Cardiomyocyte-Specific Ablation of Med1 Subunit of the Mediator Complex Causes Lethal Dilated Cardiomyopathy in Mice

A MED13-dependent skeletal muscle gene program controls systemic glucose homeostasis and hepatic metabolism

(2016) Leonela Amoasii et al.   GENES & DEVELOPMENT

Connective tissue growth factor regulates cardiac function and tissue remodeling in a mouse model of dilated cardiomyopathy

(2015) Yevgeniya E. Koshman et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The Mediator complex: a central integrator of transcription

(2015) Benjamin L. Allen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Liver Med23 ablation improves glucose and lipid metabolism through modulating FOXO1 activity

(2014) Yajing Chu et al.   CELL RESEARCH

Integrins and Integrin-Associated Proteins in the Cardiac Myocyte

(2014) Sharon Israeli-Rosenberg et al.   CIRCULATION RESEARCH

Med1 Subunit of the Mediator Complex in Nuclear Receptor-Regulated Energy Metabolism, Liver Regeneration, and Hepatocarcinogenesis

(2014) Yuzhi Jia et al.   GENE EXPRESSION

Cardiac-specific ablation of ARNT leads to lipotoxicity and cardiomyopathy

(2014) Rongxue Wu et al.   JOURNAL OF CLINICAL INVESTIGATION

Integrin-linked kinase mediates force transduction in cardiomyocytes by modulating SERCA2a/PLN function

(2014) Alexandra Traister et al.   Nature Communications

Perturbation of NCOA6 Leads to Dilated Cardiomyopathy

(2014) Jae-il Roh et al.   Cell Reports

MED12related disorders

(2013) John M. Graham et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Mitochondrial fatty acid oxidation alterations in heart failure, ischaemic heart disease and diabetic cardiomyopathy

(2013) N Fillmore et al.   BRITISH JOURNAL OF PHARMACOLOGY

Peroxisome proliferator-activated receptors modulate cardiac dysfunction in diabetic cardiomyopathy

(2013) T.-I. Lee et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Dosage changes of MED13L further delineate its role in congenital heart defects and intellectual disability

(2013) Reza Asadollahi et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

The Med1 Subunit of the Mediator Complex Induces Liver Cell Proliferation and Is Phosphorylated by AMP Kinase

(2013) Navin Viswakarma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Calcium cycling proteins and heart failure: mechanisms and therapeutics

(2013) Andrew R. Marks   JOURNAL OF CLINICAL INVESTIGATION

Genetic mutations and mechanisms in dilated cardiomyopathy

(2013) Elizabeth M. McNally et al.   JOURNAL OF CLINICAL INVESTIGATION

The heart is better protected against myocardial infarction in the fed state compared to the fasted state

(2013) Edgars Liepinsh et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

ERK and AKT Signaling Drive MED1 Overexpression in Prostate Cancer in Association with Elevated Proliferation and Tumorigenicity

(2013) Feng Jin et al.   MOLECULAR CANCER RESEARCH

Adult Cardiac Expression of the Activating Transcription Factor 3, ATF3, Promotes Ventricular Hypertrophy

(2013) Lilach Koren et al.   PLoS One

The multitalented Mediator complex

(2013) Jonas O.P. Carlsten et al.   TRENDS IN BIOCHEMICAL SCIENCES

Mediating lipid biosynthesis: Implications for cardiovascular disease

(2013) Xiaoli et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Mediator Complex Dependent Regulation of Cardiac Development and Disease

(2013) Chad E. Grueter   GENOMICS PROTEOMICS & BIOINFORMATICS

Mitochondrial transcription factor A regulates mitochondrial transcription initiation, DNA packaging, and genome copy number

(2012) Christopher T. Campbell et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

The Mediator complex in thyroid hormone receptor action

(2012) Joseph D. Fondell   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Revisiting Global Gene Expression Analysis

(2012) Jakob Lovén et al.   CELL

TheACE2gene: its potential as a functional candidate for cardiovascular disease

(2012) Louise M. Burrell et al.   CLINICAL SCIENCE

PGC1  and mitochondrial metabolism - emerging concepts and relevance in ageing and neurodegenerative disorders

(2012) S. Austin et al.   JOURNAL OF CELL SCIENCE

Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks

(2012) Cole Trapnell et al.   Nature Protocols

Inherited calcium channelopathies in the pathophysiology of arrhythmias

(2012) Luigi Venetucci et al.   Nature Reviews Cardiology

GeneCodis3: a non-redundant and modular enrichment analysis tool for functional genomics

(2012) D. Tabas-Madrid et al.   NUCLEIC ACIDS RESEARCH

Hallmarks of the channelopathies associated with L-type calcium channels : A focus on the Timothy mutations in Cav1.2 channels

(2011) Isabelle Bidaud et al.   BIOCHIMIE

Protection Against Myocardial Infarction and No-Reflow Through Preservation of Vascular Integrity by Angiopoietin-Like 4

(2011) Ariane Galaup et al.   CIRCULATION

Transcription coactivator mediator subunit MED1 Is required for the development of fatty liver in the mouse

(2011) Liang Bai et al.   HEPATOLOGY

Increased RNA editing in children with cyanotic congenital heart disease

(2011) Sharon Borik et al.   INTENSIVE CARE MEDICINE

Activating Transcription Factor 3 Deficiency Promotes Cardiac Hypertrophy, Dysfunction, and Fibrosis Induced by Pressure Overload

(2011) Heng Zhou et al.   PLoS One

Lethal mitochondrial cardiomyopathy in a hypomorphic Med30 mouse mutant is ameliorated by ketogenic diet

(2011) P. Krebs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mediator-dependent nuclear receptor function

(2011) Wei Chen et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Mediator and human disease

(2011) Jason M. Spaeth et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Reduction in Hexokinase II Levels Results in Decreased Cardiac Function and Altered Remodeling After Ischemia/Reperfusion Injury

(2010) Rongxue Wu et al.   CIRCULATION RESEARCH

Regulation and significance of atrial and brain natriuretic peptides as cardiac hormones

(2010) Koichiro Kuwahara et al.   ENDOCRINE JOURNAL

ATF3, a Hub of the Cellular Adaptive-Response Network, in the Pathogenesis of Diseases: Is Modulation of Inflammation a Unifying Component?

(2010) TSONWIN HAI et al.   GENE EXPRESSION

Cardiac fibrosis in mice with hypertrophic cardiomyopathy is mediated by non-myocyte proliferation and requires Tgf-β

(2010) Polakit Teekakirikul et al.   JOURNAL OF CLINICAL INVESTIGATION

Transforming growth factor (TGF)-β signaling in cardiac remodeling

(2010) Marcin Dobaczewski et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The metazoan Mediator co-activator complex as an integrative hub for transcriptional regulation

(2010) Sohail Malik et al.   NATURE REVIEWS GENETICS

Regulation and Cytoprotective Role of Hexokinase III

(2010) Eugene Wyatt et al.   PLoS One

A muscle-specific knockout implicates nuclear receptor coactivator MED1 in the regulation of glucose and energy metabolism

(2010) W. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcription coactivator PBP/MED1-deficient hepatocytes are not susceptible to diethylnitrosamine-induced hepatocarcinogenesis in the mouse

(2009) K. Matsumoto et al.   CARCINOGENESIS

Intergenic transcription and developmental regulation of cardiac myosin heavy chain genes

(2007) Fadia Haddad et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY