Article
Oncology
Yung-Lung Chang, Chung-Hsing Chou, Yao-Feng Li, Li-Chun Huang, Ying Kao, Dueng-Yuan Hueng, Chia-Kuang Tsai
Summary: This study examined the effects of three angiotensin II receptor blockers (ARBs) on the proliferation of glioblastoma multiforme (GBM) cell lines. Telmisartan was found to significantly suppress cell proliferation, migration, and invasion in these GBM cell lines. It also induced cell cycle arrest and apoptosis and targeted the SOX9 pathway. Additionally, telmisartan inhibited tumor growth in an animal model. These findings suggest that telmisartan could potentially be used as a treatment for GBM in humans.
CANCER CELL INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Irina Smirnova, George Draghici, Oxana Kazakova, Lavinia Vlaia, Stefana Avram, Alexandra Mioc, Marius Mioc, Ioana Macasoi, Cristina Dehelean, Adrian Voicu, Codruta Soica
Summary: The use of natural compounds as starting points for semisynthetic derivatives has shown to be a valuable source of active anticancer agents. Hollongdione, obtained from dammarane type triterpenoid dipterocarpol, was modified and a series of derivatives were obtained. These derivatives displayed strong anticancer activity, with 2,21-Bis-[3-pyridinyl]-methylidenohollongdione 9 being the most active one. It showed apoptotic and antiangiogenic activities, and also inhibited mitochondrial respiration. Further analysis at the gene level confirmed its pro-survival/proapoptotic activity. Hollongdione derivatives have potential as therapeutic options for melanoma and breast cancer.
BIOORGANIC CHEMISTRY
(2022)
Article
Oncology
Mariusz L. Hartman, Anna Gajos-Michniewicz, Julita A. Talaj, Aleksandra Mielczarek-Lewandowska, Malgorzata Czyz
Summary: Targeting therapies for BRAF(V600) and MEK1/2 rarely have lasting effects in melanoma patients. By studying BRAF(V600E) melanoma cell lines, it was found that encorafenib can modulate the balance of apoptosis-regulating proteins, predict induction of apoptosis, and demonstrate that MCL-1 is a druggable target to potentiate encorafenib activity.
Article
Biochemistry & Molecular Biology
Qiting Zhang, Ziyan Wang, Xinyuan Chen, Haoxiang Qiu, Yifan Gu, Ning Wang, Tao Wang, Ze Wang, Huabin Ma, Yufen Zhao, Bin Zhang
Summary: The compound 8a acts as an HDAC1 inhibitor with anti-proliferative and pro-apoptotic activities against leukemia cells, mainly entering the nucleus and inducing cell apoptosis through the mitochondrial pathway. It also affects the expression of DNMT1, leading to inhibition of proliferation and promotion of apoptosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Imtiaz Khan, Sumera Zaib, Mohsin Javed, Faisal Rashid, Jamshed Iqbal, Aliya Ibrar
Summary: By synthesizing a series of coumarinyl thiazolotriazole hybrids, compounds 6m and 6c were identified as the most potent against HeLa and MCF cells, showing better efficacy compared to cisplatin. Apoptosis was observed in HeLa cells treated with the most active compound 6m, accompanied by the release of Lactate Dehydrogenase and an increase in caspase-9 and-3 activity.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Giordana Feriotto, Federico Tagliati, Arianna Brunello, Simone Beninati, Claudio Tabolacci, Carlo Mischiati
Summary: This study found that caffeic acid (CA) has antiproliferative and pro-apoptotic effects on chronic myeloid leukemia (CML) cells. The activity of TG2 enzyme was found to be related to the anticancer effects of CA, by increasing reactive oxygen species (ROS) and inhibiting caspase activation and apoptosis. Knocking down TGM2 transcripts confirmed the importance of TG2 activation in CML cell death.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Mona K. Younis, Islam A. Khalil, Nancy S. Younis, Rasha R. Fakhr Eldeen, Rana M. Abdelnaby, Reem A. Aldeeb, Amal A. Taha, Doaa H. Hassan
Summary: This study aimed to evaluate the antiproliferative effects of an aceclofenac/citronellol oil nanoemulsion on melanoma. The nanoemulsion exhibited potent cytotoxicity and pro-apoptotic effects, with a lower IC50 value compared to aceclofenac or citronellol alone. In silico studies provided insights into the molecular mechanism underlying the observed antitumor activity.
