Article
Clinical Neurology
Arunnjah Vivekanandarajah, Morgan E. Nelson, Hannah C. Kinney, Amy J. Elliott, Rebecca D. Folkerth, Hoa Tran, Jacob Cotton, Perri Jacobs, Megan Minter, Kristin McMillan, Jhodie R. Duncan, Kevin G. Broadbelt, Kathryn Schissler, Hein J. Odendaal, Jyoti Angal, Lucy Brink, Elsie H. Burger, Jean A. Coldrey, Johan Dempers, Theonia K. Boyd, William P. Fifer, Elaine Geldenhuys, Coen Groenewald, Ingrid A. Holm, Michael M. Myers, Bradley Randall, Pawel Schubert, Mary Ann Sens, Colleen A. Wright, Drucilla J. Roberts, Laura Nelsen, Shabbir Wadee, Dan Zaharie, Robin L. Haynes
Summary: Pre-natal exposure to nicotine and alcohol are known risk factors for sudden infant death syndrome (SIDS), with this study showing decreased nicotinic receptor binding in the brainstems of SIDS infants compared to infants who died from other known causes. The study also found a significant decrease in binding in relation to maternal smoking, but no effect of maternal drinking on nicotinic receptor binding.
FRONTIERS IN NEUROLOGY
(2021)
Article
Neurosciences
Robert Morris, Gibret Umeukeje, Kun Bu, Feng Cheng
Summary: The study found that patients prescribed rivastigmine were more likely to report pneumonia as an adverse event compared to other drugs, especially among males and those over 65 years old. This may be due to a cholinergic crisis induced by rivastigmine, leading to respiratory issues and gastrointestinal discomfort.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Multidisciplinary Sciences
Patrick S. Hosford, Jack A. Wells, Shereen Nizari, Isabel N. Christie, Shefeeq M. Theparambil, Pablo A. Castro, Anna Hadjihambi, L. Felipe Barros, Ivan Ruminot, Mark F. Lythgoe, Alexander Gourine
Summary: The study indicates that CO2 plays a crucial role in regulating neurovascular coupling by mediating signaling between neurons and cerebral blood vessels to adjust local brain blood flow based on neuronal activity. The neurovascular coupling mechanism ensures an adequate energy supply for the brain to meet demands.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Nathan Suiter, Sandor Volkan-Kacso
Summary: A model-based method is used to extract a short-lived state in the rotation kinetics of PdF1. It is found that PdF1 takes large 120° steps during its rotation, without further substeps. By comparing experimental data with theoretical calculations, a 20 microsecond lifetime state is identified at 40° after ATP binding. This study reveals a three-nucleotide occupancy state and suggests a common mechanism for removing a nucleotide release bottleneck in the rotary mechanism.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Article
Biology
Colin M. Cleary, Brenda M. Milla, Fu-Shan Kuo, Shaun James, William F. Flynn, Paul Robson, Daniel K. Mulkey
Summary: The study reveals a limited diversity of inhibitory neurons in the parafacial region around RTN, with Sst+ neurons seemingly uniquely inhibited by CO2/H+. These neurons play an important role in the respiratory activity of RTN.
Article
Biochemistry & Molecular Biology
Deborah H. Brotherton, Christos G. Savva, Timothy J. Ragan, Nicholas Dale, Alexander D. Cameron
Summary: This study reveals that an increase in PCO2 leads to the closure of Cx26 gap junctions, which is correlated with the size of the pore aperture. The analysis indicates that the size of the pore is controlled by the N-terminal helices, and CO2 alone is sufficient to induce conformational changes in the protein.
Article
Chemistry, Analytical
Fan Zhou, Mingxing Xiao, Defen Feng, Peihui Yang
Summary: A ratiometric electrochemiluminescence system based on gold nanostars was constructed for the determination of hypotonicity-induced ATP release from HepG2 cells. The method showed a wide linear range and low detection limit, and the results were in good agreement with commercial ELISA test.
