High Uric Acid Induces Insulin Resistance in Cardiomyocytes In Vitro and In Vivo

High uric acid directly inhibits insulin signalling and induces insulin resistance

(2014) Yuzhang Zhu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Apelin protects sarcoplasmic reticulum function and cardiac performance in ischaemia-reperfusion by attenuating oxidation of sarcoplasmic reticulum Ca2+-ATPase and ryanodine receptor

(2013) Chen Wang et al.   CARDIOVASCULAR RESEARCH

The AP-1 Complex Regulates Intracellular Localization of Insulin Receptor Substrate 1, Which Is Required for Insulin-Like Growth Factor I-Dependent Cell Proliferation

(2013) Y. Yoneyama et al.   MOLECULAR AND CELLULAR BIOLOGY

Uric acid induces oxidative stress and growth inhibition by activating adenosine monophosphate-activated protein kinase and extracellular signal-regulated kinase signal pathways in pancreatic β cells

(2013) Yongneng Zhang et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Cardiac PI3K-Akt Impairs Insulin-Stimulated Glucose Uptake Independent of mTORC1 and GLUT4 Translocation

(2012) Yi Zhu et al.   MOLECULAR ENDOCRINOLOGY

Lycopene Protects against Hypoxia/Reoxygenation-Induced Apoptosis by Preventing Mitochondrial Dysfunction in Primary Neonatal Mouse Cardiomyocytes

(2012) Rongchuan Yue et al.   PLoS One

Contribution of the serine kinase c-Jun N-terminal kinase (JNK) to oxidant-induced insulin resistance in isolated rat skeletal muscle

(2012) Fernando R. Santos et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

Vascular smooth muscle insulin resistance, but not hypertrophic signaling, is independent of angiotensin II-induced IRS-1 phosphorylation by JNK

(2011) Hirofumi Hitomi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Diabetic Downregulation of Nrf2 Activity via ERK Contributes to Oxidative Stress-Induced Insulin Resistance in Cardiac Cells In Vitro and In Vivo

(2011) Y. Tan et al.   DIABETES

Protective effects of cortex fraxini coumarines against oxonate-induced hyperuricemia and renal dysfunction in mice

(2011) Jian-Mei Li et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Reactive oxygen species and insulin-resistant cardiomyopathy

(2009) Kimberley M Mellor et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Evidence for a Causal Role of Oxidative Stress in the Myocardial Complications of Insulin Resistance

(2009) Rebecca H. Ritchie   Heart Lung and Circulation