Article
Neurosciences
Inge Volman, Abbie Pringle, Lennart Verhagen, Michael Browning, Phil J. Cowen, Catherine J. Harmer
Summary: This study found that lithium can stabilize mood by modulating reward processing in the striatum, enhancing reward anticipation activity while reducing reward outcome activity.
NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Physiology
Hande Coskun, Fatima Azzahra Elbahi, Mohammad Al-Mahdi Al-Karagholi, Hashmat Ghanizada, Majid Sheykhzade, Messoud Ashina
Summary: The study found that pretreatment with the non-selective K-ATP channel inhibitor glibenclamide did not attenuate CGRP-induced headache and hemodynamic changes in healthy volunteers.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Gastroenterology & Hepatology
Julien Pujo, Giada De Palma, Jun Lu, Heather J. J. Galipeau, Michael G. G. Surette, Stephen M. M. Collins, Premysl Bercik
Summary: Abdominal pain is common in gastrointestinal disorders, and gut microbiota and sex both play a role in determining visceral sensitivity. Germ-free mice displayed greater pain responses to colorectal distension, and the production of CGRP was higher in germ-free mice, especially in females.
Article
Neurosciences
Katharina Schmidt, Julian Kleine-Borgmann, Katrin Scharmach, Diana Muessgens, Sigrid Elsenbruch, Ulrike Bingel, Katarina Forkmann
Summary: Visceral pain is more salient and emotionally intense than somatic pain, leading to higher levels of fear. This fMRI study found that visceral pain reduces neural activity in areas involved in visual processing and memory encoding, affecting cognitive functions.
Article
Biology
Jochen Michely, Eran Eldar, Alon Erdman, Ingrid M. Martin, Raymond J. Dolan
Summary: Prolonged boosting of serotonin enhances punishment learning and reduces reward learning, while acute administration of serotonin does not significantly affect learning. These findings are important for understanding the impact of serotonergic drugs on mood disorders.
COMMUNICATIONS BIOLOGY
(2022)
Review
Neurosciences
Jie Xiong, Zhiyong Wang, Junhui Bai, Keling Cheng, Qicai Liu, Jun Ni
Summary: Ischemic stroke is a common cerebrovascular disease with high disability and mortality rates. Thrombolytic therapy is currently used for treatment, but it can cause reperfusion injury. Calcitonin gene-related peptide (CGRP) has neuroprotective effects by inducing vasodilation, reducing inflammation, reducing cerebral edema, protecting endothelial cells, and promoting angiogenesis. It can also reduce apoptosis and repair damaged nerve function. This review focuses on the role of CGRP in cerebral ischemia-reperfusion injury.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
I-Ching Hsieh, Ting-Wei Chen, Ya-Ping Chuang, Yun-Ju Lai, Ling-Hsien Tu
Summary: This study investigates the aggregation of human calcitonin (hCT) and identifies Tyr12 as a key residue in regulating hCT aggregation. By modifying Tyr12, anti-aggregation variants of hCT were successfully developed.
Article
Pharmacology & Pharmacy
Michael L. Garelja, Tyla I. Alexander, Amy Bennie, Mhairi Nimick, Jakeb Petersen, Christopher S. Walker, Debbie L. Hay
Summary: This study demonstrates that erenumab can antagonize both CGRP and AMY(1) receptors, providing insights into the clinical profile of erenumab.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Materials Science, Biomaterials
Lisa A. McIlvried, Megan A. Atherton, Nicole L. Horan, Tori N. Goch, Nicole N. Scheff
Summary: Head and neck squamous cell carcinoma are highly innervated by peripheral sensory neurons. Local neurotransmitter release, such as CGRP, from sensory neurons innervating cancer is linked to tumorigenesis. In this study, the impact of CGRP signaling on tumor growth and the associated immune response was investigated using a mouse model of oral cancer.
Article
Humanities, Multidisciplinary
Alberto Ara, Jeison Parra-Tijaro, Josep Marco-Pallares
Summary: Music processing and its hedonic value is influenced by brain activations in perceptual, cognitive, and affective areas. Theta rhythms have been proposed as a means of synchronization between network nodes involved in music valuation. This study used fMRI and EEG to investigate the relationship between these rhythmic synchronizations and music-evoked pleasantness, and found that the synchronization was modulated by the degree of pleasantness experienced.
PSYCHOLOGY OF AESTHETICS CREATIVITY AND THE ARTS
(2022)
Article
Orthopedics
Natalie K. Y. Wee, Sanja Novak, Debolina Ghosh, Sierra H. Root, Ian M. Dickerson, Ivo Kalajzic
Summary: The aim of this study was to determine if the inhibition of CGRP signaling negatively affected fracture healing. The results showed that inhibiting CGRP by deleting CLR or using BIBN-4096 delayed bone healing.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2023)
Article
Anesthesiology
Aurore Latragna, Alba Sabate San Jose, Panagiotis Tsimpos, Simon Vermeiren, Roberta Gualdani, Sampurna Chakrabarti, Gerard Callejo, Simon Desiderio, Orr Shomroni, Maren Sitte, Sadia Kricha, Maelle Luypaert, Benoit Vanhollebeke, Geoffroy Laumet, Gabriela Salinas, Ewan St John Smith, Laurence Ris, Eric J. Bellefroid
Summary: Prdm12 is a transcriptional regulator that is expressed in nociceptors of the developing peripheral nervous system. It plays a role in the transcriptional control and excitability of adult nociceptors. Mutations in Prdm12 may cause congenital insensitivity to pain, while disruption of Prdm12 expression can affect pain-related behavior.
