Review
Immunology
Raquel Ron, Elena Moreno, Javier Martinez-Sanz, Fatima Branas, Talia Sainz, Santiago Moreno, Sergio Serrano-Villar
Summary: Studies have shown the significance of CD4/CD8 ratio in monitoring HIV, but there is still debate on its ability to predict adverse outcomes. Some clinical guidelines recommend monitoring it, but knowledge gaps remain on optimal cutoff points, associated clinical events, treatment effects, and decision making improvements.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Medicine, General & Internal
Javier Martinez-Sanz, Jorge Diaz-alvarez, Marta Rosas, Raquel Ron, Jose Antonio Iribarren, Enrique Bernal, Felix Gutierrez, Andres Ruiz Sancho, Noemi Cabello, Julian Olalla, Santiago Moreno, Sergio Serrano-Villar
Summary: The study suggests that a low CD4/CD8 ratio during HIV treatment is associated with immunosenescence. Data analysis shows that patients with a CD4/CD8 ratio less than 0.3 in the second year of ART have an increased risk of developing SNAEs in the next five years.
Article
Immunology
Juanjuan Chen, Xuewu Liu, Shanfang Qin, Guangjing Ruan, Aili Lu, Jinxin Zhang, Yihua Wu, Zhiman Xie, Jie Peng
Summary: This study aimed to develop a simple and clinically applicable prognostic scoring system for AIDS-related lymphoma (ARL), which can help assess patients' risk and guide treatment decisions. The study found that the CD4/CD8 ratio is a powerful independent prognostic parameter in ARL patients, and its combination with the IPI improves prognostic ability.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Microbiology
Fengxiang Qin, Qing Lv, Wen Hong, Di Wei, Kui Huang, Ke Lan, Rongfeng Chen, Jie Liu, Bingyu Liang, Huayue Liang, Hao Liang, Shanfang Qin, Li Ye, Junjun Jiang
Summary: This study suggests that CD4/CD8 ratio recovery is associated with a lower incidence of CKD in HIV-infected patients receiving ART, and NNRTI-based regimen is a better choice for CD4/CD8 ratio recovery and reducing the risk of CKD.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Immunology
Javier Martinez-Sanz, Raquel Ron, Elena Moreno, Matilde Sanchez-Conde, Alfonso Muriel, Luis Fernando Lopez Cortes, Jose Ramon Blanco, Juan Antonio Pineda, Alvaro Mena, Sonia Calzado Isbert, Santiago Moreno, Sergio Serrano-Villar
Summary: This study compared the impact of a 2-drug regimen with dolutegravir plus lamivudine to a 3-drug regimen based on other integrase strand transfer inhibitors (INSTIs) on the recovery of the CD4/CD8 ratio in people with HIV. The results showed no difference in the normalization rates of the CD4/CD8 ratio at 48 weeks between the two treatment strategies.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Bei Li, Leidan Zhang, Ying Liu, Jing Xiao, Cuilin Li, Lina Fan, Yujiao Duan, Jiang Xiao, Yu Hao, Junyan Han, Yaxian Kong, Hongxin Zhao
Summary: Our study developed a clinical prediction model to evaluate the possibility of CD4(+)/CD8(+) ratio restoration in HIV-positive individuals. The model showed good predictive accuracy and calibration, and can be used to determine whether HIV/AIDS patients would benefit from modern antiretroviral therapy.
Article
Infectious Diseases
Alice Zhabokritsky, Leah Szadkowski, Curtis Cooper, Mona Loutfy, Alexander Wong, Alison McClean, Robert S. Hogg, Sharon L. Walmsley
Summary: The study found that early initiation of ART and having a higher baseline CD4+ T-cell count are associated with achieving CD4:CD8 ratio normalization. The type of ART class used did not impact the normalization of the ratio when adjusting for baseline characteristics.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2021)
Article
Medicine, General & Internal
Leo Placais, Faroudy Boufassa, Camille Lecuroux, Elise Gardiennet, Veronique Avettand-Fenoel, Asier Saez-Cirion, Olivier Lambotte, Nicolas Noel
Summary: In this French cohort of HIV controllers, only 30% of participants required ART during a median follow-up of 14.8 years. The results demonstrate the stability of HIC status and support a patient-centered treatment approach based on individual benefit/risk balance.
