Article
Multidisciplinary Sciences
Shirin Faraji Azad, Akbar Biglarian, Maryam Rostami, Razieh Bidhendi-Yarandi
Summary: Using the smoothing mixture model (SMM), this study aimed to identify the latent longitudinal trajectories of maternal weight associated with adverse pregnancy outcomes. Data from 877 pregnant women were analyzed, and three trajectories (low, medium, and high weight) were identified. Results showed that the low weight trajectory had significantly higher risks for certain adverse neonatal events compared to the high weight trajectory.
SCIENTIFIC REPORTS
(2023)
Article
Nutrition & Dietetics
Huiqing Gang, Hongling Zhang, Tongzhang Zheng, Wei Xia, Shunqing Xu, Yuanyuan Li
Summary: This study found a positive association between maternal urinary selenium concentrations and cord serum vitamin D levels. Increasing selenium concentrations were associated with increases in vitamin D levels, while infants from mothers with lower selenium concentrations were more likely to be vitamin D deficient.
Review
Nutrition & Dietetics
Heng Zhang, Shumin Wang, Lingjin Tuo, Qixiao Zhai, Jingjing Cui, Daozhen Chen, Dexiang Xu
Summary: Vitamin D plays an important role in pregnancy, with low levels being associated with adverse pregnancy outcomes. This review summarizes the potential mechanisms of how vitamin D regulates these outcomes and aims to provide a basis for public health intervention strategies.
Article
Agriculture, Dairy & Animal Science
Claire Stenhouse, Emma Hurst, Richard J. Mellanby, Cheryl J. Ashworth
Summary: Recent evidence suggests that vitamin D plays a crucial role in pregnancy, fetal growth, and development in various mammalian species. However, little is known about the changes in maternal vitamin D levels during pregnancy in pigs and its relationship with litter characteristics. This study examined the levels of 25(OH)D in maternal plasma at different gestational days and found a significant increase between days 18 and 30. The study also investigated the association between maternal vitamin D levels and various litter characteristics, such as gilt weight, ovulation rate, mean litter weight, number of live fetuses, prenatal survival rate, and sex ratio of the litter. The results showed that maternal 25(OH)D levels were positively associated with prenatal survival rate on day 60 and inversely associated with gilt weight on day 90. Maternal plasma 25(OH)D levels were also inversely associated with the percentage of male fetuses in the litter on day 90. This study provides valuable insights into the temporal changes in maternal vitamin D levels during pregnancy and its impact on economically important litter characteristics. Understanding the role of vitamin D in fetal growth during key developmental stages is vital for improving reproductive success in livestock species.
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2022)
Article
Obstetrics & Gynecology
Bingqian Zhang, Zijing Wang, Kexin Dai, Linlin Cui, Zi-Jiang Chen
Summary: This retrospective cohort study evaluated the long-term cardiometabolic health of offspring conceived by frozen embryo transfer and born to mothers with overweight/obesity. The study found that offspring conceived by frozen embryo transfer from overweight/obese mothers were associated with higher systolic blood pressure and adverse metabolic changes compared to those conceived by fresh embryo transfer. However, in offspring of mothers with normal weight, frozen embryo transfer was associated with lower low-density lipoprotein-cholesterol levels.
FERTILITY AND STERILITY
(2022)
Article
Multidisciplinary Sciences
Jie Tang, Xinhong Zhu, Yanbing Chen, Dongming Huang, Henning Tiemeier, Ruoling Chen, Wei Bao, Qingguo Zhao
Summary: This study found that in the Chinese population, maternal pre-pregnancy BMI was significantly associated with the risk of adverse pregnancy outcomes, and this risk varied according to maternal age. Further research is needed to explore whether and how counseling and interventions for women with either low or high BMI before pregnancy can reduce the risk of adverse pregnancy outcomes.
SCIENTIFIC REPORTS
(2021)
Article
Endocrinology & Metabolism
Stephanie W. Waldrop, Sierra Niemiec, Cheyret Wood, Lauren E. Gyllenhammer, Thomas Jansson, Jacob E. Friedman, Jeanie B. Tryggestad, Sarah J. Borengasser, Elizabeth J. Davidson, Ivana V. Yang, Katerina Kechris, Dana Dabelea, Kristen E. Boyle
Summary: This study suggests that maternal metabolic traits, particularly triglycerides, may influence DNA methylation in cord blood and subsequently affect child adiposity. The DNA methylation changes were found near genes related to immune function and lipid metabolism. Specific CpG sites associated with maternal triglycerides were also associated with child adiposity at both 4-6 months and 4-6 years of age. The findings highlight the potential role of DNA methylation in mediating the relationship between maternal metabolic traits and child adiposity.
