Transient Cerebral Ischemia Promotes Brain Mitochondrial Dysfunction and Exacerbates Cognitive Impairments in Young 5xFAD Mice

Oxidative Stress: Emerging Mitochondrial and Cellular Themes and Variations in Neuronal Injury

(2017) Gavin C. Higgins et al.   JOURNAL OF ALZHEIMERS DISEASE

The Alzheimer's Disease Mitochondrial Cascade Hypothesis

(2017) Russell H. Swerdlow et al.   JOURNAL OF ALZHEIMERS DISEASE

Mitochondrial Crisis in Cerebrovascular Endothelial Cells Opens the Blood–Brain Barrier

(2015) Danielle N. Doll et al.   STROKE

Mitochondrial dynamics and mitochondrial quality control

(2015) Hong-Min Ni et al.   Redox Biology

Behavioral and neuropathological consequences of transient global ischemia in APP/PS1 Alzheimer model mice

(2014) S. Kemppainen et al.   BEHAVIOURAL BRAIN RESEARCH

Increased mitochondrial fission and neuronal dysfunction in Huntington's disease: implications for molecular inhibitors of excessive mitochondrial fission

(2014) P. Hemachandra Reddy   DRUG DISCOVERY TODAY

Mfn2 downregulation in excitotoxicity causes mitochondrial dysfunction and delayed neuronal death

(2014) A. Martorell-Riera et al.   EMBO JOURNAL

Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS

(2014) Edward T. Chouchani et al.   NATURE

Diabetes Mellitus and the Risk of Alzheimer’s Disease: A Nationwide Population-Based Study

(2014) Chin-Chou Huang et al.   PLoS One

Inhibition of Mitochondrial P53 Abolishes the Detrimental Effects of Social Isolation on Ischemic Brain Injury

(2014) Venugopal Reddy Venna et al.   STROKE

A Mitochondrial Switch Promotes Tumor Metastasis

(2014) Paolo E. Porporato et al.   Cell Reports

Cyclophilin D deficiency rescues Aβ-impaired PKA/CREB signaling and alleviates synaptic degeneration

(2013) Heng Du et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Oxidative stress and mitochondrial dysfunction in Alzheimer's disease

(2013) Xinglong Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Inhibition of ERK-DLP1 signaling and mitochondrial division alleviates mitochondrial dysfunction in Alzheimer's disease cybrid cell

(2013) Xueqi Gan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Membranes in motion: mitochondrial dynamics and their role in apoptosis

(2013) Begoña Ugarte-Uribe et al.   BIOLOGICAL CHEMISTRY

Cell death and diseases related to oxidative stress:4-hydroxynonenal (HNE) in the balance

(2013) S Dalleau et al.   CELL DEATH AND DIFFERENTIATION

Neuron loss in the 5XFAD mouse model of Alzheimer’s disease correlates with intraneuronal Aβ42 accumulation and Caspase-3 activation

(2013) William A Eimer et al.   Molecular Neurodegeneration

Fuelling transport

(2013) Darran Yates   NATURE REVIEWS NEUROSCIENCE

In vivo evaluation of amyloid deposition and brain glucose metabolism of 5XFAD mice using positron emission tomography

(2013) Santiago Rojas et al.   NEUROBIOLOGY OF AGING

Cyclophilin D Deficiency Rescues Axonal Mitochondrial Transport in Alzheimer’s Neurons

(2013) Lan Guo et al.   PLoS One

Mitochondrial Dynamics Associated with Oxygen-Glucose Deprivation in Rat Primary Neuronal Cultures

(2013) Edina A. Wappler et al.   PLoS One

p53 Opens the Mitochondrial Permeability Transition Pore to Trigger Necrosis

(2012) Angelina V. Vaseva et al.   CELL

Abnormal interaction between the mitochondrial fission protein Drp1 and hyperphosphorylated tau in Alzheimer's disease neurons: implications for mitochondrial dysfunction and neuronal damage

(2012) M. Manczak et al.   HUMAN MOLECULAR GENETICS

Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature

(2012) Peter T. Nelson et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Effects of mild chronic cerebral hypoperfusion and early amyloid pathology on spatial learning and the cellular innate immune response in mice

(2012) Pedro M. Pimentel-Coelho et al.   NEUROBIOLOGY OF AGING

Transient Focal Cerebral Ischemia/Reperfusion Induces Early and Chronic Axonal Changes in Rats: Its Importance for the Risk of Alzheimer's Disease

(2012) Qinan Zhang et al.   PLoS One

Transient Focal Cerebral Ischemia Induces Long-term Cerebral Vasculature Dysfunction in a Rodent Experimental Stroke Model

(2012) Ali Winters et al.   Translational Stroke Research

Mitochondrial Dynamics and Parkinson's Disease: Focus on Parkin

(2011) Kah-Leong Lim et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondrial dynamics and mitophagy in Parkinson's disease: disordered cellular power plant becomes a big deal in a major movement disorder

(2011) Yuzuru Imai et al.   CURRENT OPINION IN NEUROBIOLOGY

Consistent Injury to Medium Spiny Neurons and White Matter in the Mouse Striatum after Prolonged Transient Global Cerebral Ischemia

(2011) Hideyuki Yoshioka et al.   JOURNAL OF NEUROTRAUMA

Mutant huntingtin binds the mitochondrial fission GTPase dynamin-related protein-1 and increases its enzymatic activity

(2011) Wenjun Song et al.   NATURE MEDICINE

MFN2 mutations cause severe phenotypes in most patients with CMT2A

(2011) S. M. E. Feely et al.   NEUROLOGY

Mitochondrial Dynamics in Alzheimerʼs Disease

(2010) David J. Bonda et al.   DRUGS & AGING

Overexpression of Glutaminyl Cyclase, the Enzyme Responsible for Pyroglutamate Aβ Formation, Induces Behavioral Deficits, and Glutaminyl Cyclase Knock-out Rescues the Behavioral Phenotype in 5XFAD Mice

(2010) Sadim Jawhar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The genetic architecture of Alzheimer's disease: beyond APP, PSENs and APOE

(2010) Rita J. Guerreiro et al.   NEUROBIOLOGY OF AGING

Alzheimer's Disease

(2010) Henry W. Querfurth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Early deficits in synaptic mitochondria in an Alzheimer's disease mouse model

(2010) H. Du et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impaired Balance of Mitochondrial Fission and Fusion in Alzheimer's Disease

(2009) X. Wang et al.   JOURNAL OF NEUROSCIENCE

Cyclophilin D deficiency improves mitochondrial function and learning/memory in aging Alzheimer disease mouse model

(2009) Heng Du et al.   NEUROBIOLOGY OF AGING

Effect of infarcts on dementia in the Baltimore longitudinal study of aging

(2008) Juan C. Troncoso et al.   ANNALS OF NEUROLOGY

Hypometabolism as a therapeutic target in Alzheimer's disease

(2008) Lauren C Costantini et al.   BMC NEUROSCIENCE

Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease

(2008) Heng Du et al.   NATURE MEDICINE

Amyloid beta, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer's disease

(2008) P. Hemachandra Reddy et al.   TRENDS IN MOLECULAR MEDICINE