Article
Cardiac & Cardiovascular Systems
Lise Lotte Torvin Andersen, Annemarie Helt, Lene Sperling, Martin Overgaard
Summary: The study evaluated the predictive performance and decision threshold of Kryptor sFlt-1/PlGF ratio in managing women with symptoms of preeclampsia, showing good predictive value for both early-onset and late-onset preeclampsia. A single threshold of 66 is recommended for clinical use in ruling out and ruling in preeclampsia within 1 week.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Review
Medicine, Research & Experimental
Alexandros Velegrakis, Elisavet Kouvidi, Persefoni Fragkiadaki, Stavros Sifakis
Summary: Preeclampsia (PE) is a serious complication of pregnancy with a high incidence rate and causes significant maternal and fetal health risks. Studies have shown that differences in maternal serum levels of angiogenic factors can be used as biomarkers to predict the development of PE. Specifically, the sFlt-1/PlGF ratio has been identified as the optimal predictive tool. However, further research is needed to enhance its clinical applicability and provide universal guidelines for consistent management of PE.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2023)
Article
Developmental Biology
S. Rowson, M. Reddy, D. L. De Guingand, A. Langston-Cox, S. A. Marshall, F. da Silva Costa, K. R. Palmer
Summary: This study found that using placental-specific sFLT-1 e15a performs comparably to total sFLT-1 in diagnosing preeclampsia, which is particularly helpful in diagnosing early-onset preeclampsia.
Article
Rheumatology
Rugina Neuman, Hieronymus T. W. Smeele, A. H. Jan Danser, Radboud J. E. M. Dolhain, Willy Visser
Summary: This study shows that the sFlt-1/PlGF ratio is not altered due to disease activity in pregnant women with RA, and a cut-off of <= 38 can be used to exclude preeclampsia. Additionally, the use of SSZ does not affect the levels of sFlt-1 or PlGF in this population.
Article
Immunology
Marwa Ben Ali Gannoun, Meriem Mehdi, Hedia Zitouni, Manel Boussabah, Ines Zouari, Ali Jlali, Wassim Y. Almawi
Summary: This study tested the link between altered PlGF and sFLT-1 levels, and their ratio with PE and PE-associated features, and found that increased sFlt-1 levels and sFlt-1/PlGF ratio are independent risk factors for PE.
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2023)
Article
Peripheral Vascular Disease
Akihide Ohkuchi, Shigeru Saito, Tatsuo Yamamoto, Hisanori Minakami, Hisashi Masuyama, Keiichi Kumasawa, Jun Yoshimatsu, Takeshi Nagamatsu, Angela Dietl, Sonja Grill, Martin Hund
Summary: The subanalysis of Japanese women with suspected preeclampsia showed a high predictive value of Elecsys sFlt-1/PlGF ratio cutoff of 38 for short-term prediction of preeclampsia. This ratio can effectively rule out or diagnose preeclampsia within 1 week, helping to accurately determine the condition of pregnant women.
HYPERTENSION RESEARCH
(2021)
Article
Obstetrics & Gynecology
M. Wind, M. E. van den Akker-van Marle, B. E. P. B. Ballieux, C. M. Cobbaert, T. J. Rabelink, J. M. M. van Lith, Y. K. O. Teng, M. Sueters
Summary: This study investigated the clinical value of adding the sFlt-1/PlGF ratio to the spot urine protein/creatinine ratio (PCr) in women with suspected pre-eclampsia. The results showed that this combined test could improve the selection of low-risk pregnant women and reduce hospital care for women with suspected pre-eclampsia.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Article
Developmental Biology
Fengyuan Zhang, Mengqi Gu, Pengzheng Chen, Shuting Wan, Qian Zhou, Yuan Lu, Lei Li
Summary: This study found that the concentrations of sFlt-1 and PLGF, as well as the sFlt-1/PLGF ratio, can help distinguish patients with placenta accreta from those with placenta previa.
Article
Obstetrics & Gynecology
Hae Rin Jeon, Da Hoe Jeong, Jin Young Lee, Eun Young Woo, Gwi Taek Shin, Suk-Young Kim
Summary: The sFlt-1/PlGF ratio is a useful indicator in predicting adverse pregnancy outcomes in preeclampsia. The high-risk group had lower gestational weeks, lighter neonatal weight, and longer stay in the neonatal intensive care unit compared to the low-risk group.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2021)
Article
Peripheral Vascular Disease
Akihide Ohkuchi, Hisashi Masuyama, Tatsuo Yamamoto, Takashi Kikuchi, Naoko Taguchi, Cyrill Wolf, Shigeru Saito
Summary: The introduction of the sFlt-1/PlGF ratio test with a cutoff value of 38 can reduce unnecessary hospitalizations in low-risk patients and identify high-risk individuals for appropriate management. This would result in significant cost savings in the Japanese healthcare system.
