A New Generation of FRET Sensors for Robust Measurement of Gαi1, Gαi2 and Gαi3 Activation Kinetics in Single Cells

Receptor Level Mechanisms Are Required for Epidermal Growth Factor (EGF)-stimulated Extracellular Signal-regulated Kinase (ERK) Activity Pulses

(2015) Breanne Sparta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Platelet Giprotein Gαi2is an essential mediator of thrombo-inflammatory organ damage in mice

(2015) Vasudharani Devanathan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Development of inhibitors of heterotrimeric Gαi subunits

(2014) Kathryn M. Appleton et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Suppression of GNAI2 message in ovarian cancer

(2014) John R Raymond et al.   Journal of Ovarian Research

The Regulating Function of Heterotrimeric G Proteins in the Immune System

(2013) Yantang Wang et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Development of FRET biosensors for mammalian and plant systems

(2013) Danny Hamers et al.   PROTOPLASMA

Structure-guided evolution of cyan fluorescent proteins towards a quantum yield of 93%

(2012) Joachim Goedhart et al.   Nature Communications

Real-time visualization of heterotrimeric G protein Gq activation in living cells

(2011) Merel JW Adjobo-Hermans et al.   BMC BIOLOGY

A mTurquoise-Based cAMP Sensor for Both FLIM and Ratiometric Read-Out Has Improved Dynamic Range

(2011) Jeffrey B. Klarenbeek et al.   PLoS One

LPA Is a Chemorepellent for B16 Melanoma Cells: Action through the cAMP-Elevating LPA5 Receptor

(2011) Maikel Jongsma et al.   PLoS One

Quantitative Co-Expression of Proteins at the Single Cell Level – Application to a Multimeric FRET Sensor

(2011) Joachim Goedhart et al.   PLoS One

Role of phosphoinositide 3-kinase β in platelet aggregation and thromboxane A2generation mediated by Gisignalling pathways

(2010) Analia Garcia et al.   BIOCHEMICAL JOURNAL

FRET-based sensors for the human M1-, M3-, and M5-acetylcholine receptors

(2010) Nicole Ziegler et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Regulation of PLC 1a membrane anchoring by its substrate phosphatidylinositol (4,5)-bisphosphate

(2008) M. J. W. Adjobo-Hermans et al.   JOURNAL OF CELL SCIENCE