Article
Neurosciences
Giancarlo Valente, Agustin Lage Castellanos, Lars Hausfeld, Federico De Martino, Elia Formisano
Summary: The study focuses on the false positive control of different permutation strategies and the statistical power of different cross-validation schemes. Simulations demonstrate that estimating the entire cross-validation error on each permuted dataset is the only statistically valid permutation strategy. Among different cross-validation schemes, a repeated split-half cross-validation is the most powerful.
Article
Water Resources
Angel Merida-Ortega, Stephen J. Rothenberg, Mariano E. Cebrian, Luis Antonio Arias-Medellin, Ana Lidia Salgado-Salgado, Lizbeth Lopez-Carrillo
Summary: The urinary concentrations of potentially toxic metal(loids) in Northern Mexican women were measured and found to be higher than comparison values for arsenic, aluminium, and cadmium. Factors such as age, education, body mass index, tobacco use, and state of residence were associated with metal(loid) concentrations, highlighting the importance of education in preventing and controlling metal exposure.
EXPOSURE AND HEALTH
(2022)
Review
Environmental Sciences
Amir Shiani, Kiomars Sharafi, Abdullah Khalid Omer, Amir Kiani, Behzad Karamimatin, Tooraj Massahi, Gholamreza Ebrahimzadeh
Summary: This study aims to investigate the relationship between exposure to toxic metals and Autism Spectrum Disorder (ASD). Meta-analysis of qualified papers revealed that autistic individuals had higher levels of lead, mercury, arsenic, and aluminum in their bodies compared to healthy controls, while they had lower levels of lead, cadmium, and mercury in their urine. These findings contribute to a better understanding of the role of toxic metals as environmental factors in the development of ASD.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Engineering, Multidisciplinary
Mintode Nicodeme Atchade, Yves Morel Sokadjo
Summary: This study aimed to propose the best model to forecast COVID-19 cumulative cases using machine learning technique, focusing on time series univariate models and avoiding many variables modeling. The findings indicated that ETS model has the smallest MAPE statistics compared to other models, requiring at least 100 days for good forecasts.
ALEXANDRIA ENGINEERING JOURNAL
(2022)
Article
Behavioral Sciences
Laura Turriziani, Arianna Ricciardello, Francesca Cucinotta, Fabiana Bellomo, Giada Turturo, Maria Boncoddo, Silvestro Mirabelli, Maria Luisa Scattoni, Maddalena Rossi, Antonio M. Persico
Summary: The study shows that gut mobilization significantly reduces symptoms such as hyperactivity, anxiety, irritability, and repetitive behaviors in chronically constipated autistic children. While urinary p-cresol levels varied, they were not significantly correlated with changes in behavioral parameters.
Review
Behavioral Sciences
Cecilia N. Amadi, Chinna N. Orish, Chiara Frazzoli, Orish E. Orisakwe
Summary: Recently, environmental factors have been linked to the development of autism spectrum disorder (ASD). Toxic metals, their involvement in the generation of reactive oxygen species, and their epigenetic effects have been implicated in ASD. This systematic review examines the association of toxic metals with autism in children. The review found that there is a higher concentration of toxic metals in the blood, urine, and hair samples of children with autism compared to healthy children, suggesting increased metal exposure.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2022)
Article
Psychology, Clinical
Bethany F. M. Oakley, Emily J. H. Jones, Daisy Crawley, Tony Charman, Jan Buitelaar, Julian Tillmann, Declan G. Murphy, Eva Loth
Summary: The study found that autistic individuals have significantly higher levels of alexithymia, with difficulties in identifying and describing emotions playing a role in social-communication difficulties and anxiety severity. Difficulty in describing feelings is associated with social-communication difficulties, while difficulty in identifying feelings is associated with anxiety severity, impacting long-term clinical outcomes for individuals with autism.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Behavioral Sciences
