Article
Endocrinology & Metabolism
Yun Yu, Kaipeng Xie, Qinglin Lou, Hui Xia, Dan Wu, Lingli Dai, Cuining Hu, Shan Shan, Kunlin Wang, Wei Tang
Summary: The clinical characteristics of elderly patients with type 2 diabetes vary with different durations of diabetes. Achieving control targets for various indicators and the occurrence of diabetic vascular complications differ among different durations of diabetes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xiao Li, Beibei Sun, Lingling Wang, Jin Zhang, Jianjian Zhang, Zizhou Zhao, Hengqu Wu, Xiaosheng Liu, Yan Zhou, Mahmud Mossa-Basha, David L. Tirschwell, Jianrong Xu, Huilin Zhao, Chengcheng Zhu
Summary: This study aimed to evaluate the association of diabetes and glycemic control with intracranial atherosclerotic plaque characteristics in patients after acute ischemic stroke. The results showed that T2DM was associated with increased intracranial plaque number, and higher HbA1c levels were associated with stronger plaque enhancement.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Rui-Ying Li, Jia-Wei Yu, Xiao-Hui Chen, Qiao-Qiao Han, Hong Ge, Cheng Li, Shenghong Ju, Deng-Ling Zhao
Summary: The study investigated the association between pre-diabetes and Type 2 diabetes mellitus with intracranial plaque characteristics in patients with acute ischemic stroke. It was found that pre-diabetes and T2DM patients showed similar vulnerability in intracranial atherosclerotic plaques, with increased plaque burden and enhancement ratio. Monitoring blood glucose levels in non-diabetic stroke patients may be necessary to prevent plaque vulnerability.
BRITISH JOURNAL OF RADIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Louise Menegaut, Aline Laubriet, Valentin Crespy, Damien Leleu, Thomas Pilot, Kevin Van Dongen, Jean-Paul Pais de Barros, Thomas Gautier, Jean-Michel Petit, Charles Thomas, Maxime Nguyen, Eric Steinmetz, David Masson
Summary: This study aimed to investigate the increase of 2-AA-LPC in carotid plaques from T2DM and control patients and explore its association with plaque vulnerability and biomarkers altered during diabetes. The results showed that 2-AA-LPC was significantly enriched in plaques from diabetic patients and correlated with inflammatory markers within the plaques. This highlights the involvement of local inflammation, arachidonic acid metabolism, and diabetes in the pathogenesis of atherosclerosis.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Endocrinology & Metabolism
Minhua Shen, Zhen Li, Huizhi Li, Xinfeng Yan, Bo Feng, Lei Xu
Summary: The aim of this study was to investigate the association between periodontitis and tooth loss with the extent of diabetic coronary atherosclerosis. The results showed that both tooth loss and clinical attachment loss (CAL) were significantly higher in patients with moderate-to-severe coronary atherosclerosis. Salivary inflammatory factors and oral bacteremia may serve as new biomarkers for moderate-to-severe coronary atherosclerosis.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Zhe Huang, Lucija Klaric, Justina Krasauskaite, Stela McLachlan, Mark W. J. Strachan, James F. Wilson, Jackie F. Price
Summary: The study investigated the association between serum metabolomic profile and ankle brachial index (ABI) as well as CVD in individuals with type 2 diabetes. The results showed that certain metabolites were associated with ABI and prevalent as well as incident CVD, suggesting their potential role as biomarkers in atherosclerotic CVD in individuals with type 2 diabetes.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Endocrinology & Metabolism
Meng Zhang, Gezhi Xu, Lu Ruan, Xin Huang, Ting Zhang
Summary: This study investigated the clinical features and surgical outcomes of proliferative diabetic retinopathy (PDR) in patients with type 2 diabetes. The study found that young patients with PDR had more severe clinical characteristics before surgery and a higher incidence of postoperative recurrent retinal detachment.
