Article
Oncology
Kenji Sawa, Izumi Sato, Masato Takeuchi, Koji Kawakami
Summary: The risk of developing pneumonitis with ICIs for NSCLC patients with preexisting ILD was similar to that with conventional chemotherapy.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Article
Oncology
Kenji Makita, Yasushi Hamamoto, Hiromitsu Kanzaki, Kei Nagasaki, Yoshifumi Sugawara, Toshiyuki Kozuki
Summary: This study evaluated the risk of acute exacerbations or acute lung injury, including radiation pneumonitis, in patients with interstitial lung disease who received palliative-intent radiotherapy. The results showed that a higher pulmonary fibrosis score and lung irradiation were significant risk factors for acute exacerbations or acute lung injury grade ≥ 3.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Chi Wan Koo, James M. Williams, Grace Liu, Ananya Panda, Parth P. Patel, Livia Maria M. Frota Lima, Ronald A. Karwoski, Teng Moua, Nicholas B. Larson, Alex Bratt
Summary: QCT features and QCT feature-based ML models successfully differentiate interstitial lung diseases (ILDs). The performance of QCT-ML models outperforms a DL model in ILD classification. Further investigations are needed to determine the superior approach for ILD classification.
EUROPEAN RADIOLOGY
(2022)
Review
Medicine, General & Internal
Ahmad Abu Qubo, K. M. Capaccione, Elana J. Bernstein, Maria Padilla, Mary Salvatore
Summary: This article describes the role of radiology in the diagnosis and follow-up of PF-ILD. The manuscript reviews the radiographic diagnosis and unique CT characteristics associated with specific types of fibrosis. Radiology has the potential to make an important contribution to the multidisciplinary discussion for this important diagnosis.
FRONTIERS IN MEDICINE
(2022)
Review
Oncology
Angela J. Frank, Ibiayi Dagogo-Jack, Ioana A. Dobre, Sarah Tait, Lana Schumacher, Florian J. Fintelmann, Leah M. Fingerman, Florence K. Keane, Sydney B. Montesi
Summary: Patients with interstitial lung disease (ILD), especially those with pulmonary fibrosis, are at increased risk of developing lung cancer. Managing lung cancer in these patients is challenging as diagnosis can be complicated, surgical resection can exacerbate ILD, radiotherapy and systemic therapies carry increased risk of pneumonitis, and the safety of immunotherapy remains unclear. This review summarizes evidence and discusses considerations for tissue diagnosis, chemotherapy, immunotherapy, radiotherapy, and surgery in this patient population, as well as the importance of a multidisciplinary approach and monitoring ILD progression during lung cancer treatment.
Article
Oncology
Masayuki Okumura, Hidehiro Hojo, Masaki Nakamura, Takashi Hiyama, Naoki Nakamura, Sadamoto Zenda, Atsushi Motegi, Yasuhiro Hirano, Shun-Ichiro Kageyama, Raturi Vijay Parshuram, Takeshi Fujisawa, Hirofumi Kuno, Tetsuo Akimoto
Summary: This study investigated the risk of radiation pneumonitis (RP) after palliative radiotherapy in cancer patients with interstitial lung disease. The results showed that ILD pattern was a significant predictive factor for severe RP. Careful administration of radiotherapy involving a lung field to ILD patients is recommended, and evaluation of the ILD pattern on pretreatment CT images may be helpful in treatment decisions.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Oncology
Haruki Kobayashi, Kazushige Wakuda, Tateaki Naito, Nobuaki Mamesaya, Shota Omori, Akira Ono, Hirotsugu Kenmotsu, Haruyasu Murakami, Masahiro Endo, Hideyuki Harada, Yasuhiro Gon, Toshiaki Takahashi
Summary: ILAs were found to be a predictive factor for radiation pneumonitis in patients with LS-SCLC treated with chemoradiotherapy. Patients with LS-SCLC and ILAs who were treated with chemoradiotherapy had both the possibility of long-term survival and risk of radiation pneumonitis.
