Article
Chemistry, Multidisciplinary
Eric Palomo, Akhilesh K. Sharma, Zhaofeng Wang, Liyin Jiang, Feliu Maseras, Marcos G. Suero
Summary: We report the first successful generation of Fischer-type acyloxy Rh(II)-carbenes from carboxylic acids and Rh(II)-carbynoids. This novel class of transient donor/acceptor Rh(II)-carbenes evolves through a cyclopropanation process and allows access to densely functionalized cyclopropyl-fused lactones with excellent diastereoselectivity. DFT calculations were performed to analyze the properties of both Rh(II)-carbynoids and acyloxy Rh(II)-carbenes, as well as to characterize the reaction mechanism.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Organic
Rohit Sarthi, Rohit Kumar, Tamanna Sharma, Upendra Sharma
Summary: In this study, a concise Rh(III)-catalyzed C(sp3)-H alkylation of 8-methylquinolines with oxabenzonorbornadiene scaffolds and other strained olefins was presented. The developed catalytic methodology exhibits key features such as the retention of the oxabenzonorbornadiene skeleton, broad substrate scope, and wide-ranging functional group tolerance. Mechanistic studies revealed that the reaction proceeds through a non-radical pathway, with the five membered rhodacycle serving as the key intermediate. This is the first report on the C(sp3)-H alkylation of 8-methylquinolines with strained oxabenzonorbornadiene scaffolds (with ring retention).
Article
Chemistry, Multidisciplinary
Masato Tsuda, Taiki Morita, Hiroyuki Nakamura
Summary: This paper reports the synthesis of benzoisoxazoloborines via gold(I)-catalyzed propargyl azaClaisen rearrangement and electrophilic borylative cyclization. The in situ generation of aminoisoxazole intermediate with allenyl functionality is crucial for obtaining highly substituted compounds. Furthermore, the N-O bond insertion of a zinc carbenoid was used to synthesize oxazine-fused azaborine.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Shuai Liu, Pengchen Ma, Lu Zhang, Shenyu Shen, Hong-Jie Miao, Le Liu, K. N. Houk, Xin-Hua Duan, Li-Na Guo
Summary: An efficient alkoxyl radical-triggered ring expansion/cross-coupling cascade was developed under cheap metal catalysis. A wide range of medium-sized lactones and macrolactones were constructed in moderate to good yields, along with diverse functional groups. The proposed catalytic cycle for this tandem reaction involves Cu(i)/Cu(ii)/Cu(iii).
Article
Chemistry, Multidisciplinary
Mauro Mato, Marc Montesinos-Magraner, Arnau R. Sugranyes, Antonio M. Echavarren
Summary: A new two-step methodology has been developed for the synthesis of alkynylcyclopropanes, which avoids the usual problems associated with these substrates under metal catalysis. This approach allows for rapid access to a diverse library of alkynylcyclopropanes, including versatile intermediates that previously required lengthier synthetic approaches. Through experiments and DFT calculations, the complete mechanistic picture for the divergent reactivity of alkynylcycloheptatrienes under metal catalysis has been unveiled, explaining the unique selectivity displayed by rhodium(II) complexes.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Multidisciplinary
Shusuke Ochi, Zining Zhang, Ying Xia, Guangbin Dong
Summary: In this study, a unique one-carbon ring-expansion strategy was developed to synthesize multi-substituted 2-indanones from benzocyclobutenones and styrene-type olefins. The use of a cationic ligandless rhodium catalyst enabled high reactivity and selectivity towards the (4+1) product. The method exhibited broad functional group tolerance and scalability.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Applied
Wen-Jing Yan, Hai-Yong Tu, Zhiyong Liao, Xiao-Qin Shen, Xing-Guo Zhang
Summary: A method for constructing the indane skeleton was described, involving a palladium-catalyzed ring-opening diarylation of Cyclobutanols with aryl 1,2-dihalides. The reaction proceeds through beta-carbon elimination and subsequent alpha-carbon arylation of ketone, resulting in the formation of 2-acylindanes in yields of 42-93%.
