Article
Gastroenterology & Hepatology
Kazuto Tajiri, Yuka Hayashi Futsukaichi, Aiko Murayama, Masami Minemura, Terumi Takahara, Ichiro Yasuda
Summary: Although patients with chronic liver disease (CLD) usually show few symptoms, their overall health-related quality of life (HRQOL) is decreased with occurrence of complications. The Chronic Liver Disease Questionnaire (CLDQ) is a useful tool for assessing HRQOL in CLD patients and predicting their prognosis, and can be used for management in clinical practice.
HEPATOLOGY RESEARCH
(2022)
Article
Gastroenterology & Hepatology
Marlen I. Castellanos-Fernandez, Susana A. Borges-Gonzalez, Maria Stepanova, Mirtha E. Infante-Velazquez, Caridad Ruenes-Domech, Sila M. Gonzalez-Suero, Zaily Dorta-Guridi, Enrique R. Arus-Soler, Andrei Racila, Zobair M. Younossi
Summary: This study assessed health-related quality of life (HRQL) in Cuban patients with compensated chronic liver disease (CLD). The results showed that patients with HCV and autoimmune liver diseases (AILD) had the worst PRO scores, likely due to severe underlying liver disease and/or extrahepatic manifestations. Male gender and regular exercise were predictors of better HRQL, while fatigue, abdominal pain, anxiety, and depression were strong independent predictors of HRQL impairment.
ANNALS OF HEPATOLOGY
(2021)
Article
Anesthesiology
Luis Lopez-Lopez, Emmanuel Navarro-Flores, Marta Elena Losa-Iglesias, Israel Casado-Hernandez, Ricardo Becerro-de-Bengoa-Vallejo, Carlos Romero-Morales, Daniel Lopez-Lopez, Carmen de Labra
Summary: This study describes the impact of foot health and health in general in a sample of adult people with chronic foot pain compared with a control group. Results show significant differences between chronic foot pain patients and the control group in foot pain, foot function, general health, and physical activity.
Article
Urology & Nephrology
Chandana Guha, Anita van Zwieten, Rabia Khalid, Siah Kim, Amanda Walker, Anna Francis, Madeleine Didsbury, Armando Teixeira-Pinto, Belinda Barton, Chanel Prestidge, Emily Lancsar, Fiona Mackie, Joseph Kwon, Kirsten Howard, Kylie-Ann Mallitt, Martin Howell, Allison Jaure, Alison Hayes, Rakhee Raghunandan, Stavros Petrou, Suncica Lah, Steven McTaggart, Jonathan C. Craig, Germaine Wong
Summary: This multi-center longitudinal cohort study aimed to assess the trajectories of health-related quality of life (HRQoL) in children with chronic kidney disease (CKD) over time. The results showed that the HRQoL scores differed between children with different CKD stages, and the transition from dialysis to transplantation was significantly associated with the improvement in HRQoL. Children with CKD stage 1-5 and transplant recipients at baseline had stable HRQoL over time.
KIDNEY INTERNATIONAL
(2023)
Article
Gastroenterology & Hepatology
Toshihiko Tomita, Kiyoyasu Kazumori, Kenji Baba, Xiahong Zhao, Yirong Chen, Hiroto Miwa
Summary: Chronic constipation has a significant impact on health-related quality of life, work productivity, and healthcare resource use in Japan, with a higher burden compared to type 2 diabetes mellitus, irritable bowel syndrome, and gastroesophageal reflux disease. Effective treatment for Japanese patients with chronic constipation is urgently needed to improve their quality of life.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Review
Medicine, General & Internal
Simin Li, Wanchen Ning, Wei Wang, Dirk Ziebolz, Aneesha Acharya, Gerhard Schmalz, Jianjiang Zhao, Shaohong Huang, Hui Xiao
Summary: This systematic review evaluates the oral health-related quality of life (OHRQoL) of patients with chronic respiratory diseases. Results indicate that patients with chronic respiratory diseases have a worse OHRQoL. The relationship between oral health, health-related quality of life, disease-related parameters, and OHRQoL is rarely examined.
