Article
Medicine, General & Internal
Olivier Peyrony, Danae Gamelon, Romain Brune, Anthony Chauvin, Daniel Aiham Ghazali, Youri Yordanov, Aude Arsicaud, Pauline Gilleron, Sonja Curac, Marie-Caroline Richard, Anne-Laure Feral-Pierssens, Barbara Villoing, Sebastien Beaune, Helene Goulet, Jean-Paul Fontaine, Anne Francois, France Pirenne
Summary: RBC transfusions in the emergency department involved patients with a variety of medical conditions, most of whom had chronic anemia, primarily due to vitamin or iron deficiency or malignancy. The majority of transfusion motives were not documented in the medical charts.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Dania Fischer, Fabian Thies, Omar Awad, Camilla Brat, Patrick Meybohm, Patrick C. Baer, Markus M. Mueller, Anja Urbschat, Thorsten J. Maier, Kai Zacharowski, Jessica Roos
Summary: The relationship between allogeneic blood transfusions and increased rates of cancer recurrence, metastasis and death in colorectal cancer patients is still not fully understood. This study focused on the in vitro effects of microparticles derived from red blood cell units on colon carcinoma cells and found that these microparticles did not significantly affect cell characteristics or signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Narges Hadjesfandiari, Mona Khorshidfar, Dana V. Devine
Summary: This review article examines the molecular differences impacting the quality of blood components, with a focus on factors affecting the quality of red blood cells and platelets, and emphasizes the importance of donor individual molecular and genetic profile in improving blood component quality.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Ziya Isiksacan, Angelo D'Alessandro, Susan M. Wolf, David H. McKenna, Shannon N. Tessier, Erdem Kucukal, A. Aslihan Gokaltun, Nishaka William, Rebecca D. Sandlin, John Bischof, Narla Mohandas, Michael P. Busch, Caglar Elbuken, Umut A. Gurkan, Mehmet Toner, Jason P. Acker, Martin L. Yarmush, O. Berk Usta
Summary: Transfusion of red blood cells is a valuable and widespread treatment in modern medicine. Current practices in blood transfusion overlook the variability in stored red blood cell quality. It is necessary to rethink transfusion medicine workflows and utilize novel technologies for assessing red blood cell quality.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Gastroenterology & Hepatology
Eliza W. Beal, Allan Tsung, Ann Scheck McAlearney, Megan Gregory, Kyi Phyu Nyein, Scott Scrape, Timothy M. Pawlik
Summary: The study evaluated surgeons' practice and knowledge of red blood cell transfusion for surgical patients and found wide variations in transfusion practice and knowledge among surgeons. Further education on transfusion medicine and practice, as well as the use of transfusion alternatives, may lead to improved patient outcomes.
JOURNAL OF GASTROINTESTINAL SURGERY
(2021)
Article
Medicine, General & Internal
Pilar Solves, Javier Marco-Ayala, Miguel Angel Sanz, Ines Gomez-Segui, Aitana Balaguer-Rosello, Ana Facal, Marta Villalba, Juan Montoro, Guillermo Sanz, Javier de la Rubia, Jaime Sanz
Summary: This study compares the transfusion requirements of patients undergoing different modalities of hematopoietic stem cell transplantation (HSCT) over a twelve-year period. The results show that transfusion requirements have significantly increased for matched related donor HSCT, while there were no significant changes for matched unrelated donor and haploidentical transplant HSCT.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Xiangjian Liu, Yuying Hu, Wenqian Zhang, Deyi Yang, Yuxin Pan, Marlene Davis Ekpo, Jingxian Xie, Rui Zhao, Songwen Tan
Summary: Tricine has been found to significantly improve the recovery rate and maintain the properties of thawed red blood cells. It has a good osmotic regulation capacity and inhibits ice recrystallization, as well as reduces oxidative damage. This study is important for the exploration of novel cryoprotectants and the development of red blood cell cryopreservation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, General & Internal
Mathieu Laflamme, Hourmazd Haghbayan, Manoj M. Lalu, Ryan Zarychanski, Francois Lauzier, Amelie Boutin, Malcolm R. Macleod, Dean A. Fergusson, Lynne Moore, Olivier Costerousse, Jacques Lacroix, Cheryl Wellington, Jamie Hutchison, Alexis F. Turgeon
Summary: This study aims to estimate the association between different transfusion strategies and neurobehavioral outcome in animal models of acute brain injury through systematic review of comparative studies. The primary outcome is neurological function, with secondary outcomes including mortality, infarct size, and cerebral perfusion parameters. Subgroup analyses will be conducted based on animal model characteristics, co-interventions, and risk of bias.
