Article
Multidisciplinary Sciences
Ming Tian, Hwei-Ling Cheng, Michael T. Kimble, Kelly McGovern, Peyton Waddicor, Yiwei Chen, Elizabeth Cantor, Mengting Qiu, Marie-Elen Tuchel, Mai Dao, Frederick W. Alt
Summary: The study demonstrates a humanized mouse model approach to diversify an anti-PD1 therapeutic antibody and derive variants with novel properties by mimicking V(D)J recombination and SHM mechanisms. These variants can have different biological activities, with some even reversing the original function of the antibody, potentially offering clinical implications in treating autoimmune diseases.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Multidisciplinary Sciences
Ik Jun Moon, Mi Ra Yun, Hae Kyeong Yoon, Keon Hee Lee, Sun Young Choi, Woo Jin Lee, Sung Eun Chang, Chong Hyun Won
Summary: Cold atmospheric plasma has been shown to improve the severity of atopic dermatitis, reduce transepidermal water loss, and lower serum immunoglobulin E levels in an animal model, indicating its potential as a novel therapeutic modality for this chronic skin condition.
SCIENTIFIC REPORTS
(2021)
Review
Engineering, Environmental
M. Magureanu, F. Bilea, C. Bradu, D. Hong
Summary: Large amounts of antibiotics are being produced and consumed globally, leading to significant water contamination due to inefficient wastewater treatment. The high concentrations of antibiotics in the environment exert selective pressure on clinically important bacteria, increasing resistance prevalence. Efforts to improve contaminated wastewater treatment are essential in order to reduce uncontrollable spread of antibiotic resistance, as a drastic reduction in antibiotic use is not anticipated. This review paper analyzes recent progress on using non-thermal plasma technology to degrade antibiotics in water, discussing removal efficiency, energy efficiency, and degradation pathways for various classes of antibiotics. Ways to enhance the efficiency of the plasma process are also addressed.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Energy & Fuels
Hawraa Srour, Elodie Devers, Adrien Mekki-Berrada, Joumana Toufaily, Tayssir Hamieh, Catherine Batiot-Dupeyrat, Ludovic Pinard
Summary: This study compared the regeneration efficiency of an aged industrial hydrodesulfurization catalyst using conventional thermal oxidation and non-thermal plasma technology. Non-thermal plasma treatment showed promising results in fully regenerating the catalyst at lower temperatures and removing coke compared to traditional thermal treatment. The use of low temperature-assisted non-thermal plasma for HDS catalyst regeneration is a potential alternative to thermal combustion.
Article
Engineering, Marine
Yan Li, Xinying Bai, Chunlei Xia
Summary: In this study, an improved YOLOV5 model is proposed for automatic detection of marine organisms. Techniques such as attention mechanism, multiple-scale detection strategies, and image enhancement module are employed to enhance the performance of image recognition. Ablation studies and performance evaluation results demonstrate the effectiveness and superiority of the proposed model. Moreover, the deployment of the model on an embedded device enables real-time observation.
JOURNAL OF MARINE SCIENCE AND ENGINEERING
(2022)
Article
Engineering, Chemical
Yaxin Fan, Kaiqi Zhang, Huayun Xiao, Christopher J. Hogan, Chenxi Li
Summary: Recently, it has been shown that non-thermal plasmas can be used as nanoparticle processing reactors, heating particles selectively and inducing chemical reactions and structural transformations. In this study, the sintering of metallic nano-aggregates in a non-thermal plasma and a traditional tube furnace was compared. The behavior of silver aggregates was similar in both systems, while the behavior of bismuth aggregates was different due to early particle vaporization. The plasma reactor was found to be more effective in sintering bismuth particles, possibly due to the reducing environment and partial oxidation of the bismuth aggregates.
JOURNAL OF AEROSOL SCIENCE
(2023)
Article
Engineering, Biomedical
Amy Drexelius, Daniel Fehr, Vincent Vescoli, Jason Heikenfeld, Mathias Bonmarin
Summary: An optical method using an infrared camera was developed to monitor individual sweat gland activity and calculate sweat rates. The feasibility of this method in measuring individual gland sweat rates was demonstrated, and a potential explanation for the lack of pulsatile sweat expulsion during chemically stimulated sweating was proposed.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2022)
Review
Biochemistry & Molecular Biology
Ana Bessa Muniz, Mariana Raquel da Cruz Vegian, Lady Daiane Pereira Leite, Diego Morais da Silva, Noala Vicensoto Moreira Milhan, Konstantin Georgiev Kostov, Cristiane Yumi Koga-Ito
Summary: The potential of non-thermal atmospheric pressure plasma (NTPP) application in Endodontics was evaluated through a literature review. NTPP showed a disinfection property against important endodontic microorganisms, mainly Enterococcus faecalis and Candida albicans. The association of NTPP and conventional antimicrobial solutions was shown to be more effective than both treatments separately, with potential implications for clinical practice. However, more studies are still required to standardize the parameters and explore the use of plasma-activated liquids in endodontic treatments.