Jacek Baj, Wojciech Flieger, Michal Flieger, Alicja Forma, Elzbieta Sitarz, Katarzyna Skorzynska-Dziduszko, Cezary Grochowski, Ryszard Maciejewski, Hanna Karakula-Juchnowicz
Summary: Identification of biomarkers for neurological developmental disorders like schizophrenia, ADHD, and ASD remains a challenge. Studies show that children with ASD have a reduced ability to eliminate toxic metals, leading to their accumulation and worsening of symptoms. Extensive metallomic studies help understand the role of trace elements in ASD pathogenesis, but further research is needed for relevant tests and reference levels.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Biochemistry & Molecular Biology
Mian H. R. Mahmood, Muhammad Abdul Qayyum, Farhan Yaseen, Tahir Farooq, Zahid Farooq, Muhammad Yaseen, Ahmad Irfan, Khawaja Muddassir, Muhammad Nadeem Zafar, Muhammad Tariq Qamar, Arshad Mehmood Abbasi, Hai-Yang Liu
Summary: The study revealed significant imbalances in the concentrations of toxic and essential elements in the serum of colorectal cancer patients compared to healthy donors. These differences were also observed among different types and stages of CRC patients.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2022)
Article
Urology & Nephrology
Tiago Rodrigues, Antonio Andrade, Nuno Neuparth, Paulo Dinis
Summary: The study validated a visual scale, VASUS, for assessing lower urinary tract symptoms (LUTS), particularly in developing countries. VASUS showed strong correlations with IPSS and free flowmetry, making it a valuable tool for objective evaluation of LUTS in urology practice.
WORLD JOURNAL OF UROLOGY
(2021)
Article
Environmental Sciences
Ana Carolina Cavalheiro Paulelli, Jonas Carneiro Cruz, Bruno Alves Rocha, Marilia Cristina Oliveira Souza, Silvana Ruella de Oliveira, Cibele Aparecida Cesila, Paula Picoli Devoz, Walter dos Reis Pedreira Filho, Monica Soares de Campos, Jose L. Domingo, Fernando Barbosa
Summary: This study investigated the association between toxic metals/metalloids and the biomarker 8OHdG in individuals affected by the Fundão dam failure in Brazil. The results showed that high exposure to toxic metals/metalloids might increase 8OHdG levels, potentially leading to adverse health effects. Further studies are needed to monitor exposure levels and explore additional health impacts.
ENVIRONMENTAL RESEARCH
(2023)
Article
Environmental Sciences
Yuting Chen, Zhipeng Pan, Jiran Shen, Ye Wu, Lanlan Fang, Shanshan Xu, Yubo Ma, Hui Zhao, Faming Pan
Summary: Accumulating evidence suggests that environmental exposure to toxic metals is harmful to human health. However, little is known about the effects of metal mixtures on psoriasis. This study investigated the independent and comprehensive associations between co-exposure to heavy metals and psoriasis in adults. The results showed that certain urinary metals were positively correlated with psoriasis risk, while one urinary metal was identified as a protective factor. Moreover, co-exposure to urinary metal mixtures was found to significantly increase the risk of psoriasis, especially in the young and middle-aged group.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Review
Behavioral Sciences
Behrang Mahjani, Lotta Renstrom Koskela, Anita Batuure, Christina Gustavsson Mahjani, Magdalena Janecka, Christina M. Hultman, Abraham Reichenberg, Joseph D. Buxbaum, Olof Akre, Dorothy E. Grice
Summary: The study found a significant association between clinically significant anxiety and LUTS in both males and females. However, there is limited research on younger individuals and those with clinically significant anxiety, suggesting the need for further studies in these areas. Understanding the co-occurrence of anxiety and LUTS can lead to better prevention and interventions to improve quality of life.
BRAIN AND BEHAVIOR
(2021)
Article
Biotechnology & Applied Microbiology
Shehla Sattar, Shah Jehan, Samina Siddiqui
Summary: The study revealed significant increases in total concentrations of Cd, Cu, Mn, Ni, and Pb in petroleum waste contaminated soils, leading to moderate soil contamination and high ecological risk to the surrounding environment. The enrichment factor was found to be highest for Cd, followed by Mn, Co, Cr, Cu, Ni, Zn, and Pb. Human health risk assessment indicated non-carcinogenic risk values >= 1 for both children and adults.
