Article
Immunology
Encheng Sun, Lianyu Huang, Xianfeng Zhang, Jiwen Zhang, Dongdong Shen, Zhenjiang Zhang, Zilong Wang, Hong Huo, Wenqing Wang, Haoyue Huangfu, Wan Wang, Fang Li, Renqiang Liu, Jianhong Sun, Zhijun Tian, Wei Xia, Yuntao Guan, Xijun He, Yuanmao Zhu, Dongming Zhao, Zhigao Bu
Summary: Recently, genotype I ASFVs have emerged in China, with SD/DY-I/21 showing low virulence, high transmissibility, mild infection onset, and chronic disease in pigs, along with causing necrotic skin lesions and joint swelling. The emergence of genotype I ASFVs presents more challenges for the control and prevention of African swine fever in China.
EMERGING MICROBES & INFECTIONS
(2021)
Article
Veterinary Sciences
Shuchao Wang, Jingyuan Zhang, Yanyan Zhang, Jinjin Yang, Lidong Wang, Yu Qi, Xun Han, Xintao Zhou, Faming Miao, Teng Chen, Ying Wang, Fei Zhang, Shoufeng Zhang, Rongliang Hu
Summary: African swine fever, caused by ASFV, is a highly contagious hemorrhagic disease in domestic pigs. The lack of effective vaccine development is largely due to gaps in knowledge regarding pathogenesis and immunology, specifically the role of cytokines in the host's immune response. Increased understanding of cytokine dynamics during ASFV infection could provide insights into developing potential therapeutic interventions.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Virology
Julia Sehl-Ewert, Virginia Friedrichs, Tessa Carrau, Paul Deutschmann, Sandra Blome
Summary: African swine fever can be efficiently transmitted to sows through artificial insemination using semen from infected boars. The infection causes visible changes in the reproductive organs of boars, including hemorrhages, edema, and proliferations. Histopathological analysis shows vasculitis, perivasculitis, and degeneration of the testicular and epididymal tubules. The impact of these changes on the long-term persistence of the virus should be further studied.
Article
Agriculture, Dairy & Animal Science
Alvydas Malakauskas, Katja Schulz, Indre Kukanauskaite, Marius Masiulis, Franz Josef Conraths, Carola Sauter-Louis
Summary: This study investigated potential risk factors associated with African swine fever (ASF) outbreaks in pig farms in Lithuania in 2019. The study found that veterinary inspections significantly reduced the risk of ASF occurrence in a pig farm, while certain activities increased the odds of an outbreak. These findings are important for improving ASF control and prevention.
Article
Veterinary Sciences
Rachel Schambow, Yoder Colin, Wright Dave, Daniella N. Schettino, Andres M. Perez
Summary: As the threat of African swine fever continues, there is a need for new tools to detect and monitor the disease early. Questionnaires and focus group discussions revealed the potential value of enhanced passive surveillance protocols, but also highlighted challenges such as participation motivation, data sharing, and diagnostic testing costs.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Infectious Diseases
Katherukamem Rajukumar, Dhanapal Senthilkumar, Govindarajulu Venkatesh, Fateh Singh, Vishnu P. Patil, Subbiah Kombiah, Chakradhar Tosh, Chandan K. Dubey, Arnab Sen, Nagendra N. Barman, Amitav Chakravarty, Biswajit Dutta, Seema R. Pegu, Arpita Bharali, Vijendra P. Singh
Summary: African swine fever (ASF) has caused high mortality outbreaks in pigs in the states of Arunachal Pradesh and Assam in India, with the first confirmed cases of ASF in domestic pigs in the country. Genetic analyses show that the Indian ASF viruses are similar to post-2007-p72-genotype II viruses reported from Asia and Europe, indicating the transboundary expansion of ASF outbreaks in the region.
