Article
Food Science & Technology
Chen Chen, David Lim, Zuchao Cai, Fengmei Zhang, Guochao Liu, Chao Dong, Zhihui Feng
Summary: Exposure to PAHs in food is closely linked to breast cancer, possibly due to changes in immunotoxicity and immune regulation. HDACis have been found to reshape the tumor immune microenvironment and have an anti-tumor effect. However, the immune regulatory mechanism of HDACis in PAH-induced breast tumors is still unclear.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Review
Oncology
Minjie Pan, Xiaoshan Wei, Xuan Xiang, Yanhong Liu, Qiong Zhou, Weibing Yang
Summary: This article summarizes the mechanism of how the CXCL9/10/11-CXCR3 axis affects the tumor microenvironment, and lists the latest research findings on its prognostic value in different cancers. Furthermore, the article describes new approaches to restoring sensitivity to immune checkpoint inhibitors through the CXCL9/10/11-CXCR3 axis.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2023)
Article
Nutrition & Dietetics
Koji Sato, Hinata Kihara, Yoka Kumazawa, Koki Tatara
Summary: The study investigated the effects of chronic sulforaphane ingestion on heavy resistance exercise-induced muscle damage parameters, finding that sulforaphane intake decreased levels of creatine kinase and interleukin-6, potentially reducing muscle damage and inflammation caused by exercise.
Article
Biochemistry & Molecular Biology
Zihui Huang, Jiayan Qian, Quanyong Jin, Fang Liu, Guoying Zhang, Hongwei Gu, Liangjie Fu, Yuling Wang, XiaoYang Zhang, Yang Yu, Jiayue Sun
Summary: This study investigated the biological functions, signaling pathways, inflammation, and immune biomarkers in ulcerative cutaneous tuberculosis (UCT). Transcriptomic analysis revealed differentially expressed genes and hub genes. Moreover, a novel plasma CXC chemokine signature was discovered to differentiate UCT from noncutaneous tuberculous ulcers.
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
(2022)
Article
Multidisciplinary Sciences
Shotaro Nakajima, Kosaku Mimura, Takuro Matsumoto, Aung Kyi Thar Min, Misato Ito, Hiroshi Nakano, Prajwal Neupane, Yasuyuki Kanke, Hirokazu Okayama, Motonobu Saito, Tomoyuki Momma, Yohei Watanabe, Hiroyuki Hanayama, Suguru Hayase, Zenichiro Saze, Koji Kono
Summary: Trastuzumab deruxtecan (T-DXd) exhibits an excellent anti-tumor effect through increasing the number of tumor-infiltrating CD8(+) T cells and enhancing major-histocompatibility-complex class I expression in a mouse model. However, its impact on anti-tumor immune responses in human cancers remains largely unknown.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Jing Zhang, Xiao Zhang, Xingjie Shi, Yuqi Liu, Danqian Cheng, Qianwen Tian, Ning Lin, Wei Wei, Huaxun Wu
Summary: Primary Sjogren's syndrome (pSS) is a systemic autoimmune disease characterized by dysfunction of secretory glands. This study investigated the role of the CXCL9, 10, 11/CXCR3 axis and GRK2 in promoting T lymphocyte migration in pSS using a mouse model. The results showed increased levels of CO + GRK2 and Th17 + CXCR3, and decreased levels of Treg + CXCR3 in the spleen of NOD mice. In the submandibular gland tissue, there was an increase in IFN-gamma, CXCL9, 10, 11, and infiltration of Th17 cells. In vitro experiments demonstrated that IFN-gamma stimulated HSGECs to increase CXCL9, 10, 11 expression and enhance Jurkat cell migration via GRK2 activation. The findings suggest that the CXCL9, 10, 11/CXCR3 axis contributes to T lymphocyte migration in pSS through GRK2 activation.
