Effect of Polyaryl Hydrocarbons on Cytotoxicity in Monocytic Cells: Potential Role of Cytochromes P450 and Oxidative Stress Pathways

Chronic exposure to low benzo[a]pyrene level causes neurodegenerative disease-like syndromes in zebrafish (Danio rerio)

(2015) Dongxu Gao et al.   AQUATIC TOXICOLOGY

The impact of p53 on DNA damage and metabolic activation of the environmental carcinogen benzo[a]pyrene: effects in Trp53(+/+), Trp53(+/–) and Trp53(−/−) mice

(2015) Annette M. Krais et al.   ARCHIVES OF TOXICOLOGY

Polycyclic Aromatic Hydrocarbons in the Mainstream Smoke of Popular U.S. Cigarettes

(2015) An T. Vu et al.   CHEMICAL RESEARCH IN TOXICOLOGY

TP53 mutations induced by BPDE in Xpa-WT and Xpa-Null human TP53 knock-in (Hupki) mouse embryo fibroblasts

(2015) Jill E. Kucab et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Pulmonary Inflammation Impacts on CYP1A1-Mediated Respiratory Tract DNA Damage Induced by the Carcinogenic Air Pollutant Benzo[a]pyrene

(2015) Volker M. Arlt et al.   TOXICOLOGICAL SCIENCES

Effect of Mild-to-Moderate Smoking on Viral Load, Cytokines, Oxidative Stress, and Cytochrome P450 Enzymes in HIV-Infected Individuals

(2015) Anusha Ande et al.   PLoS One

Carcinogenic polycyclic aromatic hydrocarbons induce CYP1A1 in human cells via a p53-dependent mechanism

(2014) Laura E. Wohak et al.   ARCHIVES OF TOXICOLOGY

Oxidative Stress and Antioxidants in Disease and Cancer: A Review

(2014) Rakesh Kumar Gupta et al.   Asian Pacific Journal of Cancer Prevention

Implications for chronic toxicity of benzo[a]pyrene in sea bream cultured hepatocytes: Cytotoxicity, inflammation, and cancerogenesis

(2014) Maria Pia Santacroce et al.   ENVIRONMENTAL TOXICOLOGY

Curcumin and Vitamin E Protect against Adverse Effects of Benzo[a]pyrene in Lung Epithelial Cells

(2014) Wenbin Zhu et al.   PLoS One

Cytochrome b5 and epoxide hydrolase contribute to benzo[a]pyrene-DNA adduct formation catalyzed by cytochrome P450 1A1 under low NADPH:P450 oxidoreductase conditions

(2014) Marie Stiborová et al.   TOXICOLOGY

In vivo exposure to benzo(a)pyrene induces significant DNA damage in mouse oocytes and cumulus cells

(2013) L. Einaudi et al.   HUMAN REPRODUCTION

Smoke carcinogens cause bone loss through the aryl hydrocarbon receptor and induction of Cyp1 enzymes

(2013) J. Iqbal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The cigarette smoke constituent benzo[a]pyrene disrupts metabolic enzyme, and apoptosis pathway member gene expression in ovarian follicles

(2013) Jean Clair Sadeu et al.   REPRODUCTIVE TOXICOLOGY

Polycyclic aromatic hydrocarbons stimulate human CYP3A4 promoter activity via PXR

(2013) Claudia Luckert et al.   TOXICOLOGY LETTERS

Benzo[a]pyrene sensitizes MCF7 breast cancer cells to induction of G1 arrest by the natural flavonoid eupatorin-5-methyl ether, via activation of cell signaling proteins and CYP1-mediated metabolism

(2013) Vasilis P. Androutsopoulos et al.   TOXICOLOGY LETTERS

BPDE-like DNA adduct level in oral tissue may act as a risk biomarker of oral cancer

(2012) Chun-Yi Chuang et al.   ARCHIVES OF ORAL BIOLOGY

Polycyclic aromatic hydrocarbons as skin carcinogens: Comparison of benzo[a]pyrene, dibenzo[def,p]chrysene and three environmental mixtures in the FVB/N mouse

(2012) Lisbeth K. Siddens et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Polycyclic Aromatic Hydrocarbons Activate CYP3A4 Gene Transcription through Human Pregnane X Receptor

(2011) Takeshi Kumagai et al.   Drug Metabolism and Pharmacokinetics

A LC-MS/MS Method for Concurrent Determination of Nicotine Metabolites and Role of CYP2A6 in Nicotine Metabolism in U937 Macrophages: Implications in Oxidative Stress in HIV + Smokers

(2011) Mengyao Jin et al.   Journal of Neuroimmune Pharmacology

Metabolism of [D10]Phenanthrene to Tetraols in Smokers for Potential Lung Cancer Susceptibility Assessment: Comparison of Oral and Inhalation Routes of Administration

(2011) Y. Zhong et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

AHR2 knockdown prevents PAH-mediated cardiac toxicity and XRE- and ARE-associated gene induction in zebrafish (Danio rerio)

(2011) Lindsey A. Van Tiem et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Effect of Alcohol on Drug Efflux Protein and Drug Metabolic Enzymes in U937 Macrophages

(2010) Mengyao Jin et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Reactive oxygen species, cellular redox systems, and apoptosis

(2010) Magdalena L. Circu et al.   FREE RADICAL BIOLOGY AND MEDICINE

PAH–DNA Adducts, Cigarette Smoking, GST Polymorphisms, and Breast Cancer Risk

(2008) Kathleen M. McCarty et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Evaluation of Time Dependence and Interindividual Differences in Benzo[a]pyrene-MediatedCYP1A1Induction and Genotoxicity in Porcine Urinary Bladder Cell Cultures∗

(2008) Sabine Plöttner et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES