Article
Biochemistry & Molecular Biology
Sadia Afrin, Malak El Sabah, Ahmed Manzoor, Mariko Miyashita-Ishiwata, Lauren Reschke, Mostafa A. Borahay
Summary: The aim of this study was to determine the cellular and molecular mechanisms by which adipocytes contribute to the initiation and promotion of uterine leiomyoma tumors. The results showed that adipocytes promote inflammation, fibrosis, and angiogenesis in leiomyoma cells by upregulating associated factors and transferring free fatty acids. Adipocyte-leiomyoma cell interaction increases the phosphorylation of NF-.B and enhances cell proliferation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Agriculture, Dairy & Animal Science
Wenxiang Shen, Ayodele Olaolu Oladejo, Xiaoyu Ma, Wei Jiang, Juanshan Zheng, Bereket Habte Imam, Shengyi Wang, Xiaohu Wu, Xuezhi Ding, Baohua Ma, Zuoting Yan
Summary: This study found that Cl-amidine effectively alleviated the inflammatory response to LPS-induced endometritis in rats by inhibiting the formation of NETs. Therefore, Cl-amidine could be a potential candidate for the treatment of endometritis.
Article
Environmental Sciences
Chenglin Yang, Yunqin Chen, Mengran Yang, Jiayan Li, You Wu, Hui Fan, Xiangyi Kong, Can Ning, Siqi Wang, Wenguang Xiao, Zhihang Yuan, Jine Yi, Jing Wu
Summary: Zearalenone (ZEA) is a mycotoxin that has estrogen-like biological activity and poses a major threat to animal reproduction. Betulinic acid (BA) is a natural plant compound with antioxidant and anti-inflammatory properties. This study found that ZEA caused uterine damage and altered hormone secretion, while BA showed a protective effect and reversed the damage caused by ZEA.
ENVIRONMENTAL POLLUTION
(2023)
Article
Pharmacology & Pharmacy
Chong Won Choi, Hyeongseop Keum, Seoyun Yang, Bo Mi Kang, Dohyeon Kim, Haiying Piao, Jee Woo Kim, Bo Ri Kim, Sang Woong Youn, Sangyong Jon
Summary: In this study, the antioxidant and anti-inflammatory effects of bilirubin-based nanoparticles (BRNPs) are investigated in the LL-37-induced rosacea-like mouse model. The results show that BRNPs significantly alleviate LL-37-induced inflammatory manifestation in the rosacea mouse model, decrease the level of ROS in the skin, and ameliorate vascular changes.
ADVANCED THERAPEUTICS
(2023)
Article
Immunology
Zhili Deng, San Xu, Qinqin Peng, Ke Sha, Wenqin Xiao, Tangxiele Liu, Yiya Zhang, Ben Wang, Hongfu Xie, Mengting Chen, Ji Li
Summary: Aspirin can improve skin inflammation in rosacea by modulating immune responses, suppressing Th1 and Th17 skewed immune responses, and reducing microvessel density and VEGF expression.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Immunology
Xiangyu Fan, Jini Qiu, Tianjie Yuan, Jing Zhang, Jianjiang Xu
Summary: The study demonstrates that Piperlongumine (PL) can exhibit both anti-angiogenic and anti-inflammatory effects in preventing corneal allograft rejection.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Erlinda The, Dennis M. de Graaf, Yufeng Zhai, Qingzhou Yao, Lihua Ao, David A. Fullerton, Charles A. Dinarello, Xianzhong Meng
Summary: This study found that IL-38 levels are lower in aortic valve interstitial cells (AVICs) from patients with calcific aortic valve disease (CAVD) compared to those without CAVD. Recombinant IL-38 suppressed inflammation and calcium deposition in AVICs. IL-38 also reduced the production of inflammatory mediators and inhibited the NLRP3 inflammasome and caspase-1 activation in AVICs. These findings suggest that IL-38 has therapeutic potential for preventing CAVD progression.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Biochemistry & Molecular Biology
Geraldine Brichant, Ines Laraki, Laurie Henry, Carine Munaut, Michelle Nisolle
Summary: Endometriosis is a chronic inflammatory disease causing pain and infertility, with current treatments focusing on medication and surgery. Medical treatments have not been able to cure the disease, highlighting the need for new biomedical targets. Non-coding RNAs are emerging as potential key players in the treatment of endometriosis and other human diseases like cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Joe A. Arosh, JeHoon Lee, Sakhila K. Banu
Summary: Endometriosis is an estrogen-dependent and progesterone-resistant inflammatory disease with a prevalence of 5-10% in reproductive-age women, increasing to 20-30% in women with subfertility. Dual inhibition of AKT and ERK1/2 pathways suppresses the growth of endometriotic lesions, decreases proinflammatory cytokines, E2 biosynthesis and signaling, and restores progesterone receptor-B signaling, suggesting a potential long-term nonsteroidal therapy for endometriosis.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Viktoria Denes, Akos Lukats, Gergely Szarka, Rovena Subicz, Adrienn Mester, Andrea Kovacs-Valasek, Peter Geck, Gergely Berta, Robert Herczeg, Etelka Postyeni, Attila Gyenesei, Robert Gabriel
Summary: Degenerative retinal disorders cause progressive cell death and inflammation, leading to blindness. The neuropeptide PACAP38 shows promise as a therapeutic agent due to its ability to promote cell proliferation and suppress microglia-mediated inflammation. This study aimed to investigate the effects of PACAP38 on cell proliferation and inflammatory response in the retina.