Review
Biochemistry & Molecular Biology
Byung Chul Jung, Sona Kang
Summary: Obesity is strongly associated with insulin resistance, and chronic low-grade tissue inflammation and systemic inflammation are proposed as major mechanisms. Adipose tissue serves as a crucial link between inflammation and metabolism, while epigenetic modifications play a key role in gene regulation in response to environmental changes.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2021)
Article
Cell Biology
Shihab Kochumon, Amal Hasan, Fatema Al-Rashed, Sardar Sindhu, Reeby Thomas, Texy Jacob, Amnah Al-Sayyar, Hossein Arefanian, Ashraf Al Madhoun, Ebaa Al-Ozairi, Fawaz Alzaid, Heikki A. Koistinen, Fahd Al-Mulla, Jaakko Tuomilehto, Rasheed Ahmad
Summary: Chronic low-grade inflammation induced by obesity is a central risk factor for the development of metabolic syndrome. This study found that high LDL-c levels were associated with increased expression of adipose IL-23, suggesting that IL-23 may act as an inflammatory biomarker for disease progression in people with high LDL-c.
Article
Biochemistry & Molecular Biology
Amelia Barilli, Rossana Visigalli, Francesca Ferrari, Massimiliano G. Bianchi, Valeria Dall'Asta, Bianca Maria Rotoli
Summary: This study found that exposure to supernatants from S1-activated macrophages caused A549 cells to release inflammatory mediators, with massive concentrations of IL-8. Molecular pathway analyses revealed the involvement of NF-kB in the transcription of IP-10 and RANTES, and that STATs drive the expression of various cytokines/chemokines, except for IL-8 which is regulated by AP-1. The cytokines/chemokines produced by spike-activated macrophages may contribute to dysfunction in barrier integrity of alveolar epithelial cells.
Article
Microbiology
Farzaneh Hassanshahi, Mojgan Noroozi Karimabad, Elahe Miranzadeh, Gholamhossein Hassanshahi, Seyedeh Atekeh Torabizadeh, Ali Jebali
Summary: The study investigated the association between Brucella infection and the chemokines CXCL9, 10, and 11. The results showed that the serum levels of these chemokines were significantly increased in patients with acute brucellosis, suggesting their potential as markers for the disease.
CURRENT MICROBIOLOGY
(2023)
Article
Biology
Cristina Antinozzi, Paolo Sgro, Francesco Marampon, Daniela Caporossi, Francesco Del Galdo, Ivan Dimauro, Luigi Di Luigi
Summary: Oxidative stress is crucial in the pathogenesis of systemic sclerosis (SSc), affecting the inflammatory state, fibrosis, and tissue damage. Studies show that the phosphodiesterase type 5 inhibitor sildenafil can reduce the expression and secretion of pro-inflammatory chemokines in dermal fibroblasts of SSc patients.
Article
Multidisciplinary Sciences
Xu Quan, Ying Xin, He-Ling Wang, Yingjie Sun, Chanchan Chen, Jiangying Zhang
Summary: Sirtuins are a group of enzymes with diverse activities that modify cellular proteins through histone deacetylation or ADP ribosylation. They play crucial roles in regulating various cellular functions, including mitochondrial functions, metabolism, cancer, longevity, and ageing. Dysfunctional sirtuins and altered expression levels contribute to pathological conditions and oral carcinogenesis. This review provides an overview of the characteristics and molecular mechanisms of mammalian sirtuins, highlighting their involvement in metabolic regulation and their potential connections to oral cancers. It also suggests the possibility of targeting sirtuins for novel therapeutic approaches against oral malignancies.
Article
Toxicology
Adelaide Sousa, Rui Azevedo, Vera Marisa Costa, Sara Oliveira, Ines Preguica, Sofia Viana, Flavio Reis, Agostinho Almeida, Paulo Matafome, Patricia Dias-Pereira, Felix Carvalho, Eduarda Fernandes, Marisa Freitas
Summary: Silver nanoparticles (AgNP) are widely used nanomaterials in medicine and the food industry, but their increased use has raised concerns about potential pro-inflammatory effects in the intestine. This study evaluated the effects of two subacute doses of 5 nm polyvinylpyrrolidone (PVP)-AgNP in mice, and found that ingested AgNP are distributed throughout the body but mostly excreted in feces. The accumulation of AgNP in the intestine led to a prominent inflammatory response, driven by the activation of the NF-kB pathway and the generation of multiple cytokines and chemokines.
