Article
Fisheries
Bei Li, Jianlin Chen, Pujiang Huang, Tingting Weng, Yiming Wen, Huiyuan Yang, Yansheng Liu, Liqun Xia
Summary: This study successfully obtained two attenuated N. seriolae strains S-250 and U-20, which demonstrated strong immune response and provided protective efficacy against N. seriolae in hybrid snakehead. These attenuated strains are potential candidates for the development of live vaccines to control fish nocardiosis in aquaculture.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Immunology
Ning Zhang, Hairui Zhang, Zhongdian Dong, Wei Wang
Summary: In this study, the pathogen causing infection in hybrid snakehead fish was identified as Nocardia seriolae. RNA-Seq analysis revealed differentially expressed immune-related genes in diseased fish, providing insights into the immune response of hybrid snakehead to Nocardia seriolae and the potential screening of biomarkers for fish-borne Nocardia species.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Fisheries
Rodolfo Enrique del Rio-Rodriguez, Jose Gustavo Ramirez-Paredes, Sonia Araceli Soto-Rodriguez, Yechiam Shapira, Mariana del Jesus Huchin-Cortes, Judith Ruiz-Hernandez, Monica Isela Gomez-Solano, David J. Haydon
Summary: An outbreak of ulcerative granulomatous disease in red drum cultured in a commercial marine farm in Campeche Bay Mexico was caused by Nocardia, a type of filamentous bacteria. This is the first report of piscine nocardiosis in Mexico and the first detection of the disease in red drum species. The pathogen was definitively identified and characterized through PCR and gene sequencing methods.
JOURNAL OF FISH DISEASES
(2021)
Review
Fisheries
Yansheng Liu, Guoquan Chen, Liqun Xia, Yishan Lu
Summary: This review summarizes the current knowledge of host diversity, drug resistance, genotype and phenotype, virulence factor, molecular detection, and vaccine development of N. seriolae. Future research prospects on the pathogenic mechanism and control of N. seriolae infection are also discussed.
REVIEWS IN AQUACULTURE
(2022)
Article
Fisheries
Quanquan Cao, Ju Zhao, Mingyao Yan, Zhong Luo, Fu Luo, Lin Feng, Weidan Jiang, Pei Wu, Yan Wang, Debin Li, Haifeng Liu, Jun Jiang
Summary: This study investigates the effects of Vitamin D3 (VD3) on the immune response and xenophagy of largemouth bass after Nocardia seriolae challenge. The results demonstrate that VD3 can enhance the innate immune response and xenophagy through VDR-mediated immunomodulation, contributing to the resistance of largemouth bass to N. seriolae infection.
Article
Genetics & Heredity
Cuong T. Le, Erin P. Price, Derek S. Sarovich, Thu T. A. Nguyen, Daniel Powell, Hung Vu-Khac, D. Ipek Kurtboke, Wayne Knibb, Shih-Chu Chen, Mohammad Katouli
Summary: The study analyzed outbreaks of nocardiosis caused by Nocardia seriolae in Vietnam between 2010 and 2015. It found that all Vietnamese strains belonged to a single unique clade and were likely transmitted between mariculture facilities in Vietnam. The Vietnamese strains shared a common ancestor with strains from Japan and China, and several putative virulence factors were identified.
MICROBIAL GENOMICS
(2022)
Article
Fisheries
Shoulin Cao, Jiaojiao Chang, Xiaozhen Yue, Jinnian Li, Xuelan Liu
Summary: This study identified a new strain of Nocardia seriolae and analyzed its virulence factors at the genome level. The findings provide a foundation for further understanding the pathogenic mechanism of fish nocardiosis.
JOURNAL OF FISH DISEASES
(2023)
Article
Biotechnology & Applied Microbiology
Jian Teng, Yan Zhao, Qing Lei Meng, Shu Ren Zhu, Hong Ju Chen, Liang Yi Xue, Xiang Shan Ji
Summary: This study conducted transcriptomic comparison and functional analysis to investigate the immune response of Northern snakehead after N. seriolae infection. The results revealed the expression changes of multiple immune-related genes and signaling pathways during the infection process.
