Article
Genetics & Heredity
Xiaolong Tian, Jun Ma, Yijing Wu, Pan Zhang, Qinggang Li, Hao Zhang, Changxin Wu
Summary: High-altitude adaptation in Tibetan pigs is associated with positively-selected genes, with the BNP gene playing a critical role. The C-1780G polymorphic site in the BNP gene is advantageous for high-altitude adaptation in pigs by upregulating BNP expression. This study provides insights into the mechanism underlying the involvement of the BNP gene in high-altitude adaptation.
Article
Genetics & Heredity
Tao Wang, Yuanyuan Guo, Shengwei Liu, Chaoxin Zhang, Tongyan Cui, Kun Ding, Peng Wang, Xibiao Wang, Zhipeng Wang
Summary: By analyzing the transcriptional data of Tibetan pigs and Rongchang pigs, it was found that lung tissue may play a crucial role in the adaptation of Tibetan pigs to high-altitude hypoxic environments, with some potential regulatory genes identified.
FRONTIERS IN GENETICS
(2021)
Article
Veterinary Sciences
Binlong Chen, Diyan Li, Bo Ran, Pu Zhang, Tao Wang
Summary: The study identified specific miRNAs and genes related to high-altitude adaptation in Tibetan chickens, shedding light on the physiological mechanisms of adaptation to extreme environmental conditions. These findings may contribute to breeding efforts for improved high-altitude breeds.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Cell Biology
Matthew A. Reyer, Shriram Chennakesavalu, Emily M. Heideman, Xiangqian Ma, Magda Bujnowska, Lu Hong, Aaron R. Dinner, Carin K. Vanderpool, Jingyi Fei
Summary: Small RNAs (sRNAs) are important gene regulators in bacteria, acting post-transcriptionally by affecting translation and degradation of target mRNAs. Some sRNAs can regulate targets co-transcriptionally early in an mRNA's lifetime, potentially mediated by Rho-dependent termination. Data also reveals that certain kinetic steps and sRNA binding to target mRNA may dictate the regulation hierarchy within sRNA regulons.
Article
Physiology
Huifang Liu, Noryung Tenzing, Martha Tissot van Patot, Muge Qile, Ri-li Ge, Tana Wuren
Summary: The Tibetan population has adapted to the challenges of high-altitude living over thousands of years, with their placental mitochondria showing greater respiratory function compared to lower-altitude Tibetans and Han Chinese. This increased mitochondrial respiration in high-altitude Tibetans may represent an acute response that induces mitochondrial adaptations to protect against acute ischemic/hypoxic insult during labor.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Kevin Rychel, Katherine Decker, Anand Sastry, Patrick Phaneuf, Saugat Poudel, Bernhard O. Palsson
Summary: iModulonDB is a knowledgebase of prokaryotic transcriptional regulation computed from high-quality transcriptomic datasets using Independent Component Analysis (ICA). Users can select an organism, search or browse curated iModulons, and access interactive dashboards with plots and tables for each iModulon and gene. This site enhances research by providing scientists with co-expressed gene sets and their activities, improving understanding of regulator-gene relationships and facilitating the discovery of transcription factors.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Multidisciplinary Sciences
Shaoli Yao, Xiwen Chen, Yao Zhou, Li Xu, Qi Zhang, Shimin Bao, Huiru Feng, Weihong Ge
Summary: This study investigated the relationship between residence altitude and serum folate levels in healthy Tibetans living on the Tibetan Plateau, and found a negative correlation between altitude and serum folate levels.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Applied
Weikang Zheng, Shiqi Yu, Wang Zhang, Shanshan Zhang, Jialing Fu, Hong Ying, Gesang Pingcuo, Shengjun Liu, Fan Zhao, Qingjiang Wu, Qiang Xu, Zhaocheng Ma, Xiuli Zeng
Summary: This study found that there is abundant variation in carotenoids in Tibetan peach fruit growing on the Tibetan Plateau, and it is highly associated with high-altitude adaptations.
Article
Multidisciplinary Sciences
Pawel Mikulski, Philip Wolff, Tiancong Lu, Mathias Nielsen, Elsa Franco Echevarria, Danling Zhu, Julia Questa, Gerhard Saalbach, Carlo Martins, Caroline Dean
Summary: This study reveals that cold-induced silencing of Arabidopsis FLC requires the binding of VAL1 to an intronic motif. Additionally, the interacting partner complexes of VAL1, ASAP and PRC1, mediate co-transcriptional repression and chromatin modulation to effectively co-ordinate different steps in FLC silencing.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Chunhuai Yang, Chunwei Cao, Jiali Liu, Ying Zhao, Jianfei Pan, Cong Tao, Yanfang Wang
Summary: Cold stress leads to piglet death and economic losses. This study revealed the different transcriptional responses of skeletal muscle to cold stimulation in Tibetan pigs and Bama pigs, providing novel insights for future investigation of the cold adaptation mechanism in pigs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Agriculture, Dairy & Animal Science
Pengfei Zhao, Shaobin Li, Zhaohua He, Fangfang Zhao, Jiqing Wang, Xiu Liu, Mingna Li, Jiang Hu, Zhidong Zhao, Yuzhu Luo
Summary: The study reveals the physiological and proteomic basis of Tibetan sheep lungs during their adaptation to high-altitude hypoxia, providing a reference for the prevention of altitude sickness in humans.