SYSTEMATIC REVIEWS
(2021)
Article
Medicine, General & Internal
Piotr F. Czempik, Dawid Gierczak, Dawid Wilczek, Lukasz J. Krzych
Summary: The study analyzed the impact of red blood cell transfusion (RBCT) on blood lactate and the factors that may increase its concentration. It found that RBCT did not normalize mildly elevated lactate and common causes of elevated lactate had no impact on its concentration. Therefore, lactate may have a limited role as a physiologic RBCT trigger in non-bleeding severely anemic critically ill patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Nchafatso G. Obonyo, Lawrence Y. Lu, Nicole M. White, Declan P. Sela, Reema H. Rachakonda, Derek Teo, Matthew Tunbridge, Beatrice Sim, Louise E. See Hoe, Jonathon P. Fanning, John-Paul Tung, Matthew McKnoulty, Gianluigi Li Bassi, Jacky Y. Suen, John F. Fraser
Summary: This study investigated the association between transfusion of blood products close to the end of shelf-life and clinical outcomes in obstetric inpatients. The results showed that transfusing older red blood cells or platelets was not associated with increased morbidity or mortality.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Review
Cardiac & Cardiovascular Systems
Roby Sebastian, M. Iqbal Ahmed
Summary: Pediatric cardiac surgery is often associated with significant blood loss requiring transfusion, which poses serious risks and challenges in management. Factors such as immaturity of the hemostatic system and metabolic differences in children contribute to the complexity of transfusion management in this population.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Medicine, General & Internal
Jan A. Graw, Victoria Buenger, Lorenz A. Materne, Alexander Krannich, Felix Balzer, Roland C. E. Francis, Axel Pruss, Claudia D. Spies, Wolfgang M. Kuebler, Steffen Weber-Carstens, Mario Menk, Oliver Hunsicker
Summary: This study investigated the effects of different storage durations of PRBCs on ARDS patients. The results showed that prolonged storage of PRBCs did not increase mortality in adults with ARDS, but transfusion of long-term stored PRBCs was associated with prolonged dependence on RRT in critically ill patients with ARDS.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Ying Guo, Lili You, Huijun Hu, Anli Tong, Xiaoyun Zhang, Li Yan, Shaoling Zhang
Summary: This study developed and validated a nomogram for predicting red blood cell transfusion in pheochromocytoma surgery, incorporating clinical and radiological risk factors. The nomogram showed good discrimination and clinical usefulness, helping to improve preoperative management efficiency.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Veterinary Sciences
Barbara Steblaj, Jasmin Galli, Paul Torgerson, Annette Kutter
Summary: The aim of this retrospective study was to investigate the association between leukoreduction of packed red blood cell units and transfusion reactions in dogs. The results showed no correlation between leukoreduction and reduction in transfusion reactions or better outcomes.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Review
Cardiac & Cardiovascular Systems
Yeshen Zhang, Zhengrong Xu, Yuming Huang, Qirao Ye, Nianjin Xie, Lihuan Zeng, Xingji Lian, Yining Dai, Jiyan Chen, Pengcheng He, Ning Tan, Yuanhui Liu
Summary: Both restrictive and liberal red blood cell transfusion strategies have similar effects on overall mortality and follow-up mortality in anemic AMI patients, but restrictive transfusion tends to have a higher risk of in-hospital mortality. There were no significant differences between the two groups in secondary outcomes, suggesting that further evaluation of transfusion strategy is needed in future studies.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)