ARCHIVES OF TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Tingting Jiang, Duo Su, Xin Liu, Yan Wang, Linjie Wang
Summary: This study found that FGF11 is enriched in brown adipose tissue of goats and promotes differentiation and thermogenesis in brown adipocytes by promoting UCP1 gene expression through EBF2 binding to the UCP1 promoter.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Hironaka Yamanobe, Kenta Yamamoto, Saki Kishimoto, Kei Nakai, Fumishige Oseko, Toshiro Yamamoto, Osam Mazda, Narisato Kanamura
Summary: Oral mucositis, a common side effect of chemotherapy, causes oral pain and affects patients' quality of life. The effects of beta-cryptoxanthin (beta-cry), a carotenoid found in citrus fruits with antioxidant and anti-inflammatory properties, on oral mucositis are unclear. In this study, we found that beta-cry can enhance cell proliferation and suppress the expression of inflammatory cytokines and matrix metalloproteinases induced by 5-fluorouracil (5-FU) in human normal oral mucosal keratinocytes (hOMK). These findings suggest that beta-cry can alleviate chemotherapy-induced oral mucositis when combined with oral care.
Article
Biochemistry & Molecular Biology
Lara Marie DeAngelis, Nicola Cirillo, Alexis Perez-Gonzalez, Michael McCullough
Summary: This study used multiplex immunohistochemistry (mIHC) to investigate the presence and abundance of mucosal-associated invariant T (MAIT) cells in oral lichen planus (OLP) tissue samples, as well as their relationship with Candida infection and symptoms. The results showed the presence of MAIT cell phenotypes in OLP tissue, with significant differences in the percentage of positive cells between different OLP groups. The relative abundance of triple-stained cells also varied significantly. Reduced percentage of certain cells was observed in symptomatic OLP with and without Candida, suggesting a potential role of these cells in OLP pathogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Jordan Nguyen, Tze Wei Chong, Hafsa Elmi, Jiani Ma, John Madi, Asha Mamgain, Eileen Melendez, Julian Messina, Nikhil Mongia, Sanjana Nambiar, Tsu Jie Ng, Huy Nguyen, Michael McCullough, Federica Canfora, Lorraine A. O'Reilly, Nicola Cirillo, Rita Paolini, Antonio Celentano
Summary: Oral potentially malignant disorders and oral cancer are associated with structural and molecular modifications of hemidesmosomes, which may serve as potential biomarkers for evaluating oral carcinogenesis.
Review
Oncology
Gary Brierly, Antonio Celentano, Omar Breik, Elham Moslemivayeghan, Romeo Patini, Michael McCullough, Tami Yap
Summary: TNF-alpha is important in oral squamous cell carcinoma (OSCC), enhancing proliferation and invasion. TNF-alpha gene polymorphisms are associated with increased risk for oral pre-cancer and cancer. This review summarizes the role of TNF-alpha in the aetiology, pathogenesis, and potential therapies of OSCC.
Review
Biochemistry & Molecular Biology
Robert H. Guirguis, Leonard P. Tan, Rebecca M. Hicks, Aniqa Hasan, Tina D. Duong, Xia Hu, Jordan Y. S. Hng, Mohammad H. Hadi, Henry C. Owuama, Tamara Matthyssen, Michael McCullough, Federica Canfora, Rita Paolini, Antonio Celentano
Summary: Invasive dental treatment in patients taking antiresorptive and antiangiogenic drugs may lead to medication-related osteonecrosis of the jaw (MRONJ). However, the exact pathogenesis of this disease is still unclear. This study reviewed in vitro studies and found that these drugs have cytotoxic effects on oral cells.
Review
Medicine, General & Internal
Alexander Ivon King Murdoch, Jordan Blum, Jie Chen, Dean Baziotis-Kalfas, Angelie Dao, Kevin Bai, Marina Bekheet, Nimret Atwal, Sarah Sung Hee Cho, Mahen Ganhewa, Nicola Cirillo
Summary: Clinical decision-making for oral and dental diseases relies on multiple sources of complex information, but individual judgements are often made intuitively on limited heuristics, which can result in errors and harm to patients. This study systematically evaluated dental practitioners' decision-making processes and identified six major themes influencing clinical decisions in dentistry. The findings suggest that treatment recommendations can be inconsistent, and evidence-based practice is just one factor among many in driving clinical decision making. Sub-optimal treatment and poorer patient outcomes can be a result of individual clinical decisions made by dental practitioners.
