Article
Clinical Neurology
Lili Kokoti, Mohammad Al-Mahdi Al-Karagholi, Cherie Amalie Waldorff Nielsen, Messoud Ashina
Summary: This study investigated the effect of the K-ATP channel blocker glibenclamide on levcromakalim-induced headache in healthy volunteers and found that glibenclamide did not attenuate levcromakalim-induced headache. Future studies should further explore the role of different isoforms of sulfonylurea receptor subunits of K-ATP channels in the pathogenesis of headache and migraine.
Review
Biochemistry & Molecular Biology
Alain Boussuges, Jeremy Bourenne, Farid Eloufir, Julien Fromonot, Giovanna Mottola, Jean Jacques Risso, Nicolas Vallee, Fabienne Bregeon, Regis Guieu
Summary: Exposure to extreme oxygen partial pressures can induce changes in the adenosinergic system, which play important roles in protecting the brain and lungs in high-altitude and deep-sea environments. Increased adenosine concentration helps protect the brain against hypoxia and is involved in the pathogenesis of mountain illness and neurological disorders. It also contributes to the prevention of high-altitude pulmonary edema and lung oxygen toxicity. On the other hand, decreased adenosine concentration during hyperoxic exposure leads to vasoconstriction and decreased cerebral blood flow, serving as a preventive measure against cerebral oxygen toxicity.
Article
Biochemistry & Molecular Biology
Alice Cattivelli, Angela Conte, Davide Tagliazucchi
Summary: Several studies have found that a diet rich in phenolic compounds may protect against colon cancer. These compounds are not easily absorbed in the small intestine and are metabolized by gut microbiota in the colon. This study examined the anti-proliferative effects of quercetins, chlorogenic acids, their colon metabolites, and mixtures of parent compounds/metabolites on colon cancer cell lines. The results suggest that phenolic compounds and their metabolites have anti-proliferative effects on human colon cancer cells, and the metabolism of phenolic compounds by gut microbiota is important in explaining the protective effect of phenolic-rich foods against colon cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Physiology
Katarzyna Buszko, Krystian Kubica, Eva-Luise Hobl, Piotr Adamski, Kacper Wnuk, Bernd Jilma, Jacek Kubica
Summary: This study aimed to build a mathematical model describing the pharmacokinetics of ticagrelor and its active metabolite in a stable setting with concomitant administration of morphine. The model accurately reproduced experimental results and led to conclusions consistent with clinical observations that morphine delays the time of maximum drug concentration. The model also allowed for predicting the effect of drug dose on receptor blocking efficacy.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Chemistry, Medicinal
Jin Wang, Huan Zhang, Rui Wang, Yun Cai
Summary: In this study, the pharmacokinetics, bioequivalence and safety profiles of 90 mg ticagrelor tablets and their active metabolite were evaluated in healthy Chinese subjects under fasting and fed conditions. The results showed no significant differences in PK parameters and bioequivalence between the test and reference drugs, with no severe adverse events observed.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Pharmacology & Pharmacy
Chengmei Dong, Xiaonan Zhang, Yalan Zhang, Wenjuan Ouyang, Daizhuang Peng, Xiaomin Li, Dai Li, Qun Qin
Summary: This study investigated the effects of food on the pharmacokinetics, bioequivalence, and safety of ticagrelor tablets in healthy Chinese volunteers. The results showed that food consumption increased ticagrelor concentrations, decreased C-max, and prolonged the half-life of AR-C124910XX.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2023)
Article
Food Science & Technology
Juergen Grafeneder, Ulla Derhaschnig, Farsad Eskandary, Nina Buchtele, Nadine Sus, Jan Frank, Bernd Jilma, Christian Schoergenhofer
Summary: The study found that micellar curcumin has better bioavailability compared to native curcumin, but does not exhibit anti-inflammatory effects in the chosen model. However, subjects receiving micellar curcumin showed a significant reduction in PCSK9 concentrations after 7 days.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Marianne Bauer
Summary: This article discusses how organisms regulate their genes using a signal processing chain. It introduces theoretical models and information theory approaches to understand gene regulation, specifically focusing on fly embryo gene regulation as an example.
BIOCHEMICAL SOCIETY TRANSACTIONS
(2022)
Article
Environmental Sciences
Yan Pu, Jie Guo, Hao Yang, Liqiao Zhong, Huiwu Tian, Huatang Deng, Xinbin Duan, Shaoping Liu, Daqing Chen
Summary: This study evaluated the effects of environmental-related concentrations of Hg2+ on the growth hormone/insulin-like growth factor (GH/IGF) axis in silver carp. The results showed that Hg2+ exposure leads to growth inhibition and oxidative stress in juvenile silver carp.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Chemistry, Physical
Monika Holubova, Volodymyr Lobaz, Lenka Loukotova, Mariia Rabyk, Jirina Hromadkova, Olga Trhlikova, Zdislava Pechrova, Ondrej Groborz, Petr Stepanek, Martin Hruby
Summary: This study investigated the influence of various polysaccharides on amyloid fibril formation and found that all polysaccharides accelerated the process. At high concentrations, glycogen significantly accelerated amyloid fibril formation in HEWL. This suggests that dietary glucose intake may affect amyloid fibril formation through direct glycogen-amyloid precursor protein interaction.
Article
Microbiology
Keith A. Rodvold, Mark H. Gotfried, Vipul Gupta, Amanda Ek, Praveen Srivastava, Angela Talley, Jon Bruss
Summary: This study evaluated the pharmacokinetics and distribution of TBP-PI-HBr in healthy adults, and found that Tebipenem can effectively distribute into the lungs, supporting further evaluation for the treatment of lower respiratory tract bacterial infections.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Dermatology
Koichiro Shinya, Yuki Nishimura, Kakei Ryu, Takehiko Sambe, Masaya Fujishiro, Akihiro Nakauchi, Yumika Kashiwabuchi, Mariko Iwase, Hirokazu Chokki, Norimitsu Kurata, Takaaki Matsuyama, Yuji Kiuchi
Summary: This study investigated the inhibitory effect of Polypodium leucotomos extract on CYP3A4-mediated midazolam metabolism in humans. The results showed that short-term oral administration of Polypodium leucotomos extract did not cause food-drug interactions mediated by CYP3A4 inhibition in humans.
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2023)
Article
Allergy
Yan Zhang, Niels P. J. de Graaf, Sanne Roffel, Sander W. Spiekstra, Thomas Rustemeyer, Cees J. Kleverlaan, Albert J. Feilzer, Hetty Bontkes, Dongmei Deng, Susan Gibbs
Summary: Metal salts applied at patch test-relevant concentrations were found to cause localized cytotoxicity, with some showing strong cytotoxic effects. The patch test itself may be damaging to the skin of the patient being tested, highlighting the need for further research and verification. The challenge for the future is to maintain above the elicitation threshold at noncytotoxic metal concentrations.
CONTACT DERMATITIS
(2021)
Article
Multidisciplinary Sciences
Hongsun Guo, Sarah J. Offutt, Mark Hamilton, Yohan Kim, Cory D. Gloeckner, Daniel P. Zachs, Jamu K. Alford, Hubert H. Lim
Summary: This study shows that ultrasound can reliably inhibit nerve activity through a thermal mechanism but cannot directly activate an isolated nerve. The suppressive effects are correlated with increases in nerve temperature and can be eliminated by preventing temperature increase.
SCIENTIFIC REPORTS
(2022)
Article
Pharmacology & Pharmacy
Yanli Wang, Qiaohuan Deng, Zhenyue Gao, Guangwen Liu, Zhengjie Su, Yicheng Zhao, Lixiu Zhang, Haimiao Yang
Summary: This study investigated the pharmacokinetics, bioequivalence, and safety of generic sunitinib and its original product Sutent (R) in healthy Chinese subjects through a phase-I clinical trial. The results demonstrated that the two drugs had comparable pharmacokinetics and were bioequivalent. Both drugs also exhibited good safety profiles.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Hematology
Helin Tercan, Niels P. Riksen, Leo A. B. Joosten, Mihai G. Netea, Siroon Bekkering
Summary: Trained immunity is a persistent hyperresponsive phenotype developed by innate immune cells after stimulation, causing cells to remember pathogens and endogenous molecules. While providing cross-protection in infectious diseases, trained immunity may lead to excessive immune responses in diseases driven by chronic systemic inflammation.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Niels P. Riksen, Mihai G. Netea
Summary: Trained immunity refers to the long-term inflammatory phenotypes adopted by innate immune cells following brief encounters with exogenous or endogenous stimuli. This phenomenon can enhance host defense against infections but may also be maladaptive in chronic inflammatory disorders. Understanding the mechanisms driving trained immunity, including changes in intracellular metabolism and epigenetic reprogramming, is crucial for future therapeutic exploitation.
MOLECULAR ASPECTS OF MEDICINE
(2021)
Article
Immunology
Dennis M. de Graaf, Martin Jaeger, Inge C. L. van den Munckhof, Rob ter Horst, Kiki Schraa, Jelle Zwaag, Matthijs Kox, Mayumi Fujita, Takeshi Yamauchi, Laura Mercurio, Stefania Madonna, Joost H. W. Rutten, Jacqueline de Graaf, Niels P. Riksen, Frank L. van de Veerdonk, Mihai G. Netea, Leo A. B. Joosten, Charles A. Dinarello
Summary: IL-38 (IL1F10) suppresses inflammatory and autoimmune conditions and its plasma concentrations in healthy Europeans correlate positively with circulating memory B cells and plasmablasts. In individuals at high risk for cardiovascular disease, IL-38 levels were significantly lower and correlated inversely with markers of inflammation. This suggests a potential role for IL-38 deficiency in aging-related systemic inflammation and diseases.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
Article
Substance Abuse
Thomas Knuijver, Arnt Schellekens, Maarten Belgers, Rogier Donders, Toon van Oosteren, Kees Kramers, Robbert Verkes
Summary: This study found that ibogaine treatment for patients with opioid use disorder can induce clinically relevant but reversible QTc prolongation, bradycardia, and severe ataxia. However, no Torsades de Pointes were observed, and most patients tolerated withdrawal and psychomimetic effects well.
Article
Cardiac & Cardiovascular Systems
Marlies P. Noz, Annemieke ter Telgte, Kim Wiegertjes, Anil M. Tuladhar, Charlotte Kaffa, Simone Kersten, Siroon Bekkering, Charlotte D. C. C. van der Heijden, Alexander Hoischen, Leo A. B. Joosten, Mihai G. Netea, Marco Duering, Frank-Erik de Leeuw, Niels P. Riksen
Summary: The study found that individuals with progressive SVD have circulating monocytes with an inflammatory phenotype, characterized by increased cytokine production capacity and a pro-inflammatory transcriptional signature.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Laurienne Edgar, Naveed Akbar, Adam T. Braithwaite, Thomas Krausgruber, Hector Gallart-Ayala, Jade Bailey, Alastair L. Corbin, Tariq E. Khoyratty, Joshua T. Chai, Mohammad Alkhalil, Andre F. Rendeiro, Klemen Ziberna, Ritu Arya, Thomas J. Cahill, Christoph Bock, Jurga Laurencikiene, Mark J. Crabtree, Madeleine E. Lemieux, Niels P. Riksen, Mihai G. Netea, Craig E. Wheelock, Keith M. Channon, Mikael Ryden, Irina A. Udalova, Ricardo Carnicer, Robin P. Choudhury
Summary: The study found that hyperglycemia-induced trained immunity may explain the ineffectiveness of targeting elevated glucose in reducing macrovascular risk in diabetes, and suggests new targets for disease prevention and therapy.