Article
Endocrinology & Metabolism
Rui Zhou, Furong Li, Guochong Chen, Qiang Fu, Shanyuan Gu, Xianbo Wu
Summary: This study found that both general and abdominal obesity were associated with an increased risk of incident diabetic neuropathy among individuals with type 2 diabetes mellitus, regardless of sex.
JOURNAL OF DIABETES
(2021)
Article
Endocrinology & Metabolism
Julia Bandres-Meriz, Christina Kunz, Jesper F. Havelund, Nils J. Faergeman, Alejandro Majali-Martinez, Regina Ensenauer, Gernot Desoye
Summary: The study found that the metabolome of pregnant women with overweight/obesity is already altered early in pregnancy due to changes in C-peptide. Lipid and amino acid metabolites related to obesity and insulin play a key role in these alterations.
INTERNATIONAL JOURNAL OF OBESITY
(2023)
Article
Nutrition & Dietetics
Hai-Tao Yu, Wen-Hui Xu, Yi-Ru Chen, Ye Ji, Yi-Wei Tang, Yue-Ting Li, Jia-Yu Gong, Yi-Fei Chen, Guo-Liang Liu, Lin Xie
Summary: Maternal pre-BMI is associated with maternal-fetal plasma fatty acid profiles, with more noticeable adverse profiles in overweight mothers before pregnancy.
FRONTIERS IN NUTRITION
(2022)
Article
Psychology, Developmental
Delia A. Gheorghe, Chenlu Li, John Gallacher, Sarah Bauermeister
Summary: Adversity experiences are significant risk factors for psychiatric illness, with changes in brain structure increasing vulnerability. This study investigated the associations between childhood and adult adversity experiences and multiple brain phenotypes in a large population sample, demonstrating the impact of adversity on the brain using big datasets.
JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
(2021)
Article
Nutrition & Dietetics
Oraporn Dumrongwongsiri, Pattanee Winichagoon, Nalinee Chongviriyaphan, Umaporn Suthutvoravut, Veit Grote, Berthold Koletzko
Summary: Maternal nutritional status and mode of delivery are significantly associated with zinc and iron stores at birth, highlighting the importance of ensuring adequate nutrition during preconception and pregnancy to build sufficient nutrient stores for infants.
Article
Multidisciplinary Sciences
Qing-Xiang Zheng, Hai-Wei Wang, Xiu-Min Jiang, Yan Lin, Gui-Hua Liu, Mian Pan, Li Ge, Xiao-Qian Chen, Jing-Ling Wu, Xiao-Yun Zhang, Yu-Qing Pan, Hong-Gu He
Summary: This study aimed to determine the ranges of gestational weight gain (GWG) in Chinese women with gestational diabetes mellitus (GDM) and investigate the associations between prepregnancy body mass index (BMI), GWG, and maternal-infant adverse outcomes. The findings revealed that the ranges of GWG in Chinese women with GDM were different from the National Academy of Medicine's recommendation, and GDM women with high prepregnancy BMI and excessive GWG were associated with higher risks of adverse outcomes for both the mother and the infant.
SCIENTIFIC REPORTS
(2022)
Article
Nutrition & Dietetics
Angelica Avila Castillo, Tobias Hagemann, Anne Hoffmann, Ronny Baber, Ronald Biemann, Kerstin Wirkner, Sontje Krupka, Michael Stumvoll, Matthias Blueher, Nora Kloeting
Summary: The prevalence of allergies and obesity has increased, and low vitamin D (25(OH)D) levels have been linked to higher body mass index (BMI) and allergies. This study aimed to explore the relationship between 25(OH)D concentrations and allergen-specific IgE concentrations, and investigate VDR gene expression in abdominal subcutaneous and visceral adipose tissue. The study found that individuals with higher BMI had lower 25(OH)D concentrations, and higher IgE concentrations were detected in women.
FRONTIERS IN NUTRITION
(2023)
Article
Medicine, General & Internal
Jiao-Jiao Zou, Qian Wei, Yu-Yang Shi, Ke Wang, Yun-Hui Zhang, Hui-Jing Shi
Summary: This study analyzed data from 4574 pregnant women and their offspring, finding an association between maternal glucose levels during pregnancy and fetal intrauterine growth. Gestational diabetes or hyperglycemia were related to altered fetal growth patterns, highlighting the importance of monitoring and managing maternal glucose levels during pregnancy for optimal birth outcomes.
Article
Endocrinology & Metabolism
Anna J. Wood, I-Lynn Lee, Elizabeth L. M. Barr, Federica Barzi, Jacqueline A. Boyle, Christine Connors, Elizabeth Moore, Jeremy J. N. Oats, Harold D. McIntyre, Angela Titmuss, Alison Simmonds, Paul Z. Zimmet, Alex D. H. Brown, Sumaria Corpus, Jonathan E. Shaw, Louise J. Maple-Brown
Summary: This study aimed to determine the rates and predictors of postpartum diabetes screening among Aboriginal and/or Torres Strait Islander and non-Indigenous women with gestational diabetes mellitus (GDM). The study found that postpartum screening rates were lower among Aboriginal and/or Torres Strait Islander women compared to non-Indigenous women. Early postpartum screening should be prioritized to detect prediabetes and diabetes among high-risk populations.