Article
Dentistry, Oral Surgery & Medicine
Yan Wu, Shuai Wang, Weixian Zhang, Feng Zhu, Lei Zhang, Sheng Chen, Chuanjin Ye, Yawei Sun, Xiaofeng Huang, Antonio Celentano, Yanhong Ni
Summary: This study aimed to assess the prognostic value of muscle invasion (MI) in buccal mucosa squamous cell carcinoma (BMSCC) and construct a superior prognostic prediction model. The results showed that MI was associated with poor prognosis in BMSCC patients. The combination of MI and the TNM staging system improved the predictive performance. These findings have important implications for risk stratification and clinical decision-making in BMSCC patients.
Article
Dentistry, Oral Surgery & Medicine
Shuai Wang, Ke Li, Tong Zhao, Yawei Sun, Tao Zeng, Yan Wu, Liang Ding, Xiaofeng Huang, Antonio Celentano, Xihu Yang, Qingang Hu, Yanhong Ni
Summary: This study identified the metabolic characteristics of oral tongue squamous cell carcinoma (OTSCC) and established a diagnostic model with high accuracy. The research contributes to the investigation of the pathogenesis of OTSCC.
Review
Dentistry, Oral Surgery & Medicine
S. R. Porter, A. Ukwas
Summary: Cachexia is a common feature in patients with advanced malignancy of the head and neck, driven by various mechanisms induced by the tumor itself, leading to reduced nutritional intake, increased metabolism, and loss of adipose and skeletal tissue.
Article
Dentistry, Oral Surgery & Medicine
Vito Carlo Alberto Caponio, Khrystyna Zhurakivska, Marco Mascitti, Lucrezia Togni, Francesca Spirito, Nicola Cirillo, Lorenzo Lo Muzio, Giuseppe Troiano
Summary: This study explores the predictive value of TP53 mutations in treatment outcomes for HNSCC patients. It demonstrates that high-risk-of-death mutations are associated with a higher risk of stable/progressive disease, particularly in older patients with a history of alcohol consumption. Additionally, it suggests the potential usefulness of two classification systems for TP53 mutational landscapes.
Article
Cell Biology
Ali I. Mohammed, Antonio Celentano, Rita Paolini, Jun T. Low, John Silke, Lorraine A. O' Reilly, Michael McCullough, Nicola Cirillo
Summary: Oral and intestinal mucositis (OIM) are inflammatory diseases caused by oxidative stress, which are frequently observed in cancer patients undergoing chemo-radiotherapy. Hyaluronic acid (HA) preparations have shown protective effects in oral mucositis, but their underlying mechanisms are not fully understood. This study evaluated the mechanisms of multiple formulations of enriched HA in in vitro and in vivo models of mucositis. The results showed that HA formulations protected against oxidative stress-induced damage and attenuated the severity of 5-FU-induced OIM by inhibiting apoptosis, oxidative stress, and inflammatory cytokines. These findings support the development of HA preparations for preventing OIM in chemotherapy patients.
CELL DEATH & DISEASE
(2023)
Review
Oncology
Vito Carlo Alberto Caponio, Khrystyna Zhurakivska, Lorenzo Lo Muzio, Giuseppe Troiano, Nicola Cirillo
Summary: The cells of the immune system have a dual effect on cancer development and growth. On one hand, the immune system can be activated to elicit an antitumor response. On the other hand, the inflammatory environment in the tumor microenvironment can promote tumor growth.
Article
Biochemistry & Molecular Biology
Ali I. Mohammed, Simran Sangha, Huynh Nguyen, Dong Ha Shin, Michelle Pan, Hayoung Park, Michael J. Mccullough, Antonio Celentano, Nicola Cirillo
Summary: Reactive oxygen species (ROS) are highly reactive molecules generated in living organisms. Excessive production of ROS leads to oxidative stress and cellular damage. This study investigated the oxidative stress signatures associated with oral toxicity and identified the effects of oxidative stress on oral epithelial cells.