Article
Biotechnology & Applied Microbiology
Lei Zhang, Shijie Meng, Bo Yan, Jie Chen, Li Zhou, Letian Shan, Ying Wang
Summary: The study showed that theaflavin exerts anti-proliferative, pro-apoptotic, anti-migrative, and tumor-inhibitory effects on melanoma cells through modulation of multiple signaling pathways.
ONCOTARGETS AND THERAPY
(2021)
Article
Oncology
Jonghae Lee, Hannah Savage, Shinji Maegawa, Riccardo Ballaro, Sumedha Pareek, Bella Samia Guerrouahen, Vidya Gopalakrishnan, Keri Schadler
Summary: Exercise increases pro-apoptotic ceramide and activates p53 signaling, promoting tumor cell apoptosis in melanoma. This finding suggests that exercise may be most effective as an adjuvant therapy in tumors with downregulated ceramide generation.
Article
Biochemistry & Molecular Biology
Daniela Claudia Maresca, Lia Conte, Benedetta Romano, Angela Ianaro, Giuseppe Ercolano
Summary: Erucin (ERU), a major isothiocyanate in rocket salads, has shown high efficacy as an anticancer agent. Recent studies have revealed that ERU has chemopreventive effects and acts as a H2S donor in human pancreatic adenocarcinoma. This study demonstrated that ERU can inhibit melanoma cell proliferation, induce apoptosis and cell cycle arrest, and inhibit migration, invasiveness, and clonogenic abilities. These effects are associated with melanogenesis impairment and mitochondrial fitness modulation.
Article
Pharmacology & Pharmacy
Gustavo Moreno-Quintero, Emmanuel Betancur-Zapata, Angie Herrera-Ramirez, Wilson Cardona-Galeano
Summary: A series of 5-FU-Curcumin hybrids were synthesized and evaluated for their chemopreventive potential against colorectal cancer cell lines. The hybrids showed higher cytotoxicity and selectivity compared to curcumin alone and the reference drug 5-fluorouracil. Furthermore, specific hybrids induced cell cycle arrest and apoptosis in the tested cell lines, suggesting their potential as therapeutic agents in colorectal cancer treatment.
Article
Biology
Patrizia Virdis, Irene Marchesi, Francesco Paolo Fiorentino, Rossana Migheli, Luca Sanna, Valentina Bordoni, Giorgio Pintore, Grazia Galleri, Maria Rosaria Muroni, Luigi Bagella, Claudio Fozza, Maria Rosaria De Miglio, Luigi Podda
Summary: The sesquiterpene lactone tomentosin extracted from I. viscosa has shown promising anti-tumor properties in therapeutic oncologic fields. This study demonstrates that tomentosin exerts its antiproliferative effects through cell cycle arrest and induction of cell apoptosis in Burkitt's lymphoma cells. The microarray gene expression analysis revealed 75 deregulated genes, with downregulated genes enriched in pathways favoring proliferation, and upregulated genes related to cellular death, particularly apoptosis. Overall, tomentosin shows potential as a natural product with limited toxicity and significant anti-tumoral activity for BL patients.
Article
Multidisciplinary Sciences
Yona Goldshmit, Rita Perelroizen, Alex Yakovchuk, Evgeni Banyas, Lior Mayo, Sari David, Amit Benbenishty, Pablo Blinder, Moshe Shalom, Angela Ruban
Summary: Inhibition of extracellular glutamate release can reduce melanoma growth by decreasing tumor cell proliferation and increasing pro-apoptotic signaling. Additionally, treatment with BGS supports recruitment of CD8(+) cells and invasion of CD68(+) macrophages in the tumor micro-environment, suggesting potential therapeutic relevance in the treatment of metastatic melanoma.