DIABETES METABOLIC SYNDROME AND OBESITY
(2023)
Article
Endocrinology & Metabolism
Jie Lin, Xin Xiang, Yahui Qin, Jing Gui, Qin Wan
Summary: This study found a negative correlation between thyroid-related hormones fT3 and fT3/fT4 ratio and the prevalence of diabetic peripheral neuropathy (DPN) in T2DM patients, while fT4 was positively correlated with DPN prevalence.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Multidisciplinary Sciences
Diana Indyk, Agnieszka Bronowicka-Szydelko, Andrzej Gamian, Aleksandra Kuzan
Summary: This study discusses the role of Advanced Glycation End Products (AGEs) in patients with diabetes, including the determination of the concentrations of different AGEs and their receptors in serum samples, as well as the correlation with treatments such as metformin and aspirin. The results demonstrate the involvement of AGEs in the pathogenesis of diabetes and other degenerative diseases, highlighting the potential of AGEs as important diagnostic markers for disease progression and therapy effectiveness.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Rakin Hadad, Sarah F. Akobe, Philip Weber, Christoffer Madsen, Bjorn Stroier Larsen, Sten Madsbad, Olav W. Nielsen, Maria Helena Dominguez, Steen B. Haugaard, Ahmad Sajadieh
Summary: Autonomic imbalance reflected by higher resting heart rate and reduced parasympathetic tone may be driven by low-grade inflammation and impaired glycemic control in type 2 diabetes mellitus (T2DM) and pre-diabetes. This study found that parasympathetic activity, measured by heart rate variability (HRV), was significantly inversely correlated with levels of HbA1c and CRP in individuals with T2DM and pre-diabetes. The association remained significant even after adjusting for age, sex, smoking, and BMI, suggesting that glycemic control may play a larger role in parasympathetic tone than inflammation.
SCIENTIFIC REPORTS
(2022)
Article
Endocrinology & Metabolism
Aleksander L. Hansen, Reimar W. Thomsen, Charlotte Brons, Helene M. L. Svane, Rasmus T. Jensen, Mette K. Andersen, Torben Hansen, Jens S. Nielsen, Peter Vestergaard, Kurt Hojlund, Niels Jessen, Michael H. Olsen, Henrik T. Sorensen, Allan A. Vaag
Summary: Low birthweight is associated with earlier onset of type 2 diabetes and lower BMI and waist circumference. Individuals with low birthweight have more comorbidities and require more medication for glucose-lowering and hypertension control.
Article
Immunology
Yanyan Que, Man Cao, Jianquan He, Qiang Zhang, Qiongyun Chen, Changsheng Yan, Aiqiang Lin, Luxi Yang, Zezhen Wu, Dan Zhu, Fengwu Chen, Zhangran Chen, Chuanxing Xiao, Kaijian Hou, Bangzhou Zhang
Summary: Research shows significant differences in microbial diversity between individuals with type 2 diabetes mellitus (T2DM) and controls, but not in microbial alpha diversity. Various operational taxonomic units (OTUs) and bacterial genera with significant odds ratios for T2DM were identified. The microbial characteristics of T2DM can be applied to other studies, improving detection accuracy and disease specificity for T2DM through training on multiple research studies.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Gisoo Darban Hosseini Amirkhiz, Mohammad Reza Babaei, Nahid Hashemi Madani, Mohammad Ebrahim Khamseh
Summary: In patients with type 2 diabetes, TBI is significantly correlated with right carotid intima-media thickness and can be used as a predictor for subclinical carotid atherosclerosis, while there is no significant association between ABI and increased CIMT.
Review
Endocrinology & Metabolism
Shenghui Ge, Mengge Yang, Yuying Cui, Jing Wu, Lusi Xu, Jianjun Dong, Lin Liao
Summary: MODY5, a rare disease, is easily misdiagnosed as type 2 diabetes. Clinical characteristics of MODY5 include low or normal BMI, renal cysts, hypomagnesemia, and pancreatic dysplasia. Genetic testing can help differentiate MODY5 from other types of diabetes at an earlier stage.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Daniel C. Parker, Ma Wan, Kurt Lohman, Li Hou, Anh Tram Nguyen, Jingzhong Ding, Alain Bertoni, Steve Shea, Gregory L. Burke, David R. Jacobs, Wendy Post, David Corcoran, Ina Hoeschele, John S. Parks, Yongmei Liu
Summary: miRNAs play a role in the occurrence and development of type 2 diabetes (T2D) and are also associated with lipid levels.
