Review
Biochemistry & Molecular Biology
Yidan Zhang, Jie Tian, Fan Xiao, Leting Zheng, Xiaoxia Zhu, Ling Wu, Cheng Zhao, Shengjun Wang, Ke Rui, Hejian Zou, Liwei Lu
Summary: B cells play a pivotal role in autoimmune diseases, and B cell-activating factor (BAFF) is key in driving autoreactive B cell response. Increased BAFF levels have been observed in patients with autoimmune diseases and mouse models where autoantibody production is prominent. Recent clinical studies have shown BAFF as a potential therapeutic target for treating autoimmune diseases.
CYTOKINE & GROWTH FACTOR REVIEWS
(2022)
Review
Endocrinology & Metabolism
Nicole Lafontaine, Scott G. Wilson, John P. Walsh
Summary: This review summarizes the current understanding of DNA methylation (DNAm) in autoimmune thyroid disease (AITD), highlighting differential DNAm in several genes implicated in AITD. However, further replication and functional studies are needed to support the causal roles of these differential DNAm in AITD pathogenesis. Additionally, the influence of thyroid hormones on DNAm and the confounding effects of reverse causation need to be considered. Recent studies suggest a potential mechanism for the association between iodine and AITD through differential DNAm patterns in candidate genes. The research focus is shifting towards epigenome-wide studies to elucidate the role of DNAm in AITD and identify diagnostic, prognostic, and therapeutic targets.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Oncology
Yee-Ming Melody Cheung, Wei Wang, Bradley McGregor, Ole-Petter Riksfjord Hamnvik
Summary: The development of immune-related thyroid dysfunction during immune checkpoint inhibitor therapy is associated with improved overall survival and progression free survival for cancer patients. This suggests that thyroid immune-related adverse events can be used as a surrogate marker for clinical response to ICIs.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2022)
Review
Endocrinology & Metabolism
Dania Akeil Abed Alkader, Naweedullah Asadi, Uzma Solangi, Ransherjit Singh, Sayed Farhad Rasuli, Muhammad Jawad Farooq, F. N. U. Raheela, Radeyah Waseem, Syed Mujahid Gilani, Kiran Abbas, Moiz Ahmed, Desmond Boakye Tanoh, Hussain Haider Shah, Ayusha Dulal, Muhammad Sheheryar Hussain, Abdul Subhan Talpur
Summary: There is a significant difference in the diversity and composition of the gut microbiota in patients with autoimmune thyroid diseases (AITDs).
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Qing Zhou, Shuai Xue, Li Zhang, Guang Chen
Summary: Trace elements are crucial for thyroid function and metabolism, and their imbalance can lead to thyroid disorders. The relationship between trace elements and thyroid diseases is still unclear and requires further research.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Immunology
Zilin Xiao, Shuoming Luo, Yuemin Zhou, Haipeng Pang, Wenfeng Yin, Jiabi Qin, Zhiguo Xie, Zhiguang Zhou
Summary: This study examined the association between three SNPs in the IFIH1 gene and autoimmune diseases. The rs1990760 SNP was not significantly associated with type 1 diabetes in the Chinese population. However, the meta-analysis showed significant associations between rs1990760 and rs3747517 and autoimmune diseases susceptibility, especially in the Caucasian population.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Rheumatology
Markus Mueller, Michael E. Gschwandtner, Wolfgang Emminger, Hans Kiener, Sebastian Schnaubelt, Georgiana-Aura Giurgea, Robin Ristl, Thomas Perkmann, Renate Koppensteiner, Oliver Schlager
Summary: The objective of this study was to characterize the associations between individual nailfold capillary aberrations and autoantibodies in children and adults with Raynaud's phenomenon (RP). Nailfold capillaroscopy and laboratory tests were conducted on consecutive RP patients without previously known connective tissue disease. The prevalence of nailfold capillary aberrations and antinuclear antibodies (ANA) was assessed and analyzed separately for children and adults, revealing a less pronounced association between nailfold capillary aberrations and ANA in children. Further studies are needed to validate these observations in children with RP.
