Development and Evaluation of a Fluorescent Antibody-Drug Conjugate for Molecular Imaging and Targeted Therapy of Pancreatic Cancer

Site-Specific Antibody–Drug Conjugates: The Nexus of Bioorthogonal Chemistry, Protein Engineering, and Drug Development

(2015) Paresh Agarwal et al.   BIOCONJUGATE CHEMISTRY

Functional native disulfide bridging enables delivery of a potent, stable and targeted antibody–drug conjugate (ADC)

(2015) João P. M. Nunes et al.   CHEMICAL COMMUNICATIONS

Advances in Chemical Protein Modification

(2015) Omar Boutureira et al.   CHEMICAL REVIEWS

A Novel Anti-CD22 Anthracycline-Based Antibody-Drug Conjugate (ADC) That Overcomes Resistance to Auristatin-Based ADCs

(2015) S.-F. Yu et al.   CLINICAL CANCER RESEARCH

Methods to analyze SNARE-dependent vesicular fusion events that regulate autophagosome biogenesis

(2015) Kevin Moreau et al.   METHODS

Design of Coltuximab Ravtansine, a CD19-Targeting Antibody–Drug Conjugate (ADC) for the Treatment of B-Cell Malignancies: Structure–Activity Relationships and Preclinical Evaluation

(2015) E. Erica Hong et al.   MOLECULAR PHARMACEUTICS

Current ADC Linker Chemistry

(2015) Nareshkumar Jain et al.   PHARMACEUTICAL RESEARCH

A plug-and-play approach to antibody-based therapeutics via a chemoselective dual click strategy

(2015) Antoine Maruani et al.   Nature Communications

Fluorescence-guided Surgery with a Fluorophore-conjugated Antibody to Carcinoembryonic Antigen (CEA), that Highlights the Tumor, Improves Surgical Resection and Increases Survival in Orthotopic Mouse Models of Human Pancreatic Cancer

(2014) Cristina A. Metildi et al.   ANNALS OF SURGICAL ONCOLOGY

Specific tumor labeling enhanced by polyethylene glycol linkage of near infrared dyes conjugated to a chimeric anti-carcinoembryonic antigen antibody in a nude mouse model of human pancreatic cancer

(2014) Ali A. Maawy et al.   JOURNAL OF BIOMEDICAL OPTICS

Successful Fluorescence-Guided Surgery on Human Colon Cancer Patient-Derived Orthotopic Xenograft Mouse Models Using a Fluorophore-Conjugated Anti-CEA Antibody and a Portable Imaging System

(2014) Yukihiko Hiroshima et al.   Journal of Laparoendoscopic & Advanced Surgical Techniques

Advantages of Fluorescence-Guided Laparoscopic Surgery of Pancreatic Cancer Labeled with Fluorescent Anti–Carcinoembryonic Antigen Antibodies in an Orthotopic Mouse Model

(2014) Cristina A. Metildi et al.   JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS

Next generation maleimides enable the controlled assembly of antibody–drug conjugates via native disulfide bond bridging

(2014) Felix F. Schumacher et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Polyethylene Glycol (PEG) Linked to Near Infrared (NIR) Dyes Conjugated to Chimeric Anti-Carcinoembryonic Antigen (CEA) Antibody Enhances Imaging of Liver Metastases in a Nude-Mouse Model of Human Colon Cancer

(2014) Ali A. Maawy et al.   PLoS One

β-Arrestin 2 Mediates G Protein-Coupled Receptor 43 Signals to Nuclear Factor-κB

(2013) Su Ui Lee et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Location Matters: Site of Conjugation Modulates Stability and Pharmacokinetics of Antibody Drug Conjugates

(2013) Pavel Strop et al.   CHEMISTRY & BIOLOGY

Comparison of a chimeric anti-carcinoembryonic antigen antibody conjugated with visible or near-infrared fluorescent dyes for imaging pancreatic cancer in orthotopic nude mouse models

(2013) Ali A. Maawy et al.   JOURNAL OF BIOMEDICAL OPTICS

Fluorescently labeled chimeric anti-CEA antibody improves detection and resection of human colon cancer in a patient-derived orthotopic xenograft (PDOX) nude mouse model

