P21-Activated Kinase Inhibitors FRAX486 and IPA3: Inhibition of Prostate Stromal Cell Growth and Effects on Smooth Muscle Contraction in the Human Prostate

P21 activated kinase-1 mediates transforming growth factor β1-induced prostate cancer cell epithelial to mesenchymal transition

(2015) Ahmad Al-Azayzih et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

A novel role for RhoA GTPase in the regulation of airway smooth muscle contraction

(2015) Wenwu Zhang et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Overexpression of PAK1 Promotes Cell Survival in Inflammatory Bowel Diseases and Colitis-associated Cancer

(2015) Vineeta Khare et al.   INFLAMMATORY BOWEL DISEASES

The Role of the Pleckstrin Homology Domain-containing Protein CKIP-1 in Activation of p21-activated Kinase 1 (PAK1)

(2015) Yong-Bae Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Salvage Lymph Node Dissection for Nodal Recurrence of Prostate Cancer after Radical Prostatectomy

(2015) Derya Tilki et al.   JOURNAL OF UROLOGY

Pak2 Regulates Hematopoietic Progenitor Cell Proliferation, Survival, and Differentiation

(2015) Yi Zeng et al.   STEM CELLS

Thromboxane-induced actin polymerization in hypoxic neonatal pulmonary arterial myocytes involves Cdc42 signaling

(2014) Jena Fediuk et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Rate and associated factors of solifenacin add-on after tamsulosin monotherapy in men with voiding and storage lower urinary tract symptoms

(2014) H. N. Lee et al.   INTERNATIONAL JOURNAL OF CLINICAL PRACTICE

PAKs inhibitors ameliorate schizophrenia-associated dendritic spine deterioration in vitro and in vivo during late adolescence

(2014) A. Hayashi-Takagi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prospective comparison of one year follow-up outcomes for the open complete intrafascial retropubic versus interfascial nerve-sparing radical prostatectomy

(2014) Wael Y Khoder et al.   SpringerPlus

p21-Activated kinase 5: A pleiotropic kinase

(2013) Yi-Yang Wen et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

PakD, a Putative p21-Activated Protein Kinase in Dictyostelium discoideum, Regulates Actin

(2013) Miguel Garcia et al.   EUKARYOTIC CELL

Systematic Review of Combination Drug Therapy for Non-neurogenic Male Lower Urinary Tract Symptoms

(2013) Claudius Füllhase et al.   EUROPEAN UROLOGY

EAU Guidelines on the Treatment and Follow-up of Non-neurogenic Male Lower Urinary Tract Symptoms Including Benign Prostatic Obstruction

(2013) Matthias Oelke et al.   EUROPEAN UROLOGY

Nuclear Factor of Activated T Cells c1 Mediates p21-activated Kinase 1 Activation in the Modulation of Chemokine-induced Human Aortic Smooth Muscle Cell F-actin Stress Fiber Formation, Migration, and Proliferation and Injury-induced Vascular Wall Remodeling

(2013) Venkatesh Kundumani-Sridharan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prostatic α1-adrenoceptors: New concepts of function, regulation, and intracellular signaling

(2013) Martin Hennenberg et al.   NEUROUROLOGY AND URODYNAMICS

p21-Activated Kinase 3 (PAK3) Is an AP-1 Regulated Gene Contributing to Actin Organisation and Migration of Transformed Fibroblasts

(2013) Nina Holderness Parker et al.   PLoS One

Evidence for a Novel Mechanism of the PAK1 Interaction with the Rho-GTPases Cdc42 and Rac

(2013) Yong Jae Shin et al.   PLoS One

Rescue of fragile X syndrome phenotypes in Fmr1 KO mice by the small-molecule PAK inhibitor FRAX486

(2013) B. M. Dolan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of adrenergic human prostate smooth muscle contraction by the inhibitors of c-Jun N-terminal kinase, SP600125 and BI-78D3