Article
Construction & Building Technology
Yuxin Wu, Aleksi Maki, Juha Jokisalo, Risto Kosonen, Simo Kilpelainen, Sonja Salo, Hong Liu, Baizhan Li
Summary: Demand response of district heating is a useful tool for reducing costs and emissions in the energy system, but it is important to consider thermal comfort. An experimental study showed that limiting the surface temperature of windows can help minimize draught risk, especially with poorly insulated windows.
JOURNAL OF BUILDING ENGINEERING
(2021)
Article
Thermodynamics
Yalu Han, Yanlong Wang, Chenyang Liu, Xinmin Hu, Yin An, Zhengcai Li, Jiaxun Jiang, Lizhi Du
Summary: This paper investigates the calculation method of thermal conductivity in NAPLs-contaminated soils. By establishing NAPLs-contaminated soil models and using the Lattice Boltzmann Method (LBM) for calculation, an optimized three-dimensional model with high computational accuracy and efficiency is obtained. The study also finds that saturation and Nz parameters have a significant impact on calculation time, while the thermal conductivity of the two-dimensional model is more sensitive to anisotropy. The influence of porosity and NAPLs content on thermal conductivity should be considered during in-situ thermal desorption.
INTERNATIONAL JOURNAL OF THERMAL SCIENCES
(2024)
Article
Food Science & Technology
Roghayeh Pourbagher, Mohammad Hossein Abbaspour-Fard, Farshad Sohbatzadeh, Abbas Rohani
Summary: This study investigated the inactivation of Pseudomonas tolaasii on button mushroom using non-thermal plasma, finding it reduced bacterial count, delayed softening, increased vitamin C content, and decreased color changes. Therefore, NTP has great potential for improving microbial contamination and enhancing qualitative properties of Agaricus bisporus.
Article
Chemistry, Physical
Hawraa Srour, Nadia Guignard, Mehrad Tarighi, Elodie Devers, Adrien Mekki-Berrada, Joumana Toufaily, Tayssir Hamieh, Catherine Batiot-Dupeyrat, Ludovic Pinard
Summary: This study describes the regeneration of an aged industrial hydrodesulfurization catalyst using non-thermal plasma at a low temperature. The oxidation rate during regeneration depends on the nature of the coke, with the formation of hot spots indicated by CoMoO4 formation after long treatment time.
Article
Polymer Science
Irena Maliszewska, Malgorzata Gazinska, Maciej Lojkowski, Emilia Choinska, Daria Nowinski, Tomasz Czapka, Wojciech Swieszkowski
Summary: The aim of this study was to investigate the effect of non-thermal plasma treatment on the physicochemical properties and biodegradability of ultra-thin PET films. The results showed that plasma treatment led to changes in the surface properties of PET, resulting in a more developed surface. Additionally, plasma pretreatment influenced the crystallinity and melt crystallization behavior of PET after soil degradation.
Article
Construction & Building Technology
Bart Merema, Dirk Saelens, Hilde Breesch
Summary: In educational buildings, the HVAC system plays a major role in energy consumption. This study developed a model predictive control (MPC) framework for an all-air system to control room temperature and CO2 concentrations. Two model identification techniques, autoregressive with exogenous input (ARX-MPC) and grey-box resistor-capacitor nonlinear model (RC-NMPC), were compared. The study showed that the ARX-MPC had advantages in simplicity and computational efficiency. The implemented MPC strategies in a real-use educational building achieved energy savings of 10%-40% for electric energy use and 21%-55% for thermal energy use.
BUILDING AND ENVIRONMENT
(2022)
Article
Agronomy
Diana Guadalupe Gutierrez-Leon, Tomas Serrano-Ramirez, Regulo Lopez-Callejas, Benjamin Gonzalo Rodriguez-Mendez
Summary: The scarcity and contamination of water, exacerbated by climate change, pose serious threats to food supply and human health. New research has shown that non-thermal plasma technology can improve water quality, enhance the growth of legume crops, and reduce the presence of pathogens, such as E. coli and Salmonella, thereby ensuring food safety.
