Article
Reproductive Biology
M. Florencia Gallelli, Carolina Bianchi, Enzo Zampini, Mariana Bertuzzi, Marcelo Aba, Deborah Neild, Marcelo Miragaya
Summary: The administration of hCG on Day 7 post-mating in llamas was found to be effective in developing an accessory corpus luteum (CL) and increasing plasma progesterone (P4) concentration. This treatment had no impact on the original corpus luteum in pregnant llamas, but resulted in a larger corpus luteum diameter in treated non-pregnant llamas. The accessory CL was detected throughout the study in both pregnant and non-pregnant llamas, but its vascularization started to decrease around Day 16 post-mating in non-pregnant animals.
Article
Obstetrics & Gynecology
Jialyu Huang, Jiaying Lin, Hongyuan Gao, Jing Zhu, Xuefeng Lu, Ning Song, Renfei Cai, Yanping Kuang
Summary: The study found that changes in endometrial thickness after hCG administration did not significantly impact pregnancy outcomes in IVF/ICSI cycles, with both decreases and increases in EMT not affecting the likelihood of live birth.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2021)
Article
Endocrinology & Metabolism
Dzhamilyat Abdulkhalikova, Eda Vrtacnik Bokal, Martin Stimpfel, Primoz Ciglar, Sara Korosec
Summary: This study evaluated the reproductive outcomes of GnRHa triggered cycles combined with modified luteal support in women with high ovarian response. The results showed no significant differences in pregnancy rate per embryo transfer, rate of early pregnancy loss, and live birth rate per pregnancy between the GnRHa and hCG trigger groups. However, the birth weight in the GnRHa trigger group was significantly lower.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Reproductive Biology
Ahmad Mahran, Mohammed Khairy, Reham Elkhateeb, Abdel Rahman Hegazy, Ayman Abdelmeged, Gaber El-Saber Batiha, Khalaf F. Alsharif, Helal F. Hetta, Haitham Ahmed Bahaa
Summary: This study aimed to compare the predictive value of serum progesterone/MII oocyte ratio with serum progesterone level and progesterone/estradiol level ratio in predicting pregnancy rates after assisted reproduction treatment (ART). The results showed that the serum progesterone/MII oocyte ratio had higher sensitivity and specificity in predicting no pregnancy in IVF/ICSI compared to progesterone level and progesterone/estradiol ratio.
JOURNAL OF OVARIAN RESEARCH
(2021)
Article
Medical Laboratory Technology
Christopher Kyriacou, Wei Yang, Shikha Kapur, Shanuja Maheetharan, Margaret Pikovsky, Nina Parker, Jennifer Barcroft, Shabnam Bobdiwala, Shyamaly Sur, Catriona Stalder, Deborah Gould, Dede Ofili-Yebovi, Andrea Day, Nick Unsworth, Edmund H. Wilkes, Tricia Tan, Tom Bourne
Summary: This study verifies the use of two hCG POCT devices in clinical practice and highlights the importance of considering practical factors when choosing which device to use.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Article
Obstetrics & Gynecology
Shiming Wang, Lin Qi, Yaping Liu, Hao Shi, Xiaoli Chen, Ningning Wang, Yingchun Su
Summary: This retrospective study investigated the impact of endometrial thickness on ectopic pregnancy rate and clinical pregnancy rate in fresh embryo transfer patients with early follicular phase long-acting regimen. The results showed that endometrial thickness was positively correlated with clinical pregnancy rate and negatively correlated with ectopic pregnancy rate. When the endometrial thickness was greater than or equal to 11mm, it could achieve lower ectopic pregnancy rate and higher clinical pregnancy rate simultaneously.
BMC PREGNANCY AND CHILDBIRTH
(2023)
Article
Oncology
R. Cortes-Charry, L. Hennah, F. E. M. Froeling, D. Short, X. Aguiar, T. Tin, R. Harvey, N. Unsworth, B. Kaur, P. Savage, N. Sarwar, M. J. Seckl
Summary: Increasing the hCG cut-off from <= 300 to <= 1000 IU/l for choosing patients for ActD following MTX-R spares more women with GTN from the greater toxicity of EMA/CO without compromising 100% survival outcomes.
Article
Endocrinology & Metabolism
Haiqing Tian, Hejiang Zhang, Hong Qiu, Xuejiao Yang, Xiaolin La, Lei Cui
Summary: In frozen-thawed embryo transfer cycles, endometrial thickness (EMT) has different effects on ongoing pregnancy rates (OPR) depending on maternal age and embryo stage. For women under 35 years old with EMT <= 8 mm, OPR significantly increases with each 1 mm increase in EMT for both cleavage stage and blastocyst transfers. However, for women aged 35 and above, there is a linear relationship between EMT and OPR. When blastocysts are transferred, OPR significantly increases by 12% with each 1 mm increase in EMT. However, OPR after frozen-thawed cleavage stage embryo transfer does not significantly increase with increased EMT.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Nutrition & Dietetics
Kiwamu Noshiro, Takeshi Umazume, Rifumi Hattori, Soromon Kataoka, Takashi Yamada, Hidemichi Watari
Summary: This study found that serum ketone levels peak in the third trimester of pregnancy, but do not directly correlate with neonatal body shape. Weight loss during pregnancy may be related to morning sickness, with a higher pre-pregnancy body mass index leading to greater weight loss.
Article
Medicine, Research & Experimental
Danbi Lee, Yu-Gyeong Lee, Jieun Won, Seon-Hwa Hong, Jee Hyun Kim, Youn-Jung Kang
Summary: This study aimed to investigate the optimal timing of hCG administration to enhance embryo implantation rates. The results showed that hCG administration induced a significant increase in endometrial receptivity and angiogenesis-related gene expression levels within 72 hours, and promoted the stability of embryo attachment in an in vitro model.
Article
Immunology
Zixing Zhong, Yuhan Wang, Guiqin Wang, Feifei Zhou
Summary: This study reports on ten pregnant women who experienced early declines in hCG levels and were treated with TNFi, resulting in positive obstetric outcomes without any adverse effects observed. This case series supports the safety of TNFi in pregnancy and offers new insights into its use in cases of embryo endangerment. Further well-designed clinical trials are needed to validate these findings.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medical Laboratory Technology
Christopher J. Mattiello, Douglas F. Stickle
Summary: We used image analysis to characterize the dose vs response curve of a qualitative serum hCG lateral flow immunoassay, which helped us understand the transition from negative to positive. The results showed that the curve could be described by a simple hyperbola equation, which was useful for verifying the assay's performance characteristics.
CLINICA CHIMICA ACTA
(2023)
Article
Obstetrics & Gynecology
Li Chen, Qianwen Xi, Shutian Jiang, Yining Gao, Hui Long, Yao Wang, Yanping Kuang
Summary: This study compared the pregnancy and neonatal outcomes of patients triggered with GnRHa, hCG, and dual trigger in LE-IUI cycles. The study found that there was no significant difference in the clinical pregnancy rate between GnRHa and dual trigger compared to hCG trigger in LE-HMG IUI cycles. However, the miscarriage rate was lower in the GnRHa trigger group and higher in the dual trigger group compared to the hCG group. There were no significant differences in neonatal outcomes. Therefore, both GnRHa and dual trigger can be used to trigger ovulation in LE-HMG IUI cycles, but dual trigger must be used with caution.
BMC PREGNANCY AND CHILDBIRTH
(2023)
Article
Peripheral Vascular Disease
Ruijuan Wang, Li Chen, Xiaobing Wang, Yanjun Liu
Summary: The aberrant increase of circulating β-human chorionic gonadotropin (?-HCG) at early stages of pregnancy is associated with predicting gestational hypertension. Inflammatory and oxidative stress markers play a significant role in severe pregnancy-induced hypertension during the perinatal stage.
MICROVASCULAR RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Mikhail Krapivin, Andrei Tikhonov, Olga A. Efimova, Anna A. Pendina, Anna A. Smirnova, Olga G. Chiryaeva, Olga E. Talantova, Lubov' Petrova, Vera S. Dudkina, Vladislav S. Baranov
Summary: The study found differences in TL in chorionic cytotrophoblast cells between karyotypically abnormal and normal samples, with higher TL observed in ongoing pregnancies with abnormal karyotypes. TL asymmetry was similar across all chorion samples but significantly different from PHA-stimulated lymphocytes. Longer telomeres were predominantly present in chromosomes with hemihydroxymethylation, indicating a potential link to telomere lengthening through recombination.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)