RADIATION ONCOLOGY
(2021)
Article
Respiratory System
Margaret Kypreos, Kiran Batra, Craig S. Glazer, Traci N. Adams
Summary: Antigen identification is important for patients with hypersensitivity pneumonitis, but may not have a significant impact on other interstitial lung diseases. Diagnosis with bronchoalveolar lavage and transbronchial biopsy prior to recommending antigen removal is recommended.
BMC PULMONARY MEDICINE
(2023)
Article
Medicine, General & Internal
Yun Zhang, Qunli Ding, Chengna Lv, Yanan Ying, Zekai Cen, Haijun Zhou, Tingting Wu
Summary: The study aimed to determine the clinical characteristics and prognosis of microscopic polyangiitis (MPA) with pulmonary involvement. The results showed that ILD is the most common manifestation of MPA with pulmonary involvement. Elevated serum creatinine level was associated with shorter survival, but treatment with glucocorticoids and/or immunosuppressants may improve the outcome of MPA patients.
ANNALS OF MEDICINE
(2023)
Article
Respiratory System
Elias Seidl, Nicolaus Schwerk, Julia Carlens, Martin Wetzke, Nagehan Emiralioglu, Nural Kiper, Joanna Lange, Katarzyna Krenke, Zsolt Szepfalusi, Florian Stehling, Winfried Baden, Susanne Haemmerling, Silvija-Pera Jerkic, Marijke Proesmans, Nicola Ullmann, Frederik Buchvald, Katrin Knoflach, Matthias Kappler, Matthias Griese
Summary: The characteristics and impact of acute exacerbations (AEs) on children's interstitial lung disease (chILD) were comprehensively analyzed in this study. The results showed that AEs have a significant and deleterious effect on the clinical course and health-related quality of life in chILD.
Article
Medicine, General & Internal
Shuuhei Ohno, Yoshiaki Zaizen, Goushi Matama, Tomonori Chikasue, Saeko Tokisawa, Masaki Okamoto, Kazuhiro Tabata, Masaki Tominaga, Jun Akiba, Kiminori Fujimoto, Junya Fukuoka, Tomoaki Hoshino
Summary: This study investigated the effectiveness of transbronchial lung cryobiopsy (TBLC) in diagnosing hypersensitivity pneumonitis (HP). The results showed that evaluating airway disease with TBLC for the diagnosis of HP is challenging and requires multidisciplinary discussion (MDD). Therefore, understanding the characteristics of TBLC is crucial for accurately diagnosing HP through MDD.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Bing Li, Xiaoli Zheng, Jiang Zhang, Saikit Lam, Wei Guo, Yunhan Wang, Sunan Cui, Xinzhi Teng, Yuanpeng Zhang, Zongrui Ma, Ta Zhou, Zhaoyang Lou, Lingguang Meng, Hong Ge, Jing Cai
Summary: The study evaluates the effectiveness of features obtained from proposed incremental-dose-interval-based lung subregion segmentation for predicting grade >= 2 acute radiation pneumonitis (ARP) in lung cancer patients. Results show that features from lung subregions outperform those from the whole lung in predicting ARP, especially when using dosiomics or combined radiomics-dosiomics features. This improved model performance could enhance clinical management and patient quality of life.