Article
Biotechnology & Applied Microbiology
Abraham Lin, Joey De Backer, Delphine Quatannens, Bart Cuypers, Hanne Verswyvel, Edgar Cardenas de la Hoz, Bart Ribbens, Vasiliki Siozopoulou, Jonas van Audenaerde, Elly Marcq, Filip Lardon, Kris Laukens, Steve Vanlanduit, Evelien Smits, Annemie Bogaerts
Summary: Research shows that non-thermal plasma (NTP) treatment can reduce melanoma burden and prolong survival, while enhancing the cancer-immunity cycle. This finding helps develop new treatment options and guide rational combination strategies to address challenges in melanoma therapy.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2022)
Article
Cell Biology
Shridhar Sanghvi, Kalina Szteyn, Devasena Ponnalagu, Divya Sridharan, Alexender Lam, Inderjot Hansra, Ankur Chaudhury, Uddalak Majumdar, Andrew R. Kohut, Shubha Gururaja Rao, Mahmood Khan, Vidu Garg, Harpreet Singh
Summary: This study reveals the presence of BKCa channels in the plasma membrane and mitochondria of neonatal murine and rodent cardiomyocytes, and demonstrates their protective effect on the heart. Inhibition of plasma membrane BKCa channels can protect the neonatal heart from ischemia-reperfusion injury.
CELL DEATH DISCOVERY
(2022)
Article
Physics, Fluids & Plasmas
Ajinkya M. Trimukhe, K. N. Pandiyaraj, Mukesh Patekar, Vandana Miller, Rajendra R. Deshmukh
Summary: This article reviews the application of nonthermal plasma (NTP) in cancer treatment. NTP devices, through the action of reactive oxygen and nitrogen species, selectively trigger cancer cell death pathways and exhibit pro-immunogenic properties. Research results have shown that NTP can be synergistically applied with anticancer drugs/treatments and used in plasma-conditioned medium (PCM) applications against various cancer cells.
IEEE TRANSACTIONS ON PLASMA SCIENCE
(2022)
Article
Nutrition & Dietetics
Rosemary D. Dall, May M. Cheung, Patricia A. Shewokis, Asma Altasan, Stella L. Volpe, Renee Amori, Harpreet Singh, Deeptha Sukumar
Summary: High-dose vitamin D supplementation may reduce insulin resistance by increasing total osteocalcin concentrations in individuals at risk for prediabetes or diabetes mellitus. This study aimed to investigate the combined effect of vitamin D and magnesium supplementation on glycemic indices and bone turnover markers in overweight and obese individuals. The results showed that combined supplementation did not lead to short-term improvements in glycemic indices or bone turnover markers.
NUTRITION RESEARCH
(2023)
Review
Chemistry, Multidisciplinary
Milica Zivanic, Albert Espona-Noguera, Abraham Lin, Cristina Canal
Summary: Cold atmospheric plasma (CAP) is a partially ionized gas that shows promise as a cancer treatment by enhancing anti-tumor immune responses. This review discusses the mechanisms by which CAP can assist in anti-tumor immunity and proposes a novel modality, plasma-treated hydrogels (PTHs), to overcome clinical limitations and improve therapeutic responses. The integration of biomaterials and plasma medicine holds great potential for the development of PTHs.
Article
Oncology
Lea Miebach, Hager Mohamed, Kristian Wende, Vandana Miller, Sander Bekeschus
Summary: This study suggests that gas plasma-oxidized liquids enriched with free radicals can be used as an additive option for treating pancreatic cancer, inducing tumor toxicity and provoking immunogenicity.
Article
Biochemistry & Molecular Biology
Hager Mohamed, Rachel Berman, Jennifer Connors, Elias K. Haddad, Vandana Miller, Michael R. Nonnemacher, Will Dampier, Brian Wigdahl, Fred C. Krebs
Summary: In people living with HIV-1, antiretroviral therapy eventually becomes necessary to suppress virus replication, but immunotherapies are proposed to enhance immune responses and achieve ART-free control of HIV-1.
Review
Pharmacology & Pharmacy
Abraham Lin, Maxime Sahun, Eline Biscop, Hanne Verswyvel, Jorrit De Waele, Joey De Backer, Claudia Theys, Bart Cuypers, Kris Laukens, Wim Vanden Berghe, Evelien Smits, Annemie Bogaerts
Summary: This study aimed to investigate the mechanisms of NTP therapy sensitivity and resistance by using the first-ever NTP-resistant cell line derived from sensitive melanoma cells. The cells were exposed to NTP for 12 weeks and evaluated against the parental control cells. Transcriptome sequencing and metabolic analysis revealed a preference towards aerobic glycolysis and increased vulnerability to lipid peroxidation and ferroptosis in NTP-resistant cells.