Review
Biochemistry & Molecular Biology
Adriano Bonura, Nicoletta Brunelli, Marilena Marcosano, Gianmarco Iaccarino, Luisa Fofi, Fabrizio Vernieri, Claudia Altamura
Summary: The calcitonin gene-related peptide (CGRP) is a neuropeptide with complex systemic impact beyond nociception. It plays a crucial role in vasodilation, inflammation, intestinal motility, and apoptosis. CGRP has contradictory effects, acting as a potent vasodilator in the cardiovascular system but not inducing arterial hypertension. It also exhibits both anti-inflammatory and pro-inflammatory effects as an immunomodulator.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Qichang Wang, Haotian Qin, Jiapeng Deng, Huihui Xu, Su Liu, Jian Weng, Hui Zeng
Summary: Calcitonin gene-related peptide (CGRP) is a 37-amino acid peptide initially known for its vasodilatory and nociceptive effects. Recent research has revealed its close association with bone metabolism and shown CGRP to be a bridge between the nervous system and the skeletal muscle system. CGRP can promote osteogenesis, inhibit bone resorption, stimulate vascular growth, and regulate the immune microenvironment. Various signaling pathways, including the G protein-coupled pathway, MAPK, Hippo, and NF-κB, play a role in CGRP's effects on cell proliferation and differentiation. This review provides a comprehensive overview of the bone repair effects of CGRP and discusses therapeutic approaches such as drug injection, gene editing, and novel bone repair materials.
Article
Neurosciences
Mangor Pedersen, Andrew Zalesky
Summary: This study examined the effects of intracranial brain stimulation on brain network dynamics in epilepsy patients. The results showed a decrease in network switching and synchrony after the stimulation, followed by a more consistent pattern over time. This change was commonly observed in cortical networks and adjacent to the electrode targets.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Stig P. Cramer, Henrik B. W. Larsson, Maria H. Knudsen, Helle J. Simonsen, Mark B. Vestergaard, Ulrich Lindberg
Summary: This study investigates the reproducibility of DCE-MRI in healthy controls and evaluates the impact of arterial input function selection and manual region of interests delineation versus automated global segmentation. The results show excellent reproducibility of pharmacokinetic variables derived from DCE-MRI in healthy controls.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Anesthesiology
Janu Thuraiaiyah, Mohammad Al-Mahdi Al-Karagholi, Fatima Azzahra Elbahi, Zixuan Alice Zhuang, Messoud Ashina
Summary: In a randomized, double-blinded, placebo-controlled, crossover study, researchers found that adenosine does not significantly induce migraine attacks but does cause headache. Adenosine increases heart rate, facial skin blood flow, and superficial temporal artery diameter, while decreasing middle cerebral artery blood flow.
Review
Clinical Neurology
Irene de Boer, Iris Elsa Verhagen, Marcio Nattan Portes Souza, Messoud Ashina
Summary: New acute therapies such as ditans and gepants may be effective alternatives for patients who cannot use or do not respond to triptans. However, further studies are needed to determine their place and safety in migraine treatment.
Review
Clinical Neurology
Mohammad Al-Mahdi Al-Karagholi, Veberka Kalatharan, Hashmat Ghanizada, Christian Gram, Gregory Dussor, Messoud Ashina
Summary: This systematic review examined clinical studies on the role of prolactin and its receptors in headache and migraine. The findings suggest that prolactin and its receptors play a key role in migraine pathophysiology. Further randomized and placebo-controlled clinical studies are needed to clarify the influence of prolactin in migraine attack initiation.
Article
Clinical Neurology
Messoud Ashina, Stewart J. Tepper, Uwe Reuter, Andrew M. Blumenfeld, Susan Hutchinson, Jing Xia, Rosa Miceli, Lawrence Severt, Michelle Finnegan, Joel M. Trugman
Summary: This study assessed the long-term safety, tolerability, and efficacy of once-daily oral atogepant 60 mg in adults with migraine. The results showed that daily use of atogepant for preventive treatment of migraine during this 1-year trial was safe, well tolerated, and efficacious.
Review
Clinical Neurology
Lionesa Bahtiri, Andreas Vinther Thomsen, Messoud Ashina, Anders Hougaard
Summary: This systematic review summarizes and evaluates cases of migraine aura-like episodes triggered by sclerotherapy of veins of the lower extremities, and explores possible underlying mechanisms.