TRANSBOUNDARY AND EMERGING DISEASES
(2021)
Article
Microbiology
Alexey D. Sereda, Sanzhi Namsrayn, Vladimir M. Balyshev, Mikhail E. Vlasov, Irina P. Sindryakova, Galina Koltsova, Denis V. Kolbasov
Summary: The extreme genetic and immunobiological heterogeneity of African swine fever virus poses challenges to vaccine development. This article provides a comprehensive description of biological techniques for the classification of ASFV by seroimmunotypes, emphasizing the importance of conducting immunological tests on pigs to ensure accuracy.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Veterinary Sciences
Aleksandra Kosowska, Jose A. Barasona, Sandra Barroso-Arevalo, Luisa Blondeau Leon, Estefania Cadenas-Fernandez, Jose M. Sanchez-Vizcaino
Summary: African swine fever (ASF) is a lethal infectious disease that affects domestic and wild pigs. The virus can be transmitted directly through contact with infected animals or indirectly through contaminated feed or environments. The transmission patterns of different ASF virus isolates at the wildlife-livestock interface are still limited.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Review
Microbiology
Mary-Louise Penrith, Juanita Van Heerden, Livio Heath, Edward Okoth Abworo, Armanda D. S. Bastos
Summary: The region in eastern, central and southern Africa (ECSA) is the origin of African swine fever (ASF) in a sylvatic cycle and is home to all identified p72 genotypes of ASF virus. While five genotypes have extended presence in domestic pigs, two have spread beyond the African continent. It is crucial to prioritize the study of genetic, antigenic characteristics, and history of these viruses for vaccine development efforts.
Article
Infectious Diseases
Alexander Schaefer, Laura Zani, Jutta Pikalo, Jane Huehr, Julia Sehl, Thomas C. Mettenleiter, Angele Breithaupt, Sandra Blome, Ulrike Blohm
Summary: Infection with ASFV causes a deadly disease in pigs, with different immunological responses observed in wild boar and domestic pigs. CD8 alpha(+) gamma delta T cells were found to respond differently in wild boar, while domestic pigs showed higher levels of ICOS+ and CD8 alpha(+) invariant Natural Killer T cells after infection with a moderately virulent ASFV strain. These disparities in T-cell responses may explain the differences in disease progression between wild boar and domestic pigs.
TRANSBOUNDARY AND EMERGING DISEASES
(2021)
Article
Veterinary Sciences
Ki-Hyun Cho, Hyun-Joo Kim, Min-Kyung Jang, Ji-Hyoung Ryu, Daesung Yoo, Hae-Eun Kang, Jee-Yong Park
Summary: A suspect case of African swine fever (ASF) was detected in October 2020 at an abattoir in the north-central border region of South Korea. The farm of origin was confirmed positive for ASF. The identical isolates from 2020 and 2019 indicate the continued spread and circulation of ASF in the wild boar population, posing an increased risk of outbreaks in domestic pigs. Therefore, additional control measures should be implemented in the region.
VETERINARY SCIENCES
(2022)
Article
Agriculture, Dairy & Animal Science
Huan Wang, Meijun Chen, Ziyao Guo, Yangyang Shen, Yufan Chen, Ting Luo, Yuying Liu, Jianqiang Li, Fang Wang, Jiangjun Wan
Summary: African swine fever has had a significant impact on China's pig industry, causing fluctuations in live pig supply and prices, resulting in substantial economic losses for farmers. This study analyzed survey data to examine the current situation and factors influencing farmers' epidemic prevention and control behaviors. The findings indicate that the overall biosecurity level on pig farms is low. Factors such as technical training, farm size, income share, production organization, and government inspection significantly influence farmers' adoption of biosecurity measures. The study emphasizes the importance of biosecurity in enhancing farm resilience to major animal diseases and provides insights for policymakers.
Article
Infectious Diseases
Axel Mauroy, Pieter Depoorter, Claude Saegerman, Brigitte Cay, Nick De Regge, Maria-Eleni Filippitzi, Claude Fischer, Martine Laitat, Dominiek Maes, Kevin Morelle, Hans Nauwynck, Xavier Simons, Thierry van den Berg, Xavier Van Huffel, Etienne Thiry, Jeroen Dewulf
Summary: Since the introduction of an African swine fever (ASF) virus strain in Georgia in 2007, it has rapidly spread to Western European and Asian countries, posing a major threat to the global swine industry. In Belgium, where only wild boar were infected, the transmission routes are suspected to be related to the 'human factor'. The risk of spillover at the wild/domestic pig interface remains poorly assessed, emphasizing the importance of prioritizing risk mitigation measures against ASF introduction and spread in domestic pig industry.