FRONTIERS IN MEDICINE
(2022)
Article
Health Care Sciences & Services
Oana-Mihaela Plotogea, Gina Gheorghe, Madalina Stan-Ilie, Gabriel Constantinescu, Nicolae Bacalbasa, Simona Bungau, Camelia Cristina Diaconu
Summary: The study revealed that patients with chronic liver diseases commonly experience sleep disturbances, which are associated with impaired health-related quality of life (HRQOL). Cirrhotic patients showed poorer sleep and HRQOL compared to pre-cirrhotics.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Public, Environmental & Occupational Health
Abdulaziz Abdullah Alsaif, Thamer Adel Alkhadra, AlBandary Hassan AlJameel
Summary: This study assessed the oral health and its impact on oral health-related quality of life (OHRQoL) among foundling, delinquent, and mainstream children in Riyadh, Saudi Arabia. The results showed that the delinquent group had poorer oral health status and higher OHRQoL scores compared to the mainstream group.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Geriatrics & Gerontology
C. G. N. Voorend, M. van Oevelen, M. Nieberg, Y. Meuleman, C. F. M. Franssen, H. Joosten, N. C. Berkhout-Byrne, A. C. Abrahams, S. P. Mooijaart, W. J. W. Bos, M. van Buren
Summary: This study found that older patients with advanced chronic kidney disease experienced disease-related anxiety, increased depressive symptoms, and reduced physical health-related quality of life during the COVID-19 pandemic. The decrease in quality of life was mostly attributed to the COVID-19 pandemic.
Article
Oncology
Fangyuan Zheng, Xuelin Dou, Liqiang Zhang, Jie Jin, Yanli Zhang, Bingcheng Liu, Li Meng, Xiaofan Zhu, Zesheng Lu, Yueping Jia, Huilan Liu, Hai Lin, Li Zhou, Xielan Zhao, Wei Yang, Hui Sun, Sixuan Qian, Hongxia Ma, Runhui Wu, Leping Zhang, Qian Jiang
Summary: The study found that TKI-related symptoms, mother's low education level, and age are significantly associated with HRQoL in children with CML. Children and their parents have different priorities in terms of HRQoL.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2022)
Article
Urology & Nephrology
Julia M. T. Colombijn, Anna A. Bonenkamp, Anita van Eck van der Sluijs, Joost A. Bijlsma, Arnold H. Boonstra, Akin Ozyilmaz, Alferso C. Abrahams, Brigit C. van Jaarsveld
Summary: A higher number of medications were associated with a lower HRQoL, more symptoms, and worse self-rated health in dialysis patients after adjusting for confounders such as comorbidity.
AMERICAN JOURNAL OF NEPHROLOGY
(2021)
Article
Psychology, Multidisciplinary
Aline Schoenenberg, Hannah M. Zipprich, Ulrike Teschner, Tino Prell
Summary: This study explores the impact of depression, resilience, and health locus of control (HLC) on the perception of the difference between desired and current experiences in patients with chronic neurological disorders. The findings suggest that there is a gap between current and desired states for various aspects of life, and this gap is influenced by depression, resilience, HLC, age, and sociodemographic factors. Adjusting expectations and maintaining a reasonably increased desired state may help improve the perception of the current situation, especially in older patients with declining health.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Medicine, General & Internal
Janine Wirkner, Matthias Scheuch, Thomas Dabers, Sabrina Freiin von Rheinbaben, Beate Fiene, Simone Aymanns, Karlhans Endlich, Nicole Endlich, Uwe Lendeckel, Rainer Rettig, Hans Joergen Grabe, Sylvia Stracke
Summary: This study examined various factors influencing health-related quality of life (HRQOL) in chronic kidney disease (CKD) patients, with a focus on the impact of dialysis, depression, and diabetes. The results highlighted the importance of recognizing and treating depression to improve HRQOL and potentially enhance patient outcomes and reduce hospitalization rates.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Yun Soo Hong, Hoon Kim, Di Zhao, Ajin Cho
Summary: This study using KNHANES data found that HRQoL in patients with DM worsened with the severity of CKD stages, with pain/discomfort being the most common problem among DM patients. As CKD advanced, patients were more likely to experience problems in all dimensions of EQ-5D, except for the anxiety/depression dimension.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Medicine, General & Internal
Amber Hager, Diana Mager, Cheri Robert, David Nicholas, Susan Gilmour
Summary: The study found that there is a certain consistency in parental and child perceptions of HRQOL in pediatric liver transplant recipients, but it is related to age and ethnicity. When children have comorbidities related to mental and neurocognitive development, there may be differences in how parents and children perceive HRQOL.
