nicola Marengo, Umberto Manera, Andrea Calvo, Adriano Chio, Diego Garbossa, Cristina Moglia
Summary: Diagnosing the occurrence of ALS in patients with CSM can be challenging, but the Awaji criteria show good accuracy with a sensitivity of 55.6% and specificity of 95.8%. The positive predictive value is 83.3% and the negative predictive value is 85.2%.
EUROPEAN NEUROLOGY
(2021)
Article
Clinical Neurology
D. J. L. Stikvoort Garcia, B. Sleutjes, L. J. van Schelven, H. S. Goedee, L. H. van den Berg
Summary: This study aimed to evaluate the diagnostic accuracy of a novel electrophysiological protocol in patients with suspected motor neuron disease (MND). The study found that this electrophysiological protocol can effectively diagnose ALS in the early stages and provide clinical selection and baseline measures for clinically challenging patients.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Neurosciences
Maxim De Schaepdryver, Pegah Masrori, Philip Van Damme, Koen Poesen
Summary: The aim of this study was to investigate the impact of measuring neurofilament levels in cerebrospinal fluid (CSF) before referral to a neuromuscular reference center (NMRC) on the diagnostic delay in patients with amyotrophic lateral sclerosis (ALS). The results showed that measuring neurofilament levels in CSF before referral shortened the diagnostic delay in specific cases, but this effect disappeared when other covariates were taken into account.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Clinical Neurology
Kelly G. Gwathmey, Philippe Corcia, Chris J. McDermott, Angela Genge, Stefan Sennfalt, Mamede de Carvalho, Caroline Ingre
Summary: ALS is a fatal neurodegenerative disease with a long delay in diagnosis. This delay is influenced by lack of recognition and misdiagnosis by general practitioners, as well as patient factors such as illness behavior and site of symptom onset.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Medicine, General & Internal
A. Panio, C. Cava, S. D'Antona, G. Bertoli, D. Porro
Summary: Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease characterized by the neurodegeneration of motoneurons. This study aims to identify specific blood miRNAs with diagnostic abilities for sporadic ALS (sALS) through a meta-analysis of the literature and bioinformatics approaches. A panel of 10 miRNAs was identified, and the expression levels of miR-193b/miR-4745-5p could potentially be used for the clinical diagnosis of sALS.
FRONTIERS IN MEDICINE
(2022)
Article
Oncology
Qinming Zhou, Lu He, Jin Hu, Yining Gao, Dingding Shen, You Ni, Yuening Qin, Huafeng Liang, Jun Liu, Weidong Le, Sheng Chen
Summary: The role of CORO1A in ALS pathogenesis was discovered, potentially affecting the disease onset and progression by blocking autophagic flux. Therefore, CORO1A might be a potential biomarker and therapeutic target for ALS.
FRONTIERS OF MEDICINE
(2022)
Article
Clinical Neurology
Lucia Catherine Greco, Andrea Lizio, Jacopo Casiraghi, Valeria Ada Sansone, Lucio Tremolizzo, Nilo Riva, Federica Solca, Silvia Torre, Nicola Ticozzi, Massimo Filippi, Vincenzo Silani, Barbara Poletti, Christian Lunetta
Summary: The study compared the ability of ECAS and ALS-CBS in stratifying ALS patients and found some differences in classifying patients according to Strong criteria. Further studies will be conducted to better understand the reasons underlying the differences between these two tests in classifying the different subtypes of fronto-temporal dysfunction in ALS.
JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Cara Donohue, Jennifer L. Chapin, Amber Anderson, Lauren DiBiase, Lauren Tabor Gray, James P. Wymer, Emily K. Plowman
Summary: This study aimed to determine the sensitivity and specificity of the ALSFRS-R bulbar subscale and speech item to detect dysarthria in ALS patients. The results showed that the ALSFRS-R bulbar subscale score and speech item score can be useful tools for monitoring dysarthria status in ALS.