Review
Oncology
Elizabeth Y. Chiao, Anna Coghill, Darya Kizub, Valeria Fink, Ntokozo Ndlovu, Angela Mazul, Keith Sigel
Summary: Non-AIDS-defining cancers are becoming a growing source of morbidity for people with HIV globally, with ageing, behavioral, and HIV-specific factors affecting the incidence and outcomes. While HIV-infected individuals have an increased risk of developing virally mediated cancers, the burden of non-AIDS-defining cancers, such as prostate cancer, is on the rise, presenting different challenges for addressing global morbidity and mortality from these cancers. Treatment trials for the optimal management of people living with HIV and non-AIDS-defining cancer, including interventions such as immunotherapies, are needed to improve outcomes.
Article
Medicine, General & Internal
Sergio Serrano-Villar, Kunling Wu, Peter W. Hunt, Judith J. Lok, Raquel Ron, Talia Sainz, Santiago Moreno, Steven G. Deeks, Ronald J. Bosch
Summary: Increased CD8 counts during treated HIV are related to immunosenescence, but the additional predictive values of CD8 counts and CD4/CD8 ratio to identify individuals with higher risk of clinical events in HIV remain controversial. Patients with CD8 counts >1500/μL have a higher risk of clinical events during years 3-7, while CD4/CD8 ratio is not predictive of greater event risk.
Article
Infectious Diseases
Dan Yuan, Yan Zhang, Yiping Li, Ling Li, Hong Yang, Wei Yang, Hang Yu, Liao Feng, Shu Liang
Summary: This study analyzed the CD4(+) T cell count changes of PLWH infected with different HIV-1 subtypes in Sichuan Province after treatment, identifying factors such as virus subtype, gender, age, and education level that influence CD4(+) T cell count growth.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Multidisciplinary Sciences
Vincenzo Malagnino, Carlotta Cerva, Elisabetta Teti, Laura Campogiani, Mirko Compagno, Luca Foroghi Biland, Laura Saderi, Daniele Armenia, Romina Salpini, Valentina Svicher, Giovanni Sotgiu, Marco Iannetta, Massimo Andreoni, Loredana Sarmati
Summary: The study divided patients into HBV positive and negative groups, finding that HBV coinfected patients had slower growth in CD4/CD8 ratio and higher CD8+ T cell counts, while HIV monoinfected patients had faster growth in CD4/CD8 ratio after starting combination antiretroviral therapy (cART).
SCIENTIFIC REPORTS
(2021)
Article
Immunology
H. Manisha Yapa, Hae-Young Kim, Kathy Petoumenos, Frank A. Post, Awachana Jiamsakul, Jan-Walter De Neve, Frank Tanser, Collins Iwuji, Kathy Baisley, Maryam Shahmanesh, Deenan Pillay, Mark J. Siedner, Till Barnighausen, Jacob Bor
Summary: The implementation of UTT in rural South Africa led to an immediate increase in CD4 count at ART initiation, but had modest long-term effects. Men initiated ART at lower CD4 counts than women throughout the study, indicating a need for more efforts to promote early ART initiation in individuals living with HIV, especially men.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Virology
Lucia Taramasso, Antonio Falletta, Elena Ricci, Giancarlo Orofino, Nicola Squillace, Barbara Menzaghi, Giuseppe Vittorio De Socio, Chiara Molteni, Giovanni Francesco Pellicano, Roberto Gulminetti, Giordano Madeddu, Eleonora Sarchi, Francesca Vichi, Benedetto Maurizio Celesia, Paolo Bonfanti, Antonio Di Biagio
Summary: The aim of this study was to evaluate CD4/CD8 dynamics in patients on dolutegravir-based two-drug regimens (2DRs) and compare them with dolutegravir-containing triple-drug regimens (3DRs). The study found that in the SCOLTA cohort, only patients on the DTG + 3TC 2DR experienced a significant increase in the CD4/CD8 ratio.
