Article
Multidisciplinary Sciences
Minfei Su, Jinan Wang, Guoqing Xiang, Hung Nguyen Do, Joshua Levitz, Yinglong Miao, Xin-Yun Huang
Summary: α(1)-adrenergic receptors (α(1)-ARs) are crucial in regulating blood pressure, cognition, and metabolism. The lack of specific agonists for all subtypes of α(1)-ARs has hindered our understanding of their physiological roles and drug development. This study reveals the molecular mechanisms underlying the discrimination between α(1A)-AR and α(1B)-AR by the agonist A61603, providing insights for the rational design of subtype-specific agonists.
NATURE COMMUNICATIONS
(2023)
Article
Endocrinology & Metabolism
Manuel Gado, Annett Heinrich, Denise Wiedersich, Katrin Sameith, Andreas Dahl, Vasileia I. Alexaki, Michael M. Swarbrick, Ulrike Baschant, Ingo Grafe, Nikolaos Perakakis, Stefan R. Bornstein, Martina Rauner, Lorenz C. Hofbauer, Holger Henneicke
Summary: This study demonstrates that activation of the sympathetic nervous system through cold exposure or selective I33-adrenergic receptor agonist can alleviate the adverse metabolic effects caused by chronic glucocorticoid exposure. Cold exposure preserves the function of brown adipose tissue and reverses white adipose tissue lipid accumulation, correcting obesity, hyperinsulinemia, and hyperglycemia caused by glucocorticoids.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Milind Padmakar Shipra, Manoj Kumar Tembhre, Milind Padmakar Hote, Neetu Bhari, Ramakrishnan Lakshmy, S. Senthil Kumaran
Summary: Cardiomyopathy significantly contributes to heart failure, and inflammatory factors worsen the symptoms. In this study, a PGC-1a agonist was used to rescue the deleterious effects of doxorubicin-induced cardiomyopathy. The results suggest that PGC-1a agonist has therapeutic potential in mitigating the effects of cardiomyopathy.
Article
Environmental Sciences
Ran Ji, Mengqiao Cui, Dongyu Zhou, Xiaoyuan Pan, Yuqi Xie, Xiling Wu, Xin Liang, Hongxing Zhang, Weiyi Song
Summary: BPA exposure during adulthood can lead to sex-specific anxiety-like behaviors in mice, particularly in males. The hyperactivity of glutamatergic neurons in the paraventricular thalamus appears to be a key factor contributing to this anxiety. The down-regulation of alpha-1D adrenergic receptor in the PVT may also play a role in BPA-induced anxiety.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Hematology
Huiying Zhi, Douglas Sheridan, Debra K. Newman, Peter J. Newman
Summary: The study found that HPA-1a-specific antibody therapy can prevent FNAIT by quickly eliminating circulating HPA-1a(+) platelets and preventing the production of alloantibodies. In mouse experiments, prophylactic treatment with HPA-1a antibodies significantly improved platelet counts and prevented bleeding symptoms.
Article
Pharmacology & Pharmacy
Cristiane M. Pinto, Laila S. Horta, Amanda P. Soares, Barbara A. Carvalho, Enio Ferreira, Eduardo B. Lages, Lucas A. M. Ferreira, Andre A. G. Faraco, Helton C. Santiago, Gisele A. C. Goulart
Summary: Loading DOX into nanostructured lipid carriers (NLCs) successfully reduced the drug toxicity to mucosal structures and attenuated DOX-induced mucositis in mice. NLC-DOX showed stable drug release capabilities, improved intestinal barrier function, alleviated inflammation, and may offer a new solution for the side effects of chemotherapy treatments.