DRUG RESISTANCE UPDATES
(2023)
Review
Biochemistry & Molecular Biology
Julia Sutter, Peter J. Bruggeman, Brian Wigdahl, Fred C. Krebs, Vandana Miller
Summary: Herpes simplex virus type 1 (HSV-1) is a contagious pathogen that causes lifelong infections. Current antiviral therapies are effective against HSV-1 replication in epithelial cells but not in neurons where the virus can remain dormant. Non-thermal plasma (NTP) therapy shows promise in controlling HSV-1 by manipulating oxidative stress responses and stimulating antiviral immune responses. NTP application can decrease the size of the viral reservoir in the nervous system, addressing the challenge of latency.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Physics, Applied
Hanne Verswyvel, Christophe Deben, An Wouters, Filip Lardon, Annemie Bogaerts, Evelien Smits, Abraham Lin
Summary: Live-cell imaging with fluorescence microscopy is a powerful tool in cancer research but can result in phototoxicity, causing disruption of redox balance and an overload of reactive oxygen species. We investigated the impact of phototoxicity on cellular homeostasis and response to non-thermal plasma (NTP), revealing increased sensitivity to NTP in cells used for live-cell imaging, likely due to altered proliferation rates and ROS levels. These findings have important implications for research using this technique and evaluating redox-based therapies.
JOURNAL OF PHYSICS D-APPLIED PHYSICS
(2023)
Article
Chemistry, Multidisciplinary
Maxime Sahun, Angela Privat-Maldonado, Abraham Lin, Naomi De Roeck, Lisa Van der Heyden, Michael Hillen, Johan Michiels, Gunther Steenackers, Evelien Smits, Kevin K. Arien, Philippe G. Jorens, Peter Delputte, Annemie Bogaerts
Summary: As highlighted by the recent SARS-CoV-2 pandemic, viruses have become a growing burden on health, the global economy, and the environment. The control of virus transmission through contact with contaminated materials is a major challenge in hospital settings, and current disinfection methods have limitations. A study found that non-thermal plasma can effectively inactivate SARS-CoV-2 on commonly found healthcare materials, offering a potential alternative solution for rapid, efficient, and low-cost disinfection.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2023)
Article
Biochemistry & Molecular Biology
Veronica Loyo-Celis, Devendra Patel, Shridhar Sanghvi, Kamalpreet Kaur, Devasena Ponnalagu, Yang Zheng, Sahej Bindra, Harmeet Rireika Bhachu, Isabelle Deschenes, Shubha Gururaja Rao, Harpreet Singh
Summary: CLIC6 is a protein implicated in various cancers and known to interact with dopamine receptors. This study characterized the biophysical properties of CLIC6 and found it to localize to the plasma membrane, exhibit high permeability to chloride ions, and be regulated by pH and redox potential.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2023)
Article
Endocrinology & Metabolism
Rizaldy C. Zapata, Dinghong Zhang, Dongmin Yoon, Chanond A. Nasamran, Daisy R. Chilin-Fuentes, Avraham Libster, Besma S. Chaudry, Mariela Lopez-Valencia, Devasena Ponnalagu, Harpreet Singh, Michael Petrascheck, Olivia Osborn
Summary: Clic1 inhibition reduces food intake and body weight in mouse models, suggesting it as a potential therapeutic target for obesity treatment.
MOLECULAR METABOLISM
(2023)
Article
Chemistry, Multidisciplinary
Maxime Sahun, Angela Privat-Maldonado, Abraham Lin, Naomi De Roeck, Lisa Van der Heyden, Johan Michiels, Gunther Steenackers, Evelien Smits, Kevin K. Arien, Philippe G. Jorens, Peter Delputte, Annemie Bogaerts
Summary: As highlighted by the SARS-CoV-2 pandemic, viruses have become a growing burden on health, the global economy, and the environment. The control of transmission through contact with contaminated materials is a major challenge, particularly in hospital settings. However, the current disinfection methods in hospitals have several drawbacks, leading to shortages and waste, thus prompting the search for alternative solutions.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2023)
Article
Physics, Fluids & Plasmas
Julia Sutter, Jascha Brettschneider, Sara Mamchur, Fred Krebs, Sophia Gershman, Vandana Miller
Summary: In this study, the impact of cell structure, size, and viability on the physical properties of non-thermal plasma was explored. The results showed that the structural integrity and enzymic processes of cells can change the electrical properties of plasma, and correlations were found between hydrogen peroxide, nitrite, and capacitance measurements.