Article
Immunology
Win Min Han, Anchalee Avihingsanon, Reena Rajasuriar, Junko Tanuma, Sanjay Mundhe, Man-Po Lee, Jun Yong Choi, Sanjay Pujari, Yu-Jiun Chan, Agus Somia, Fujie Zhang, Nagalingeswaran Kumarasamy, Oon Tek Ng, Yasmin Gani, Romanee Chaiwarith, Thach Ngoc Pham, Cuong Duy Do, Rossana Ditangco, Sasisopin Kiertiburanakul, Vohith Khol, Jeremy Ross, Awachana Jiamsakul
Summary: This study evaluated the trends in CD4/CD8 ratio and the incidence of CD4/CD8 ratio normalization among HIV-infected individuals starting ART with INSTI compared to non-INSTI-based ART. The results showed that INSTI use was associated with higher rates of CD4/CD8 ratio recovery and normalization.
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
(2023)
Article
Infectious Diseases
Lise Cuzin, Clotilde Allavena, Laurent Cotte, Cyrille Delpierre, Thomas Huleux, Romain Palich, Pierre Delobel, Francois Raffi, Andre Cabie
Summary: Despite free access to care and universal ART in France, disparities remain in the HIV continuum care across age, country of birth and way of HIV acquisition. Clinical and public health interventions targeting specific patients' conditions are needed.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2021)
Article
Immunology
Romain Palich, Elisa Teyssou, Sophie Sayon, Basma Abdi, Cathia Soulie, Lise Cuzin, Roland Tubiana, Marc-Antoine Valantin, Luminita Schneider, Sophie Seang, Marc Wirden, Valerie Pourcher, Christine Katlama, Vincent Calvez, Anne-Genevieve Marcelin
Summary: The presence of drug-resistant viral variants (DRVs) with the M184V mutation decreases over time in HIV DNA, but it persists more frequently in patients with longer treatment experience and past replication under 3TC/FTC.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Letter
Infectious Diseases
Lise Cuzin, Ornella Cabras, Athena Marquise, Sandrine Pierre-Francois, Mathilde Pircher, Andre Cabie
SEXUALLY TRANSMITTED INFECTIONS
(2022)
Letter
Infectious Diseases
Lise Cuzin, Pierre Delobel, Guillaume Martin-Blondel
Article
Infectious Diseases
Rebecca Lajaunie, Lise Cuzin, Romain Palich, Alain Makinson, Firouze Bani-Sadr, Claudine Duvivier, Cedric Arvieux, David Rey, Isabelle Poizot-Martin, Cyril Delpierre, Pierre Delobel, Guillaume Martin-Blondel
Summary: A retrospective analysis of PLHIV with a history of KS and controlled HIV replication found that switching from a PI-based regimen to a PI-free one did not increase the risk of KS relapse.
Article
Infectious Diseases
Colin Deschanvres, Jacques Reynes, Isabelle Lamaury, David Rey, Romain Palich, Firouze Bani-Sadr, Olivier Robineau, Claudine Duvivier, Laurent Hocqueloux, Lise Cuzin, Veronique Joly, Francois Raffil, Andre Cabie, Clotilde Allavena
Summary: Maintenance ART with dolutegravir-based dual regimens has shown efficacy in HIV-1infected subjects, but real-life data are limited. In this study, virological failure and resistance-associated mutations were assessed in dolutegravir maintenance regimens. Results indicated that careful virological screening is essential before switching to dolutegravir maintenance regimens in virologically suppressed patients.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Infectious Diseases
Andrea Cara, Tristan Ferry, Frederic Laurent, Jerome Josse
Summary: Gram-negative bacilli can cause prosthetic joint infection, and the treatment becomes challenging due to increased antibiotic resistance and biofilm formation. Loading bone cement with antibiotics can help reduce the risk of infection during arthroplasties with cemented prosthesis. The study compared the efficacy of various antibiotic-loaded bone cements in preventing biofilm formation by different strains of Gram-negative bacteria.