HYPERTENSION RESEARCH
(2021)
Article
Medicine, General & Internal
Katarzyna Kosinska-Kaczynska, Ewa Malicka, Iwona Szymusik, Norbert Dera, Michal Pruc, Stepan Feduniw, Zubaid Rafique, Lukasz Szarpak
Summary: COVID-19 infection in pregnant women is associated with an increased risk of adverse pregnancy outcomes, including preeclampsia. This meta-analysis found that pregnant women with COVID-19 have higher sFlt-1/PlGF ratios compared to those without COVID-19. Severe COVID-19 and SARS-CoV-2 infection in hypertensive pregnant women were also associated with significantly higher sFlt-1/PlGF ratios.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Anca-Florina Tataru-Copos, Mircea Ioachim Popescu, Romina Murvai, Amin El Kharoubi
Summary: This study investigates the correlation between sFlt-1/PlGF ratio and preeclampsia in pregnant women. The results show a positive correlation between sFlt-1/PlGF values and the severity of preeclampsia, which can be used to predict the development of early-onset severe preeclampsia. Additionally, the sFlt-1/PlGF ratio has high accuracy in differentiating preeclampsia patients from pregnant women without symptoms of preeclampsia.
MEDICINA-LITHUANIA
(2022)
Review
Obstetrics & Gynecology
Stefan Verlohren, Shaun P. Brennecke, Alberto Galindo, S. Ananth Karumanchi, Ljiljana B. Mirkovic, Dietmar Schlembach, Holger Stepan, Manu Vatish, Harald Zeisler, Sarosh Rana
Summary: Preeclampsia poses significant morbidity and mortality risks for both mother and baby. The discovery of circulating angiogenic factors in preeclampsia pathogenesis has advanced diagnosis and prognosis, but there is currently no consensus or clear guidance on their practical use in routine clinical practice.
PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH
(2022)
Article
Obstetrics & Gynecology
Karoline Mayer-Pickel, Christina Stern, Katharina Eberhard, Uwe Lang, Barbara Obermayer-Pietsch, Mila Cervar-Zivkovic
Summary: Preeclampsia is characterized by increased platelet consumption and elevated mean platelet volume (MPV). Research suggests that MPV can be a valuable predictor for preeclampsia, particularly for early onset cases. This study found that MPV is significantly elevated in women who develop preeclampsia in early pregnancy, indicating its potential for early detection of the condition. Additionally, ROC curve analysis showed that MPV has a high predictive value for early-onset preeclampsia.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2021)
Article
Medicine, General & Internal
Szymon Kozlowski, Anna Stelmaszczyk-Emmel, Iwona Szymusik, Aleksandra Saletra-Bielinska, Robert Brawura-Biskupski-Samaha, Pawel Pietruski, Agnieszka Osinska, Katarzyna Kosinska-Kaczynska
Summary: In this study, it was found that the concentration of sFlt-1 is higher in dichorionic twin pregnancies compared to monochorionic pregnancies. PlGF and sEng levels did not significantly differ between mono- and dichorionic gestation. Additionally, the concentrations of PlGF, sFlt-1 and sEng increased significantly during gestation and were much higher in the third trimester compared to the first trimester.
Article
Obstetrics & Gynecology
Marina Maier, Andreas Brueckmann, Ekkehard Schleussner, Dietmar Schlembach
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2017)
Review
Hematology
Heiko Lier, Christian von Heymann, Wolfgang Korte, Dietmar Schlembach
TRANSFUSION MEDICINE AND HEMOTHERAPY
(2018)
Article
Obstetrics & Gynecology
Dietmar Schlembach, Hanns Helmer, Wolfgang Henrich, Christian von Heymann, Franz Kainer, Wolfgang Korte, Maritta Kuehnert, Heiko Lier, Holger Maul, Werner Rath, Susanne Steppat, Daniel Surbek, Juergen Wacker
GEBURTSHILFE UND FRAUENHEILKUNDE
(2018)
Article
Multidisciplinary Sciences
Vassiliki Kolovetsiou-Kreiner, Manfred Georg Moertl, Ilona Papousek, Karin Schmid-Zalaudek, Uwe Lang, Dietmar Schlembach, Mila Cervar-Zivkovic, Helmut Karl Lackner
Article
Health Care Sciences & Services
Dietmar Schlembach, Martin Hund, Annabel Schroer, Cyrill Wolf
BMC HEALTH SERVICES RESEARCH