(2013) Cristina A. Metildi et al.   JOURNAL OF SURGICAL ONCOLOGY

Methods for site-specific drug conjugation to antibodies

(2013) Christopher R Behrens et al.   mAbs

Erratum: Maturing antibody–drug conjugate pipeline hits 30

(2013) Asher Mullard   NATURE REVIEWS DRUG DISCOVERY

Molecular Mechanism of Hepcidin-Mediated Ferroportin Internalization Requires Ferroportin Lysines, Not Tyrosines or JAK-STAT

(2012) Sandra L. Ross et al.   Cell Metabolism

Antibody-Drug Conjugates for the Treatment of Cancer

(2012) John A. Flygare et al.   Chemical Biology & Drug Design

Antibody–drug conjugates: Basic concepts, examples and future perspectives

(2012) Giulio Casi et al.   JOURNAL OF CONTROLLED RELEASE

Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates

(2012) Ben-Quan Shen et al.   NATURE BIOTECHNOLOGY

Site-specific chemical protein conjugation using genetically encoded aldehyde tags

(2012) David Rabuka et al.   Nature Protocols

Synthesis of site-specific antibody-drug conjugates using unnatural amino acids

(2012) J. Y. Axup et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Brentuximab Vedotin (SGN-35)

(2011) J. Katz et al.   CLINICAL CANCER RESEARCH

Site-Specific and Stoichiometric Modification of Antibodies by Bacterial Transglutaminase

(2010) Simone Jeger et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Engineered Thio-Trastuzumab-DM1 Conjugate with an Improved Therapeutic Index to Target Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer

(2010) J. R. Junutula et al.   CLINICAL CANCER RESEARCH

Half-Antibody Functionalized Lipid−Polymer Hybrid Nanoparticles for Targeted Drug Delivery to Carcinoembryonic Antigen Presenting Pancreatic Cancer Cells

(2010) Che-Ming Jack Hu et al.   MOLECULAR PHARMACEUTICS

Methodological considerations for assessing autophagy modulators: A study with calcium phosphate precipitates

(2009) Sovan Sarkar et al.   Autophagy

Molecularly Defined Antibody Conjugation through a Selenocysteine Interface

(2009) Thomas Hofer et al.   BIOCHEMISTRY

Site Specific Conjugation of Fluoroprobes to the Remodeled Fc N-Glycans of Monoclonal Antibodies Using Mutant Glycosyltransferases: Application for Cell Surface Antigen Detection

(2009) Elizabeth Boeggeman et al.   BIOCONJUGATE CHEMISTRY

Chemical Modification of Proteins at Cysteine: Opportunities in Chemistry and Biology

(2009) Justin M. Chalker et al.   Chemistry-An Asian Journal

The Monoclonal Antibody nBT062 Conjugated to Cytotoxic Maytansinoids Has Selective Cytotoxicity Against CD138-Positive Multiple Myeloma Cells In vitro and In vivo

(2009) H. Ikeda et al.   CLINICAL CANCER RESEARCH

Synthesis and Preliminary Biological Evaluation of High-Drug-Load Paclitaxel-Antibody Conjugates for Tumor-Targeted Chemotherapy

(2009) Sherly Quiles et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pathways and mechanisms of endocytic recycling

(2009) Barth D. Grant et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Kinetics of anti-carcinoembryonic antigen antibody internalization: effects of affinity, bivalency, and stability

(2008) Michael M. Schmidt et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Antibodies for Molecular Imaging of Cancer

(2008) Anna M. Wu et al.   CANCER JOURNAL

Antibody-Drug Conjugates for Cancer Therapy

(2008) Paul J. Carter et al.   CANCER JOURNAL

Targeting HER2-Positive Breast Cancer with Trastuzumab-DM1, an Antibody-Cytotoxic Drug Conjugate

(2008) G. D. Lewis Phillips et al.   CANCER RESEARCH

In vitro and in vivo evaluation of a paclitaxel conjugate with the divalent peptide E-[c(RGDfK)2] that targets integrin αvβ3

(2008) Claudia Ryppa et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Fluorophore-conjugated anti-CEA Antibody for the Intraoperative Imaging of Pancreatic and Colorectal Cancer

(2008) Sharmeela Kaushal et al.   JOURNAL OF GASTROINTESTINAL SURGERY

Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index

(2008) Jagath R Junutula et al.   NATURE BIOTECHNOLOGY

High-content analysis in neuroscience

(2008) Mike Dragunow   NATURE REVIEWS NEUROSCIENCE