Article
Gastroenterology & Hepatology
Julia Dietz, Beat Muellhaupt, Peter Buggisch, Christiana Graf, Kai-Henrik Peiffer, Katrin Matschenz, Joern M. Schattenberg, Christoph Antoni, Stefan Mauss, Claus Niederau, Thomas Discher, Janina Trauth, Georg Dultz, Julian Schulze zur Wiesch, Felix Piecha, Hartwig Klinker, Tobias Mueller, Thomas Berg, Christoph Neumann-Haefelin, Christoph P. Berg, Stefan Zeuzem, Christoph Sarrazin
Summary: This study evaluated the long-term persistence of resistance-associated substitutions (RASs) in HCV patients treated with DAAs. Low-to medium-level RASs were found to persist over time, while high-level resistant RASs gradually disappeared. Different patterns of RAS persistence according to HCV subtype could have implications for retreatment with first-generation DAAs and for global HCV elimination goals.
JOURNAL OF HEPATOLOGY
(2023)
Article
Health Care Sciences & Services
Maurice Michel, Alisha Wahl, Malena Anders, Saleh A. Alqahtani, Wolfgang M. Kremer, Peter R. Galle, Christian Labenz, Daniel Grimm, Martin Sprinzl, Joern M. Schattenberg
Summary: Metabolic comorbidities, significant fibrosis, and a lower socioeconomic status may negatively affect the health-related quality of life in people living with human immunodeficiency virus (HIV).
QUALITY OF LIFE RESEARCH
(2023)
Article
Oncology
Chiun Hsu, Michel Ducreux, Andrew X. Zhu, Shukui Qin, Masafumi Ikeda, Tae-You Kim, Peter R. Galle, Richard S. Finn, Ethan Chen, Ning Ma, Youyou Hu, Lindong Li, Ann-Lii Cheng
Summary: The IMbrave150 trial showed that atezolizumab + bevacizumab is safe and effective in treating patients with hepatocellular carcinoma, including those with hepatitis B or hepatitis C infection.
Review
Gastroenterology & Hepatology
Joost Boeckmans, Alexandra Gatzios, Joern M. Schattenberg, Ger H. Koek, Robim M. Rodrigues, Tamara Vanhaecke
Summary: This study investigates the impact of the PNPLA3 gene mutation on the treatment of non-alcoholic fatty liver disease (NAFLD), finding that carrying the PNPLA3 148M allele may not benefit from omega-3 carboxylic acids to reduce liver fat, while lifestyle changes are more effective for these patients.
LIVER INTERNATIONAL
(2023)
Article
Multidisciplinary Sciences
Markus Schepers, Irene Schmidtmann, Daniela Zahn, Philipp Wild, Manfred Beutel, Alexander K. Schuster, Thomas Muenzel, Karl J. Lackner, Katharina Geschke, Joern Schattenberg, Rieke Baumkoetter, Simge Yilmaz, Daniel Wollschlaeger
Summary: This study examined the impact of the COVID-19 pandemic on medical care provision in the Mainz region of Germany until April 2021. The findings suggest that the rate of cancelled medical appointments was low and the number of appointments being made remained similar to pre-pandemic levels. Patient cancellations were more common than provider cancellations, and specialists were more likely to cancel appointments compared to general practitioners.
Article
Gastroenterology & Hepatology
Andreas Geier, Monika Rau, Anita Pathil-Warth, Manfred von der Ohe, Joern Schattenberg, Nektarios Dikopoulos, Kerstin Stein, Yvonne Serfert, Thomas Berg, Peter Buggisch, Muenevver Demir, Elke Roeb, Bianka Wiebner, Heiner Wedemeyer, Stefan Zeuzem, Wolf P. Hofmann
Summary: The German NAFLD-Registry is a prospective study that aims to describe clinical characteristics and observe outcomes in patients with NAFLD. From the baseline data of the first 501 patients, it was found that approximately 13% had a high risk for advanced fibrosis, about one-third had a liver stiffness value greater than 9.6kPa, and 10% had a clinical diagnosis of liver cirrhosis. Comorbidities such as arterial hypertension, hypercholesterolemia, and type 2 diabetes mellitus were more prevalent in high-risk patients.
ZEITSCHRIFT FUR GASTROENTEROLOGIE
(2023)
Article
Oncology
Masatoshi Kudo, Richard S. Finn, Ann-Lii Cheng, Andrew X. Zhu, Michel Ducreux, Peter R. Galle, Naoya Sakamoto, Naoya Kato, Michitaka Nakano, Jing Jia, Arndt Vogel
Summary: This exploratory analysis examined the prognostic impact of baseline albumin-bilirubin (ALBI) score in patients with unresectable hepatocellular carcinoma (HCC) treated with atezolizumab + bevacizumab or sorafenib. The study found that atezolizumab + bevacizumab improved overall survival and progression-free survival compared to sorafenib in patients with ALBI score of 1, but not in patients with ALBI score of 2. ALBI grade appeared to be prognostic for outcomes in both treatment groups.