ADVANCED SYNTHESIS & CATALYSIS
(2023)
Article
Chemistry, Organic
Bang-Hong Zhang, Wen Bao, Fu Cheng, Ke-Yang Yu, Jia-Xuan Wang, Zi-Hao Zhang, Long-Jun Dong, Ze-Sen Xue, Dao-Yong Zhu, Xue-Tao Xu, Shao-Hua Wang
Summary: A Rh(I)-catalyzed [5 + 2]/[2 + 2] cycloaddition cascade was developed to synthesize a complex and highly strained [4-5-6-7] tetracyclic framework with high yield and diastereoselectivity. Three rings, three C-C bonds, and four contiguous stereocenters were efficiently formed during the transformation. Mechanistically, the sterically congested multi-substituted cyclobutanes were readily constructed through a Michael addition and Mannich reaction cascade.
Article
Chemistry, Organic
Bang-Hong Zhang, Wen Bao, Fu Cheng, Ke-Yang Yu, Jia-Xuan Wang, Zi-Hao Zhang, Long-Jun Dong, Ze-Sen Xue, Dao-Yong Zhu, Xue-Tao Xu, Shao-Hua Wang
Summary: A Rh(I)-catalyzed [5 + 2]/[2 + 2] cycloaddition cascade has been developed to efficiently form a complex and highly strained [4-5-6-7] tetracyclic framework with good yields and excellent diastereoselectivities. The formation of three rings, three C-C bonds, and four contiguous stereocenters is achieved through the readily construction of rare sterically congested multi-substituted cyclobutanes using Michael addition and a Mannich reaction cascade.
Article
Chemistry, Applied
Rui She, Jialin Qiu, Yan Liu, Yungui Peng
Summary: A synthetic method for the construction of 3-benzoxepin skeleton using a silver-catalyzed annulation/nucleophilic/ring-expansion reaction has been reported. This method yielded a series of 1-phosphonate-3-benzoxepin analogs in yields ranging from 39% to 95%. The resulting benzoxepins with halogen and phosphonate groups could be further modified into other derivatives.
ADVANCED SYNTHESIS & CATALYSIS
(2023)
Article
Chemistry, Physical
Haitao Liu, Feng Chen, Nannan Zhao, Sai V. C. Vummaleti, Michael B. Sullivan, Jackie Y. Ying, Lei Wang
Summary: Ring expansion reactions are efficient tools in synthetic and medicinal chemistry, but the strategy involving sulfur ylide-initiated [1,4]-sigmatropic rearrangement is still underexploited. In this study, a rhodium-catalyzed ring expansion of thiochromenes and aromatic thiophenes was disclosed, enabling the straightforward assembly of polyaromatic oxathionines and oxathiocines with diverse functionalities.
Article
Chemistry, Physical
Haitao Liu, Feng Chen, Nannan Zhao, Sai V. C. Vummaleti, Michael B. Sullivan, Jackie Y. Ying, Lei Wang
Summary: A rhodium-catalyzed ring expansion reaction has been discovered for the synthesis of polyaromatic oxathionines and oxathiocines with diverse functionalities.
Article
Chemistry, Physical
Eiji Yamamoto, Yuta Takaki, Yasutaka Kawai, Kei Takakura, Moemi Kimura, Haruno Murayama, Takafumi Nagao, Takashi Kamachi, Hironobu Matsueda, Shujiro Otsuki, Hiroshi Sakata, Makoto Tokunaga
Summary: Here, we report a heterogeneous cobalt-catalyzed synthetic method for producing polysulfanes without the use of H2S reagent. These polysulfanes are widely used as extreme-pressure additives in tribology. The study provides insights into the role of catalysts and the reaction mechanism through both experimental and computational investigations.
