Article
Oncology
Huimin Jin, Yu Zhu, Ming Hong, Yujie Wu, Hairong Qiu, Rong Wang, Hui Jin, Qian Sun, Jianxin Fu, Jianyong Li, Sixuan Qian, Chun Qiao
Summary: Molecular abnormalities are common in core-binding factor (CBF) AMLs, with mutations such as KIT, NRAS, and ASXL1 present in a significant percentage of patients. Co-mutations of KIT and NRAS are associated with poor prognosis, along with age >= 60 years and additional chromosomal abnormalities.
LEUKEMIA & LYMPHOMA
(2021)
Article
Biophysics
Takaaki Konuma, Tadakazu Kondo, Masayoshi Masuko, Hiroaki Shimizu, Souichi Shiratori, Takahiro Fukuda, Jun Kato, Masashi Sawa, Yukiyasu Ozawa, Shuichi Ota, Naoyuki Uchida, Yoshinobu Kanda, Shinichi Kako, Shin Fujisawa, Kentaro Fukushima, Tatsuo Ichinohe, Yoshiko Atsuta, Masamitsu Yanada
Summary: The study found that pretransplant measurable residual disease (MRD) has different prognostic values in core binding factor AML patients, depending on the specific genotype. Effective therapeutic strategies are needed for MRD-positive patients.
BONE MARROW TRANSPLANTATION
(2021)
Article
Oncology
Sara A. Vayrynen, Jinming Zhang, Chen Yuan, Juha P. Vayrynen, Andressa Dias Costa, Hannah Williams, Vicente Morales-Oyarvide, Mai Chan Lau, Douglas A. Rubinson, Richard F. Dunne, Margaret M. Kozak, Wenjia Wang, Diana Agostini-Vulaj, Michael G. Drage, Lauren Brais, Emma Reilly, Osama Rahma, Thomas Clancy, Jiping Wang, David C. Linehan, Andrew J. Aguirre, Charles S. Fuchs, Lisa M. Coussens, Daniel T. Chang, Albert C. Koong, Aram F. Hezel, Shuji Ogino, Jonathan A. Nowak, Brian M. Wolpin
Summary: The study revealed a diverse set of myeloid cells within the PDAC tumor microenvironment, which are distributed heterogeneously across patient tumors. Beyond cell density, the spatial locations of immune cells are also associated with patient outcomes, underscoring the potential role of spatially resolved myeloid cell subtypes as quantitative biomarkers for PDAC prognosis and therapy.
CLINICAL CANCER RESEARCH
(2021)
Article
Multidisciplinary Sciences
Feng-Ting Dao, Jun Wang, Lu Yang, Ya-Zhen Qin
Summary: The study identified 64 immune-related differentially expressed genes (DEGs) associated with mutations in AML and developed an immune prognostic model (IPM) composed of PYCARD and PEAR1 genes, which independently predicted lower 2-year overall survival rates in AML patients. The IPM was validated in different databases and found to be associated with specific immune cell proportions and expression of checkpoint molecules in the AML cohort. The IPM derived from poor prognosis mutations in AML provides new biomarkers for patient stratification and personalized immunotherapy.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Nevine F. Shafik, Dalia Ibraheem, Marwa Mahmoud Selim, Rasha Mahmoud Allam, Lamiaa A. Fathalla
Summary: C-KIT mutations are common in core binding factor acute myeloid leukemia and have a significant impact on the prognosis of pediatric patients, but not on adult patients.
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA
(2022)
Review
Oncology
Naval G. G. Daver, Shahed Iqbal, Camille Renard, Rebecca J. J. Chan, Ken Hasegawa, Hao Hu, Preston Tse, Jiajun Yan, Michael J. J. Zoratti, Feng Xie, Giridharan Ramsingh
Summary: This study conducted a systematic review and meta-analysis to compare the treatment outcomes of different therapies for TP53-mutated AML in newly diagnosed patients. The results showed that although IC and VEN + HMA had better treatment responses compared to HMA, the overall survival was uniformly poor, highlighting the need for improved treatment for this difficult-to-treat population.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2023)
Article
Genetics & Heredity
Hongwei Luo, Yingchun Zhang, Nan Hu, Yancheng He, Chengcheng He
Summary: This study established a prognostic model of a 12-RBP signature that showed high prediction accuracy for stratifying the risk of AML patients. The model outperformed cytogenetics and provided valuable insights into the role of RBPs in AML, potentially laying the foundation for future treatment strategies.
FRONTIERS IN GENETICS
(2021)
Article
Oncology
Yamei Zhai, Qingya Wang, Li Ji, Hanyun Ren, Yujun Dong, Fan Yang, Yue Yin, Zeyin Liang, Qian Wang, Wei Liu, Yan Mei, Lu Zhang, Yuan Li
Summary: Core binding factor (CBF) gene chromosomal translocations in acute myeloid leukemia (AML) patients in China account for 15% of cases. Despite being classified as a favorable-risk group by the European Leukemia Net (ELN), CBF-AML patients have a higher relapse rate of up to 40%. This study suggests that CBF-AML prognosis is worse than what ELN guidelines indicate, and highlights the need for rational risk stratification strategies for inv(16) and t(8;21) subtypes.
