Article
Biology
Vadim Mett, Oleg V. Kurnasov, Ivan A. Bespalov, Ivan Molodtsov, Craig M. Brackett, Lyudmila G. Burdelya, Andrei A. Purmal, Anatoli S. Gleiberman, Ilia A. Toshkov, Catherine A. Burkhart, Yakov N. Kogan, Ekaterina L. Andrianova, Andrei V. Gudkov, Andrei L. Osterman
Summary: GP532, a substantially deimmunized derivative of the TLR5 agonist entolimod, retains potent NF-kappa B activation while eliminating key B- and T-cell epitopes and an inflammasome-activating domain. It is suitable for multi-dose therapies and patients with high titers of preexisting flagellin-neutralizing antibodies.
COMMUNICATIONS BIOLOGY
(2021)
Article
Veterinary Sciences
Jaeeun Ko, Jaehwan Kim, Yang-Kyu Choi, Sang-Soep Nahm, Jayon Kim, Sun-Min Seo, Jin-Seok Seo, Woojong Lee, Weon Kuu Chung, Kidong Eom
Summary: This study evaluated the clinical safety and radiomitigative effect of KMRC011 in beagle dogs with radiation-induced oral mucositis. The results suggest that KMRC011 may be used as an adjuvant for short-term radiotherapy without severe adverse effects.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Immunology
Lian-Yun Wu, Shao-Feng Liu, Guo-Hong Hua, Ru-Min Jia, Yan-Hong Yong, Ravi Gooneratne, Xiang-Hong Ju
Summary: Research on the Magang goose TLR5 gene revealed that it is widely expressed in various tissues, highly homologous in function, structure, and sequence with TLR5 of other species, and plays an important role in bacterial recognition.
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY
(2021)
Review
Critical Care Medicine
Sahil Gupta, James N. Tsoporis, Song-Hui Jia, Claudia C. dos Santos, Thomas G. Parker, John C. Marshall
Summary: This article discusses how host cells recognize danger signals using pattern recognition receptors, focusing on Toll-like receptors (TLRs) as the most studied class of PRRs. It reviews the expression, regulation, and function of different TLRs, emphasizing TLR-4, and how TLR adaptor protein binding directs intracellular signaling to activate or terminate an innate immune response. The recent progress in research on the involvement of S100 proteins as ligands for TLR-4 in inflammatory disease is also highlighted.
Article
Immunology
Andreja Novak, Elder Pupo, Esther van't Veld, Victor P. M. G. Rutten, Femke Broere, Arjen Sloots
Summary: This study reveals that TLR2 and TLR4 are involved in the recognition of Leptospira strains used in canine Leptospira vaccines. The findings contribute to the understanding of Leptospira-induced innate immune responses in dogs, humans, and mice.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Connor Sharp, Kevin R. Foster
Summary: Humans and many other species carry a large set of beneficial microbes, and the vital relationships with these microbes only work when hosts can control their microbiome and suppress wayward symbionts. Cooperation evolution is not only driven by mutual benefits, but also relies on host control and constraints limiting symbiont counter evolution.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Ajaya Kumar Rout, Varsha Acharya, Diptimayee Maharana, Budheswar Dehury, Sheela Rani Udgata, Rajkumar Jena, Bhaskar Behera, Pranaya Kumar Parida, Bijay Kumar Behera
Summary: TLR5 is a crucial pattern recognition receptor involved in the first-line defense against invading pathogenic bacteria. Studies on mrigala have shown the structural basis of TLR5-flagellin recognition, highlighting differences in binding interface compared to zebrafish. The findings suggest TLR5 in mrigala recognizes a conserved site on flagellin, emphasizing the importance of exploring host-specific differences in receptor activation.
Article
Materials Science, Biomaterials
Melanie Cote-Cyr, Ximena Zottig, Laurie Gauthier, Denis Archambault, Steve Bourgault
Summary: Proteinaceous nanoparticles can be effective antigen carriers for vaccination, especially when modified to form ring-like nanostructures with specific antigens attached, which can stimulate immune responses, enhance antibody production, and protect against lethal infections like the influenza A virus.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2022)
Article
Environmental Sciences
Ying Tu, Yongyong Yang, Yue Wang, Nana Wu, Junyan Tao, Guanghong Yang, Mingdan You
Summary: The study suggests that developmental exposure to CPF may lead to neuroinflammation and activation of microglia in the hippocampus, resulting in necroptosis, release of pro-inflammatory cytokines, etc., a process regulated by TLR4/TRIF signaling.