Review
Chemistry, Organic
Tanumay Sarkar, Kangkan Talukdar, Bijay Ketan Das, Tariq A. Shah, Bijoy Debnath, Tharmalingam Punniyamurthy
Summary: In recent years, the transition-metal-aided stereoselective construction of sp(3)-carbon-rich heterocyclic scaffolds using strained-ring systems has received considerable attention. Catalytic ring-enlargement of vinylaziridines and vinyloxiranes plays a predominant role in synthesizing high sp(3)-content biorelevant heterocyclic compounds.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2021)
Article
Chemistry, Organic
Xanath Ispizua-Rodriguez, Vinayak Krishnamurti, Vanessa Carpio, Colby Barrett, G. K. Surya Prakash
Summary: An efficient method for direct difluoromethylation of terminal alkynes and desilylation-difluoromethylation of (trimethylsilyl)acetylenes is reported. Copper-catalyzed transformation using a (difluoromethyl)zinc reagent and an organic oxidant provides access to a variety of structurally diverse CF2H alkynes in good yields. The synthetic utility of these (difluoromethyl)alkynes is demonstrated by selected cycloaddition reactions, and a slight modification to the reaction conditions allows the selective preparation of a 2-difluoromethylindole.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Review
Chemistry, Multidisciplinary
Peng-hao Chen, Guangbin Dong
CHEMISTRY-A EUROPEAN JOURNAL
(2016)
Article
Polymer Science
Colin O. Hayes, Peng-hao Chen, R. Paxton Thedford, Christopher J. Ellison, Guangbin Dong, C. Grant Willson
Article
Chemistry, Physical
Rong Zeng, Peng-hao Chen, Guangbin Dong
Article
Chemistry, Organic
Michael E. Dalziel, Penghao Chen, Diane E. Carrera, Haiming Zhang, Francis Gosselin
Article
Chemistry, Physical
Peng-hao Chen, Brent A. Billett, Tatsuhiro Tsukamoto, Guangbin Dong
Article
Chemistry, Physical
Zixi Zhu, Xinghan Li, Sicong Chen, Peng-hao Chen, Brent A. Billett, Zhongxing Huang, Guangbin Dong
Article
Multidisciplinary Sciences
Bin Bin Huang, Shao Fei Zhang, Peng Hao Chen, Gang Wu
SCIENTIFIC REPORTS
(2017)
Article
Chemistry, Multidisciplinary
Jun Zhu, Peng-hao Chen, Gang Lu, Peng Liu, Guangbin Dong
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2019)
Article
Chemistry, Multidisciplinary
Jiliang Qiu, Xinyu Liu, Rusong Chen, Qinghao Li, Yi Wang, Penghao Chen, Luyu Gan, Sang-Jun Lee, Dennis Nordlund, Yijin Liu, Xiqian Yu, Xuedong Bai, Hong Li, Liquan Chen
ADVANCED FUNCTIONAL MATERIALS
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Youcai Li, Xinqing Lin, Yi Li, Jie Lv, Peng Hou, Shaoyu Liu, Penghao Chen, Min Wang, Chengzhi Zhou, Xinlu Wang
Summary: The study compared the primary staging of F-18 labeled fibroblast activation protein inhibitor ([F-18]F-FAPI) with that of F-18 labeled fluordesoxyglucose positron emission tomography/computed tomography ([F-18]F-FDG PET/CT) in patients with lung adenocarcinoma (LAD). The results showed that [F-18]F-FAPI PET/CT had a high detection rate for primary LAD and provided clearer tumor delineation and more lesions, especially in lymph nodes, the brain, and pleura. However, brain MRI could identify more and smaller lesions than [F-18]F-FAPI PET/CT.
MOLECULAR IMAGING AND BIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Junyang Wang, Rusong Chen, Lufeng Yang, Mingwei Zan, Penghao Chen, Yu Li, Wenjun Li, Huigen Yu, Xiqian Yu, Xuejie Huang, Liquan Chen, Hong Li
Summary: Battery safety concerns have become more prominent as the demand for higher energy density lithium-ion batteries (LIBs) increases. This study demonstrates the use of solid electrolyte Li6.5La3Zr1.5Ta0.5O12 (LLZTO) to supply lithium ions to charged LiCoO2, effectively improving the safety performance of the battery.