NEUROCHEMICAL RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Jiaxuan Tang, Chaofan Liu, Shiying Liu, Xing Zhou, Jinghao Lu, Ming Li, Lubing Zhu
Summary: 2-Methoxyestradiol (2-ME) has shown significant inhibition on proliferation, angiogenesis, and inflammation, making it a promising therapeutic agent for psoriasis.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Zeang Wu, Guangyuan Zhou, Haixia Wang, Ping Yao
Summary: This study identifies KIF23 as a key gene involved in idiopathic pulmonary arterial hypertension (IPAH) and pyroptosis. Knockdown of KIF23 suppresses pyroptosis and proliferation in pulmonary arterial smooth muscle cells (PASMCs), leading to a reduction in pulmonary arterial pressure and other symptoms of IPAH. The regulatory role of KIF23 may involve the PI3K/AKT and MAPK pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Liang-Hsuan Chen, Wei-Che Lo, Hong-Yuan Huang, Hsien-Ming Wu
Summary: Endometriosis is a chronic inflammatory disease that causes bothersome symptoms and long-term systemic impacts. It is characterized by the presence of endometrial-like tissue outside the uterus, leading to menstrual disorders, chronic pelvic pain, and infertility. The disease can also spread to extra-pelvic sites and cause systemic effects such as metabolic disorder, immune dysregulation, and cardiovascular diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Marie-Madeleine Dolmans, Jacques Donnez
Summary: Endometriosis is a chronic inflammatory disease that requires lifelong management. This review evaluates the pathways involved in endometriosis and explores new therapies. Inflammation and inflammatory molecules play a crucial role in the disease, and targeting inflammation, nuclear factor kappa B and cytokines, as well as pathways related to apoptosis and autophagy, may offer new perspectives for non-hormonal treatment.
Article
Obstetrics & Gynecology
A. Nenicu, K. Yordanova, Y. Gu, M. D. Menger, M. W. Laschke
Summary: The study found that there were no differences in growth, microvessel density, and cell proliferation between endometriotic lesions forming from menstrual and non-menstrual tissue fragments in non-ovariectomized mice. However, lesion formation from non-menstrual tissue fragments was suppressed in ovariectomized mice, which could be reversed by estrogen supplementation. On the other hand, endometriotic lesions from menstrual tissue fragments showed smaller volume in ovxthornE2 mice, indicating reduced hormone sensitivity.
