Article
Cell Biology
Xi Liu, Peter Nagy, Alessandro Bonfini, Philip Houtz, Xiao-Li Bing, Xiaowei Yang, Nicolas Buchon
Summary: Gut microbes play an important role in the differentiation of gut stem cells, influencing epithelial composition and gut physiology. The balance between microbial pattern recognition pathways and damage response pathways is crucial for stem cell differentiation.
Article
Neurosciences
Ines Schoberleitner, Birte Mertens, Ingo Bauer, Alexandra Lusser
Summary: The ATP-dependent chromatin remodeling factor CHD1 plays a crucial role in the incorporation of the histone variant H3.3 in the fly brain, affecting sensory perception genes and leading to defects in olfactory and gustatory response behavior. Additionally, Chd1-mutant flies exhibit shortened lifespan and indications of premature functional aging, including impaired negative geotaxis and exploratory walking. Neuronal re-expression of Chd1 rescues the exploratory walking phenotype but not the olfactory defects.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Yuri Prozzillo, Stefano Cuticone, Diego Ferreri, Gaia Fattorini, Giovanni Messina, Patrizio Dimitri
Summary: The chromatin organization in Drosophila melanogaster is regulated by Tip60 chromatin remodeling complex (dTip60), DOM-A.C and DOM-B.C complexes, which share most subunits. This study combined genetics and cell biology to investigate the biological roles of these subunits in Drosophila melanogaster development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Microbiology
Lucas P. Henry, Julien F. Ayroles
Summary: The microbial diversity in response to host selection differed significantly across studies associated with host traits, rather than selection duration. The study suggests that incorporating the microbiome into E&R experiments can provide critical insights into host-microbiome interactions and the genomic basis of adaptation.
Article
Microbiology
Lauren E. Fuess, Stijn den Haan, Fei Ling, Jesse N. Weber, Natalie C. Steinel, Daniel Bolnick
Summary: This study explores the correlations between gene expression and microbiome composition in laboratory-raised fish, highlighting the strong positive associations between microbial alpha diversity and host immune gene expression. Additionally, 15 microbial families are found to be highly correlated with host gene expression, particularly with immune processes. These findings support the understanding of intimate links between host immunity and gut microbiome composition in nonmodel vertebrate species.
Article
Biochemistry & Molecular Biology
Jordi Bernues, Andrea Izquierdo-Boulstridge, Oscar Reina, Lucia Castejon, Elena Fernandez-Castaner, Nuria Leal, Nancy Guerrero-Pepinosa, Carles Bonet-Costa, Olivera Vujatovic, Paula Climent-Canto, Fernando Azorin
Summary: Post-translational modifications of core histones, such as dH1K27me2, play crucial roles in epigenetic regulation of chromatin. In Drosophila, dH1K27me2 is a major modification of heterochromatin and contributes to heterochromatin organization independently of H3K9 methylation.
NUCLEIC ACIDS RESEARCH
(2022)
Review
Gastroenterology & Hepatology
Lauren Walsh, Colin Hill, R. Paul Ross
Summary: This review focuses on the potential effect of glyphosate exposure on the composition and functionality of the gut microbiome, highlighting the significance of gut microbiota to health.
Article
Microbiology
Xin Liu, Meng Yang, Runzhou Liu, Fan Zhou, Haibing Zhu, Xiaoyun Wang
Summary: This study investigates the impact of Parkinson's disease (PD)-associated gut microbiota on host transcriptome using various PD models with fecal microbiota transplantation in Drosophila. The results reveal that PD-associated gut microbiota can influence host gene expression and regulate diverse metabolic pathways. This study helps to better understand the link between gut microbiota and PD pathogenesis through the gut-brain axis.
MICROBIOLOGY SPECTRUM
(2023)
Article
Microbiology
Xin Liu, Meng Yang, Runzhou Liu, Fan Zhou, Haibing Zhu, Xiaoyun Wang
Summary: This study reveals the influence of PD-associated gut microbiota on host gene expression, and provides insights into the link between gut microbiota and PD pathogenesis through the gut-brain axis.