ADVANCED MATERIALS
(2022)
Meeting Abstract
Chemistry, Multidisciplinary
Michael Dalziel, Penghao Chen, Diane Carrera, Haiming Zhang, Francis Gosselin
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2017)
Meeting Abstract
Chemistry, Multidisciplinary
Penghao Chen, Guangbin Dong
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2015)
Meeting Abstract
Chemistry, Multidisciplinary
Colin Hayes, Philip Liu, Brennen Mueller, Penghao Chen, Paxton Thedford, William Bell, Paul Kohl, Guanbin Dong, Carlton Willson
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2015)
Article
Chemistry, Multidisciplinary
Alexander M. Prophet, Kritanjan Polley, Gary J. Van Berkel, David T. Limmer, Kevin R. Wilson
Summary: The oxidation kinetics of iodide by ozone at the air-water interface is studied in single microdroplets. Molecular simulations and kinetic modeling are used to understand the underlying multiphase mechanism.
Article
Chemistry, Multidisciplinary
Rong Zhang, Jiajing Lan, Fei Wang, Shumei Chen, Jian Zhang
Summary: By utilizing 1,1'-ferrocene dicarboxylic acid as a chelating and surface protection ligand, we have synthesized multi-nuclear indium oxide clusters with varying nuclear sizes, including heptanuclear and thirteen-nuclear clusters. These clusters possess labile coordination sites, allowing for structural modification and self-assembly, resulting in the formation of various cluster structures.
Article
Chemistry, Multidisciplinary
Hui Wang, Hui Liu, Mingsen Wang, Jiaheng Hou, Yongjun Li, Yuancheng Wang, Yingjie Zhao
Summary: Two supramolecular complexes were prepared using CBs and M1, and their single-crystal structures were analyzed by SCXRD. The unexpected 1:2 self-assembly structure between M1 and CB[8] was discovered for the first time. These complexes exhibit unique photophysical properties and provide valuable information about the structure and photophysical properties of supramolecular complexes.
Article
Chemistry, Multidisciplinary
Chang-Hee Lee, Sookil Park, Sanggil Kim, Ji Young Hyun, Hyun Soo Lee, Injae Shin
Summary: The epidermal growth factor receptor (EGFR) is a cell-surface glycoprotein involved in cell proliferation and tumor development. This study used a fluorescently labeled EGFR to investigate its time-dependent endocytosis in live cells and found that appended glycans affect EGFR internalization. Additionally, the study detected sialic acid residues attached to EGFR on the live cell surface using FRET-based imaging. This research provides valuable insights into the cellular functions of EGFR.
Article
Chemistry, Multidisciplinary
Subhankar Sahu, Lokesh Kumar, Sumita Das, Dipti Gupta, Ruchi Anand
Summary: This study proposes a strategy that combines organic electronics with biosensor scaffolds to create a compact device for monitoring environmental aromatic pollution. By coupling biosensing protein MopR with an organic electrochemical transistor (OECT), a sensor module capable of efficient detection of phenol was designed. Exclusive phenol detection with minimal loss of sensitivity could be achieved in complex pollutant mixtures and real environmental samples.
Review
Chemistry, Multidisciplinary
Changseok Lee, Hyung-Joon Kang, Sungwoo Hong
Summary: The formation of C-N bonds through hydroamination reactions catalyzed by nickel hydrides has been a topic of recent interest. This approach offers a way to efficiently transform a variety of alkene and alkyne substrates into compounds enriched with C-N bonds. The review provides a concise overview of the underlying reaction mechanisms and aims to stimulate further progress in NiH-catalytic techniques and catalyst design.