SCIENTIFIC REPORTS
(2021)
Article
Biology
Samaira Mumtaz, Shaukat Ali, Asim Pervaiz, Muhammad Zahid Qureshi, Kinzah Kanwal, Talha Saleem
Summary: In this study, sericin was isolated through the degumming process and the formation of sericinAgNO3 NPs was confirmed using various analytical techniques. The effects of sericin and sericinAgNO3 NPs on human breast cancer cells were investigated, and they exhibited significant antiproliferative and apoptotic effects.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Chemistry, Medicinal
Sara Carpi, Egeria Scoditti, Beatrice Polini, Simone Brogi, Vincenzo Calderone, Peter Proksch, Sherif S. Ebada, Paola Nieri
Summary: The marine environment, particularly sponges with algae, is an untapped source of anticancer compounds. In this study, two compounds (PEL and EPI) extracted from Dactylospongia elegans were found to inhibit melanoma cell growth and induce apoptosis through cell cycle arrest and DNA fragments accumulation. These compounds also affected the expression of miRNAs and their downstream targets, suggesting their potential as lead compounds in anti-melanoma drug research.
Article
Oncology
Anna V. Komina, Nadezhda V. Palkina, Mariya B. Aksenenko, Semyon N. Lavrentev, Anton V. Moshev, Andrey A. Savchenko, Anton S. Averchuk, Yuri A. Rybnikov, Tatiana G. Ruksha
Meeting Abstract
Dermatology
M. Aksenenko, N. Palkina, A. Komina, T. Ruksha
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2019)
Meeting Abstract
Hematology
Igor A. Olkhovskiy, Aleksey S. Gorbenko, Marina A. Stolyar, Anna V. Komina, Evgeniy V. Vasiliev, Mikhail A. Mikhalev, Tatiana I. Olkhovik, Varvara I. Bakhtina
Review
Cell Biology
Tatiana G. Ruksha
Article
Biochemistry & Molecular Biology
Anna Tyumentseva, Roman N. Yaroslavtsev, Sergey Stolyar, Alina T. Saitova, Ekaterina S. Tyutrina, Alexey S. Gorbenko, Marina A. Stolyar, Igor A. Olkhovskiy
Summary: The study developed magnetic nanoparticles based on iron oxide for DNA isolation from blood cells and found that this method can effectively obtain intact DNA without causing nucleic acid damage, suitable for studies on JAK2 V617F.
GENETIC TESTING AND MOLECULAR BIOMARKERS
(2021)
Article
Oncology
Anna Tyumentseva, Anton Averchuk, Nadezhda Palkina, Ivan Zinchenko, Anton Moshev, Andrey Savchenko, Tatiana Ruksha
Summary: In this study, differentially expressed genes in melanoma cell lines treated with dacarbazine were screened to determine transcriptomic profiles and associated alterations in cell phenotype. Signaling pathways and gene expression related to tumor dissemination were found to be affected, with Plexin A2 upregulation potentially playing a key role in the phenotypic shift of melanoma cells after dacarbazine treatment.
FRONTIERS IN ONCOLOGY
(2021)
Review
Medicine, General & Internal
A. Komina, S. N. Lavrentiev, T. G. Ruksha
BYULLETEN SIBIRSKOY MEDITSINY
(2020)
Article
Pathology
Mariya B. Aksenenko, Nadezhda Palkina, Olga N. Sergeeva, Ekaterina Yu Sergeeva, Andrey K. Kiriehenko, Tatiana G. Ruksha
INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY
(2019)
Article
Dermatology
Mariya Aksenenko, Nadezhda Palkina, Anna Komina, Liubov Tashireva, Tatiana Ruksha
Review
Medicine, General & Internal
O. N. Sergeeva, M. B. Aksenenko, Yu F. Fefelova, E. Yu Sergeeva, T. G. Ruksha
BYULLETEN SIBIRSKOY MEDITSINY
(2019)