Article
Obstetrics & Gynecology
Sumaiya Adam, Harold David McIntyre, Kit Ying Tsoi, Anil Kapur, Ronald C. Ma, Stephanie Dias, Pius Okong, Moshe Hod, Liona C. Poon, Graeme N. Smith, Lina Bergman, Esraa Algurjia, Patrick O'Brien, Virna P. Medina, Cynthia Maxwell, Lesley Regan, Mary L. Rosser, Bo Jacobsson, Mark A. Hanson, Sharleen L. O'Reilly, Fionnuala M. McAuliffe
Summary: Gestational diabetes (GDM) affects approximately 17 million pregnancies worldwide. Women with a history of GDM are at a significantly higher risk of developing type 2 diabetes and cardiovascular disease compared to those without prior GDM. Although prevention and delayed progression of GDM to type 2 diabetes is possible, it is not widely practiced. Considering the increasing rates of type 2 diabetes and CVD in women globally, it is crucial to utilize pregnancy as an opportunity for early identification and preventive intervention.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Obstetrics & Gynecology
Cynthia Maxwell, Rachelle Shirley, Amy C. O'Higgins, Mary L. Rosser, Patrick O'Brien, Moshe Hod, Sharleen L. O'Reilly, Virna P. Medina, Graeme N. Smith, Mark A. Hanson, Sumaiya Adam, Ronald C. Ma, Anil Kapur, Harold David McIntyre, Bo Jacobsson, Liona C. Poon, Lina Bergman, Lesley Regan, Esraa Algurjia, Fionnuala M. McAuliffe
Summary: Obesity is a chronic, progressive, relapsing, and treatable neurobehavioral disease that affects women's health and requires a focus on optimizing health outcomes rather than weight loss. Appropriate and sensitive language, as well as trauma-informed care, is necessary when discussing obesity.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Obstetrics & Gynecology
Liona C. Poon, Long Nguyen-Hoang, Graeme N. Smith, Lina Bergman, Patrick O'Brien, Moshe Hod, Pius Okong, Anil Kapur, Cynthia Maxwell, Harold David McIntyre, Bo Jacobsson, Esraa Algurjia, Mark A. Hanson, Mary L. Rosser, Ronald C. Ma, Sharleen L. O'Reilly, Lesley Regan, Sumaiya Adam, Virna P. Medina, Fionnuala M. McAuliffe
Summary: Hypertensive disorders of pregnancy (HDP) are the leading cause of maternal and perinatal morbidity and mortality, accounting for 16% of maternal deaths in high-income countries and approximately 25% in low- and middle-income countries. HDP increases the risk of future cardiovascular disease. Failure to achieve normal cardiovascular adaptation during pregnancy is associated with the development of HDP. Women with a history of HDP may experience long-term hemodynamic alterations, predisposing them to cardiovascular morbidity and mortality. Therefore, it is crucial to identify underlying cardiovascular risk factors during pregnancy and the postpartum period and develop strategies for lifestyle and therapeutic interventions to reduce the risk of future cardiovascular disease in women with a history of HDP.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Review
Obstetrics & Gynecology
Sarah Louise Killeen, Niamh Donnellan, Sharleen L. O'Reilly, Mark A. Hanson, Mary L. Rosser, Virna P. Medina, Chandni Maria Jacob, Hema Divakar, Moshe Hod, Liona C. Poon, Lina Bergman, Patrick O'Brien, Anil Kapur, Bo Jacobsson, Cynthia Maxwell, Harold David McIntyre, Lesley Regan, Esraa Algurjia, Ronald C. Ma, Sumaiya Adam, Fionnuala M. McAuliffe
Summary: The period before and during pregnancy is crucial for addressing malnutrition and reducing noncommunicable disease risks. The FIGO Nutrition Checklist is a tool designed to address these issues by assessing dietary requirements, body mass index, diet quality, and micronutrients. It generates awareness, identifies risks, and collects information for health-promoting conversations between women and healthcare professionals.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Medicine, Research & Experimental
Evan R. Edwards, Inbal Hazkani, Eli Stein, Jami L. Josefson, Jill H. Samis, Jennifer L. Miller, Jeffrey Rastatter
Summary: This study evaluated weight gain in children after thyroidectomy and identified predictors. It found that younger age at thyroidectomy and Hispanic ethnicity were associated with increased body mass index z-scores in the first 2 years post-operation.