Article
Biochemistry & Molecular Biology
Adelina S. Plachokova, Sergio Andreu-Sanchez, Marlies P. Noz, Jingyuan Fu, Niels P. Riksen
Summary: This study explores the relationship between the oral microbiome of periodontitis patients and disease severity and systemic inflammation. Significant differences in microbial composition were found between severe and mild periodontitis, particularly in subgingival microbiome, which was positively associated with systemic inflammatory markers like interleukin-6 and white blood cell count. The findings suggest that systemic inflammation in severe periodontitis may be driven by the oral microbiome, supporting the indirect inflammatory mechanism linking periodontitis to cardiovascular disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Loes H. Willems, Dick H. J. Thijssen, Laszlo A. Groh, Nina Kooijman, Hugo Ten Cate, Henri M. H. Spronk, A. Rogier T. Donders, Rozemarijn J. Van der Vijver-Coppen, Frank van Hoek, Magdolna Nagy, Michel M. P. J. Reijnen, Michiel C. Warle
Summary: The study investigated the effects of combining rivaroxaban and ASA on endothelial function in PAD patients, and the results showed that this combination therapy did not affect carotid artery reactivity and plasma endothelin-1 concentrations.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Physiology
Jorge Dominguez-Andres, Jessica Cristina dos Santos, Siroon Bekkering, Willem J. M. Mulder, Jos W. M. van der Meer, Niels P. Riksen, Leo A. B. Joosten, Mihai G. Netea
Summary: Trained immunity is a non-specific enhanced responsiveness of innate immune cells that relies on epigenetic, transcriptional, and metabolic programs. It improves the response to infections and vaccines but may also contribute to the pathogenesis of cardiovascular, autoinflammatory, and neurodegenerative diseases.
PHYSIOLOGICAL REVIEWS
(2023)
Article
Cell Biology
Nils Rother, Cansu Yanginlar, Geoffrey Prevot, Inge Jonkman, Maaike Jacobs, Mandy M. T. van Leent, Julia van Heck, Vasiliki Matzaraki, Anthony Azzun, Judit Morla-Folch, Anna Ranzenigo, William Wang, Roy van der Meel, Zahi A. Fayad, Niels P. Riksen, Luuk B. Hilbrands, Rik G. H. Lindeboom, Joost H. A. Martens, Michiel Vermeulen, Leo A. B. Joosten, Mihai G. Netea, Willem J. M. Mulder, Johan van der Vlag, Abraham J. P. Teunissen, Raphael Duivenvoorden
Summary: Innate immune memory, also known as trained immunity, is a functional state of myeloid cells that enhances immune responses. This study demonstrates that sphingolipids and sphingolipid metabolizing enzymes play a role in modulating trained immunity. Acid ceramidase, an enzyme that converts ceramide to sphingosine, is shown to regulate histone-modifying enzymes and subsequently affect immune responses. Single-nucleotide polymorphisms in the gene encoding acid ceramidase are associated with trained immunity cytokine response. This research highlights the immunomodulatory effect of sphingolipids and identifies acid ceramidase as a potential therapeutic target for immune-driven disorders.
Article
Cardiac & Cardiovascular Systems
Lara S. F. Konijnenberg, Dasa Zugwitz, Henk Everaars, Nina W. van der Hoeven, Ahmet Demirkiran, Laura Rodwell, Maarten A. H. van Leeuwen, Albert C. van Rossum, Saloua El Messaoudi, Niels P. Riksen, Niels van Royen, Robin Nijveldt
Summary: The study aimed to investigate the suppressive effect of ticagrelor on CMR T1 and T2 values in remote myocardium. The results showed that ticagrelor maintenance therapy was not superior to prasugrel in preventing early remote myocardial inflammation in revascularized STEMI patients as assessed by CMR T1 and T2 mapping.
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
H. Tercan, R. C. Van Deuren, K. Schraa, R. Ter Horst, I. C. Van den Munckhof, S. Bekkering, J. H. Rutten, M. G. Netea, L. A. B. Joosten, A. Hoischen, N. P. Riksen
Meeting Abstract
Cardiac & Cardiovascular Systems
J. Van Tuijl, J. I. P. Van Heck, H. Bahrar, J. H. Wijma, P. Noz, Y. M. Ten Have, H. E. E. Zweers, L. A. Afman, L. A. B. Joosten, M. G. Netea, S. Bekkering, N. P. Riksen
Meeting Abstract
Cardiac & Cardiovascular Systems
S. Bekkering, C. Saner, B. Novakovic, Z. Mccallum, M. G. Netea, N. P. Riksen, M. A. Sabin, R. Saffery, D. P. Burgner
Meeting Abstract
Cardiac & Cardiovascular Systems
L. A. Groh, D. Verel, C. D. C. C. Van der Heijden, V. Matzaraki, S. J. C. F. M. Moorlag, L. C. De Bree, V. A. C. M. Koeken, V. P. Mourits, S. T. Keating, J. H. Van Puffelen, L. A. B. Joosten, M. G. Netea, N. P. Riksen