Article
Medical Laboratory Technology
Jiajia Ni, Yu Long, Li Zhang, Qingqing Yang, Chunjia Kou, Shuqi Li, Jingyi Li, Haiqing Zhang
Summary: The prevalence of THAb in AITD patients was lower than that in NTAID patients in China. Only 9.18% of patients with positive THAb had falsely elevated TH levels among all subjects.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2022)
Review
Biochemistry & Molecular Biology
Yu Zhang, Dong-Dong Jia, Yi-Fei Zhang, Meng-Die Cheng, Wen-Xiu Zhu, Pei-Feng Li, Yin-Feng Zhang
Summary: Thyroid cancer is a common malignant tumor with high morbidity and mortality rates worldwide. Circular RNAs may serve as potential biomarkers and therapeutic targets for both thyroid cancer and autoimmune thyroid disease.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Review
Genetics & Heredity
Zubo Wu, Suyuan Wu, Tao Liang
Summary: The association between two NLRP3 gene polymorphisms and susceptibility to autoimmune diseases is controversial, with rs35829419 showing no significant association but potentially protective effect in rheumatoid arthritis, and rs10754558 significantly reducing the risk of AIDs, especially in Latin American individuals.
FRONTIERS IN GENETICS
(2021)
Review
Endocrinology & Metabolism
Viktor Kravchenko, Tamara Zakharchenko
Summary: Thyroid hormones and essential elements such as iodine, selenium, iron, copper, zinc, calcium, and magnesium play important roles in various organs and systems of the body, including the immune system and the thyroid gland, and disruptions in their supply can cause pathological changes. This review examines the immunomodulatory role of thyroid hormones and minerals, their properties, and their involvement in the pathogenesis of autoimmune thyroid diseases. It also discusses the imbalance between oxidants and antioxidants and the potential use of immunocorrection with dietary supplements in the treatment and prevention of autoimmune thyroid diseases.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Fariba Karimi, Fatemeh Lavaee, Aida Nematollahi, Sarina Sahmeddini
Summary: Research on an Iranian population has shown that patients with autoimmune thyroid diseases (ATDs) have a higher risk and frequency of recurrent aphthous stomatitis (RAS) compared to healthy individuals. These findings provide valuable insights into the underlying mechanisms and potential treatment strategies for both conditions.
Article
Endocrinology & Metabolism
Pablo Sacristan-Gomez, Ana Serrano-Somavilla, Roberto Gonzalez-Amaro, Rebeca Martinez-Hernandez, Monica Marazuela
Summary: This study investigated the expression levels of HDACs and Tip60 HAT in the thyroid gland and immune cells of patients with AITD. The findings showed a significant increase in HDAC9 expression in AITD patients, while Tip60 expression was reduced in patients with Hashimoto thyroiditis.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Review
Immunology
Tianyu Liu, Lei Yang, Xiaolong Lv, Chunjian Zuo, Chenhao Jia, Zelin Yang, Chongqi Fan, Huanwen Chen
Summary: This study provides updated and comprehensive evidence that variants in the IL-17 family genes are significantly associated with susceptibility to cervical cancer, lung cancer, asthma, multiple sclerosis, rheumatoid arthritis, and spondyloarthritis. Bioinformatics analysis suggests that the variants with strong evidence might be located in putative functional regions.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Endocrinology & Metabolism
Moein Zangiabadian, Mehdi Mirsaeidi, Mohammad H. Pooyafar, Mehdi Goudarzi, Mohammad Javad Nasiri
Summary: The study found a significant association between Yersinia enterocolitica infection and autoimmune thyroid diseases, especially an increased risk of Graves' disease. Further research is needed to explore the underlying mechanisms.
ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
(2021)
Article
Environmental Sciences
Cheng-Chen Huang, Chun-Wen Su, Po-Hui Wang, Yen-Ting Lu, Yu-Ting Ho, Shun-Fa Yang, Chung-Han Hsin, Chiao-Wen Lin
Summary: This study found that dihydromyricetin (DHM) inhibited the migration and invasion of nasopharyngeal carcinoma (NPC) cells by suppressing the expression of matrix metalloproteinases-2 (MMP-2) via down regulating the extracellular signal-regulated kinase 1 and 2 (ERK1/2) signaling pathway.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Liang-Tsai Yeh, Chiao-Wen Lin, Ko-Hsiu Lu, Yi-Hsien Hsieh, Chao-Bin Yeh, Shun-Fa Yang, Jia-Sin Yang
Summary: Niclosamide inhibits migration and invasion of osteosarcoma cells by suppressing TGFBI expression and phosphorylation of the ERK pathway. This study suggests that niclosamide may be a promising preventive and therapeutic agent for osteosarcoma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Chi-Wei Chen, Ming-Ju Hsieh, Po-Chung Ju, Yi-Hsien Hsieh, Chun-Wen Su, Yen-Lin Chen, Shun-Fa Yang, Chiao-Wen Lin
Summary: In this study, the therapeutic effect and mode of action of the curcumin analog, HO-3867, against human oral squamous cell carcinoma (OSCC) cells were explored. The results showed that HO-3867 effectively suppressed the growth of OSCC cells and induced apoptosis through the c-Jun N-terminal kinase (JNK)1/2 pathway.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Endocrinology & Metabolism
Huai-Ching Tai, Shih-Wei Wang, Sanskruti Swain, Liang-Wei Lin, Hsiao-Chi Tsai, Shan-Chi Liu, Hsi-Chin Wu, Jeng-Hung Guo, Chun-Lin Liu, Yu-Wei Lai, Tien-Huang Lin, Shun-Fa Yang, Chih-Hsin Tang
Summary: Melatonin has been found to inhibit the migratory and invasive abilities of osteoblastic prostate cancer cells by targeting kinases and transcriptional activity, suggesting its potential as a therapeutic option for treating osteoblastic bone lesions in prostate cancer.
JOURNAL OF PINEAL RESEARCH
(2022)
Article
Ophthalmology
Chia-Chen Lin, Chia-Yi Lee, Jing-Yang Huang, Sheng-Min Hsu, Jia-Horung Hung, Shun-Fa Yang
Summary: This study provides an in-depth analysis of the trends in DR, DME, and related comorbidities in patients with T2DM. It shows that the prevalence and incidence of DR and PDR decreased over time, while the prevalence and incidence of DME increased. Additionally, the percentage of patients with hyperlipidaemia increased in all forms of DR, while the percentage of patients with ESRD increased only in DME.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Plant Sciences
Chien-Feng Huang, Tung-Wei Hung, Shun-Fa Yang, Yi-Lun Tsai, Jen-Te Yang, Chia-Liang Lin, Yi-Hsien Hsieh
Summary: The study found that asiatic acid (AA) can inhibit the metastatic properties of renal cell carcinoma (RCC) cells by suppressing the p-ERK/p-p38MAPK axis and down-regulating MMP-15 expression. These findings are important for exploring AA as a potential anti-metastatic agent for RCC.
Article
Cell Biology
Shan-Chi Liu, Chun-Hao Tsai, Yu-Han Wang, Chen-Ming Su, Hsi-Chin Wu, Yi-Chin Fong, Shun-Fa Yang, Chih-Hsin Tang
Summary: This study investigated the effects of melatonin on osteoarthritis and its underlying mechanisms. The results demonstrated that melatonin reversed the pathological changes and reduced the expression of inflammatory factors by targeting the MT1 melatonin receptor. Furthermore, the anti-osteoarthritic activities of melatonin were associated with the upregulation of microRNA-185a through the PI3K/Akt and ERK signaling pathways.