Article
Pharmacology & Pharmacy
Isabel Gonzalez-Mariscal, Beatriz Carmona-Hidalgo, Matthias Winkler, Juan D. Unciti-Broceta, Alejandro Escamilla, Maria Gomez-Canas, Javier Fernandez-Ruiz, Bernd L. Fiebich, Silvana-Yanina Romero-Zerbo, Francisco J. Bermudez-Silva, Juan A. Collado, Eduardo Munoz
Summary: Natural cannabidiol and its derivatives, particularly the enantiomer (+)-CBD-HPE, showed enhanced binding and functional activities on cannabinoid receptors CB1R and CB2R. The compound demonstrated potential in preventing hyperglycemia and its complications in a mouse model, with promising pharmacological profile for metabolic and immune-related disorders.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Hye Min Jang, Jong Youl Lee, Hyeong Seok An, Yu Jeong Ahn, Eun Ae Jeong, Hyun Joo Shin, Kyung Eun Kim, Jaewoong Lee, Jin Sin Koh, Gu Seob Roh
Summary: The deletion of Lipocalin-2 (LCN2) increases autophagic flux in Doxorubicin-treated hearts, leading to partial restoration of cardiac function and amelioration of cardiomyocyte diameter. Results suggest that LCN2 may exacerbate Doxorubicin-induced cardiomyopathy by inhibiting autophagic flux.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biochemical Research Methods
Xinyi Yuan, Aerduosi Shayiranbieke, Ru Xu, Hongmei Jiang, Yushan Yang, Yajun Zhang, Guowei Yin, Xinfeng Zhao
Summary: Immobilized G protein-coupled receptor has been synthesized through a site-selective covalent method, and the oriented immobilization enhances the ligand-binding activity of the receptor. The covalently immobilized receptor is a benchmark for chromatographic determination of binding parameters in ligand-receptor interactions and an effective approach for rapid analysis of drug-protein interactions.
JOURNAL OF CHROMATOGRAPHY A
(2022)
Article
Cardiac & Cardiovascular Systems
Mateusz M. Tomczyk, Kyle G. Cheung, Bo Xiang, Nahid Tamanna, Ana L. Fonseca Teixeira, Prasoon Agarwal, Stephanie M. Kereliuk, Victor Spicer, Ligen Lin, Jason Treberg, Qiang Tong, Vernon W. Dolinsky
Summary: The study found that SIRT3 expression can attenuate doxorubicin-induced changes in cardiac structure and function by preventing the acetylation of mitochondrial proteins, suggesting SIRT3 as a potential therapeutic target for mitigating doxorubicin-induced dilated cardiomyopathy.
CIRCULATION-HEART FAILURE
(2022)
Article
Cardiac & Cardiovascular Systems
C. Rupert, J. E. Lopez, E. Cortez-Toledo, O. De la Cruz Cabrera, N. C. Chesler, P. C. Simpson, S. G. Campbell, A. J. Baker
Summary: Chronic stimulation of cardiac oc1A-adrenergic receptors (oc1A-ARs) improves symptoms in multiple preclinical models of heart failure. Human engineered heart tissues (EHTs) were used to study the effects of chronic oc1A-AR stimulation on human cardiomyocyte physiology. The results showed that chronic oc1A-AR stimulation increased length-dependent activation (LDA) of contraction, suggesting that it might be beneficial for treating human heart failure.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Article
Biology
Sobia Ahsan Halim, Muhammad Waqas, Ajmal Khan, Hanan A. Ogaly, Gehan Othman, Ahmed Al-Harrasi
Summary: Sinusitis is a common respiratory inflammatory condition worldwide, requiring the urgent development of new drug candidates to combat side effects of existing drug regimens. Through screening drug-like molecules targeting alpha 2-adrenergic receptor, ten potential candidates were identified, showing strong binding affinity for alpha 2-AR.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Article
Immunology
Younian Xu, Yangyang Ge, Miaomiao Zhou, Zongze Zhang
Summary: This study found that enhanced 02-adrenergic signaling after stroke can inhibit or limit post-stroke pneumonia but increase stroke volume. Therefore, careful consideration should be given to manipulating 02-adrenergic receptors to improve post-stroke outcomes.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Oksana Raabe, Thomas Birchler, Hubert Rehrauer, Elisabeth Eppler
Summary: The study showed that TNFR1-/- mice exhibited reduced immune activation and liver inflammation after CD40 mAb treatment, indicating that the development of immune activation and liver inflammation in CD4OL interactions depends on TNFR1-mediated signaling pathways.
Article
Biochemistry & Molecular Biology
Jia Liao, Kaiying Li, Xingyu Su, Yihua Chen, Yingwei Wang, Xiangxu Tang, Yun Xing, Yaqian Xu, Xiaomeng Dai, Jiashuo Teng, Hongmei Li, Huadong Wang, Xiuxiu Lv, Yiyang Wang
Summary: The study showed that DEX could effectively accelerate LPS-induced differentiation of CFs into myofibroblasts by activating alpha(2A)-AR and the PKC-p38-Smad2/3 signaling pathway. Moreover, TNF-alpha released from nonpassage CFs was significantly higher after LPS stimulation compared to passage CFs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)