(2018)
Correction
Obstetrics & Gynecology
Marina Maier, Andreas Brueckmann, Ekkehard Schleussner, Dietmar Schlembach
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2018)
Article
Obstetrics & Gynecology
Sally L. Collins, Bahrin Alemdar, Heleen J. van Beekhuizen, Charline Bertholdt, Thorsten Braun, Pavel Calda, Pierre Delorme, Johannes J. Duvekot, Lene Gronbeck, Gilles Kayem, Jens Langhoff-Roos, Louis Marcellin, Pasquale Martinelli, Olivier Morel, Mina Mhallem, Maddalena Morlando, Lone N. Noergaard, Andreas Nonnenmacher, Petra Pateisky, Philippe Petit, Marcus J. Rijken, Mariola Ropacka-Lesiak, Dietmar Schlembach, Loic Sentilhes, Vedran Stefanovic, Gita Strindfors, Boris Tutschek, Siri Vangen, Alexander Weichert, Katharina Weizsaecker, Frederic Chantraine
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2019)
Article
Endocrinology & Metabolism
F. Hauffe, U. M. Schaefer-Graf, R. Fauzan, A. L. Schohe, D. Scholle, L. Sedlacek, K. A. Scherer, C. Klapp, B. Ramsauer, W. Henrich, D. Schlembach, M. Abou-Dakn
Review
Obstetrics & Gynecology
Dietmar Schlembach, Martin Hund, Cyrill Wolf, Manu Vatish
PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH
(2019)
Article
Obstetrics & Gynecology
Matthias David, Oliver Razum, Wolfgang Henrich, Babett Ramsauer, Dietmar Schlembach, Juergen Breckenkamp
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2019)
Article
Medical Laboratory Technology
Holger Stepan, Martin Hund, Peter Dilba, Johanna Sillman, Dietmar Schlembach
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2019)
Article
Obstetrics & Gynecology
Richard Berger, Harald Abele, Franz Bahlmann, Ivonne Bedei, Klaus Doubek, Ursula Felderhoff-Mueser, Herbert Fluhr, Yves Garnier, Susanne Grylka-Baeschlin, Hanns Helmer, Egbert Herting, Markus Hoopmann, Irene Hoesli, Udo Hoyme, Alexandra Jendreizeck, Harald Krentel, Ruben Kuon, Wolf Luetje, Silke Mader, Holger Maul, Werner Mendling, Barbara Mitschdoerfer, Tatjana Nicin, Monika Nothacker, Dirk Olbertz, Werner Rath, Claudia Roll, Dietmar Schlembach, Ekkehard Schleussner, Florian Schuetz, Vanadin Seifert-Klauss, Susanne Steppat, Daniel Surbek
GEBURTSHILFE UND FRAUENHEILKUNDE
(2019)
Article
Obstetrics & Gynecology
Richard Berger, Harald Abele, Franz Bahlmann, Ivonne Bedei, Klaus Doubek, Ursula Felderhoff-Mueser, Herbert Fluhr, Yves Garnier, Susanne Grylka-Baeschlin, Hanns Helmer, Egbert Herting, Markus Hoopmann, Irene Hoesli, Udo Hoyme, Alexandra Jendreizeck, Harald Krentel, Ruben Kuon, Wolf Luetje, Silke Mader, Holger Maul, Werner Mendling, Barbara Mitschdoerfer, Tatjana Nicin, Monika Nothacker, Dirk Olbertz, Werner Rath, Claudia Roll, Dietmar Schlembach, Ekkehard Schleussner, Florian Schuetz, Vanadin Seifert-Klauss, Susanne Steppat, Daniel Surbek
GEBURTSHILFE UND FRAUENHEILKUNDE
(2019)
Article
Obstetrics & Gynecology
Richard Berger, Harald Abele, Franz Bahlmann, Ivonne Bedei, Klaus Doubek, Ursula Felderhoff-Mueser, Herbert Fluhr, Yves Garnier, Susanne Grylka-Baeschlin, Hanns Helmer, Egbert Herting, Markus Hoopmann, Irene Hoesli, Udo Hoyme, Alexandra Jendreizeck, Harald Krentel, Ruben Kuon, Wolf Luetje, Silke Mader, Holger Maul, Werner Mendling, Barbara Mitschdoerfer, Tatjana Nicin, Monika Nothacker, Dirk Olbertz, Werner Rath, Claudia Roll, Dietmar Schlembach, Ekkehard Schleussner, Florian Schuetz, Vanadin Seifert-Klauss, Susanne Steppat, Daniel Surbek
ZEITSCHRIFT FUR GEBURTSHILFE UND NEONATOLOGIE
(2019)
Article
Obstetrics & Gynecology
Richard Berger, Harald Abele, Franz Bahlmann, Ivonne Bedei, Klaus Doubek, Ursula Felderhoff-Mueser, Herbert Fluhr, Yves Garnier, Susanne Grylka-Baeschlin, Hanns Helmer, Egbert Herting, Markus Hoopmann, Irene Hosli, Udo Hoyme, Alexandra Jendreizeck, Harald Krentel, Ruben Kuon, Wolf Luetje, Silke Mader, Holger Maul, Werner Mendling, Barbara Mitschdoerfer, Tatjana Nicin, Monika Nothacker, Dirk Olbertz, Werner Rath, Claudia Roll, Dietmar Schlembach, Ekkehard Schleussner, Florian Schuetz, Vanadin Seifert-Klauss, Susanne Steppat, Daniel Surbek
ZEITSCHRIFT FUR GEBURTSHILFE UND NEONATOLOGIE
(2019)