Article
Immunology
Shohei Takahashi, Hotaka Fukushima, Zhiqian Yu, Hiroaki Tomita, Satoshi Kida
Summary: Neural inflammation, particularly the generation of cytokine TNFα, has been shown to negatively impact cognitive function, especially learning and memory. Experimental results demonstrate that TNFα disrupts the retrieval and reconsolidation processes of contextual fear and spatial memories, providing insight into how neural inflammation affects hippocampus-dependent memory.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Allergy
Fabian Gendrisch, Lukas Voelkel, Melanie Fluck, Petya Apostolova, Robert Zeiser, Thilo Jakob, Stefan F. Martin, Philipp R. Esser
Summary: The study demonstrates that contact sensitizers can activate IRE-1 and PERK signaling pathways, leading to the unfolded protein response and ultimately determining inflammatory immune responses in vitro and in vivo. Blocking the unfolded protein response signaling pathway can reduce NF-kappa B activation and cytokine production, and can eliminate contact hypersensitivity responses in vivo.
Article
Multidisciplinary Sciences
Matthew L. Mendoza, Lilyana D. Quiley, Thomas Dunhan, Lenora J. Volk
Summary: A growing body of literature suggests that KIBRA is involved in memory and neurodevelopmental disorders. This study uses knockout mice to show that deleting KIBRA in adult mice impairs long-term spatial memory and long-term potentiation (LTP), while deleting it in juvenile mice has minimal effects. The findings indicate that KIBRA plays a unique role in adult hippocampal function.
Article
Psychology, Multidisciplinary
Jiacheng Cui, Jianglin Wen, Dong Wang
Summary: The purpose of this study was to explore the abnormalities in cognitive manipulation in patients with depression and analyze its possible role in the pathogenesis and maintenance of depression. The results showed that patients with depression had obvious difficulties in cognitive manipulation, especially when dealing with sad stimuli. Furthermore, the difficulty in cognitive operation was closely related to the level of rumination.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Mohammad Khoonkari, Dong Liang, Marina Trombetta Lima, Tjitze van der Land, Yuanke Liang, Jianwu Sun, Amalia Dolga, Marleen Kamperman, Patrick van Rijn, Frank A. E. Kruyt
Summary: Glioblastoma multiforme (GBM) is the most aggressive brain tumor in adults, and ECM stiffening plays a significant role in its progression. This study identifies a novel mechano-adaptive mechanism involving PERK/FLNA/F-Actin and provides new insights into the cellular adaptation to ECM stiffening.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biology
Kyra Schapiro, Kresimir Josic, Zachary P. Kilpatrick, Joshua Gold
Summary: This study used human psychophysics to examine the impact of working-memory limitations on the accuracy of continuous decision variables. The results suggest that the degradation of the decision variable depends on the strategy used to form it, either as a single value or as multiple values stored in memory.
Article
Biochemistry & Molecular Biology
Jiunn-Chang Lin, Pei-Ming Yang, Tsang-Pai Liu
Summary: The study identified lncRNA ZFAS1 as a potential biomarker for sorafenib therapy resistance in HCC, and showed that sorafenib induces ER stress and the unfolded protein response pathways through the PERK/ATF4/ZFAS1 signaling axis. This finding suggests a new direction for the treatment and prognosis of HCC patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Saie Mogre, Nicholas Blazanin, Hailey Walsh, Jack Ibinson, Chase Minnich, Chih-Chi Andrew Hu, Adam B. Glick
Summary: The study found that TGF beta 1 plays a critical role in regulating tumor progression and can induce ER stress. The results showed that TGF beta 1 suppresses the phosphorylation and activation of IRE1 alpha through activating the PERK pathway, thereby exerting tumor-suppressive effects. In addition, TGF beta 1 also partially depends on the PERK-induced IRE1 alpha dephosphorylation and inactivation through PERK-dependent IRE1 alpha phosphatase.
MOLECULAR CARCINOGENESIS
(2022)
Article
Plant Sciences
Zhiyang Zhai, Jantana K. Blanford, Yingqi Cai, Jing Sun, Hui Liu, Hai Shi, Jorg Schwender, John Shanklin
Summary: CDK8 plays a crucial role in lipid synthesis regulation. It promotes lipid synthesis by activating WRINKLED1 through its interaction with GEMINIVIRUS REP INTERACTING KINASE1. However, KIN10 can degrade CDK8 and inhibit lipid synthesis.
Article
Multidisciplinary Sciences
Lisa Tilokani, Fiona M. Russell, Stevie Hamilton, Daniel M. Virga, Mayuko Segawa, Vincent Paupe, Anja V. Gruszczyk, Margherita Protasoni, Luis -Carlos Tabara, Mark Johnson, Hanish Anand, Michael P. Murphy, D. Grahame Hardie, Franck Polleux, Julien Prudent
Summary: This study identifies MTFR1L as a critical mitochondrial protein that transduces AMPK-dependent metabolic changes through regulation of mitochondrial dynamics. The phosphorylation of MTFR1L by AMPK controls its function in regulating mitochondrial morphology and stress-induced AMPK-dependent mitochondrial fragmentation.
Article
Neurosciences
Frank Raven, Youri G. Bolsius, Lara van Renssen, Elroy L. Meijer, Eddy A. van der Zee, Peter Meerlo, Robbert Havekes
Summary: Protein synthesis is crucial for long-term memory formation and consolidation, with protein synthesis inhibition selectively impairing context-fear memory consolidation at certain time points. The temporal dynamics of protein synthesis-dependent memory consolidation appear to be similar for daytime and nighttime learning.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Hanuman T. Kale, Rajendra Singh Rajpurohit, Debabrata Jana, Vijay V. Vishnu, Mansi Srivastava, Preeti R. Mourya, Gunda Srinivas, P. Chandra Shekar
Summary: In this study, it was found that NANOG induces the expression of Fgfbp1 and Fgfr2 to activate ERK signaling, triggering autorepression in Nanog-high cells. Phosphorylated ERK recruits NONO to the Nanog locus to repress transcription, establishing a reciprocal NANOG-pERK regulatory circuit. This circuit regulates ERK signaling dynamics and Nanog autoregulation in pluripotent cells.
Review
Neurosciences
Timothy J. Buschman
Summary: Working memory is crucial for cognition, but has a limited capacity of only three to four items at once. It relies on interactions between the prefrontal cortex and sensory cortex to maintain arbitrary representations flexibly, while the distributed nature of working memory leads to interference and limits its capacity. To maximize effective capacity, the brain uses mechanisms to reduce interference.
ANNUAL REVIEW OF VISION SCIENCE, VOL 7, 2021
(2021)
Article
Medicine, General & Internal
Yuko Arioka, Emiko Shishido, Itaru Kushima, Toshiaki Suzuki, Ryo Saito, Atsu Aiba, Daisuke Mori, Norio Ozaki
Summary: The study revealed that the 22q11.2 deletion causes various vulnerabilities in dopaminergic neurons, dependent on PERK dysfunction.
Article
Neurosciences
Na Li, Shuai-Wen Teng, Ling Zhao, Jing-Rui Li, Jia-Ling Xu, Na Li, Jia-Cheng Shuai, Zhe-Yu Chen
Summary: The study reveals a crucial role of CPE in controlling the surface delivery of TrkB receptor, which in turn impacts the activity of neurons and synapses. This finding may contribute to a better understanding of the role of CPE in TrkB-dependent synaptic plasticity and memory modulation.
JOURNAL OF NEUROSCIENCE
(2021)