MICROBIOLOGY SPECTRUM
(2023)
Article
Biochemistry & Molecular Biology
Elze R. Timmers, J. Casper Swarte, Ranko Gacesa, Johannes R. Bjoerk, Rinse K. Weersma, Marina A. Tijssen, Tom J. de Koning, Hermie J. M. Harmsen, Klary E. Niezen-Koning
Summary: This study investigates the relationship between gut microbiome and (non-)motor symptoms in dystonia, and finds differences in abundance of certain bacteria and alterations in related neuro-active metabolic pathways. It suggests the involvement of the gut-brain axis in the pathophysiology of dystonia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Microbiology
Alexander S. F. Berry, Meghann K. Pierdon, Ana M. Misic, Megan C. Sullivan, Kevin O'Brien, Ying Chen, Samuel J. Murray, Lydia A. Ramharack, Robert N. Baldassano, Thomas D. Parsons, Daniel P. Beiting
Summary: The study reveals that parity is an important factor modulating the gut microbiome during pregnancy, impacting the community of bacteria that colonize the offspring gut early in life, potentially influencing host metabolism. The results underscore the importance of considering parity in human microbiome studies during pregnancy and in infants.
Review
Gastroenterology & Hepatology
Vivienne Woo, Theresa Alenghat
Summary: The complex relationship between the gastrointestinal tract and microbiota is regulated by epigenetic modifications, including modifications to DNA or histones and regulation of non-coding RNAs. Further research is needed to fully understand the mechanisms of epigenetic regulation.
Article
Multidisciplinary Sciences
Jiandong Chen, Hyuntae Byun, Rui Liu, I-Ji Jung, Qinqin Pu, Clara Y. Zhu, Ethan Tanchoco, Salma Alavi, Patrick H. Degnan, Amy T. Ma, Manuela Roggiani, Joris Beld, Mark Goulian, Ansel Hsiao, Jun Zhu
Summary: The genotoxin colibactin produced by commensal Escherichia coli can not only induce DNA damage in host intestinal cells, but also target a variety of enteric pathogens and commensals via a contact-dependent mechanism. Furthermore, colibactin can shape the microbiome by species-specific targeting of Bacteroides fragilis, a common gut-associated microbe.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Microbiology
Dongxu Ji, Hao Sun, Weichao Yang, Mingfu Gao, Hui Xu
Summary: Laboratory animals with human microbiome have been used to study the interaction between bacteria and host. In this study, the human gut microbiome was successfully transferred to drosophila using antibiotic therapy and fecal exposure strategy. The male drosophila inherited more microbiota from the donor and showed improved lifespan and climbing ability. Differential gene expression patterns were observed between male and female drosophila recipients.
Article
Nutrition & Dietetics
Kirra Borrello, Unhee Lim, Song-Yi Park, Kristine R. Monroe, Gertraud Maskarinec, Carol J. Boushey, Lynne R. Wilkens, Timothy W. Randolph, Loic Le Marchand, Meredith A. Hullar, Johanna W. Lampe
Summary: This study found that racial/ethnic differences in GM composition may be influenced by differences in diet. Overall diet quality and intake of certain foods were found to have significant effects on GM composition, which may contribute to racial/ethnic health disparities.
