Review
Chemistry, Medicinal
Stephen T. Sonis
Summary: Toxicities associated with radiation therapy can be effectively mitigated through interventions aimed at disrupting the biological cascade of toxicity development, with oxidative stress being a key initiator of normal tissue injury. Attempts to supplement endogenous superoxide dismutases or develop synthetic dismutase mimetics have shown some potential, with avasopasem manganese emerging as a promising dismutase mimetic in clinical trials for reducing severe oral mucositis in head and neck cancer patients undergoing chemoradiation.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Chemistry, Multidisciplinary
Ruomei Li, Zhiyu Zhu, Bolin Zhang, Ting Jiang, Cheng Zhu, Peng Mei, Yu Jin, Ruiqing Wang, Yixin Li, Weiming Guo, Chengxiao Liu, Lunguo Xia, Bing Fang
Summary: Manganese doping is used to enhance bone regeneration by regulating adaptive immunity. It leads to increased recruitment of CD4+ T cells and promotes Th2 cell polarization while inhibiting Th1 cell polarization. This immune environment facilitates the osteogenic ability of bone marrow stromal cells and achieves consequential regeneration of mandibular bone defect.
Article
Chemistry, Multidisciplinary
M. Dolores Garrido, Jamal El Haskouri, Maria D. Marcos, Francisco Perez-Pla, Jose Vicente Ros-Lis, Pedro Amoros
Summary: This study reports the preparation of a novel nanocomposite with enzyme-like activity for decomposing reactive oxygen species (ROS). The nanocomposite, consisting of MnOx needles covered with SiO2 porous material, was synthesized using a two-step procedure. The material was characterized, and its bimodal porosity and efficient enzyme activities were observed. The study also proposed reaction mechanisms and demonstrated the role of silica in catalase activity.
Article
Medicine, Research & Experimental
Ken-Ichiro Tanaka, Mikako Shimoda, Maho Kubota, Ayaka Takafuji, Masahiro Kawahara, Tohru Mizushima
Summary: Lecithinized superoxide dismutase (PCSOD) effectively ameliorates renal ischemia/reperfusion (I/R) injury by inhibiting ROS production, reducing markers of renal damage and fibrosis, and preventing the transition from acute kidney injury (AKI) to chronic kidney disease (CKD). This suggests that PCSOD could be a promising therapeutic agent for I/R-induced renal injury.
Review
Biochemistry & Molecular Biology
Xu Zhang, Depei Zhang, Li Xiang, Qiying Wang
Summary: Manganese superoxide dismutase exhibits rapid product inhibition at high temperatures but is less inhibited at lower temperatures. The temperature-dependent kinetics can be explained by changes in coordination of manganese superoxide dismutase. Cold activation of the enzyme is an adaptive response to low temperatures and plays a role in cold stress signaling and physiological responses.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2022)
Article
Health Care Sciences & Services
Irina A. Mednova, Liudmila P. Smirnova, Alisa R. Vasilieva, Daria Kazantseva, Elena Epimakhova, Nina M. Krotenko, Arkadiy Semke, Svetlana A. Ivanova
Summary: This study demonstrates that patients with schizophrenia have SOD activity in their IgG, and the highest activity is observed in patients in therapeutic remission. The mechanism of SOD activity in IgG is similar to classical enzyme catalysis, with a higher affinity for the substrate than classical SOD enzyme.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Debbie S. Retnoningrum, Hiromi Yoshida, Muthia D. Razani, Rahmat Muliadi, Vincencius F. Meidianto, Anita Artarini, Wangsa T. Ismaya
Summary: The dimeric form of manganese superoxide dismutase is crucial for its enzymatic activity, with the introduction of a disulphide bond at the dimer interface to prevent dissociation. The mutant S126C showed imperfect bonding of S-S bonds compared to the wild type, leading to a decrease in enzyme activity.
JOURNAL OF STRUCTURAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Visarut Buranasudja, Dolly Rani, Ashwini Malla, Khwanlada Kobtrakul, Sornkanok Vimolmangkang
Summary: Formation of oxidative stress in dermal fibroblasts is crucial for skin aging, and using phytochemicals to enhance the cells' ability to combat oxidative stress is a promising strategy to prevent skin aging. Callus culture of Centella asiatica produces unique antioxidant compounds that exhibit anti-skin-aging activities, including upregulation of cellular antioxidant enzymes and inhibition of matrix metalloprotease-9 induction. This highlights the potential of C. asiatica callus extract as an effective anti-skin-aging agent in cosmeceutical preparations.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Debbie S. Retnoningrum, Hiromi Yoshida, Ismiana Pajatiwi, Rahmat Muliadi, Ratna A. Utami, Anita Artarini, Wangsa T. Ismaya
Summary: The manganese superoxide dismutase from Staphylococcus equorum (MnSODSeq) has shown robust activity under various conditions. Strengthening the interactions between the monomers is crucial for improving the enzyme stability. A new strategy using K38R-A121E/Y double substitutions has been proposed, resulting in mutants with similar enzyme activity and enhanced thermal stability. The structure of the L169W mutant was also elucidated, revealing the impact of intramolecular modification on enzyme stability.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2023)
Article
Oncology
Merce Juliachs, Mireia Pujals, Chiara Bellio, Nathalie Meo-Evoli, Juan M. Duran, Esther Zamora, Mireia Pares, Anna Sunol, Olga Mendez, Alex Sanchez-Pla, Francesc Canals, Cristina Saura, Josep Villanueva
Summary: This study aims to find circulating biomarkers for monitoring the response to cancer therapy. The research found that the release of SOD2 protein during chemotherapy treatment is associated with tumor cell death, and the increase in its circulating levels correlates with treatment response, which can be used for non-invasive monitoring of breast cancer patients.