Article
Health Care Sciences & Services
Romain Demeulemeester, Nicolas Savy, Michael Mounie, Laurent Molinier, Cyrille Delpierre, Pierre Dellamonica, Clotilde Allavena, Pascal Pugliesse, Lise Cuzin, Philippe Saint-Pierre, Nadege Costa
Summary: This study assessed the economic impact of generic antiretrovirals in France over a five-year period, finding substantial savings from the use of generics in different scenarios. This could help decision makers anticipate resource allocations and promote innovation in antiretroviral therapies and prevention.
BMC HEALTH SERVICES RESEARCH
(2022)
Letter
Infectious Diseases
Ornella Cabras, Jean-Marie Turmel, Andrea Rami, Lise Cuzin
SEXUALLY TRANSMITTED INFECTIONS
(2022)
Article
Immunology
Romain Palich, Rachid Agher, Dimoke J. Wetshikoy, Lise Cuzin, Sophie Seang, Cathia Soulie, Roland Tubiana, Marc-Antoine Valantin, Luminita Schneider, Valerie Pourcher, Anne-Genevieve Marcelin, Lambert Assoumou, Christine Katlama
Summary: This study aims to explore the differences in antiretroviral therapy (ART) prescriptions between naive and virally suppressed HIV patients born in France and Sub-Saharan Africa. The findings suggest that the differences in ART prescriptions between these two groups cannot solely be explained by different clinical and virologic situations.
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
(2023)
Article
Medicine, General & Internal
Vasileios Giovanoulis, Angelo V. Vasiliadis, Christos Koutserimpas, George Samonis, Cecile Batailler, Tristan Ferry, Sebastien Lustig
Summary: This study reports an extremely rare fungal infection caused by Candida lusitaniae after revised total knee replacement. The patient was successfully treated with multiple strategies, highlighting the importance of a multidisciplinary approach for managing severe infections.
Article
Medicine, General & Internal
Marie Berger, Delphine Daubin, Jeremy Charriot, Kada Klouche, Vincent Le Moing, David Morquin, Laurence Halimi, Audrey Jaussent, Patrice Taourel, Maurice Hayot, Jean-Paul Cristol, Nicolas Nagot, Pierre Fesler, Camille Roubille
Summary: The objective of this study was to explore the mid-term outcomes of patients hospitalized in ICU for severe COVID-19 infection. The results showed that a significant number of patients experienced post-COVID-19 symptoms such as asthenia, muscle weakness, arthralgia, and psychological issues in the mid-term. Further studies on prognostic factors are needed.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Infectious Diseases
Ornella Cabras, Jean-Marie Turmel, Claude Olive, Bastien Bigeard, Melanie Lehoux, Sandrine Pierre-Francois, Karine Guitteaud, Sylvie Abel, Lise Cuzin, Andre Cabie
Summary: This study reported potentially severe coinfections of Pasteurella multocida in COVID-19 patients, with a high mortality rate.
TROPICAL MEDICINE AND INFECTIOUS DISEASE
(2022)
Article
Infectious Diseases
Lise Cuzin, Philippe Flandre, Clotilde Allavena, Romain Palich, Claudine Duvivier, Agathe Becker, Helene Laroche, Pascal Pugliese, Andre Cabie, Dat'AIDS Study Grp
Summary: This study analyzed the occurrence of virological failure (VF) in patients starting ART with an integrase strand transfer inhibitor (INSTI)-based regimen in recent years and its relationship with previous episodes of low-level viral load (LLVL). The results showed that LLVL was associated with VF, and even in the absence of subsequent failure, LLV episodes have a cost. Therefore, any viral load value above 50 copies/mL should lead to enhanced adherence counseling.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Article
Immunology
Lise Cuzin, Adeline Morisot, Clotilde Allavena, France Lert, Pascal Pugliese
Summary: The study found significant reductions in transition time through the cascade of care, contributing to a shorter transmission period after each new infection. However, delayed diagnosis remains the primary obstacle to ending AIDS in the next decade.
CLINICAL INFECTIOUS DISEASES
(2023)