(2012) F Strittmatter et al.   BRITISH JOURNAL OF PHARMACOLOGY

Requirement for Pak3 in Rac1-induced organization of actin and myosin duringDrosophilalarval wound healing

(2012) Seung Hee Baek et al.   FEBS LETTERS

Biphasic Regulation of Myosin Light Chain Phosphorylation by p21-activated Kinase Modulates Intestinal Smooth Muscle Contractility

(2012) Ji Chu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

P21 Activated Kinase-1 (Pak1) Promotes Prostate Tumor Growth and Microinvasion via Inhibition of Transforming Growth Factor β Expression and Enhanced Matrix Metalloproteinase 9 Secretion

(2012) Anna Goc et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Efficacy of Silodosin for Relieving Benign Prostatic Obstruction: Prospective Pressure Flow Study

(2012) Yoshihisa Matsukawa et al.   JOURNAL OF UROLOGY

The link between benign prostatic hyperplasia and prostate cancer

(2012) David D. Ørsted et al.   Nature Reviews Urology

p21-Activated kinase 4 promotes prostate cancer progression through CREB

(2012) M-H Park et al.   ONCOGENE

Open Complete Intrafascial Nerve-sparing Retropubic Radical Prostatectomy: Technique and Initial Experience

(2012) Wael Y. Khoder et al.   UROLOGY

Control of mammary myoepithelial cell contractile function by α3β1 integrin signalling

(2011) Karine Raymond et al.   EMBO JOURNAL

Pak1 regulates focal adhesion strength, myosin IIA distribution, and actin dynamics to optimize cell migration

(2011) Violaine D. Delorme-Walker et al.   JOURNAL OF CELL BIOLOGY

A tension-induced mechanotransduction pathway promotes epithelial morphogenesis

(2011) Huimin Zhang et al.   NATURE

The emerging importance of group II PAKs

(2010) Claire M. Wells et al.   BIOCHEMICAL JOURNAL

Silodosin Therapy for Lower Urinary Tract Symptoms in Men with Suspected Benign Prostatic Hyperplasia: Results of an International, Randomized, Double-Blind, Placebo- and Active-Controlled Clinical Trial Performed in Europe

(2010) Christopher R. Chapple et al.   EUROPEAN UROLOGY

Cdc42GAP, reactive oxygen species, and the vimentin network

(2009) Qing-Fen Li et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Role of p47phox in regulating Cdc42GAP, vimentin, and contraction in smooth muscle cells

(2009) Qing-Fen Li et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Reciprocal Regulation of Rac1 and PAK-1 by HIF-1α: A Positive-Feedback Loop Promoting Pulmonary Vascular Remodeling

(2009) Isabel Diebold et al.   ANTIOXIDANTS & REDOX SIGNALING

The Rho protein exchange factor Vav3 regulates vascular smooth muscle cell proliferation and migration

(2009) Gilles Toumaniantz et al.   CARDIOVASCULAR RESEARCH

p21-Activated Kinase 1 Participates in Vascular Remodeling In Vitro and In Vivo

(2009) Akinari Hinoki et al.   HYPERTENSION

An allosteric kinase inhibitor binds the p21-activated kinase autoregulatory domain covalently

(2009) J. Viaud et al.   MOLECULAR CANCER THERAPEUTICS

Alphaherpesvirus US3-mediated reorganization of the actin cytoskeleton is mediated by group A p21-activated kinases

(2009) C. Van den Broeke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Isoform-Selective, Small-Molecule Inhibitor Targets the Autoregulatory Mechanism of p21-Activated Kinase

(2008) Sean W. Deacon et al.   CHEMISTRY & BIOLOGY

Is There Evidence of a Relationship between Benign Prostatic Hyperplasia and Prostate Cancer? Findings of a Literature Review

(2008) Antonio Alcaraz et al.   EUROPEAN UROLOGY

Increased PAK6 expression in prostate cancer and identification of PAK6 associated proteins

(2008) Ramneet Kaur et al.   PROSTATE