Article
Biology
Ozlem Oztopuz
Summary: This study evaluated the neuroprotective effects of melatonin on the medulla oblongata of rats treated with cisplatin. The results showed that cisplatin treatment significantly impaired the medulla oblongata, while treatment with melatonin ameliorated this injury.
TURKISH JOURNAL OF BIOLOGY
(2022)
Article
Physiology
Basu Chakrabarty, Katie Aitchison, Paul White, Carly J. McCarthy, Anthony J. Kanai, Christopher H. Fry
Summary: This study finds that the release of co-transmitters from the parasympathetic supply to the detrusor smooth muscle can be independently regulated, offering a potential targeted drug model for managing bladder pathologies. The study also demonstrates the distinct release characteristics of acetylcholine (ACh) and adenosine triphosphate (ATP), suggesting the possibility of selectively regulating the release of these transmitters. This discovery provides a new therapeutic approach for managing conditions such as overactive bladder.
EXPERIMENTAL PHYSIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Sunmoon Yu, Dohyung Kim, Zhiyuan Qi, Sheena Louisia, Yifan Li, Gabor A. Somorjai, Peidong Yang
Summary: The research demonstrates that surface ligands on nanoparticles can form an ordered ligand layer through ligand interactions, which can enhance the efficiency of CO2 conversion.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Physiology
Esteban R. Quezada, Alexis Diaz-Vegas, Enrique Jaimovich, Mariana Casas
Summary: The study demonstrates that low-frequency electrical stimulation can transiently reduce the mRNA levels of the MCU complex in mice muscle fibers, and the regulation of the MCU complex seems to be influenced by extracellular ATP and ATP concentration. This suggests a possible role of extracellular ATP in regulating the MCU complex and its associated pathways.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Chemistry, Physical
Fei Fang, Yuanxu Liu, Xiao Sun, Cong Fu, Yagna Prakash Bhoi, Wei Xiong, Weixin Huang
Summary: The study explores the impact of CuOx-TiO2 interaction on CO2 photocatalysis, with CuOx/TiO2-{001} showing the strongest interaction favoring the reduction of CO2 to CH4. Different TiO2 crystal facets exhibit varying abilities in supporting CuO species and influencing the photocatalytic reaction pathway. The results deepen the fundamental understanding of Cu-based photocatalysts and highlight the facet effect of TiO2 nanocrystals in TiO2-related photocatalysis.
APPLIED SURFACE SCIENCE
(2021)
Article
Immunology
Zhaosheng Sun, Chong Xu, Yuxi Chen, Danjie Liu, Ping Wu, Qian Gao
Summary: This study identifies and characterizes Panx1, Cx32, and Cx43 as important neuro-related immune response genes involved in inflammation-induced ATP release in spotted sea bass.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Neurosciences
Fangchen Zhu, Sarah Elnozahy, Jennifer Lawlor, Kishore V. Kuchibhotla
Summary: The study found that cholinergic signals from the basal forebrain relay auditory information to the auditory cortex. These signals are modulated by brain and behavioral states and provide repeated auditory representations across the cortical tonotopy. However, it remains unknown whether sensory cholinergic signals target the sensory cortex and how they relate to local functional topography.
