Article
Biochemistry & Molecular Biology
Amanda Schneeweis, Daniel T. S. Pak
Summary: Tau protein has been found to localize in various subcellular domains of neurons and has multiple physiological functions. However, the lack of comprehensive phosphosite analysis obscures our understanding of these functions. Therefore, establishing a comprehensive map of tau phosphorylation signatures can clarify its diverse physiological functions in different locations and guide the development of novel therapeutic strategies.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Ly Thi Huong Luu Le, Jeeyoung Lee, Dongjoon Im, Sunha Park, Kyoung-Doo Hwang, Jung Hoon Lee, Yanxialei Jiang, Yong-Seok Lee, Young Ho Suh, Hugh I. Kim, Min Jae Lee
Summary: In tauopathy conditions, tau protein aggregates into insoluble filaments, contributing to the pathology of Alzheimer's disease. This study demonstrates that a specific region of tau, called tau AD nucleation core (tau-AC), is responsible for initiating self-aggregation of tau and recruiting full-length tau to form filaments. Phosphorylation of tau-AC reduces its ability to oligomerize and seed tau aggregation. Importantly, the presence of tau-AC species impairs neuronal function and memory retrieval, highlighting its significance as a therapeutic target for Alzheimer's disease.
Review
Biochemistry & Molecular Biology
Kazunori Kageyama, Yasumasa Iwasaki, Makoto Daimon
Summary: This review focuses on the molecular mechanisms of CRF regulation in the hypothalamus during stress and stress resilience, highlighting the central role of CRF in regulating the stress response. The involvement of ACTH, glucocorticoids, various regulatory factors, and different CRF receptors in stress resilience are discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Yukiomi Nakade, Rena Kitano, Taeko Yamauchi, Satoshi Kimoto, Kazumasa Sakamoto, Tadahisa Inoue, Yuji Kobayashi, Tomohiko Ohashi, Yoshio Sumida, Kiyoaki Ito, Masashi Yoneda
Summary: The study showed that central corticotropin-releasing factor (CRF) affects hepatic de novo lipogenesis and inflammation-related gene expression in rats through the sympathetic-noradrenergic nervous system.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Xue Liu, Jiaqian Feng, Zhijing Jiang, Guangbo Zhang, Xiuwen Xu, Jixiu Wang, Jingwen Yang, Tianming Wang
Summary: In the neuroendocrine system, corticotropin-releasing hormone (CRH) activates CRHRs and plays a vital role in the HPA/HPI axis. Two CRHR1 subtypes, LcCRHR1-1 and LcCRHR1-2, were identified in Larimichthys crocea genome and were found to be highly homologous to known teleost CRHRs. These receptors were found to be localized in the cell membrane and respond to LcCRH by increasing cAMP, Ca2+ and mitogen-activated protein kinase phosphorylation. LcCRHR1s were expressed in various tissues, with high expression in the brain and ovaries, and shown to be specifically localized in ovarian follicle cells. This study suggests that the CRH/CRHR1 system may be involved in the neuroendocrine regulation of reproduction in L. crocea.
FRONTIERS IN MARINE SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Yurika Hata, Takahiro Shimizu, Suo Zou, Masaki Yamamoto, Yohei Shimizu, Hideaki Ono, Takaaki Aratake, Shogo Shimizu, Youichirou Higashi, Nobutaka Shimizu, Takashi Karashima, Motoaki Saito
Summary: This study investigated the effects of central CRF on micturition and the involvement of CRF receptor subtypes and glutamatergic receptors. The results suggest that stimulation of brain CRFR1 may facilitate rat micturition via brain NMDA/AMPA receptors.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Neurosciences
Shaaban A. Mousa, Mohammed Shaqura, Baled I. Khalefa, Li Li, Mohammed Al-Madol, Sascha Treskatsch, Michael Schaefer
Summary: The study demonstrated a preference for the expression of CRF-R2 over CRF-R1 in the dorsal horn of the rat spinal cord, and both CRF and CRF-R2 agonists elicited potent dose-dependent antinociceptive effects through the spinal CRF-R2 receptors. This suggests that CRF or CRF-R2 agonists inhibit somatic inflammatory pain predominantly through CRF-R2 receptors located on spinal enkephalinergic inhibitory interneurons.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Environmental Sciences
Emily S. Barrett, Matthew Corsetti, Drew Day, Sally W. Thurston, Christine T. Loftus, Catherine J. Karr, Kurunthachalam Kannan, Kaja Z. LeWinn, Alicia K. Smith, Roger Smith, Frances A. Tylavsky, Nicole R. Bush, Sheela Sathyanarayana
Summary: Phthalates may disrupt the endocrine pathways in pregnant women, impacting pregnancy outcomes and fetal development. This study found associations between phthalate mixtures and changes in plasma pCRH levels, with differing effects observed among women with gestational diabetes and gestational hypertension.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Pharmacology & Pharmacy
Vadim Yakhnitsa, Guangchen Ji, Matthew Hein, Peyton Presto, Zack Griffin, Olga Ponomareva, Edita Navratilova, Frank Porreca, Volker Neugebauer
Summary: Functional pain syndromes occur without tissue injury or noxious events. Stress is a common trigger for pain attacks in these syndromes. Recent research suggests that kappa opioid receptors in the central nucleus of amygdala contribute to functional pain syndromes, but the underlying mechanisms are still unclear. Blocking these receptors may represent a new therapeutic strategy for stress-induced functional pain syndromes.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Toxicology
Ying Liu, Dandan Yan, Yiqi Wang, Xing Zhang, Na Wang, Yang Jiao, Hong Yan
Summary: The study revealed that exposure to ACR resulted in gait abnormality and cerebellar neuron lesions in rats through various pathways, including promoting the expression of phosphorylated tau and neuronal damage. Furthermore, ACR also decreased BDNF expression, which may be related to the inhibition of ERK and Akt signaling pathways.
TOXICOLOGY LETTERS
(2021)
Article
Endocrinology & Metabolism
Qiang Wu, Yan Feng, Ling Liu, Yang Liu, Xin Liu, Liqiao Zhang, Yanan Li, Liqun Wang
Summary: CRF plays a proinflammatory role in ischemic stroke by activating and transforming microglial cells through the TLR4/NF-kappa B signaling pathway, leading to aggravated neuronal injuries.
Article
Neurosciences
Sofiya Hupalo, Robert C. Spencer, Craig W. Berridge
Summary: The research indicates that CRF neurons in the PFC impact working memory and sustained attention through different neural circuits, with the effect on sustained attention not dependent on local CRF receptors. The findings suggest that CRF antagonists may have potential for treating PFC cognitive dysfunction.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Immunology
Shaaban A. Mousa, Baled I. Khalefa, Mohammed Shaqura, Mohammed Al-Madol, Sascha Treskatsch, Michael Schaefer
Summary: This study found that CRF-R1 in opioid-peptide-containing brain areas plays an important role in the modulation of inflammatory pain and may be a useful therapeutic target for its control.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Environmental Sciences
Churaibhon Wisessaowapak, Daranee Visitnonthachai, Piyajit Watcharasit, Jutamaad Satayavivad
Summary: The study demonstrated that prolonged exposure to low doses of sodium arsenite may increase tau phosphorylation in neurons, partly through activation of GSK3 and ERK1/2 signaling pathways.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2021)
Article
Environmental Sciences
Ya Wang, Yajie Zhang, Zhaochun Shi, Tingting Di, Wenfeng Yu, Ling Chen
Summary: Exposure to PFOA in male mice enhances CRF expression in BLA neurons by increasing hepatic FGF21 synthesis, which then enhances CRF-R1 mediated presynaptic glutamate release to facilitate NMDAR-dependent BLA-LTP induction, leading to anxiety-like behaviors.
Article
Biochemistry & Molecular Biology
L. R. Thomas, A. M. Foshage, A. M. Weissmiller, T. M. Popay, B. C. Grieb, S. J. Qualls, V. Ng, B. Carboneau, S. Lorey, C. M. Eischen, W. P. Tansey
Article
Medicine, Research & Experimental
Wei Xu, April M. Weissmiller, Joseph A. White, Fang Fang, Xinyi Wang, Yiwen Wu, Matthew L. Pearn, Xiaobei Zhao, Mariko Sawa, Shengdi Chen, Shermali Gunawardena, Jianqing Ding, William C. Mobley, Chengbiao Wu
JOURNAL OF CLINICAL INVESTIGATION
(2016)
Article
Cell Biology
Erin R. Aho, Jing Wang, Rocco D. Gogliotti, Gregory C. Howard, Jason Phan, Pankaj Acharya, Jonathan D. Macdonald, Ken Cheng, Shelly L. Lorey, Bin Lu, Sabine Wenzel, Audra M. Foshage, Joseph Alvarado, Feng Wang, J. Grace Shaw, Bin Zhao, April M. Weissmiller, Lance R. Thomas, Christopher R. Vakoc, Matthew D. Hall, Scott W. Hiebert, Qi Liu, Shaun R. Stauffer, Stephen W. Fesik, William P. Tansey
Article
Multidisciplinary Sciences
April M. Weissmiller, Jing Wang, Shelly L. Lorey, Gregory C. Howard, Ernest Martinez, Qi Liu, William P. Tansey
NATURE COMMUNICATIONS
(2019)
Article
Multidisciplinary Sciences
Lance R. Thomas, Clare M. Adams, Jing Wang, April M. Weissmiller, Joy Creighton, Shelly L. Lorey, Qi Liu, Stephen W. Fesik, Christine M. Eischen, William P. Tansey
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Article
Biochemistry & Molecular Biology
Audra F. Bryan, Jing Wang, Gregory C. Howard, Alissa D. Guarnaccia, Chase M. Woodley, Erin R. Aho, Eric J. Rellinger, Brittany K. Matlock, David K. Flaherty, Shelly L. Lorey, Dai H. Chung, Stephen W. Fesik, Qi Liu, April M. Weissmiller, William P. Tansey
NUCLEIC ACIDS RESEARCH
(2020)
Article
Cell Biology
Alissa D. Guarnaccia, Kristie L. Rose, Jing Wang, Bin Zhao, Tessa M. Popay, Christina E. Wang, Kiana Guerrazzi, Salisha Hill, Chase M. Woodley, Tyler J. Hansen, Shelly L. Lorey, J. Grace Shaw, William G. Payne, April M. Weissmiller, Edward T. Olejniczak, Stephen W. Fesik, Qi Liu, William P. Tansey
Summary: This study demonstrates how WIN site inhibitors alter the WDR5 interactome by using quantitative proteomics, showing that the inhibitors change the interaction of WDR5 with numerous proteins, including those related to the PI3K signaling pathway. The research also proves that the master kinase PDPK1 is a high-affinity binding protein for the WIN site, modulating gene transcription in the G2 phase of the cell cycle.
Article
Biology
Tessa M. Popay, Jing Wang, Clare M. Adams, Gregory Caleb Howard, Simona G. Codreanu, Stacy D. Sherrod, John A. McLean, Lance R. Thomas, Shelly L. Lorey, Yuichi J. Machida, April M. Weissmiller, Christine M. Eischen, Qi Liu, William P. Tansey
Summary: Research has shown that HCF-1, as a critical co-factor of MYC, significantly affects MYC activity. Modulation of the MYC-HCF-1 interaction can influence cell growth, metabolite profiles, global gene expression patterns, and tumor growth in vivo.
Article
Biochemistry & Molecular Biology
Chase M. Woodley, Alexander S. Romer, Jing Wang, Alissa D. Guarnaccia, David L. Elion, Jack N. Maxwell, Kiana Guerrazzi, Tyler S. McCann, Tessa M. Popay, Brittany K. Matlock, David K. Flaherty, Shelly L. Lorey, Qi Liu, William P. Tansey, April M. Weissmiller
Summary: The SWI/SNF chromatin remodeling complex's SNF5 subunit acts as a tumor suppressor by inhibiting MYC's ability to bind chromatin. This study found that MYC can interact with multiple SWI/SNF components independently of SNF5 and in SNF5-deficient cells, MYC interacts with remaining SWI/SNF components for a purpose different from chromatin remodeling. The interaction between MYC and SWI/SNF target genes in SNF5-null cells is associated with core biological functions of MYC related to protein synthesis.
Article
Multidisciplinary Sciences
Andrew J. Siladi, Jing Wang, Andrea C. Florian, Lance R. Thomas, Joy H. Creighton, Brittany K. Matlock, David K. Flaherty, Shelly L. Lorey, Gregory C. Howard, Stephen W. Fesik, April M. Weissmiller, Qi Liu, William P. Tansey
Summary: WDR5 plays a crucial role in the assembly of histone-modifying complexes and is a significant target for cancer treatment. Most drug discovery efforts focus on blocking the WIN site of WDR5. However, the application of WIN site inhibitors is complicated by the diverse functions of WDR5, and changes in H3K4me do not fully explain the transcriptional responses.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Kylie C. Moe, Jack N. Maxwell, Jing Wang, Cheyenne A. Jones, Grace T. Csaki, Andrea C. Florian, Alexander S. Romer, Daniel L. Bryant, Anthony L. Farone, Qi Liu, William P. Tansey, April M. Weissmiller
Summary: This study reveals the connection between residual SWI/SNF complexes and oncogenic processes, providing insights into the function of SWI/SNF in maintaining tumor cells.
Article
Biochemistry & Molecular Biology
Andrea C. Florian, Chase M. Woodley, Jing Wang, Brian C. Grieb, Macey J. Slota, Kiana Guerrazzi, Chih-Yuan Hsu, Brittany K. Matlock, David K. Flaherty, Shelly L. Lorey, Stephen W. Fesik, Gregory C. Howard, Qi Liu, April M. Weissmiller, William P. Tansey
Summary: The study found that WIN site inhibitors can inhibit the proliferation of Rhabdoid tumors (RT) cells and predict that future strategies for treating RT could be based on dual inhibition of WDR5/HDM2.
Review
Genetics & Heredity
Cheyenne A. Jones, William P. Tansey, April M. Weissmiller
Summary: This review summarizes the importance of the SWI/SNF chromatin remodeling complex and its mutations in cancer, particularly in transcriptional regulation. Studies have shown that SWI/SNF mutations lead to enhancer dysregulation, inhibiting development and differentiation while promoting stemness and self-renewal. Additionally, SWI/SNF perturbations intersect with oncoprotein transcription factors AP-1 and MYC to drive malignant transcriptional programs.
EPIGENETICS INSIGHTS
(2022)
Article
Biochemical Research Methods
Alissa D. Guarnaccia, April M. Weissmiller, William P. Tansey
Summary: The study introduces an approach that combines genome engineering to tag endogenous proteins for degradation with a streamlined nuclear run-on assay to obtain gene-specific information on transcriptional changes.
Article
Genetics & Heredity
Erin R. Aho, April M. Weissmiller, Stephen W. Fesik, William P. Tansey
EPIGENETICS INSIGHTS
(2019)