Article
Medicine, General & Internal
Matthias Griese
Summary: Interstitial lung diseases (ILD) or diffuse parenchymal lung diseases (DPLD) encompass a wide range of disorders. Disease definition and classification are important for clinical decision-making, genetic/environmental risk assessment, and precision medicine treatments. This article provides a brief history of ILD classification systems and focuses on an etiologic classification, highlighting the importance of molecularly defined entities and the potential for precision medicine.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Matthew R. McFarlane, Kimberly A. Hochstedler, Anna M. Laucis, Yilun Sun, Aulina Chowdhury, Martha M. Matuszak, James Hayman, Derek Bergsma, Thomas Boike, Larry Kestin, Benjamin Movsas, Inga Grills, Michael Dominello, Robert T. Dess, Caitlin Schonewolf, Daniel E. Spratt, Lori Pierce, Peter Paximadis, Shruti Jolly, Matthew Schipper
Summary: This study analyzed pneumonitis risk after radiation therapy for lung cancer using a large, prospective dataset. Comorbidity burden, smoking status, and dosimetric parameters were incorporated in an integrated risk model to guide clinicians in assessing pneumonitis risk in individual patients.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Respiratory System
Traci N. Adams, Kiran Batra, Margaret Kypreos, Craig S. Glazer
Summary: This study aims to evaluate whether radiographic honeycombing is more predictive of transplant-free survival (TFS) than other clinical, radiographic, or histologic findings and to assess the impact of honeycombing on the efficacy of immunosuppression in fibrotic hypersensitivity pneumonitis.
BMC PULMONARY MEDICINE
(2023)
Article
Oncology
Kazuhisa Nakashima, Hiroaki Akamatsu, Haruyasu Murakami, Takashi Niwa, Yasuo Iwamoto, Yuichi Ozawa, Toshihide Yokoyama, Hiroyasu Shoda, Nobuyuki Yamamoto, Hiroshige Yoshioka, Ken Masuda, Tateaki Naito, Keita Mori, Toshiaki Takahashi
ANTICANCER RESEARCH
(2019)
Article
Oncology
Yuichi Ozawa, Yusuke Amano, Kei Kanata, Hirotsugu Hasegwa, Takashi Matsui, Takuya Kakutani, Takafumi Koyauchi, Masayuki Tanahashi, Hiroshi Niwa, Koshi Yokomura, Takafumi Suda
Article
Oncology
Hiroaki Akamatsu, Eriko Murakami, Jun Oyanagi, Ryota Shibaki, Takahiro Kaki, Eri Takase, Masanori Tanaka, Yuhei Harutani, Nao Yamagata, Yuka Okuda, Katsuyuki Furuta, Takeya Sugimoto, Shunsuke Teraoka, Atsushi Hayata, Nahomi Tokudome, Yuichi Ozawa, Keita Mori, Yasuhiro Koh, Nobuyuki Yamamoto
Article
Oncology
Mio Ikeda, Yasuhiro Koh, Shunsuke Teraoka, Koichi Sato, Kuninobu Kanai, Atsushi Hayata, Nahomi Tokudome, Hiroaki Akamatsu, Yuichi Ozawa, Keiichiro Akamatsu, Katsuya Endo, Masayuki Higuchi, Masanori Nakanishi, Hiroki Ueda, Nobuyuki Yamamoto
Article
Oncology
Kazuhisa Nakashima, Yuichi Ozawa, Haruko Daga, Hisao Imai, Motohiro Tamiya, Takaaki Tokito, Takahisa Kawamura, Hiroaki Akamatsu, Yuko Tsuboguchi, Toshiaki Takahashi, Nobuyuki Yamamoto, Keita Mori, Haruyasu Murakami
INVESTIGATIONAL NEW DRUGS
(2020)
Article
Medicine, General & Internal
Yuichi Ozawa, Takeya Sugimoto, Yuichiro Azuma, Yuhei Harutani, Takanori Yoshikawa, Nobuyuki Yamamoto, Kuninobu Kanai
Article
Oncology
Satoshi Ikeda, Yuichi Ozawa, Ken Harada, Kazuo Hasegawa, Naomi Shimizu, Takako Seki, Yoshinori Hasegawa, Tetsuya Mitsudomi
Article
Oncology
Yuichi Ozawa, Yuhei Harutani, Jun Oyanagi, Hiroaki Akamatsu, Eriko Murakami, Ryota Shibaki, Atsushi Hayata, Takeya Sugimoto, Masanori Tanaka, Toshiaki Takakura, Katsuyuki Furuta, Yuka Okuda, Kouichi Sato, Shunsuke Teraoka, Hiroki Ueda, Nahomi Tokudome, Yuka Kitamura, Junya Fukuoka, Masanori Nakanishi, Yasuhiro Koh, Nobuyuki Yamamoto
Summary: CD24 positivity is negatively associated with progression-free survival (PFS) of ICI in patients with PD-L1 TPS < 50, and is related to a significant increase in CCL2. High CD47 TPS suppresses the increase in VEGF-A, D, and PDGF-AB/BB after ICI initiation.