ENVIRONMENTAL TECHNOLOGY & INNOVATION
(2021)
Article
Engineering, Environmental
Somayeh Soltani-Gerdefaramarzi, Mohsen Ghasemi, Morteza Gheysouri
Summary: The study revealed that urban soils in Yazd City have high concentrations of toxic metals, especially As, Cd, and Pb, leading to considerable pollution in the area. The quality of urban soil in the study area is significantly influenced by toxic metals, particularly due to the prevailing wind direction, the route of the north-south highway of Iran, and the population density and traffic in certain areas.
ENVIRONMENTAL GEOCHEMISTRY AND HEALTH
(2021)
Article
Computer Science, Interdisciplinary Applications
Fenglei Fan, Hongming Shan, Mannudeep K. Kalra, Ramandeep Singh, Guhan Qian, Matthew Getzin, Yueyang Teng, Juergen Hahn, Ge Wang
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2020)
Article
Engineering, Chemical
Esteban Lopez, Juergen Hahn, Lina M. Gomez, Hernan Alvarez
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
(2020)
Review
Clinical Neurology
Troy Vargason, Genevieve Grivas, Kathryn L. Hollowood-Jones, Juergen Hahn
SEMINARS IN PEDIATRIC NEUROLOGY
(2020)
Article
Engineering, Chemical
Gloria A. Buitimea-Ceron, Juergen Hahn, Nancy Medina-Herrera, Arturo Jimenez-Gutierrez, Jose A. Loredo-Medrano, Salvador Tututi-Avila
Summary: Dividing-wall columns (DWCs) are intensified processes that have attracted attention for their cost reduction compared to traditional distillation systems. This paper studied three widely used design methodologies for DWCs, comparing and rating them against minimum total annual costs, with the modified Sotudeh and Shahraki's method found to be the most efficient.
Article
Sport Sciences
Hamish A. Kerr, Eric H. Ledet, Juergen Hahn, Kathryn Hollowood-Jones
Summary: A multimodal algorithm using cognitive testing, postural stability, and clinical assessment was developed to predict return to sports after sports-related concussion (SRC). The algorithm showed promising results in discriminating between athletes ready to return to sports and those who were not, with an acceptable sensitivity and specificity.
SPORTS HEALTH-A MULTIDISCIPLINARY APPROACH
(2022)
Article
Health Care Sciences & Services
Genevieve Grivas, Richard Frye, Juergen Hahn
Summary: A retrospective analysis of administrative claims in the US identified significant relationships between certain maternal medical events during pregnancy and the child's diagnosis of ASD. Factors such as having a biological sibling with ASD and maternal use of antidepressant medication were associated with an increased risk of ASD.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Automation & Control Systems
Uwe Kruger, Xun Wang, Mark J. Embrechts, Ali Almansoori, Juergen Hahn
Summary: This article introduces a regularized modeling technique for estimating uncertainty in operational data. By utilizing hypothesis testing and an efficient objective function, the technique outperforms existing methods and can be embedded within an advanced process analytics framework.
CONTROL ENGINEERING PRACTICE
(2022)
Article
Health Care Sciences & Services
Fatir Qureshi, James B. Adams, Tapan Audhya, Juergen Hahn
Summary: Statistical and machine-learning techniques show promise in providing insights into unique metabolomic patterns in individuals with ASD. This study re-examines the differences in metabolomic and nutrient measurements between children with ASD and typically developing peers using multivariate statistical analysis. The findings support prior work and highlight prominent areas of divergence between the two groups. Improved analysis reveals significant differences in 46 nutritional/metabolic measurements between ASD and TD groups, with strong correlations between many of these measurements. Multivariate techniques identify potential biomarker panels that can accurately discriminate between ASD and TD, with high predictive accuracy following cross-validation. The study also confirms previously identified physiological pathways and important metabolites associated with ASD.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Engineering, Chemical
Fatir Qureshi, Juergen Hahn
Summary: Autism spectrum disorder is a neurodevelopmental disorder that impairs social and communication skills. Due to the heterogeneity of the disorder, little is known about its pathophysiology. Currently, diagnosis is based solely on behavioral assessments, as there are no available biochemical tests. However, multivariate statistical methods show potential for classification and characterization based on biochemical markers.