Article
Endocrinology & Metabolism
Olivier Govaere, Megan Hasoon, Leigh Alexander, Simon Cockell, Dina Tiniakos, Mattias Ekstedt, Joern M. Schattenberg, Jerome Boursier, Elisabetta Bugianesi, Vlad K. Ratziu, Ann K. M. Daly, Quentin M. Anstee, LITMUS Investigators
Summary: Govaere et al. integrated circulating protein data with transcriptomics to develop a non-invasive diagnostic tool for identifying at-risk patients with non-alcoholic fatty liver disease (NAFLD) based on body mass index, type 2 diabetes and four circulating proteins.
Article
Gastroenterology & Hepatology
Simon Johannes Gairing, Sven Danneberg, Leonard Kaps, Michael Nagel, Eva Maria Schleicher, Charlotte Quack, Sinah Engel, Stefan Bittner, Peter Robert Galle, Jorn Markus Schattenberg, Marcus-Alexander Woerns, Felix Luessi, Jens Uwe Marquardt, Christian Labenz
Summary: In this study, it was found that serum glial fibrillary acidic protein (sGFAP) levels are associated with covert hepatic encephalopathy (CHE) in patients with cirrhosis. This suggests that astrocyte injury may already occur in patients with cirrhosis and sGFAP could be explored as a novel biomarker.
Article
Gastroenterology & Hepatology
Stephen A. Harrison, Vlad Ratziu, Quentin M. Anstee, Mazen Noureddin, Arun J. Sanyal, Joern M. Schattenberg, Pierre Bedossa, Mustafa R. Bashir, David Schneider, Rebecca Taub, Meena Bansal, Kris V. Kowdley, Zobair M. Younossi, Rohit Loomba
Summary: This study presents the design of the MAESTRO clinical program, which aims to evaluate the effectiveness of resmetirom in treating NASH. The program includes multiple clinical trials targeting different patient populations, assessing the efficacy and safety of the drug using various methods such as biopsies, biomarkers, and imaging.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Cardiac & Cardiovascular Systems
Omar Hahad, Donya A. Gilan, Julian Chalabi, Sadeer Al-Kindi, Alexander K. Schuster, Felix Wicke, Matthias Buettner, Oliver Tuescher, Karl J. Lackner, Peter R. Galle, Stavros Konstantinides, Andreas Daiber, Philipp S. Wild, Thomas Muenzel
Summary: This study aims to investigate the association between social disadvantage and cardiovascular burden and mortality. The findings suggest that low socioeconomic status is associated with increased risk of cardiovascular disease and mortality, with education and occupation being stronger predictors compared to household net income.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Tiemo Sven Gerber, Hagen Roland Witzel, Arndt Weinmann, Fabian Bartsch, Mario Schindeldecker, Peter R. Galle, Hauke Lang, Wilfried Roth, Dirk Andreas Ridder, Beate Katharina Straub
Summary: This study investigated the levels of 4-hydroxy-nonenal (4-HNE) in liver carcinomas and analyzed their correlation with clinical data and survival outcomes. The results showed that lower levels of 4-HNE were associated with unfavorable survival outcomes and aggressive tumor behavior in hepatocellular carcinoma (HCC). However, in intrahepatic cholangiocarcinoma (iCCA), 4-HNE levels were not correlated with prognostic parameters or survival outcomes.
Article
Gastroenterology & Hepatology
Simon J. Gairing, Eva M. Schleicher, Leonard Kaps, Sophia Schulte-Beerbuehl, Kristina Steiner, Joachim Labenz, Joern M. Schattenberg, Peter R. Galle, Marcus-Alexander Woerns, Christian Labenz
Summary: This study developed a virtual reality driving test to assess the driving skills of patients with cirrhosis and investigate its association with car accidents. The results showed that patients with cirrhosis had longer reaction times and a higher risk of car accidents. The VR driving test could serve as a useful tool for predicting car accidents.
HEPATOLOGY COMMUNICATIONS
(2023)
Review
Gastroenterology & Hepatology
Joost Boeckmans, Laurent Sandrin, Christian Knackstedt, Jorn M. Schattenberg
Summary: Metabolic dysfunction-associated steatotic liver disease is associated with increased liver stiffness, which is related to heart diseases. Therefore, cardiac evaluation should be considered.
LIVER INTERNATIONAL
(2023)