Journal
PLOS ONE
Volume 10, Issue 10, Pages -Publisher
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0140249
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Funding
- National Science Council of Taiwan [101-2320-B-110-003, 102-2320-B-110-007, 103-2314-B-037-064, 103-2320-B-037-014]
- KMU Center for Stem Cell Research [KMU-TP103G01, KMU-TP103G00, KMU-TP103G03, KMU-TP103G04, KMU-TP103G05]
- NSYSU-KMU Joint Research Project [NSYSUKMU2013-I006]
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Transforming growth factor-beta (TGF-beta) responsiveness in cultured cells can be modulated by TGF-beta partitioning between lipid raft/caveolae- and clathrin-mediated endocytosis pathways. Lipid rafts are plasma membrane microdomains with an important role in cell survival signaling, and cholesterol is necessary for the lipid rafts' structure and function. Euphol is a euphane-type triterpene alcohol that is structurally similar to cholesterol and has a wide range of pharmacological properties, including anti-inflammatory and anti-cancer effects. In the present study, euphol suppressed TGF-beta signaling by inducing TGF-beta receptor movement into lipid-raft microdomains and degrading TGF-beta receptors.
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