ENVIRONMENTAL POLLUTION
(2022)
Review
Biotechnology & Applied Microbiology
Danieli F. Buccini, Beatriz C. Roriz, Julia M. Rodrigues, Octavio L. Franco
Summary: Antimicrobial peptides are important molecules in the organism's defense system. They can modulate the immune system and recognize molecules present in pathogens. Overstimulation of TLR4 can lead to uncontrolled inflammatory responses, which can be counteracted by antimicrobial peptides.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Environmental Sciences
John D. Hansen, Keith A. Loftin, Zachary Laughrey, Ondrej Adamovsky
Summary: Various stressors can have profound impacts on immunity to pathogens, with little research into the effects of cyanobacterial toxins on disease resistance in mammals. Recent studies suggest that freshwater cyanotoxins may alter disease susceptibility parameters for fish, wildlife, and human health through interaction with specific components of innate immunity. However, the results of this study indicate that the tested toxins did not directly interact with key pathogen recognition receptors for innate immunity in humans.
Article
Biotechnology & Applied Microbiology
Akinobu Kajikawa, Naoto Eguchi, Shunya Suzuki
Summary: The interactions between gut microbes and immune cells are crucial for host health and disease. Ligilactobacillus agilis is a flagellated commensal bacterium found in the gut of mammals and birds. The flagellin proteins of L. agilis are immunologically attenuated due to specific amino acid residues, unlike those of pathogenic bacteria.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Koichi Yuki, Yusuke Mitsui, Miho Shibamura-Fujiogi, Lifei Hou, Kirsten C. Odegard, Sulpicio G. Soriano, Gregory P. Priebe, Sophia Koutsogiannaki
Summary: Isoflurane and sevoflurane, commonly used volatile anesthetics, show immunomodulatory effects and may impact disease progression by attenuating lung injury and inhibiting TLR5 activation. Studies suggest they have a protective effect on gas exchange in patients with cystic fibrosis. Additionally, docking simulations indicate these anesthetics interact with TLR5 and flagellin for potential therapeutic benefits.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Gastroenterology & Hepatology
Geoffroy Mallaret, Amandine Lashermes, Mathieu Meleine, Ludivine Boudieu, Julie Barbier, Youssef Aissouni, Agathe Gelot, Benoit Chassaing, Andrew T. Gewirtz, Denis Ardid, Frederic Antonio Carvalho
Summary: This study aimed to investigate the mechanisms between early life events and the development of colonic hypersensitivity (CHS). Maternal separation model (NMS) was used to mimic deleterious events in childhood. Results showed that around 50% of NMS mice exhibited increased intestinal permeability and CHS associated with intestinal dysbiosis. Furthermore, only TLR5 mRNA expression was increased in colonocytes of NMS mice with CHS. Acute intrarectal instillation of TLR5 agonist also induced transient CHS appearance.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Review
Microbiology
Nathan P. Manes, Aleksandra Nita-Lazar
Summary: Pattern recognition receptors (PRRs) serve as the front line of defense against pathogens. Understanding the molecular mechanisms of PRR signaling is crucial for developing therapeutics for diseases such as sepsis and COVID-19.
Article
Chemistry, Multidisciplinary
A. Ljubetic, I. Drobnak, H. Gradisar, R. Jerala
CHEMICAL COMMUNICATIONS
(2016)
Article
Chemistry, Multidisciplinary
Igor Drobnak, Helena Gradisar, Ajasja Ljubetic, Estera Merljak, Roman Jerala
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2017)
Article
Biophysics
Iztok Urbancic, Ajasja Ljubetic, Zoran Arsov, Janez Strancar
BIOPHYSICAL JOURNAL
(2013)
Review
Biophysics
Janez Strancar, Aleh Kavalenka, Iztok Urbancic, Ajasja Ljubetic, Marcus A. Hemminga
EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
(2010)
Article
Chemistry, Physical
Ajasja Ljubetic, Iztok Urbancic, Janez Strancar
JOURNAL OF CHEMICAL PHYSICS
(2014)
Article
Chemistry, Physical
Iztok Urbancic, Ajasja Ljubetic, Janez Strancar
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2014)
Article
Optics
Iztok Urbancic, Zoran Arsov, Ajasja Ljubetic, Daniele Biglino, Janez Strancar
Article
Biochemical Research Methods
Zoran Arsov, Iztok Urbancic, Maja Garvas, Daniele Biglino, Ajasja Ljubetic, Tilen Koklic, Janez Strancar
BIOMEDICAL OPTICS EXPRESS
(2011)