Article
Pharmacology & Pharmacy
Xingyun Zhu, Chu Lin, Li Li, Suiyuan Hu, Xiaoling Cai, Linong Ji
Summary: SGLT2 inhibitors treatment increases plasma fasting glucagon levels in patients with diabetes, potentially leading to reduced insulin levels and elevated ketone body levels.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Review
Cell Biology
Suiyuan Hu, Chu Lin, Xiaoling Cai, Xingyun Zhu, Fang Lv, Lin Nie, Linong Ji
Summary: The study found that bDMARD users had significantly reduced risks of myocardial infarction, heart failure, cardiovascular death, all-cause mortality, and 3P-MACE compared to non-users, especially in patients with rheumatoid arthritis. TNF-alpha inhibitors showed consistent benefits in reducing the risks of cardiovascular events. Furthermore, bDMARD users with follow-up over one year had significantly reduced risks of heart failure, cardiovascular death, all-cause mortality, and 3P-MACE.
MEDIATORS OF INFLAMMATION
(2021)
Review
Endocrinology & Metabolism
Xiaoling Cai, Chu Lin, Wenjia Yang, Lin Nie, Linong Ji
Summary: Compared with placebo, non-insulin antidiabetes agents as an adjunct to insulin treatment in patients with type 1 diabetes can lead to decreased glycated hemoglobin levels and body weight, as well as reduced insulin dosage, but also come with increased risks of hypoglycemia and gastrointestinal side effects.
DIABETES & METABOLISM JOURNAL
(2021)
Letter
Endocrinology & Metabolism
Chu Lin, Xiaoling Cai, Linong Ji
DIABETES OBESITY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Wei Liu, Yunke Ma, Xiaoling Cai, Yu Zhu, Mingxia Zhang, Juan Li, Jing Chen, Dawei Shi, Linong Ji
Summary: This study examines the relationship between C-peptide secretion and time in range (TIR) in adult patients with type 1 diabetes. The results show that preserved C-peptide secretion is associated with higher TIR and lower glucose variability.
ENDOCRINE CONNECTIONS
(2022)
Article
Medicine, General & Internal
Shuzhen Bai, Chu Lin, Ruoyang Jiao, Xiaoling Cai, Suiyuan Hu, Fang Lv, Wenjia Yang, Xingyun Zhu, Linong Ji
Summary: Disparities in cardiovascular and renal outcomes were found among different subtypes of glucagon-like peptide 1 receptor agonist (GLP-1RA). This study aimed to assess the association between the characteristics of GLP-1RA and the risks of cardiovascular and renal outcomes in patients with type 2 diabetes (T2D), including the steady-state concentration, duration of action, and molecular weight.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Chu Lin, Xingyun Zhu, Ruoyang Jiao, Xiaoling Cai, Suiyuan Hu, Fang Lv, Wenjia Yang, Zonglin Li, Linong Ji
Summary: This study aimed to assess the population attributable fractions (PAFs) for modifiable risk factors for microvascular complications of type 2 diabetes (T2D) in China. Data from the China National HbA1c Surveillance System were analyzed to calculate PAFs for diabetic microvascular complications, including diabetic retinopathy, diabetic kidney disease, and distal symmetric polyneuropathy. The study found that suboptimal glycemic and blood pressure control were the main contributors to these complications, while the impact of unmet LDL-C and BMI control targets was limited.
DIABETES OBESITY & METABOLISM
(2023)
Review
Medicine, General & Internal
Suiyuan Hu, Chu Lin, Xiaoling Cai, Zonglin Li, Linong Ji
Summary: A decline in baseline HbA1c levels and an increase in baseline BMI levels were observed in placebo-controlled trials over the past 35 years, indicating improved glycemic control and the urgency for obesity management in T2D.