Article
Chemistry, Multidisciplinary
Yueci Wu, Lu-Lu Sun, Hai-Hao Han, Xiao-Peng He, Weiguo Cao, Tony D. James
Summary: Drug-induced liver injury (DILI) is a common cause of acute liver failure in the USA and Europe, but most cases can be recovered or prevented by discontinuing the offending drug. Recent research has found that peroxynitrite (ONOO-) can be used as a potential indicator for early diagnosis of DILI, and there is an urgent need to establish a method to detect and track peroxynitrite in DILI cases. In this study, a FRET-based nano fluorescent probe CD-N-I was developed, which showed high selectivity and sensitivity in detecting peroxynitrite. The probe successfully detected exogenous peroxynitrite in live cells and endogenous peroxynitrite in APAP-induced liver injury of HepG2 cells.
Article
Chemistry, Multidisciplinary
Dmitry L. Lipilin, Mikhail O. Zubkov, Mikhail D. Kosobokov, Alexander D. Dilman
Summary: This article describes a direct photocatalytic method for the thiolation of unprotected acids, which was previously challenging. By using a thionocarbonate reagent with an N-O bond, the efficient conversion of carboxylic acids to thiols is achieved.
Article
Chemistry, Multidisciplinary
Jason Malenfant, Lucille Kuster, Yohann Gagne, Kouassi Signo, Maxime Denis, Sylvain Canesi, Mathieu Frenette
Summary: Raman microscopy can reveal compound-specific vibrational fingerprints without sample preparation. The combination of efficient theoretical calculations and a user-friendly software can accurately predict peak positions and provide match scores to assist with structure determination.
Article
Chemistry, Multidisciplinary
Jayoh A. Hernandez, Paul S. Micus, Sean Alec Lois Sunga, Luca Mazzei, Stefano Ciurli, Gabriele Meloni
Summary: Essential trace metals play crucial roles in the survival and virulence of bacterial pathogens. Helicobacter pylori requires nickel for colonization and persistence in the stomach, and NixA is an essential nickel transporter in this process. This study characterizes the selectivity and electrogenic nature of NixA-mediated nickel transport.
Article
Chemistry, Multidisciplinary
Tarali Devi, Kuheli Dutta, Jennifer Deutscher, Stefan Mebs, Uwe Kuhlmann, Michael Haumann, Beatrice Cula, Holger Dau, Peter Hildebrandt, Kallol Ray
Summary: This study emphasizes the importance of subtle electronic changes and secondary interactions in the stability of biologically relevant metal-dioxygen intermediates. It also shows that the role of the chloride ligand in stabilizing the Fe-III-(OOBu)-Bu-t moiety can extend to other anions, including the thiolate ligand.
Article
Chemistry, Multidisciplinary
Jacqueline R. Santhouse, Jeremy M. G. Leung, Lillian T. Chong, W. Seth Horne
Summary: By studying the folding kinetics and mechanism of the BdpA sequence, researchers found that altering the backbone connectivity can affect protein folding. This suggests that protein mimetic chains have a significant degree of plasticity in transitioning between unfolded and folded states.
Article
Chemistry, Multidisciplinary
Divanshu Gupta, Ralf Einholz, Holger F. Bettinger
Summary: This study presents the first direct spectroscopic evidence of a cyclic seven-membered iminoborane. Compared to linear amino-iminoboranes, this cyclic iminoborane exhibits weakened bond strength and lower Lewis acidity value. The study suggests that the reduced ring strain of cyclic iminoborane prevents nitrogen fixation but allows facile (2 + 2) cycloaddition reaction with C2H4.
Article
Chemistry, Multidisciplinary
Renny Mathew, Aniruddha Mazumder, Praveen Kumar, Julie Matula, Sharmarke Mohamed, Petr Brazda, Mahesh Hariharan, Brijith Thomas
Summary: This study reveals the packing arrangement of partially disordered nitro-perylenediimide (NO2-PDI) using a synergistic approach that combines 3D ED, ssNMR, and DFT techniques. By overcoming these challenges, this methodology opens up new avenues for material characterization, driving exciting advancements in the field.
