Bombyx mori and Aedes aegypti form multi-functional immune complexes that integrate pattern recognition, melanization, coagulants, and hemocyte recruitment

Mosquito hemocytes preferentially aggregate and phagocytose pathogens in the periostial regions of the heart that experience the most hemolymph flow

(2016) Leah T. Sigle et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Anopheles gambiae hemocytes exhibit transient states of activation

(2016) William B. Bryant et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

In search of a function of Manduca sexta hemolymph protease-1 in the innate immune system

(2016) Fan Yang et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

Functional Interaction between Apolipophorins and Complement Regulate the Mosquito Immune Response to Systemic Infections

(2016) Layla Kamareddine et al.   Journal of Innate Immunity

Innate Cellular Immune Responses inAedes caspius(Diptera: Culicidae) Mosquitoes

(2016) D. E. Soliman et al.   JOURNAL OF MEDICAL ENTOMOLOGY

Changes in the Plasma Proteome ofManduca sextaLarvae in Relation to the Transcriptome Variations after an Immune Challenge: Evidence for High Molecular Weight Immune Complex Formation

(2016) Yan He et al.   MOLECULAR & CELLULAR PROTEOMICS

Identification of C-type lectin-domain proteins (CTLDPs) in silkworm Bombyx mori

(2015) Xiang-Jun Rao et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Altered tyrosine metabolism and melanization complex formation underlie the developmental regulation of melanization in Manduca sexta

(2015) Kevin D. Clark   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

Structural features, evolutionary relationships, and transcriptional regulation of C-type lectin-domain proteins in Manduca sexta

(2015) Xiang-Jun Rao et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

Identification and Characterization of 30 K Protein Genes Found in Bombyx mori (Lepidoptera: Bombycidae) Transcriptome

(2015) X.-F. Shi et al.   JOURNAL OF INSECT SCIENCE

Macrophages and cellular immunity in Drosophila melanogaster

(2015) Katrina S. Gold et al.   SEMINARS IN IMMUNOLOGY

Clip-domain serine proteases as immune factors in insect hemolymph

(2015) Michael R Kanost et al.   Current Opinion in Insect Science

Biophysical Analysis of Anopheles gambiae Leucine-Rich Repeat Proteins APL1A1, APL1B and APL1C and Their Interaction with LRIM1

(2015) Marni Williams et al.   PLoS One

Hexamerin a Novel Protein Associated with Bacillus sphaericus Resistance in Culex quinquefasciatus

(2014) Subbiah Poopathi et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Damage signals in the insect immune response

(2014) Robert Krautz et al.   Frontiers in Plant Science

Synergistic action of Galleria mellonella apolipophorin III and lysozyme against Gram-negative bacteria

(2013) Agnieszka Zdybicka-Barabas et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The Drosophila clotting system and its messages for mammals

(2013) Ulrich Theopold et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Hemolymph Melanization in the SilkmothBombyx moriInvolves Formation of a High Molecular Mass Complex That Metabolizes Tyrosine

(2013) Kevin D. Clark et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Variable immune molecules in invertebrates

(2013) L. Cerenius et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Lipid transfer particle from the silkworm,Bombyx mori, is a novel member of the apoB/large lipid transfer protein family

(2013) Hiroshi Yokoyama et al.   JOURNAL OF LIPID RESEARCH

Comprehensive Genetic Dissection of the Hemocyte Immune Response in the Malaria Mosquito Anopheles gambiae

(2013) Fabrizio Lombardo et al.   PLoS Pathogens

Identification of novel members reveals the structural and functional divergence of lepidopteran-specific Lipoprotein_11 family

(2012) Yan Zhang et al.   FUNCTIONAL & INTEGRATIVE GENOMICS

Characteristics common to a cytokine family spanning five orders of insects

(2012) Hitoshi Matsumoto et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

Localization of the serine protease homolog BmSPH-1 in nodules of E. coli-injected Bombyx mori larvae and functional analysis of its role in nodule melanization

(2011) Maki Sakamoto et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Loss of Hemolectin reduces the survival of Drosophila larvae after wounding

(2011) Huan-Jui Chang et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Silkworm Apolipophorin Protein InhibitsStaphylococcus aureusVirulence

(2011) Yuichi Hanada et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Encapsidated Genome of Microplitis demolitor Bracovirus Integrates into the Host Pseudoplusia includens

(2011) M. H. Beck et al.   JOURNAL OF VIROLOGY

Factor XIII: A Coagulation Factor With Multiple Plasmatic and Cellular Functions

(2011) László Muszbek et al.   PHYSIOLOGICAL REVIEWS

Structure-Function Analysis of the Anopheles gambiae LRIM1/APL1C Complex and its Interaction with Complement C3-Like Protein TEP1

(2011) Michael Povelones et al.   PLoS Pathogens

Genome-wide identification and expression analysis of serine proteases and homologs in the silkworm Bombyx mori

(2010) Ping Zhao et al.   BMC GENOMICS

Sequence-structure-function relations of the mosquito leucine-rich repeat immune proteins

(2010) Robert M Waterhouse et al.   BMC GENOMICS

Distinct Melanization Pathways in the Mosquito Aedes aegypti

(2010) Zhen Zou et al.   IMMUNITY

Regulation of melanization by glutathione in the moth Pseudoplusia includens

(2010) Kevin D. Clark et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

Egf1.5 is a second phenoloxidase cascade inhibitor encoded by Microplitis demolitor bracovirus

(2010) Zhiqiang Lu et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

Coagulation in Invertebrates

(2010) Lage Cerenius et al.   Journal of Innate Immunity

Role and Importance of Phenoloxidase in Insect Hemostasis

(2010) Ioannis Eleftherianos et al.   Journal of Innate Immunity

Apolipophorin-III Mediates Antiplasmodial Epithelial Responses in Anopheles gambiae (G3) Mosquitoes

(2010) Lalita Gupta et al.   PLoS One

A heterodimeric complex of the LRR proteins LRIM1 and APL1C regulates complement-like immunity in Anopheles gambiae

(2010) R. H. G. Baxter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathogen Entrapment by Transglutaminase—A Conserved Early Innate Immune Mechanism

(2010) Zhi Wang et al.   PLoS Pathogens

A comparative analysis of serpin genes in the silkworm genome

(2009) Zhen Zou et al.   GENOMICS

Discovery ofPlasmodiummodulators by genome-wide analysis of circulating hemocytes inAnopheles gambiae

(2009) Sofia B. Pinto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Leucine-Rich Repeat Protein Complex Activates Mosquito Complement in Defense Against Plasmodium Parasites

(2009) M. Povelones et al.   SCIENCE

Silencing the genes for dopa decarboxylase or dopachrome conversion enzyme reduces melanization of foreign targets in Anopheles gambiae

(2008) Susan M. Paskewitz et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Control of Phenoloxidase-induced Melanin Synthesis in an Insect

(2008) Hongnan Kan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Viral Protein Egf1.0 Is a Dual Activity Inhibitor of Prophenoloxidase-activating Proteinases 1 and 3 fromManduca sexta

(2008) Zhiqiang Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mosquito RUNX4 in the immune regulation of PPO gene expression and its effect on avian malaria parasite infection

(2008) Z. Zou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transmission Blocking Immunity in the Malaria Non-Vector Mosquito Anopheles quadriannulatus Species A

(2008) Tibebu Habtewold et al.   PLoS Pathogens

Innate immunity in insects: surface-associated dopa decarboxylase-dependent pathways regulate phagocytosis, nodulation and melanization in medfly haemocytes

(2007) Maria Sideri et al.   IMMUNOLOGY