Review
Cardiac & Cardiovascular Systems
Zonglin Li, Chu Lin, Xiaoling Cai, Suiyuan Hu, Fang Lv, Wenjia Yang, Xingyun Zhu, Linong Ji
Summary: This study evaluated the association between anti-inflammatory therapies and the incidence of cardiovascular events in patients with established cardiovascular disease or high cardiovascular risks. The results showed that anti-inflammatory therapies were associated with a decreased incidence of myocardial infarction, especially those targeting the central IL-6 signaling pathway. IL-1 inhibitor treatment was associated with a reduced risk of heart failure, while colchicine treatment was associated with a lower incidence of stroke. The risk reduction of myocardial infarction by anti-inflammatory therapies appeared to be more prominent in older patients with long follow-up duration.
Article
Endocrinology & Metabolism
Fang Lv, Xiaoling Cai, Yufeng Li, Xiuying Zhang, Xianghai Zhou, Xueyao Han, Linong Ji
Summary: This study evaluated the association between sensitivity to thyroid hormone and metabolic syndrome and its components in a Chinese population. The results showed that reduced thyroid hormone sensitivity was significantly associated with metabolic syndrome and its components. This suggests that impaired thyroid hormone sensitivity may affect the distribution of adipose tissue and muscle.
JOURNAL OF DIABETES
(2023)
Article
Cardiac & Cardiovascular Systems
Zonglin Li, Fang Lv, Xin Wen, Chengcheng Guo, Li Li, Xiaoling Cai, Chu Lin, Mengqing Zhang, Wenjia Yang, Linong Ji
Summary: This study investigates the cardiovascular prognosis in an ATTR-CA mouse model with dapagliflozin treatment. The results indicate that dapagliflozin does not improve cardiovascular prognosis, including heart failure progression, cardiac inflammation, and pathological changes in ATTR-CA mice compared with placebo.
Review
Endocrinology & Metabolism
Fang Lv, Xiaoling Cai, Chu Lin, Wenjia Yang, Suiyuan Hu, Linong Ji
Summary: This study aimed to investigate the association between proprotein convertase subtilisin/kexin type 9 inhibitors (PCSK9i) therapy and the risk of fracture. The results showed that PCSK9i therapy was not associated with major osteoporotic fracture, hip fracture, osteoporotic non-vertebral fracture, and total fracture over a period of 6-64 months.
CALCIFIED TISSUE INTERNATIONAL
(2023)
Article
Endocrinology & Metabolism
Yunke Ma, Chu Lin, Xiaoling Cai, Suiyuan Hu, Xingyun Zhu, Fang Lv, Wenjia Yang, Linong Ji
Summary: The aim of this study was to investigate the association between baseline renal characteristics and disparities in renal outcomes among patients with SGLT2i treatment. Event-driven randomized controlled trials were included, and sensitivity analyses on prespecified eGFR and UACR subgroups were conducted. The use of SGLT2i was consistently associated with improved renal prognosis, with renal benefits independent of baseline eGFR and more pronounced in patients with mildly or severely increased albuminuria.
ACTA DIABETOLOGICA
(2023)
Review
Medicine, General & Internal
Wenjia Yang, Xiaoling Cai, Chu Lin, Fang Lv, Xingyun Zhu, Xueyao Han, Linong Ji
Summary: This study evaluated the reductions of CRP and LDL-C in different lipid-lowering drugs and the relationships between these reductions and cardiovascular events. The results showed that statins, ezetimibe, and PCSK9-mAbs are effective in reducing LDL-C levels. Statins and ezetimibe also had a significant effect on CRP. The traditional lipid-lowering strategy, including statins and ezetimibe, showed similar benefit on CV outcomes compared with PCSK9-mAbs treatment.
Review
Endocrinology & Metabolism
Fang Lv, Xiaoling Cai, Linong Ji
Summary: Osteogenesis imperfecta, a heterogeneous disorder characterized by bone fragility, has been studied using genetic causes and animal models, which are important for clinical diagnosis and therapeutic approaches.
CALCIFIED TISSUE INTERNATIONAL
(2022)