Article
Microbiology
Ludwig Knabl, Bettina Kuppelwieser, Astrid Mayr, Wilfried Posch, Michaela Lackner, Debora Coraca-Huber, Adrian Danita, Michael Blauth, Cornelia Lass-Floerl, Dorothea Firth-Hoeller
Correction
Genetics & Heredity
Francesca Finotello, Clemens Mayer, Christina Plattner, Gerhard Laschober, Dietmar Rieder, Hubert Hackl, Anne Krogsdam, Zuzana Loncova, Wilfried Posch, Doris Wilflingseder, Sieghart Sopper, Marieke Ijsselsteijn, Thomas P. Brouwer, Douglas Johnson, Yaomin Xu, Yu Wang, Melinda E. Sanders, Monica V. Estrada, Paula Ericsson-Gonzalez, Pornpimol Charoentong, Justin Balko, Noel Filipe da Cunha Carvalho de Miranda, Zlatko Trajanoski
Article
Multidisciplinary Sciences
Julia Wilflingseder, Michaela Willi, Hye Kyung Lee, Hannes Olauson, Jakub Jankowski, Takaharu Ichimura, Reinhold Erben, M. Todd Valerius, Lothar Hennighausen, Joseph Bonventre
NATURE COMMUNICATIONS
(2020)
Article
Multidisciplinary Sciences
Hye Kyung Lee, Michaela Willi, Tyler Kuhns, Chengyu Liu, Lothar Hennighausen
Summary: Enhancers that activate gene expression in the lactating mouse mammary gland were investigated, revealing the importance of a lactation-specific distal enhancer and a super-enhancer in coordinating with the promoter for gene activation. The study provides insights into the regulatory mechanisms of enhancers and super-enhancers during lactation.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Santhosh Kumar Ghadge, Moritz Messner, Herbert Seiringer, Thomas Maurer, Simon Staggl, Tanja Zeller, Christian Mueller, Daniela Bornigen, Wolfgang J. Weninger, Stefan H. Geyer, Sieghart Sopper, Anne Krogsdam, Gerhard Poelzl, Axel Bauer, Marc-Michael Zaruba
Summary: The chemokine CXCL12 is essential in cardiovascular development, cell trafficking, and myocardial repair, with downstream loci associated with coronary artery disease and myocardial infarction identified through human genome-wide association studies. A study using a mouse model lacking CXCL12 in smooth muscle cells showed high embryonic lethality and developmental defects, highlighting the critical role of smooth muscle-specific CXCL12 in arterial development and cardiac hypertrophy. Pharmacological stimulation of CXCR7 might be a promising approach to attenuate adverse hypertrophic remodeling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Ines Schoberleitner, Ingo Bauer, Anming Huang, Evgeniya N. Andreyeva, Johanna Sebald, Katharina Pascher, Dietmar Rieder, Melanie Brunner, Valerie Podhraski, Gregor Oemer, Daniel Cazarez-Garcia, Leila Rieder, Markus A. Keller, Robert Winkler, Dmitry Fyodorov, Alexandra Lusser
Summary: CHD1 is essential for assembling H3.3 chromatin in adult cells, particularly in the brain, playing a crucial role in regulating organismal health and longevity.
Article
Medicine, Research & Experimental
Glory Ranches, Maximilian Zeidler, Roman Kessler, Martina Hoelzl, Michael W. Hess, Jonathan Vosper, Paul Perco, Herbert Schramek, Kai K. Kummer, Michaela Kress, Anne Krogsdam, Michael Rudnicki, Gert Mayer, Alexander Huettenhofer
Summary: Exosomes are valuable biomarkers for studying chronic kidney disease (CKD). Urinary exosomes and exosomes derived from renal proximal tubular epithelial cells (RPTECs) were analyzed for microRNA (miRNA) profiles. Dysregulated exosomal miRNAs associated with pro-inflammatory and pro-fibrotic pathways were identified in RPTECs, suggesting their potential use in predicting CKD pathogenesis.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2022)
Article
Biochemistry & Molecular Biology
Isabel Heidegger, Georgios Fotakis, Anne Offermann, Jermaine Goveia, Sophia Daum, Stefan Salcher, Asma Noureen, Hetty Timmer-Bosscha, Georg Schaefer, Annemiek Walenkamp, Sven Perner, Aleksandar Beatovic, Matthieu Moisse, Christina Plattner, Anne Krogsdam, Johannes Haybaeck, Sieghart Sopper, Stefanie Thaler, Markus A. Keller, Helmut Klocker, Zlatko Trajanoski, Dominik Wolf, Andreas Pircher
Summary: This study provides a comprehensive analysis of prostate cancer tumor endothelial cells (TEC) and identifies potential therapeutic targets, specifically the CXCL12/CXCR4 interaction, to interfere with tumor angiogenesis in prostate cancer. Understanding the cell-to-cell communication networks in the tumor microenvironment contributes to the development of new therapeutic approaches for prostate cancer.