CELL DEATH & DISEASE
(2022)
Article
Environmental Sciences
Bo-Yuan Wang, Ying-Hsiang Chou, Chi-Tzu Chung, Shun-Fa Yang, Shu-Ling Tzeng, Yu-Hsun Wang, Ming-Chih Chou, Chao-Bin Yeh, Chi-Ho Chan
Summary: Patients with deep vein thrombosis (DVT) have a higher risk of sepsis compared to patients with peripheral artery occlusive disease (PAOD), with aging being a contributing factor.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Cardiac & Cardiovascular Systems
Yin-Yang Chen, Shun-Fa Yang, Han-Wei Yeh, Ying-Tung Yeh, Jing-Yang Huang, Shao-Lun Tsao, Chao-Bin Yeh
Summary: The study found that fluoroquinolones did not increase the risk of AA and AD in patients with UTI compared to first- or second-generation cephalosporins. However, the mortality risk was significantly higher in patients treated with fluoroquinolones.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Environmental Sciences
Ming-Hong Hsieh, Yi-Liang Wu, Thomas Chang-Yao Tsao, Yi-Wen Huang, Jian-Cheng Lin, Chia-Yi Lee, Ming-Ju Hsieh, Shun-Fa Yang
Summary: The study aimed to evaluate the combined effect of GAS5 SNP and EGFR phenotypes on the clinicopathological characteristics of lung adenocarcinoma. The results showed that GAS5 SNP rs145204276 variant was associated with tumor stage, lymph node metastasis, and distal metastases in patients with EGFR wild type lung adenocarcinoma.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Environmental Sciences
Ying-Ting Yeh, Yen-Shuo Tseng, Yi-Liang Wu, Shun-Fa Yang, Bo-Yuan Wang, Yu-Hsun Wang, Liang-Tsai Yeh, Ying-Tung Yeh, Chi-Ho Chan
Summary: Periodontitis is associated with peripheral artery occlusive disease (PAOD), and dental scaling can reduce the risk of PAOD. Age over 65 is also a risk factor.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Medicine, General & Internal
Cheng-Hsun Chuang, Shun-Fa Yang, Pei-Lun Liao, Jing-Yang Huang, Man-Yee Chan, Chao-Bin Yeh
Summary: The study demonstrated that the use of thiazide diuretics in hypertensive patients can reduce the risk of fractures, making it a better choice for those at heightened risk of fractures.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Environmental Sciences
Chung-Yuan Lee, Yung-Chuan Ho, Chiao-Wen Lin, Min-Chieh Hsin, Po-Hui Wang, Ya-Cheng Tang, Shun-Fa Yang, Yi-Hsuan Hsiao
Summary: The synthetic curcumin analog, EF-24, has been shown to have enhanced bioavailability and stronger anti-inflammatory and anti-cancer activity compared to curcumin. This study investigated the effects of EF-24 on TPA-induced cellular migration of cervical cancer and found that EF-24 significantly reduced cellular migration and invasion. Further analysis revealed that EF-24 modulated MMP-9 expression by inhibiting the phosphorylation of the p38 signaling pathway. These findings suggest that EF-24 may have potential as a chemopreventive agent for cervical cancer.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Ophthalmology
Hsiang-Wen Chien, Chia-Yi Lee, Jing-Yang Huang, Hung-Chi Chen, Kai Wang, Shun-Fa Yang
Summary: This study, using the National Health Insurance Research Database of Taiwan, found a relationship between congenital cytomegalovirus (CMV) infection and late-onset keratitis. Severe congenital CMV infection was found to be significantly correlated with late-onset keratitis in individuals with congenital CMV infection.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Environmental Sciences
Chih-Chun Chuang, Kai Wang, Yi-Sun Yang, Edy Kornelius, Chih-Hsin Tang, Chia-Yi Lee, Hsiang-Wen Chien, Shun-Fa Yang
Summary: The study investigates the correlation between single-nucleotide polymorphisms (SNP) of HOX transcript antisense intergenic RNA (HOTAIR) and the clinical characteristics of diabetic retinopathy (DR). The results indicate that HOTAIR SNP rs12427129 and rs1899663 are strongly associated with the presence of DR, especially in female patients with proliferative diabetic retinopathy (PDR).
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)