Article
Fisheries
Phuong Nguyen, Andre Giovanni, Li-Wu Cheng, Pei-Chi Wang, Shih-Chu Chen
Summary: This study evaluated the pathogenicity of Nocardia seriolae infection and found that different isolates of the bacteria have varying levels of virulence. The results provide a basis for further research on the virulence profile of N. seriolae in Taiwan and for the development of prevention strategies for orange-spotted groupers.
JOURNAL OF FISH DISEASES
(2023)
Article
Fisheries
Zhi-Gang Liu, Jun-Jian Dong, Xiao-Li Ke, Meng-Meng Yi, Jian-Meng Cao, Feng-Ying Gao, Miao Wang, Xing Ye, Mai-Xin Lu
Summary: The largemouth bass, an important freshwater aquaculture fish in China, recently experienced a serious outbreak of ulcer disease. By isolating and studying a pathogenic bacterium from the diseased fish, researchers identified Nocardia seriolae as the causative agent of the disease and gained important insights into its pathogenicity and control measures.
DISEASES OF AQUATIC ORGANISMS
(2022)
Article
Microbiology
Fengxia Zhao, Xingchen Huo, Pengxu Wang, Qian Liu, Chunrong Yang, Jianguo Su
Summary: This study evaluated the effects of different immunostimulants added to feed on Nocardia seriolae infection in largemouth bass. The results showed that the combined use of beta-glucan and APS significantly improved survival rates, reduced bacterial loads and tissue damage, and enhanced immune indicators. The combined treatment demonstrated promising efficacy in treating bacterial diseases in aquaculture.
Article
Plant Sciences
Yongxin Shu, Mei Luo, Zhangyong Dong
Summary: This study sequenced the entire genome of the highly virulent Fusarium oxysporum f. sp. capsici strain 14003 and identified genes possibly related to specific virulence factors, enhancing the theoretical basis for prevention and control of pepper wilt disease.
Review
Infectious Diseases
Ili Margalit, Anat Yahav, Yaara Ben Ari, Haim Ben-Zvi, Avivit Shoham, Elad Goldberg, Michal Weiler-Sagie, Noam Tau, Khitam Muhsen, Jihad Bishara, Mical Paul, Hanna Bernstine, Dafna Yahav
Summary: FDG-PET/CT plays a significant role in the diagnosis and management of nocardiosis, assisting in ruling out malignancy, determining infection extent, and guiding treatment decisions. The literature also supports the value of FDG-PET/CT in managing nocardiosis, with similar contributions reported in 80% of the cases examined.
INFECTIOUS DISEASES AND THERAPY
(2021)
Article
Biotechnology & Applied Microbiology
Xiaohua Wang, M. M. Onchari, Xueting Yang, Lin Xu, Xiulian Yin, Faxiang Wan, Yuewen Chen, Ming Guan, Bin Li, Chuping Luo
Summary: The study revealed that Bacillus subtilis JCL16 has a good biocontrol effect against fish nocardiosis, possibly due to the synergistic inhibition of Nocardia seriolae by its surfactin, bacilysin, and subtilosin A.
BIOLOGICAL CONTROL
(2022)
Article
Biochemistry & Molecular Biology
Marion Herisse, Keishi Ishida, Jordan Staiger-Creed, Louise Judd, Spencer J. Williams, Benjamin P. Howden, Timothy P. Stinear, Hans-Martin Dahse, Kerstin Voigt, Christian Hertweck, Sacha J. Pidot
Summary: Nocardia are opportunistic human pathogens that cause difficult to treat infections. However, little is known about their involvement in the pathogenesis and the natural products they produce. In this study, a new cytotoxic and antifungal polyene called terpenomycin was discovered in a human pathogenic Nocardia terpenica isolate. The biosynthetic pathway and unique features of terpenomycin were revealed, and a mutant library helped identify a terpenomycin-null mutant. These findings highlight the potential of neglected actinomycetes as producers of diverse bioactive molecules.
ACS CHEMICAL BIOLOGY
(2023)