Article
Obstetrics & Gynecology
Josephine G. Laurie, Shelley A. Wilkinson, Harold D. Mcintyre, Centaine Snoswell
Summary: This study conducted a cost-minimisation analysis comparing a novel, digital-based model for gestational diabetes mellitus (GDM) management with conventional care. The results showed that the intervention group using the digital model achieved a modest health service cost saving of approximately AU$17,441.78 (US$12,158.92) over a 12-month period, while patients saved approximately $566.56 (US$394.96) per patient. Overall, the introduction of the digital-based model resulted in a total saving of $679,872 (US$473,948.82) for the cohort of 1200 women.
AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY
(2023)
Article
Obstetrics & Gynecology
Josephine G. Laurie, Shelley A. Wilkinson, Alison Griffin, Harold D. McIntyre
Summary: This study implemented a novel digital model of care for gestational diabetes mellitus (GDM) and found that it provided similar clinical outcomes to traditional care, while also improving efficiency. The digital model of care has the potential for generalizability to culturally diverse GDM patients and offers important insights for service redesign in the digital era.
AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY
(2023)
Article
Clinical Neurology
Amber Salter, Alexander Keenan, Hoa H. Le, Kavita Gandhi, Maria Ait-Tihyaty, Samantha Lancia, Gary R. Cutter, Robert J. Fox, Ruth Ann Marrie
Summary: Fatigue is commonly experienced by multiple sclerosis patients, with a majority reporting worsening of fatigue over time. Factors associated with fatigue worsening include lower income, higher disability, lower initial fatigue level, use of injectable disease-modifying therapies, and increased levels of depression.
MULTIPLE SCLEROSIS JOURNAL-EXPERIMENTAL TRANSLATIONAL AND CLINICAL
(2023)
Article
Clinical Neurology
Gary Cutter, Richard A. Rudick, Carl de Moor, Carol M. Singh, Elizabeth Fisher, Thijs Koster, Fred D. Lublin, Jerry S. Wolinsky, Henry McFarland, Steven Jacobson, Maria L. Naylor
Summary: This study investigated the changes in serum neurofilament light-chain (sNfL) levels in response to treatment and assessed baseline sNfL as a predictor of relapse in treatment-naive RRMS patients. The results showed that sNfL levels decreased significantly within 6 months and remained low at 36 months in all treatment arms. The combination of lesion activity and sNfL was found to be a stronger predictor of relapse.
MULTIPLE SCLEROSIS JOURNAL-EXPERIMENTAL TRANSLATIONAL AND CLINICAL
(2023)
Article
Urology & Nephrology
Michael Allon, Alian Al-Balas, Carlton J. Young, Gary R. Cutter, Timmy Lee
Summary: In CKD patients with an eGFR less than 15 ml/min per 1.73 m2, placement of an AV graft instead of an AV fistula reduces the likelihood of catheter use at the initiation of dialysis.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Urology & Nephrology
Michael Allon, Gary R. Cutter, Carlton J. Young
Summary: This study found that access-related distal ischemia requiring intervention was rare. It was more common in women and patients with peripheral vascular disease or coronary artery disease. In some cases, a subsequent vascular access could be placed with a low likelihood of recurrent distal ischemia.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Health Care Sciences & Services
Marissa Betts, Kyle Fahrbach, Binod Neupane, Mahmoud Slim, Maria Pia Sormani, Gary Cutter, Thomas P. A. Debray, Marvin Rock
Summary: This study evaluates eight approaches for handling overlapping publications in network meta-analyses of real-world evidence (RWE) studies and recommends establishing an a priori hierarchy for selection.
JOURNAL OF COMPARATIVE EFFECTIVENESS RESEARCH
(2023)
Article
Pediatrics
Sean DeLacey, Miranda Gurra, Jennifer Arzu, Lynn P. Lowe, William L. Lowe, Denise M. Scholtens, Jami L. Josefson
Summary: The study found a positive association between cord blood leptin and neonatal and childhood adiposity, as well as child leptin levels. This association remained significant even after adjusting for maternal body mass index and glucose levels. Cord blood leptin may serve as a biomarker for future adiposity risk.
Article
Pediatrics
Dianna M. E. Bardo, Jill H. Samis, Jami L. Josefson, Marcelo R. Malakooti, Paul Tannous, Jeremy L. Fox, Jennifer Elhadary, Amanda Eichstaedt, Kenneth Gray, Agata Nytko, Cynthia K. Rigsby
Summary: This article discusses the FDA's guidelines on thyroid function testing in babies and young children after receiving iodinated contrast media for medical imaging exams. It also describes a hospital's response and implementation strategy to the FDA guidance statement. The hospital tracks and monitors thyroid function in patients under 3 months of age who undergo relevant exams, and has implemented a clinical care guideline.
PEDIATRIC RADIOLOGY
(2023)