Article
Biochemistry & Molecular Biology
Chao Li, Yujiang Wu, Bingchun Chen, Yudong Cai, Jiazhong Guo, Alexander S. Leonard, Peter Kalds, Shiwei Zhou, Jingchen Zhang, Ping Zhou, Shangqu Gan, Ting Jia, Tianchun Pu, Langda Suo, Yan Li, Ke Zhang, Lan Li, Myagmarsuren Purevdorj, Xihong Wang, Ming Li, Yu Wang, Yao Liu, Shuhong Huang, Tad Sonstegard, Ming-Shan Wang, Stephen Kemp, Hubert Pausch, Yulin Chen, Jian-Lin Han, Yu Jiang, Xiaolong Wang
Summary: Understanding the genetic mechanism of how animals adapt to extreme conditions is fundamental to determine the relationship between molecular evolution and changing environments. In this study, the researchers analyzed the genomes of domestic goats and wild caprid species living at different altitudes to uncover the genetic determinants underlying their adaptation to harsh conditions on the Qinghai-Tibetan Plateau. They found a strong association between the PAPSS2 gene and high-altitude adaptability in Tibetan goats. Transcriptomic data and functional experiments further supported the role of PAPSS2 in response to hypoxia. It was also discovered that the PAPSS2 haplotype in Tibetan goats originated from a recent hybridization event between goats and markhor.
MOLECULAR BIOLOGY AND EVOLUTION
(2022)
Article
Biochemistry & Molecular Biology
Yuzhou Wang, Yu Zhang, Ning Yu, Bingyan Li, Jiazhen Gong, Yide Mei, Jianqiang Bao, Shisong Ma
Summary: Researchers developed a universal human gene expression predictor called EXPLICIT-Human and used it to decode transcriptional regulation. The predictor accurately reconstructed transcriptomes for a wide range of tissues and conditions using the expression of 1613 transcription factors. It extracted significant interacting TF-target gene pairs, enabling inference of TF regulators for various pathways. The method showed better performance in recovering the correct TF regulators compared to existing tools.
JOURNAL OF GENETICS AND GENOMICS
(2023)
Article
Biochemistry & Molecular Biology
Xiuqin Yang, Xiaohan Zhang, Zewei Yang, Qian Zhang, Wanjun Hao, Yu Pang, Dongjie Zhang, Di Liu
Summary: This study reveals the important role of ACSL1 in fatty acid metabolism and fat deposition, and identifies C/EBPα as a key transcription factor regulating ACSL1 expression. Other transcription factors, such as cAMP-response element binding protein, are also involved in the regulation of ACSL1 gene expression.
Article
Biotechnology & Applied Microbiology
Chunmei Cai, Yingzhong Yang, Qin Ga, Guocai Xu, Rili Ge, Feng Tang
Summary: This study revealed the genetic adaptations of Tibetan Mastiff and Canis Lupus to high altitude, including the expansion of gene families related to DNA repair and damage response, contraction related to ATPase activity, and positive selection for fatty-acid oxidation and DNA repair genes.
Article
Agriculture, Dairy & Animal Science
H. Y. Liu, M. H. Sun, G. Q. Yang, C. L. Jia, M. Zhang, Y. J. Zhu, Y. Zhang
JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION
(2015)
Article
Genetics & Heredity
Cunling Jia, Zehui Wei
MITOCHONDRIAL DNA PART A
(2016)
Article
Genetics & Heredity
Cunling Jia, Zehui Wei
MITOCHONDRIAL DNA PART A
(2016)
Article
Biotechnology & Applied Microbiology
Zehui Wei, Pengcheng Li, Sijia Huang, Purevsuren Lkhagvagarav, Mengqi Zhu, Chuanyu Liang, Cunling Jia
Article
Agriculture, Dairy & Animal Science
S. J. Huang, L. Purevsuren, F. Jin, Y. P. Zhang, C. Y. Liang, M. Q. Zhu, F. Wang, C. L. Jia, Z. H. Wei
Summary: The study elucidated the role of AMH in regulating ovarian follicle development in laying hens by measuring expression of relevant genes and treating hens with AMH. Results showed changes in gene expressions post-follicular selection and significant effects on ovarian morphology and hormone levels after AMH injection.
Article
Genetics & Heredity
Jianfang Wang, Jie Sui, Chao Mao, Xiaorui Li, Xingyi Chen, Chengcheng Liang, Xiaohui Wang, Si-Hu Wang, Cunling Jia
Summary: Periodic changes in hair follicle development in cashmere goats are influenced by regulatory molecules and signal pathways. WGCNA analysis identified 6 coexpression modules closely related to the hair follicle cycle, suggesting potential candidate markers for improving cashmere production.