Article
Medicine, General & Internal
Hung-Chih Chen, Michael Chia-Yen Chou, Ming-Tsung Lee, Chia-Yi Lee, Che-Ning Yang, Chin-Hsin Liu, Shih-Chun Chao
Summary: This study investigated the diagnostic value of Pulsar perimetry, optical coherence tomography, and optical coherence tomography angiography in pre-perimetric glaucoma and perimetric glaucoma. Structural measurements using OCT were found to be more sensitive than vascular measurements of OCTA for pre-perimetric glaucoma, while Pulsar perimetry was more sensitive than structural and vascular measurements for perimetric glaucoma. The mean defect of Pulsar perimetry was highly correlated with the reduction of vessel density.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Ophthalmology
Yuji Yoshikawa, Takuhei Shoji, Junji Kanno, Hirokazu Ishii, Minami Chino, Yuro Igawa, Kei Shinoda, Yozo Miyake
Summary: This study evaluated the correlation between macular retinal function and changes in macular retinal vascular structure in glaucomatous eyes. The results showed that macular vessel density in the deep retinal layer had a significant positive correlation with P1-N1 amplitude. This suggests that ischemia-induced bipolar cell dysfunction may be involved in intermediate retinal dysfunction associated with glaucoma.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2022)
Article
Multidisciplinary Sciences
Naoki Soga, Shin Tanaka, Maiko Inoue, Tatsuya Inoue, Atsushi Hayashi, Eugene de Juan Jr, Kazuaki Kadonosono
Summary: This study compared macular vessel density in CRAO eyes treated with retinal arterial cannulation and standard treatment. The cannulation group showed significant improvement in macular vessel density after 7 days, while the standard treatment group did not show significant improvement. After one month, the cannulation group had significantly improved visual acuity compared to the initial visit after the onset.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, Research & Experimental
Hua Zhong, Qingqing Dong, Qing Cun, Guangyu He, Yijin Tao, Keyao Song, Yunqing Lu, Qin Zhu, Xi Chen, Qin Chen
Summary: This study identified a positive correlation between peripapillary vessel density (pVD) and visual field mean sensitivity (VFMS) in healthy myopic eyes. This correlation was particularly strong in highly myopic eyes.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Kaho Akiyama, Hitomi Saito, Shiroaki Shirato, Aiko Iwase, Koichiro Sugimoto, Takashi Fujishiro, Hiroshi Murata, Rei Sakata, Megumi Honjo, Makoto Aihara
Summary: This study evaluated the diagnostic ability of OCTA and the relationship between circumpapillary vessel density (cpVD) and macular vessel density (mVD) with visual field sensitivity in early glaucomatous (EG) eyes. The results showed significant correlations between cpVD and mVD with visual field sensitivity, indicating their potential for diagnosis.
SCIENTIFIC REPORTS
(2022)
Article
Ophthalmology
Weijing Cheng, Yunhe Song, Fengbin Lin, Jian Xiong, Fei Li, Ling Jin, Zhenyu Wang, Chunman Yang, Bin Yang, Fanyin Wang, Guili Ning, Wei Wang, Xiulan Zhang
Summary: This study evaluated the frequency of artifacts in swept-source optical coherence tomography angiography (SS-OCTA) and identified factors that influence the presence of these artifacts. The results revealed that glaucomatous eyes had a higher prevalence of SS-OCTA image artifacts compared to normal eyes. The image quality score was found to be an imperfect tool for identifying these artifacts.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2022)
Article
Ophthalmology
Taekjune Lee, Hyoung Won Bae, Gong Je Seong, Chan Yun Kim, Sang Yeop Lee
Summary: The study found that PWV was higher in NTG patients, with lower retinal vessel density, and high PWV was significantly associated with age, mean arterial pressure, and mVD. This suggests that systemic arterial stiffness may play a role in the pathogenesis of NTG.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Ophthalmology
Kendra L. Hong, Bruce Burkemper, Anna L. Urrea, Brenda R. Chang, Jae C. Lee, Vivian H. LeTran, Zhongdi Chu, Xiao Zhou, Benjamin Y. Xu, Brandon J. Wong, Brian J. Song, Xuejuan Jiang, Ruikang K. Wang, Rohit Varma, Grace M. Richter
Summary: The study found that hdVAD is higher in early glaucoma patients and may be helpful in detecting early focal damage, but its diagnostic ability is less robust in advanced glaucoma. Combining hdVAD with gRNFL can improve the diagnostic accuracy of glaucoma.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Multidisciplinary Sciences
Min-Woo Lee, Hyung-Bin Lim, Min-Su Kim, Gi-Seok Park, Ki-Yup Nam, Young-Hoon Lee, Jung-Yeul Kim
Summary: The study found that the peripapillary retinal nerve fiber layer (pRNFL) thickness in patients with type 2 diabetes (T2DM) without clinical diabetic retinopathy decreased rapidly over time, with a higher reduction rate in patients with T2DM duration >= 10 years. Results showed that best-corrected visual acuity (BCVA) and glycated hemoglobin (HbA1c) levels were significantly associated with changes in pRNFL thickness in T2DM patients.