NATURE NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Alla Korsak, Shahriar Sheikhbahaei, Asif Machhada, Alexander V. Gourine, Robert T. R. Huckstepp
SCIENTIFIC REPORTS
(2018)
Article
Multidisciplinary Sciences
Robert T. R. Huckstepp, Kathryn P. Cardoza, Lauren E. Henderson, Jack L. Feldman
Article
Biochemistry & Molecular Biology
Celine Duraffourd, Robert T. R. Huckstepp, Ingke Braren, Cathy Fernandesa, Olivier Brock, Alessio Delogu, Oleksandra Prysyazhna, Joseph Burgoyne, Philip Eaton
Editorial Material
Neurosciences
Robert T. R. Huckstepp
JOURNAL OF PHYSIOLOGY-LONDON
(2019)
Article
Statistics & Probability
Beniamino Hadj-Amar, Barbel Finkenstadt Rand, Mark Fiecas, Francis Levi, Robert Huckstepp
JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION
(2020)
Editorial Material
Physiology
Robert T. R. Huckstepp, Patrick Hosford, Alexander V. Gourine
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2019)
Article
Multidisciplinary Sciences
Joshua C. Worch, Andrew C. Weems, Jiayi Yu, Maria C. Arno, Thomas R. Wilks, Robert T. R. Huckstepp, Rachel K. O'Reilly, Matthew L. Becker, Andrew P. Dove
NATURE COMMUNICATIONS
(2020)
Article
Biology
Joseph van de Wiel, Louise Meigh, Amol Bhandare, Jonathan Cook, Sarbjit Nijjar, Robert Huckstepp, Nicholas Dale
COMMUNICATIONS BIOLOGY
(2020)
Article
Statistics & Probability
Beniamino Hadj-Amar, Barbel Finkenstadt, Mark Fiecas, Robert Huckstepp
Summary: The study proposes a method for modeling time-varying periodic and oscillatory processes using a hidden Markov model, addressing the inference problem of unknown state numbers and varying periodicities across states through a Bayesian nonparametric approach.
ANNALS OF APPLIED STATISTICS
(2021)
Article
Multidisciplinary Sciences
Andrew C. Weems, Maria C. Arno, Wei Yu, Robert T. R. Huckstepp, Andrew P. Dove
Summary: Researchers have developed 4D printed polycarbonate-based scaffolds with surface degradation properties that can fill soft tissue voids without deforming tissue and allow for tissue ingrowth with reduced immune response, showing great promise for adipose tissue engineering and repair.
NATURE COMMUNICATIONS
(2021)
Editorial Material
Neurosciences
Robert T. R. Huckstepp, Gregory D. Funk
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Multidisciplinary Sciences
Mark J. Wall, Emily Hill, Robert Huckstepp, Kerry Barkan, Giuseppe Deganutti, Michele Leuenberger, Barbara Preti, Ian Winfield, Sabrina Carvalho, Anna Suchankova, Haifeng Wei, Dewi Safitri, Xianglin Huang, Wendy Imlach, Circe La Mache, Eve Dean, Cherise Hume, Stephanie Hayward, Jess Oliver, Fei-Yue Zhao, David Spanswick, Christopher A. Reynolds, Martin Lochner, Graham Ladds, Bruno G. Frenguelli
Summary: The study discusses a method of selectively activating an intracellular pathway mediated by the adenosine A1 receptor, which provides potent analgesia without sedation or cardiorespiratory depression. This research opens up possibilities for the development of novel medicines based on selective G alpha agonism.
NATURE COMMUNICATIONS
(2022)
Article
Geriatrics & Gerontology
Reno Roberts, Mark J. Wall, Ingke Braren, Karendeep Dhillon, Amy Evans, Jack Dunne, Simbarashe Nyakupinda, Robert T. R. Huckstepp
Summary: Sleep apnoea is a prevalent and often overlooked disease that is associated with poor prognosis and exacerbates other disease states. Due to the lack of appropriate animal models, little is known about the causal link between sleep apnoea and its comorbidities. Researchers have now developed a more realistic animal model of moderate sleep apnoea, which can help to understand the severe effects of this disorder on end-organ function.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Biology
Amol Bhandare, Joseph van de Wiel, Reno Roberts, Ingke Braren, Robert Huckstepp, Nicholas Dale
Summary: Regulation of systemic PCO2 is a life-preserving mechanism. The RTN, Raphe, and pF(L) in the medulla oblongata play important roles in CO2 chemosensory and respiratory adaptive changes in awake adult mice during hypercapnia. The activity of these nuclei differs in temporal characteristics and CO2 sensitivity, suggesting coordinated generation of adaptive ventilatory responses.
Article
Biology
Robert T. R. Huckstepp, Lauren E. Henderson, Kathryn P. Cardoza, Jack L. Feldman