CANADIAN JOURNAL OF CHEMICAL ENGINEERING
(2023)
Article
Health Care Sciences & Services
Joshua Chuah, Uwe Kruger, Ge Wang, Pingkun Yan, Juergen Hahn
Summary: There has been a rapid increase in the number of artificial intelligence/machine learning-based biomarker diagnostic classifiers in recent years. This paper proposes a framework to evaluate the robustness of these classifiers by assessing the variability of their performance and parameter values. The study also found that it is possible to estimate the tolerance for replacement noise in classifiers.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Behavioral Sciences
Genevieve Grivas, Richard E. Frye, Juergen Hahn
Summary: This study examines prenatal risk factors for different subgroups of children diagnosed with autism spectrum disorder (ASD) based on co-occurring conditions (COCs). The findings suggest that each subgroup has distinct associated prenatal risk factors, supporting the importance of subgrouping children with ASD based on COCs.
Article
Biochemistry & Molecular Biology
Khemlal Nirmalkar, Fatir Qureshi, Dae-Wook Kang, Juergen Hahn, James B. Adams, Rosa Krajmalnik-Brown
Summary: The study showed that microbiome transfer therapy (MTT) resulted in an increase in beneficial microbes and important functional genes in children with ASD, leading to improvements in metabolic profile. However, two years post-treatment, there were significant shifts in microbiota and microbial genes, indicating long-term changes in the gut microbiome of ASD individuals. Further studies are recommended to better understand the role of specific microbes and functional gene expression in ASD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Health Care Sciences & Services
Jennifer Ferina, Melanie Kruger, Uwe Kruger, Daniel Ryan, Conor Anderson, Jenny Foster, Theresa Hamlin, Juergen Hahn
Summary: This study explored the use of artificial intelligence models to predict behavior episodes in individuals with autism spectrum disorder (ASD). By analyzing data on co-occurring conditions and environmental factors, the models were able to accurately predict the likelihood of behavior episodes. Environmental and gastrointestinal factors were found to be significant predictors in the population studied.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Proceedings Paper
Computer Science, Information Systems
Diego Machado Reyes, Mansu Kim, Hanqing Chaoh, Juergen Hahn, Li Shen, Pingkun Yan
Summary: This study introduces a novel transformer encoder-based model for classifying PD patients from healthy controls based on genotype data. The method effectively models complex global feature interactions and increases interpretability through attention scores. Results suggest novel SNP interactions for further investigation in wet lab and clinical settings.
2022 IEEE-EMBS INTERNATIONAL CONFERENCE ON BIOMEDICAL AND HEALTH INFORMATICS (BHI) JOINTLY ORGANISED WITH THE IEEE-EMBS INTERNATIONAL CONFERENCE ON WEARABLE AND IMPLANTABLE BODY SENSOR NETWORKS (BSN'22)
(2022)
Article
Biochemistry & Molecular Biology
Sean M. Quinn, Troy Vargason, Nilisha Pokhrel, Edwin Antony, Juergen Hahn, Susan P. Gilbert
Summary: The study found that in the heterodimeric KIF3AC, both KIF3A and KIF3C retain their intrinsic ATP-binding and hydrolysis kinetics, but KIF3A can activate the phosphate release rate of KIF3C, making them more similar in catalytic steps. These coupled steps are the rate-limiting transition for the ATPase cycle, suggesting that within KIF3AC, the stepping kinetics for each head are similar. Further research will focus on how these properties enable KIF3AC to achieve its physiological functions.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)