Article
Nutrition & Dietetics
Takashi Ogasawara, Yasuhisa Tajima, Naoto Nakamura, Hiroki Kanasaki, Wataru Matsuyama, Mitsuru Niwa, Yuichi Ozawa, Masayuki Sugiura, Masahito Ogiku, Jun Sato
Summary: This study aimed to evaluate the efficacy of 1-hydroxy-vitamin D in COVID-19 patients. The results showed that patients treated with 1-hydroxy-vitamin D had a significantly lower proportion of needing respiratory support and in-hospital mortality compared to the control group.
CLINICAL NUTRITION
(2023)
Meeting Abstract
Oncology
Mio Ikeda, Yasuhiro Koh, Shunsuke Teraoka, Koichi Sato, Nahomi Tokudome, Atsushi Hayata, Hiroaki Akamatsu, Yuichi Ozawa, Keiichiro Akamatsu, Katsuya Endo, Masayuki Higuchi, Masanori Nakanishi, Hiroki Ueda, Nobuyuki Yamamoto
CLINICAL CANCER RESEARCH
(2020)
Meeting Abstract
Oncology
Mio Ikeda, Yasuhiro Koh, Shunsuke Teraoka, Koichi Sato, Kuninobu Kanai, Atsushi Hayata, Nahomi Tokudome, Hiroaki Akamatsu, Yuichi Ozawa, Keiichiro Akamatsu, Katsuya Endo, Masayuki Higuchi, Masanori Nakanishi, Hiroki Ueda, Nobuyuki Yamamoto
MOLECULAR CANCER THERAPEUTICS
(2019)
Meeting Abstract
Oncology
Jun Oyanagi, Yasuhiro Koh, Hiroaki Akamatsu, Koichi Sato, Shunsuke Teraoka, Kuninobu Kanai, Atsushi Hayata, Nahomi Tokudome, Yuichi Ozawa, Keiichiro Akamatsu, Masanori Nakanishi, Hiroki Ueda, Nobuyuki Yamamoto
MOLECULAR CANCER THERAPEUTICS
(2019)
Meeting Abstract
Oncology
Yasuhiro Koh, Mio Ikeda, Shunsuke Teraoka, Masayuki Ishige, Yuu Fujimura, Kazuo Takeda, Nahomi Tokudome, Yuichi Ozawa, Hiroki Ueda, Nobuyuki Yamamoto
Meeting Abstract
Oncology
Jun Oyanagi, Yasuhiro Koh, Shunsuke Teraoka, Kuninobu Kanai, Atsuhsi Hayata, Nahomi Tokudome, Hiroaki Akamatsu, Yuichi Ozawa, Keiichiro Akamatsu, Masanori Nakanishi, Hiroki Ueda, Nobuyuki Yamamoto
Meeting Abstract
Oncology
Mio Ikeda, Yasuhiro Koh, Shunsuke Teraoka, Jun Oyanagi, Kuninobu Kanai, Atsushi Hayata, Nahomi Tokudome, Hiroaki Akamatsu, Yuichi Ozawa, Keiichiro Akamatsu, Masayuki Higuchi, Masanori Nakanishi, Hiroki Ueda, Nobuyuki Yamamoto