Review
Medicine, General & Internal
Wu Ye, Mingzhu Ma, Xia Wu, Jili Deng, Xiaoyan Liu, Xue Zheng, Yuping Gong
Summary: A meta-analysis was conducted to evaluate the prognostic value of KMT2A-PTD in patients with AML. The results showed that KMT2A-PTD was associated with shorter overall survival in the total population, as well as in karyotypically normal AML and old AML patients. KMT2A-PTD may serve as a promising genetic biomarker for AML patients in the future.
Review
Oncology
Stephanie Franco, Xue Geng, Valeriy Korostyshevskiy, Judith E. Karp, Catherine Lai
Summary: Acute myeloid leukemia (AML) is an oncologic emergency that typically requires immediate chemotherapy. However, with the introduction of targeted therapies, there may be a benefit in delaying treatment to identify actionable therapeutic targets. Unfortunately, cytogenetic/molecular testing can take more than 7 days to return, and the prognostic impact of time from diagnosis to treatment (TDT) in AML is not clear.
Article
Oncology
Anne Calleja, Michael Loschi, Laurent Bailly, Adeline Morisot, Alice Marceau, Lionel Mannone, Guillaume Robert, Patrick Auberger, Claude Preudhomme, Sophie Raynaud, Fabien Subtil, Pierre Sujobert, Thomas Cluzeau
Summary: Personalized medicine is a significant challenge for patients with acute myeloid leukemia (AML). This study evaluated the prognostic value of a personalized prognostic scoring algorithm known as Knowledge Bank (KB) on a cohort of 167 real-life AML patients. The results showed that the KB algorithm accurately predicted outcomes for younger patients in favorable and intermediate ELN risk categories but failed to predict survival for younger patients in the adverse ELN risk category and older patients in the favorable ELN risk category. The discrepancies may be attributed to the emergence of new therapeutic options and improvements in allogeneic stem cell transplantation (aHSCT) outcomes and supportive cares. Therefore, prospective validation of these scoring systems is necessary to incorporate recent therapeutic innovations.
Article
Hematology
Genki Yamato, Tomoko Kawai, Norio Shiba, Junji Ikeda, Yusuke Hara, Kentaro Ohki, Shin-Ichi Tsujimoto, Taeko Kaburagi, Kenichi Yoshida, Yuichi Shiraishi, Satoru Miyano, Nobutaka Kiyokawa, Daisuke Tomizawa, Akira Shimada, Manabu Sotomatsu, Hirokazu Arakawa, Souichi Adachi, Takashi Taga, Keizo Horibe, Seishi Ogawa, Kenichiro Hata, Yasuhide Hayashi
Summary: The study found that DNA methylation patterns were associated with genetic alterations in pediatric patients with acute myeloid leukemia (AML). Specific CpG sites were useful in categorizing patients into different clusters based on methylation levels, which were related to gene expression patterns and prognosis.
Article
Biochemistry & Molecular Biology
Reem Nabil, Naglaa M. Hassan, Mona S. Abdellateif, Rania M. Gawdat, Samar Sami Elshazly
Summary: The study aimed to investigate the role of C-KIT, TET1, and TET2 expression in the diagnosis and prognosis of acute myeloblastic leukemia (AML). The results showed that these biomarkers were significantly upregulated in AML patients and could be potential indicators for diagnosis and prognosis.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Oncology
Yin Wang, Wen-Jun Weng, Dun-Hua Zhou, Jian-Pei Fang, Srishti Mishra, Li Chai, Lu-Hong Xu
Summary: WT1 mutations are associated with poor prognosis in pediatric AML, especially when co-occurring with FLT3/ITD mutations. Hematopoietic stem cell transplantation may improve the prognosis of patients with WT1 mutations.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, General & Internal
Eric J. Duncavage, Molly C. Schroeder, Michele O'Laughlin, Roxanne Wilson, Sandra MacMillan, Andrew Bohannon, Scott Kruchowski, John Garza, Feiyu Du, Andrew E. O. Hughes, Josh Robinson, Emma Hughes, Sharon E. Heath, Jack D. Baty, Julie Neidich, Matthew J. Christopher, Meagan A. Jacoby, Geoffrey L. Uy, Robert S. Fulton, Christopher A. Miller, Jacqueline E. Payton, Daniel C. Link, Matthew J. Walter, Peter Westervelt, John F. DiPersio, Timothy J. Ley, David H. Spencer
Summary: This study showed that whole-genome sequencing provided rapid and accurate genomic profiling in patients with AML or MDS, with a greater diagnostic yield than conventional cytogenetic analysis, and more efficient risk stratification based on standard risk categories.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)