SCIENTIFIC REPORTS
(2021)
Article
Ophthalmology
Alice Verticchio Vercellin, Brent Siesky, Gal Antman, Francesco Oddone, Michael Chang, George Eckert, Julia Arciero, Rebecca L. Kellner, Brendan Fry, Janet Coleman-Belin, Carmela Carnevale, Alon Harris
Summary: In pre-perimetric open angle glaucoma patients, there is significant reduction in retinal nerve fiber layer, macular vessel densities, and structural parameters before detectable visual field loss. The most significant decrease in vessel density is found in the perifoveal region.
JOURNAL OF GLAUCOMA
(2023)
Article
Multidisciplinary Sciences
Anna Lee, Kyung Rim Sung, Joong Won Shin
Summary: This study found that in advanced stages of POAG eyes, vascular density loss is better than structural loss in detecting disease progression. Loss of circumpapillary and macular vessel density may help in detecting disease progression in the advanced stages of POAG.
SCIENTIFIC REPORTS
(2022)
Article
Ophthalmology
Michael M. Park, Benjamin K. Young, Liangbo L. Shen, Ron A. Adelman, Lucian Del Priore
Summary: This study used OCTA to establish a continuous topography of retinal vessel density in normal eyes, revealing significant variations in vessel density among different capillary plexuses. Continuous vessel density analysis was found to be more sensitive compared to traditional methods, providing better detection of topographic changes in vessel density.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2021)
Article
Immunology
Eva Feodora Romahn, Tun Wiltgen, Matthias Bussas, Lilian Aly, Rebecca Wicklein, Christina Noll, Achim Berthele, Vera Dehmelt, Christian Mardin, Claus Zimmer, Thomas Korn, Bernhard Hemmer, Jan S. Kirschke, Mark Muehlau, Benjamin Knier
Summary: Optical coherence tomography angiography can assess retinal vessel structures in patients with multiple sclerosis. The thinning and loss of retinal vessels are associated with brain atrophy and disability in multiple sclerosis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Si-Eun Oh, Hee-Jong Shin, Chan-Kee Park, Hae-Young Lopilly Park
Summary: Superficial and deep macular vessel density is decreased in glaucoma patients. We evaluated the vascular changes in the axon and soma/dendrite of retinal ganglion cells using adjusted macular segmentation. A lower GC/IPL VD ratio was associated with lower RNFL VD and systemic hypertension. Patients with reduced GC/IPL VD ratio were more likely to have visual field defects and paracentral scotoma, as well as receive treatment for systemic hypertension.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Ophthalmology
Yan-Jiao Huo, Ravi Thomas, Yan Guo, Wei Zhang, Lei Li, Kai Cao, Huai-Zhou Wang, Ning-Li Wang
Summary: A study was conducted to compare macular vascular microcirculation between early primary open-angle glaucoma (POAG), normal tension glaucoma (NTG), and normal subjects. It was found that there were significant losses in macular vessel density and perfusion density in both the POAG and NTG groups.
OPHTHALMIC RESEARCH
(2023)