Article
Neurosciences
Ines Schoberleitner, Birte Mertens, Ingo Bauer, Alexandra Lusser
Summary: The ATP-dependent chromatin remodeling factor CHD1 plays a crucial role in the incorporation of the histone variant H3.3 in the fly brain, affecting sensory perception genes and leading to defects in olfactory and gustatory response behavior. Additionally, Chd1-mutant flies exhibit shortened lifespan and indications of premature functional aging, including impaired negative geotaxis and exploratory walking. Neuronal re-expression of Chd1 rescues the exploratory walking phenotype but not the olfactory defects.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Editorial Material
Oncology
Erin R. Rudzinski, Alexander Drilon, Amy Moore, Susan Spinosa, Michaela Willi, Theodore W. Laetsch
Summary: This summary highlights a study on the different tests used to detect TRK fusion cancer in participants of clinical trials for larotrectinib. The study provides guidance for healthcare professionals and insights on the importance of testing different cancer types.
Article
Medicine, General & Internal
Angela Augustin, Evi M. M. Morandi, Selina Winkelmann, Ines Schoberleitner, Daniel Egle, Magdalena Ritter, Thomas Bauer, Tanja Wachter, Dolores Wolfram
Summary: This study compared patient-reported outcome measures, donor site scar assessments, and aesthetic evaluation of reconstructed breasts in patients with DIEP and PAP flap breast reconstruction. The results showed no significant differences between the two groups in terms of physical well-being, satisfaction, scar evaluation, and breast aesthetics. Therefore, the decision between DIEP and PAP reconstruction can be based on factors such as patient lifestyle, leisure activities, and preferences.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Ines Schoberleitner, Angela Augustin, Daniel Egle, Christine Brunner, Birgit Amort, Bettina Zelger, Andrea Brunner, Dolores Wolfram
Summary: Capsular fibrosis is the most common long-term complication of silicone breast implants, primarily induced by the host response towards silicone. Textured surface implants have been identified as a risk factor. Reducing surface roughness of silicone breast implants can lead to better cosmetic outcomes and fewer complications for patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Ines Schoberleitner, Klaus Faserl, Bettina Sarg, Daniel Egle, Christine Brunner, Dolores Wolfram
Summary: Exaggerated fibrous capsule formation around silicone mammary implants (SMI) is primarily induced by immune mechanisms towards silicone. This study aimed to understand the disease progression from implant insertion and immediate tissue damage response. A proteomic analysis revealed a complex composition of acute wound profile and differential protein expression on the implant surfaces. Dysregulation of signaling pathways involved in inflammation and extracellular matrix turnover was observed. Time-course variations in protein enrichment immediately post-implantation and long-term adsorption of acute wound and fibrosis-associated proteins were identified. The findings propose a potential biomarker panel for early detection and diagnosis of excessive fibrosis in implant encapsulation.
Article
Oncology
Angela Augustin, Petra Puelzl, Evi M. Morandi, Selina Winkelmann, Ines Schoberleitner, Christine Brunner, Magdalena Ritter, Thomas Bauer, Tanja Wachter, Dolores Wolfram
Summary: Both TMG and PAP flaps are safe options for autologous breast reconstruction with minimal donor-site morbidity and high patient satisfaction. However, patients in the TMG group were more satisfied with the scar and its position.
Article
Biology
Hye Kyung Lee, Harold E. Smith, Chengyu Liu, Michaela Willi, Lothar Hennighausen
COMMUNICATIONS BIOLOGY
(2020)