TRANSBOUNDARY AND EMERGING DISEASES
(2021)
Review
Agriculture, Dairy & Animal Science
Silvia Pavone, Carmen Iscaro, Annalisa Dettori, Francesco Feliziani
Summary: African swine fever is a severe viral disease caused by the African swine fever virus, with 24 genotypes reported in sub-Saharan Africa. Italy has experienced two ASF epidemics, with four ongoing infection clusters.
Article
Veterinary Sciences
Hachung Yoon, Youngmin Son, Kyung-Sook Kim, Ilseob Lee, Yeon-Hee Kim, Eunesub Lee
Summary: This study establishes a procedure for estimating the time of infection on pig farms affected by ASF outbreaks, providing valuable insights into disease control. The detection time after infection varies among different types of pig sheds.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Multidisciplinary Sciences
Camille Jahel, Maxime Lenormand, Ismaila Seck, Andrea Apolloni, Ibra Toure, Coumba Faye, Baba Sall, Mbargou Lo, Cecile Squarzoni Diaw, Renaud Lancelot, Caroline Coste
SCIENTIFIC REPORTS
(2020)
Article
Infectious Diseases
Sarah Valentin, Alize Mercier, Renaud Lancelot, Mathieu Roche, Elena Arsevska
Summary: The study found that the three event-based surveillance systems are complementary in detecting early signals of COVID-19 emergence but require improvements in timeliness. Adaptation of EBS methods to different stages of disease emergence is crucial for enhancing early detection of future unknown disease outbreaks.
TRANSBOUNDARY AND EMERGING DISEASES
(2021)
Article
Multidisciplinary Sciences
L. Laroche, S. Ravel, T. Baldet, R. Lancelot, F. Chandre, M. Rossigne, V Le Goff, M. Duhayon, J-F Fafet, A. G. Parker, J. Bouyer
SCIENTIFIC REPORTS
(2020)
Review
Infectious Diseases
Cecile Squarzoni-Diaw, Elena Arsevska, Sana Kalthoum, Pachka Hammami, Jamel Cherni, Assia Daoudi, Mohamed Karim Laoufi, Yassir Lezaar, Kechna Rachid, Ismaila Seck, Bezeid Ould Elmamy, Barry Yahya, Barbara Dufour, Pascal Hendrikx, Eric Cardinale, Facundo Munoz, Renaud Lancelot, Caroline Coste
Summary: The article presents a participative and iterative qualitative risk assessment framework to evaluate the spatial variation of the risk of infectious animal disease introduction and spread, with experts using field data and knowledge to adjust risk factors. The framework was applied to assess the risk of foot-and-mouth disease introduction and spread in Tunisia. Results showed alignment between high-risk categories and actual FMD outbreaks, indicating the usefulness of the framework as a decision support tool in risk-based disease surveillance and control.
TRANSBOUNDARY AND EMERGING DISEASES
(2021)
Article
Microbiology
Isabel Marcelino, Philippe Holzmuller, Ana Coelho, Gabriel Mazzucchelli, Bernard Fernandez, Nathalie Vachiery
Summary: Quantitative proteomic analyses revealed the dynamic interaction between E. ruminantium infection and host cells, emphasizing the importance of inflammation-related proteins, providing essential clues for the study of Heartwater disease.
Article
Biochemical Research Methods
Joana Pissarra, Juli Pagniez, Elodie Petitdidier, Martial Seveno, Oana Vigy, Rachel Bras-Goncalves, Jean-Loup Lemesre, Philippe Holzmuller
Summary: Leishmaniasis is a significant parasitic disease that threatens the lives of 1 billion people every year. In this study, the total protein content of the secretomes produced by seven different Leishmania species was analyzed, revealing the common core secretome and highlighting the importance of secreted proteins in the pathogenesis of the disease.
JOURNAL OF PROTEOME RESEARCH
(2022)
Article
Infectious Diseases
Ismaila Seck, Modou Moustapha Lo, Assane Gueye Fall, Mariane Diop, Mamadou Ciss, Catherine Beatrice Cetre-Sossah, Coumba Faye, Mbargou Lo, Adji Mareme Gaye, Caroline Coste, Cecile Squarzoni-Diaw, Rianatou Bada Alambedji, Baba Sall, Andrea Apolloni, Renaud Lancelot
Summary: Rift Valley fever (RVF) is a mosquito-borne disease that affects wild and domestic ruminants. It is widespread in Africa, and an outbreak occurred in new areas of Senegal in 2013. Lower cumulative rainfall and higher accessibility are associated with a higher risk of RVFV infection.
