Activin Receptor Type IIB Inhibition Improves Muscle Phenotype and Function in a Mouse Model of Spinal Muscular Atrophy

GDF11 Increases with Age and Inhibits Skeletal Muscle Regeneration

(2015) Marc A. Egerman et al.   Cell Metabolism

Spinal muscular atrophy—recent therapeutic advances for an old challenge

(2015) Irene Faravelli et al.   Nature Reviews Neurology

Spinal Muscular Atrophy Therapeutics: Where do we Stand?

(2015) Constantin d’Ydewalle et al.   Neurotherapeutics

Myogenic program dysregulation is contributory to disease pathogenesis in spinal muscular atrophy

(2014) Justin G. Boyer et al.   HUMAN MOLECULAR GENETICS

Survival motor neuron protein deficiency impairs myotube formation by altering myogenic gene expression and focal adhesion dynamics

(2014) Katherine V. Bricceno et al.   HUMAN MOLECULAR GENETICS

Blockade of ActRIIB Signaling Triggers Muscle Fatigability and Metabolic Myopathy

(2014) Karima Relizani et al.   MOLECULAR THERAPY

A Comparison of Three Electrophysiological Methods for the Assessment of Disease Status in a Mild Spinal Muscular Atrophy Mouse Model

(2014) Jia Li et al.   PLoS One

Elevated expression of activins promotes muscle wasting and cachexia

(2013) Justin L. Chen et al.   FASEB JOURNAL

Early onset muscle weakness and disruption of muscle proteins in mouse models of spinal muscular atrophy

(2013) Justin G Boyer et al.   Skeletal Muscle

The relationship between Bayesian motor unit number estimation and histological measurements of motor neurons in wild-type and SOD1G93A mice

(2012) S.T. Ngo et al.   CLINICAL NEUROPHYSIOLOGY

A cell-autonomous defect in skeletal muscle satellite cells expressing low levels of survival of motor neuron protein

(2012) Monica Hayhurst et al.   DEVELOPMENTAL BIOLOGY

Promiscuity and specificity in BMP receptor activation

(2012) Thomas D. Mueller et al.   FEBS LETTERS

Characterization of behavioral and neuromuscular junction phenotypes in a novel allelic series of SMA mouse models

(2012) Melissa Osborne et al.   HUMAN MOLECULAR GENETICS

Muscles in a mouse model of spinal muscular atrophy show profound defects in neuromuscular development even in the absence of failure in neuromuscular transmission or loss of motor neurons

(2011) Young il Lee et al.   DEVELOPMENTAL BIOLOGY

Pan-ethnic carrier screening and prenatal diagnosis for spinal muscular atrophy: clinical laboratory analysis of >72 400 specimens

(2011) Elaine A Sugarman et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Is functional hypertrophy and specific force coupled with the addition of myonuclei at the single muscle fiber level?

(2011) Rizwan Qaisar et al.   FASEB JOURNAL

Long-Term Systemic Myostatin Inhibition via Liver-Targeted Gene Transfer in Golden Retriever Muscular Dystrophy

(2011) Lawrence T. Bish et al.   HUMAN GENE THERAPY

Transgenic inactivation of murine myostatin does not decrease the severity of disease in a model of Spinal Muscular Atrophy

(2011) Hansjörg Rindt et al.   NEUROMUSCULAR DISORDERS

Metformin Treatment Has No Beneficial Effect in a Dose-Response Survival Study in the SOD1G93A Mouse Model of ALS and Is Harmful in Female Mice

(2011) Hannah M. Kaneb et al.   PLoS One

Activin IIB receptor blockade attenuates dystrophic pathology in a mouse model of duchenne muscular dystrophy

(2010) Kevin J. Morine et al.   MUSCLE & NERVE

Systemic Myostatin Inhibition via Liver-Targeted Gene Transfer in Normal and Dystrophic Mice

(2010) Kevin J. Morine et al.   PLoS One

Myostatin reduces Akt/TORC1/p70S6K signaling, inhibiting myoblast differentiation and myotube size

(2009) Anne Ulrike Trendelenburg et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Follistatin induces muscle hypertrophy through satellite cell proliferation and inhibition of both myostatin and activin

(2009) Hélène Gilson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

A soluble activin type IIB receptor improves function in a mouse model of amyotrophic lateral sclerosis

(2009) Brett M. Morrison et al.   EXPERIMENTAL NEUROLOGY

Inhibition of myostatin does not ameliorate disease features of severe spinal muscular atrophy mice

(2009) Charlotte J. Sumner et al.   HUMAN MOLECULAR GENETICS

Clinical Outcome Measures in Spinal Muscular Atrophy

(2009) Jacqueline Montes et al.   JOURNAL OF CHILD NEUROLOGY

Proteomic Identification and Functional Validation of Activins and Bone Morphogenetic Protein 11 as Candidate Novel Muscle Mass Regulators

(2008) Tatyana A. Souza et al.   MOLECULAR ENDOCRINOLOGY

Ramblings in the history of spinal muscular atrophy

(2008) Victor Dubowitz   NEUROMUSCULAR DISORDERS