HUMAN REPRODUCTION
(2021)
Article
Chemistry, Multidisciplinary
Tiffany H. Huang, Yi Pei, Douglas Zhang, Yanfen Li, Kristopher A. Kilian
Article
Biochemical Research Methods
Shamira Sridharan Weaver, Yanfen Li, Louis Foucard, Hassaan Majeed, Basanta Bhaduri, Alex J. Levine, Kristopher A. Kilian, Gabriel Popescu
JOURNAL OF BIOPHOTONICS
(2019)
Article
Chemistry, Multidisciplinary
Chelsea Anorma, Jamila Hedhli, Thomas E. Bearrood, Nicholas W. Pino, Sarah H. Gardner, Hiroshi Inaba, Pamela Zhang, Yanfen Li, Daven Feng, Sara E. Dibrell, Kristopher A. Kilian, Lawrence W. Dobrucki, Timothy M. Fan, Jefferson Chan
ACS CENTRAL SCIENCE
(2018)
Article
Multidisciplinary Sciences
Yanfen Li, Michael J. Fanous, Kristopher A. Kilian, Gabriel Popescu
SCIENTIFIC REPORTS
(2019)
Article
Chemistry, Multidisciplinary
Yi Pei, Sayyed Hamed Shahoei, Yanfen Li, Peter J. Reece, Erik R. Nelson, J. Justin Gooding, Kristopher A. Kilian
ADVANCED MATERIALS INTERFACES
(2018)
Article
Biochemical Research Methods
Michael J. Fanous, Yanfen Li, Mikhail E. Kandel, Amr A. Abdeen, Kristopher A. Kilian, Gabriel Popescu
JOURNAL OF BIOPHOTONICS
(2019)
Article
Multidisciplinary Sciences
L. Minh Dang, Sujin Lee, Yanfen Li, Chanmi Oh, Tan N. Nguyen, Hyoung-Kyu Song, Hyeonjoon Moon
Summary: Heat usage patterns are crucial for the effective management of district heating networks, but in-depth analyses of heat load profiles are rare. This study comprehensively investigates the major features of heat usage patterns and identifies the key factors affecting heat load patterns. Two primary daily heat usage patterns are extracted for efficient training of prediction models.
SCIENTIFIC REPORTS
(2022)
Article
Computer Science, Information Systems
Le Quan Nguyen, Van Dung Pham, Yanfen Li, Hanxiang Wang, L. Minh Dang, Hyoung-Kyu Song, Hyeonjoon Moon
Summary: The conventional heatmap regression with deep networks has achieved success in landmark detection, but fails to fully exploit the overall structure of landmarks. This paper proposes a new landmark detection method that models landmarks as a graph structure, enabling the capture of the overall structure. Experimental results demonstrate the robustness of the proposed method.
Article
Education, Scientific Disciplines
Yanfen Li, Adam St Jean
Summary: Journal clubs can enhance students' ability to analyze scientific literature and reduce stress levels in online courses. Traditional journal clubs and virtual journal clubs each have their own strengths and weaknesses.
JOURNAL OF MICROBIOLOGY & BIOLOGY EDUCATION
(2021)
Article
Nanoscience & Nanotechnology
Junmin Lee, Amr A. Abdeen, Yanfen Li, Shamalee Goonetilleke, Kristopher A. Kilian
Summary: The variability in stiffness within the tumor microenvironment impacts cancer cell phenotypes, with subtle increases in local stiffness promoting the cancer stem cell phenotype. Dynamic stiffness gradients play a role in regulating the dynamic plasticity of cancer cells during progression.
ACS APPLIED BIO MATERIALS
(2021)
Article
Education & Educational Research
Hsien-Yuan Hsu, Yanfen Li, Suzanne Dugger, James Jones
Summary: The study reveals that faculty encouragement significantly contributes to students' self-efficacy and outcome expectations, indirectly influencing their intent to persist in engineering majors through the pathway of self-efficacy. Additionally, students' perception of faculty encouragement plays a significant role in fostering self-efficacy and outcome expectations among engineering students.
EUROPEAN JOURNAL OF ENGINEERING EDUCATION
(2021)
Correction
Multidisciplinary Sciences
Yanfen Li, Michael J. Fanous, Kristopher A. Kilian, Gabriel Popescu
SCIENTIFIC REPORTS
(2020)
Article
Cell & Tissue Engineering
Yanfen Li, Claire B. Tang, Kristopher A. Kilian
CELLULAR AND MOLECULAR BIOENGINEERING
(2017)
Article
Engineering, Biomedical
Amr A. Abdeen, Junmin Lee, Yanfen Li, Kristopher A. Kilian
REGENERATIVE ENGINEERING AND TRANSLATIONAL MEDICINE
(2017)
Proceedings Paper
Optics
Shamira Sridharan, Yanfen Li, Basanta Bhaduri, Hassaan Majeed, Paul Dupenloup, Alex Levine, Kristopher A. Kilian, Gabriel Popescu
QUANTITATIVE PHASE IMAGING II
(2016)