PLOS NEGLECTED TROPICAL DISEASES
(2022)
Article
Public, Environmental & Occupational Health
Sarah Valentin, Elena Arsevska, Julien Rabatel, Sylvain Falala, Alize Mercier, Renaud Lancelot, Mathieu Roche
Summary: PADI-web is a biosurveillance system dedicated to monitoring online news sources for emerging animal infectious diseases, with over 380,000 collected news articles since 2016. It stands out for its focus on animal health, fully automated pipeline using machine-learning methods, and new functionalities like fine-grained classification, automatic term and entity extraction, semantic resources, and a notification system for end-users integrated into the ESA Platform.
Meeting Abstract
Infectious Diseases
C. Schaeffer, R. Interdonato, R. Lancelot, M. Roche, M. Teisseire
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Infectious Diseases
Madiou Thierno Bah, Vladimir Grosbois, Frederic Stachurski, Facundo Munoz, Maxime Duhayon, Ignace Rakotoarivony, Anais Appelgren, Clement Calloix, Liz Noguera, Theo Mouillaud, Charlotte Andary, Renaud Lancelot, Karine Huber, Claire Garros, Agnes Leblond, Laurence Vial
Summary: We developed a high-resolution correlative model to predict the distribution of Hyalomma marginatum ticks in southern France. The study found that the ticks were mainly found in areas with warm temperatures, low precipitation, and open natural habitats.
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
Article
Multidisciplinary Sciences
Camille Schaeffer, Roberto Interdonato, Renaud Lancelot, Mathieu Roche, Maguelonne Teisseire
Summary: This dataset consists of spatial and thematic entities related to avian influenza in social media textual data in English. It was created from three corpora to evaluate Named Entity Recognition (NER) tools and can be used to train or evaluate Natural Language Processing (NLP) approaches.
Article
Multidisciplinary Sciences
Joana Pissarra, Franck Dorkeld, Etienne Loire, Vincent Bonhomme, Denis Sereno, Jean-Loup Lemesre, Philippe Holzmuller
Summary: The R script SILVI was developed for the selection of immunogenic T-cell epitopes from HLA-binding prediction data. SILVI integrates and compares data from HLA-binding prediction servers, and considers properties such as similarity to host proteins and physical-chemical features. Applying different filters allows for the fast selection of immunogenic epitopes.
Article
Multidisciplinary Sciences
Ronan Brouazin, Iris Claudel, Renaud Lancelot, Guillaume Dupuy, Louis-Clement Gouagna, Marlene Dupraz, Thierry Baldet, Jeremy Bouyer
Summary: This study provides insights into monitoring Aedes populations in La Reunion and suggests using black plastic ovitraps placed in vacoa trees for effective detection. The ovitraps located in the tree canopy showed higher detection and apparent density for Ae. aegypti, while Ae. albopictus showed a preference for blotting paper as the oviposition surface.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Sarah Valentin, Elena Arsevska, Aline Vilain, Valerie De Waele, Renaud Lancelot, Mathieu Roche
Summary: Event-based surveillance (EBS) gathers information from various data sources, including online news articles. To overcome the challenge of processing unstructured data, diverse EBS systems have been developed. This paper describes an annotation framework for epidemiological information in animal disease-related news articles.
Article
Multidisciplinary Sciences
Iris Claudel, Ronan Brouazin, Renaud Lancelot, Louis-Clement Gouagna, Marlene Dupraz, Thierry Baldet, Jeremy Bouyer
Summary: This study aimed to identify the best trapping strategy for catching Ae. aegypti mosquitoes. The use of CO2 alone was found to increase the detection probability and apparent density of Ae. aegypti and Cx. quinquefasciatus mosquitoes. Traps with BG-Lure-alone or in combination with CO2 did not improve the detection probability. For male Ae. albopictus and female Ae. albopictus, neither CO2 nor BG-Lure had a significant effect on their trapping. The apparent densities of Ae. aegypti and Ae. albopictus mosquitoes were similar in both study sites.
SCIENTIFIC REPORTS
(2022)