Insights into the Conformation of the Membrane Proximal Regions Critical to the Trimerization of the HIV-1 gp41 Ectodomain Bound to Dodecyl Phosphocholine Micelles

Trimerization of the HIV Transmembrane Domain in Lipid Bilayers Modulates Broadly Neutralizing Antibody Binding

(2016) Timothy M. Reichart et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Dependence of Distance Distributions Derived from Double Electron-Electron Resonance Pulsed EPR Spectroscopy on Pulse-Sequence Time

(2015) James L. Baber et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The C34 Peptide Fusion Inhibitor Binds to the Six-Helix Bundle Core Domain of HIV-1 gp41 by Displacement of the C-Terminal Helical Repeat Region

(2015) John M. Louis et al.   BIOCHEMISTRY

Conditional Trimerization and Lytic Activity of HIV-1 gp41 Variants Containing the Membrane-Associated Segments

(2015) Zhou Dai et al.   BIOCHEMISTRY

pH-dependent vesicle fusion induced by the ectodomain of the human immunodeficiency virus membrane fusion protein gp41: Two kinetically distinct processes and fully-membrane-associated gp41 with predominant β sheet fusion peptide conformation

(2015) Punsisi U. Ratnayake et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Distinct Requirements for HIV-Cell Fusion and HIV-mediated Cell-Cell Fusion

(2015) Naoyuki Kondo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Complete dissociation of the HIV-1 gp41 ectodomain and membrane proximal regions upon phospholipid binding

(2015) Julien Roche et al.   JOURNAL OF BIOMOLECULAR NMR

Binding of HIV-1 gp41-Directed Neutralizing and Non-Neutralizing Fragment Antibody Binding Domain (Fab) and Single Chain Variable Fragment (ScFv) Antibodies to the Ectodomain of gp41 in the Pre-Hairpin and Six-Helix Bundle Conformations

(2014) John M. Louis et al.   PLoS One

Dissociation of the trimeric gp41 ectodomain at the lipid–water interface suggests an active role in HIV-1 Env-mediated membrane fusion

(2014) Julien Roche et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conformational dynamics of single HIV-1 envelope trimers on the surface of native virions

(2014) J. B. Munro et al.   SCIENCE

HIV-1 Envelope Protein gp41: An NMR Study of Dodecyl Phosphocholine Embedded gp41 Reveals a Dynamic Prefusion Intermediate Conformation

(2014) Nils-Alexander Lakomek et al.   STRUCTURE

Capturing Glimpses of an Elusive HIV Gp41 Prehairpin Fusion Intermediate

(2014) Lukas K. Tamm et al.   STRUCTURE

Improving the thermal, radial, and temporal accuracy of the analytical ultracentrifuge through external references

(2013) Rodolfo Ghirlando et al.   ANALYTICAL BIOCHEMISTRY

Internal Dynamics of the Homotrimeric HIV-1 Viral Coat Protein gp41 on Multiple Time Scales

(2013) Nils-Alexander Lakomek et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Reversible Folding of Human Peripheral Myelin Protein 22, a Tetraspan Membrane Protein

(2013) Jonathan P. Schlebach et al.   BIOCHEMISTRY

HIV-1 envelope glycoprotein structure

(2013) Alan Merk et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Prefusion structure of trimeric HIV-1 envelope glycoprotein determined by cryo-electron microscopy

(2013) Alberto Bartesaghi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Suppression of ghost distances in multiple-spin double electron–electron resonance

(2013) Tona von Hagens et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Conjugation of Cholesterol to HIV-1 Fusion Inhibitor C34 Increases Peptide-Membrane Interactions Potentiating Its Action

(2013) Axel Hollmann et al.   PLoS One

Molecular architecture of the uncleaved HIV-1 envelope glycoprotein trimer

(2013) Y. Mao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal Structure of a Soluble Cleaved HIV-1 Envelope Trimer

(2013) J.-P. Julien et al.   SCIENCE

Cryo-EM Structure of a Fully Glycosylated Soluble Cleaved HIV-1 Envelope Trimer

(2013) D. Lyumkis et al.   SCIENCE

HIV Entry and Envelope Glycoprotein-mediated Fusion

(2012) Robert Blumenthal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biophysical characterization of membrane proteins in nanodiscs

(2012) Sayaka Inagaki et al.   METHODS

HIV gp41 six-helix bundle constructs induce rapid vesicle fusion at pH 3.5 and little fusion at pH 7.0: understanding pH dependence of protein aggregation, membrane binding, and electrostatics, and implications for HIV-host cell fusion

(2011) Kelly Sackett et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Inhibition of HIV-1 by Fusion Inhibitors

(2010) Dirk Eggink et al.   CURRENT PHARMACEUTICAL DESIGN

Comparative Analysis of Membrane-Associated Fusion Peptide Secondary Structure and Lipid Mixing Function of HIV gp41 Constructs that Model the Early Pre-Hairpin Intermediate and Final Hairpin Conformations

(2010) Kelly Sackett et al.   JOURNAL OF MOLECULAR BIOLOGY

Rotamer libraries of spin labelled cysteines for protein studies

(2010) Yevhen Polyhach et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Crystal Structure of HIV-1 gp41 Including Both Fusion Peptide and Membrane Proximal External Regions

(2010) Victor Buzon et al.   PLoS Pathogens

Conformational Stability and Membrane Interaction of the Full-Length Ectodomain of HIV-1 gp41: Implication for Mode of Action†

(2009) Naama Lev et al.   BIOCHEMISTRY

HIV Enters Cells via Endocytosis and Dynamin-Dependent Fusion with Endosomes

(2009) Kosuke Miyauchi et al.   CELL

Improved prediction of protein side-chain conformations with SCWRL4

(2009) Georgii G. Krivov et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

HIV-1 Broadly Neutralizing Antibody Extracts Its Epitope from a Kinked gp41 Ectodomain Region on the Viral Membrane

(2008) Zhen-Yu J. Sun et al.   IMMUNITY

The Membrane-Proximal External Region of the Human Immunodeficiency Virus Type 1 Envelope: Dominant Site of Antibody Neutralization and Target for Vaccine Design

(2008) M. Montero et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Viral membrane fusion

(2008) Stephen C Harrison   NATURE STRUCTURAL & MOLECULAR BIOLOGY