Article
Biochemistry & Molecular Biology
Lara Rouco, Rebeca Alvarino, Amparo Alfonso, Maria J. Romero, Rosa Pedrido, Marcelino Maneiro
Summary: This study investigates the antioxidant properties of four manganese(II) complexes with fluorescent dyes and their protective effects on SH-SY5Y neuroblastoma cells. The complexes showed significant antioxidant activity and improved cell survival by reducing reactive oxygen species release. The incorporation of the fluorescent label allowed the study of their cellular uptake in the neuroblastoma cells.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2022)
Article
Immunology
Hangeun Kim, Hyeoung-Eun Kim, Dae Kyun Chung, Kyoung Ok Jang
Summary: Lipoteichoic acid (aLTA) from Staphylococcus aureus regulates cytokine production through multiple signaling pathways, with MnSOD playing a crucial role in this regulation.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2022)
Article
Cardiac & Cardiovascular Systems
Jung-Lye Kim, Brenda F. Reader, Curtis Dumond, Yonggyu Lee, Nahush A. Mokadam, Sylvester M. Black, Bryan A. Whitson
Summary: Polyethylene glycol-catalase (PEG-CAT) has been shown to protect against ischemia-reperfusion injury in lung transplants by reducing oxidative stress-induced cytotoxicity, maintaining cellular metabolism, and improving allograft viability.
ANNALS OF THORACIC SURGERY
(2021)
Article
Pharmacology & Pharmacy
Kai-yu Huang, Yong-wei Yu, Shuai Liu, Ying-ying Zhou, Jin-sheng Wang, Yang-pei Peng, Kang-ting Ji, Yang-jing Xue
Summary: The research shows that ASIV can alleviate myocardial I/R injury by regulating autophagy, and O-2(center dot-) plays a vital role in this process.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Plant Sciences
Pavol Melicher, Petr Dvorak, Yuliya Krasylenko, Alexey Shapiguzov, Jaakko Kangasjarvi, Jozef Samaj, Tomas Takac
Summary: This study characterized the role of FSD1 in response to oxidative stress in Arabidopsis thaliana, and found that its antioxidant function depends on the availability of Cu2+ in the growth media. Chloroplastic localization of FSD1 is crucial for maintaining redox homeostasis.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Tao Luo, Baihe Chen, Xianbao Wang
CHEMICO-BIOLOGICAL INTERACTIONS
(2015)
Article
Biochemistry & Molecular Biology
Tao Luo, Jin Kyung Kim, Baihe Chen, Ahmed Abdel-Latif, Masafumi Kitakaze, Liang Yan
CHEMICO-BIOLOGICAL INTERACTIONS
(2015)
Article
Biochemistry & Molecular Biology
Weihua Jiang, Jing Zhu, Xun Zhuang, Xiping Zhang, Tao Luo, Karyn A. Esser, Hongmei Ren
JOURNAL OF BIOLOGICAL CHEMISTRY
(2015)
Review
Cardiac & Cardiovascular Systems
Tao Luo, Jin Kyung Kim
CANADIAN JOURNAL OF CARDIOLOGY
(2016)
Article
Cardiac & Cardiovascular Systems
Yongkang Zhong, Peiyao Zhong, Shangfei He, Ya Zhang, Lu Tang, Yuanna Ling, Shanshan Fu, Ying Tang, Pingzhen Yang, Tao Luo, Baihe Chen, Aihua Chen, Xianbao Wang
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
(2017)
Article
Oncology
Huixiong Tang, Xudong Song, Yuanna Ling, Xianbao Wang, Pingzhen Yang, Tao Luo, Aihua Chen
MOLECULAR MEDICINE REPORTS
(2017)
Article
Cardiac & Cardiovascular Systems
Tao Luo, Baihe Chen, Zonglei Zhao, Nvqin He, Zhi Zeng, Bing Wu, Yasushi Fukushima, Meng Dai, Qiaobing Huang, Dingli Xu, Jianping Bin, Masafumi Kitakaze, Yulin Liao
BASIC RESEARCH IN CARDIOLOGY
(2013)
Article
Medicine, Research & Experimental
Zhi Zeng, Liang Shen, Xixian Li, Tao Luo, Xuan Wei, Jingwen Zhang, Shiping Cao, Xiaobo Huang, Yasushi Fukushima, Jianping Bin, Masafumi Kitakaze, Dingli Xu, Yulin Liao
Letter
Cardiac & Cardiovascular Systems
Xianbao Wang, Fei He, Yulin Liao, Xudong Song, Min Zhang, Lingling Qu, Tao Luo, Shanshan Zhou, Yuanna Ling, Jingbin Guo, Aihua Chen
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2013)
Article
Cardiac & Cardiovascular Systems
Yulin Liao, Jianping Bin, Tao Luo, Hui Zhao, Catherine Ledent, Masanori Asakura, Dingli Xu, Seiji Takashima, Masafumi Kitakaze
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2013)
Article
Multidisciplinary Sciences
Jing Ma, Tao Luo, Zhi Zeng, Haiying Fu, Yoshihiro Asano, Yulin Liao, Tetsuo Minamino, Masafumi Kitakaze
SCIENTIFIC REPORTS
(2016)