Article
Dermatology
Nita Katarina Frifelt Wienholtz, Jacob P. P. Thyssen, Casper Emil Christensen, Simon Francis Thomsen, Katrine Elisabeth Karmisholt, Gregor B. E. Jemec, Hans B. B. Lomholt, Michael Heidenheim, Anne Birgitte Simonsen, Carsten Sand, Christian Vestergaard, Diljit Kaur-Knudsen, Elisabeth Ammitzboll, Erik Lorup, Anne G. G. Danielsen, Gitte Strauss, Lone Skov, Peter H. H. Andersen, Marianne Hald, Luise W. W. Idorn, Messoud Ashina, Claus Zachariae, Alexander Egeberg
Summary: This study validates the Rosacea Area and Severity Index (RASI) as an effective tool for evaluating the severity of rosacea, with comparable agreement to the currently used Investigator's Global Assessment (IGA) method. RASI provides a more nuanced evaluation of various rosacea features and the extent of involvement in different facial areas, suggesting its widespread use in clinical and research settings.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Clinical Neurology
Messoud Ashina, Caroline Roos, Lily Qian Li, Mika Komori, David Ayer, Dustin Ruff, John Henry Krege
Summary: During the 12-month extension study, patients treated with lasmiditan showed significant improvements in migraine-related disability and quality of life. No new safety concerns were identified.
Article
Clinical Neurology
Stewart J. Tepper, Richard B. Lipton, Stephen D. Silberstein, David Kudrow, Messoud Ashina, Uwe Reuter, David W. Dodick, Andrea Wang, Sunfa Cheng, Jan Klatt, Daniel D. Mikol
Summary: This study evaluated the long-term efficacy and safety of erenumab in patients with chronic migraine. The results showed that long-term treatment with erenumab could consistently reduce monthly migraine days and the efficacy was similar in patients with and without acute medication overuse.
Review
Clinical Neurology
Mohammad Al-Mahdi Al-Karagholi, Veberka Kalatharan, Hashmat Ghanizada, Gregory Dussor, Messoud Ashina
Summary: The review aimed to investigate the role of prolactin signaling in the pathophysiology of headache and migraine. Sex-dependent features of migraines suggest the involvement of the hypothalamus-pituitary-gonadal axis. Prolactin signaling has been implicated in sex-related differences in pain perception.
Article
Clinical Neurology
Lili Kokoti, Mohammad Al-Mahdi Al-Karagholi, Cherie Amalie Waldorff Nielsen, Messoud Ashina
Summary: This study investigated the effect of the K-ATP channel blocker glibenclamide on levcromakalim-induced headache in healthy volunteers and found that glibenclamide did not attenuate levcromakalim-induced headache. Future studies should further explore the role of different isoforms of sulfonylurea receptor subunits of K-ATP channels in the pathogenesis of headache and migraine.
Article
Clinical Neurology
William Kristian Karlsson, Hakan Ashina, Christopher Kjaer Cullum, Rune Haeckert Christensen, Haidar Muhsen Al-Khazali, Faisal Mohammad Amin, Messoud Ashina, Afrim Iljazi, Andreas Vinther Thomsen, Basit Ali Chaudhry, Betel Tesfay, Janu Thuraiaiyah, Lili Kokoti, Nadja Bredo Rasmussen, Rogelio Dominguez-Moreno, Thien Phu Do, Zixuan Alice Zhuang
Summary: The REFORM study aims to discover biomarkers that can predict response to erenumab in migraine patients. This article provides a comprehensive description of the study methodology and the baseline characteristics of the study population. Future publications will report the results of the investigations.
JOURNAL OF HEADACHE AND PAIN
(2023)
Article
Clinical Neurology
Nadja Bredo Rasmussen, Christina Deligianni, Casper Emil Christensen, William Kristian Karlsson, Haidar Muhsen Al-Khazali, Tom Van de Casteele, Charlotte Granhall, Faisal Mohammad Amin, Messoud Ashina
Summary: Lu AG09222, an investigational humanized monoclonal antibody, inhibits PACAP38-induced vasodilation and headache, suggesting its potential as a therapy for PACAP-mediated diseases such as migraine.
JOURNAL OF HEADACHE AND PAIN
(2023)
Article
Clinical Neurology
Messoud Ashina, Richard B. Lipton, Jessica Ailani, Jan Versijpt, Simona Sacco, Dimos D. Mitsikostas, Cecilie Laurberg Christoffersen, Bjorn Sperling, Anders Ettrup
Summary: This post hoc analysis suggests that eptinezumab can reduce monthly migraine days in patients with difficult-to-treat migraines. The majority of patients who responded to eptinezumab during the initial weeks maintained or improved their response during the later weeks. Additionally, a significant number of initial non-responders showed a response after the second infusion.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Messoud Ashina, Dimos D. Mitsikostas, Verena Ramirez Campos, Steve Barash, Xiaoping Ning, Hans-Christoph Diener
Summary: This study aimed to determine the number needed to treat (NNT), number needed to harm (NNH), and likelihood of being helped or harmed (LHH) in a post hoc analysis of the phase 3b FOCUS trial. The results showed that the NNT, NNH, and LHH for quarterly and monthly fremanezumab compare favorably with those for traditional oral preventive medications, including topiramate, valproate, and propranolol.
