Clobetasol and Halcinonide Act as Smoothened Agonists to Promote Myelin Gene Expression and RxRγ Receptor Activation

Drug-based modulation of endogenous stem cells promotes functional remyelination in vivo

(2015) Fadi J. Najm et al.   NATURE

Metabolites in vertebrate Hedgehog signaling

(2014) Hanne Roberg-Larsen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Glial Development: The Crossroads of Regeneration and Repair in the CNS

(2014) Vittorio Gallo et al.   NEURON

Neuronal Activity Promotes Oligodendrogenesis and Adaptive Myelination in the Mammalian Brain

(2014) E. M. Gibson et al.   SCIENCE

Axon-glia interaction and membrane traffic in myelin formation

(2014) Robin White et al.   Frontiers in Cellular Neuroscience

Genetic Activation of Hedgehog Signaling Unbalances the Rate of Neural Stem Cell Renewal by Increasing Symmetric Divisions

(2014) Julien Ferent et al.   Stem Cell Reports

Identifying the Cellular Targets of Drug Action in the Central Nervous System Following Corticosteroid Therapy

(2013) Stuart I. Jenkins et al.   ACS Chemical Neuroscience

Itraconazole and Arsenic Trioxide Inhibit Hedgehog Pathway Activation and Tumor Growth Associated with Acquired Resistance to Smoothened Antagonists

(2013) James Kim et al.   CANCER CELL

Promoting Remyelination in Multiple Sclerosis—Recent Advances

(2013) E. Jolanda Münzel et al.   DRUGS

Sonic Hedgehog Signaling Is a Positive Oligodendrocyte Regulator during Demyelination

(2013) J. Ferent et al.   JOURNAL OF NEUROSCIENCE

Combined p21-activated kinase and farnesyltransferase inhibitor treatment exhibits enhanced anti-proliferative activity on melanoma, colon and lung cancer cell lines

(2013) Giampiero Porcu et al.   Molecular Cancer

A regenerative approach to the treatment of multiple sclerosis

(2013) Vishal A. Deshmukh et al.   NATURE

The quest for myelin in the adult brain

(2013) Emanuela Zuccaro et al.   NATURE CELL BIOLOGY

The effect of glia-glia interactions on oligodendrocyte precursor cell biology during development and in demyelinating diseases

(2013) Diego Clemente et al.   Frontiers in Cellular Neuroscience

The remyelination Philosopher's Stone: stem and progenitor cell therapies for multiple sclerosis

(2012) Janusz J. Jadasz et al.   CELL AND TISSUE RESEARCH

Clinical Pharmacokinetics and Pharmacodynamics of Prednisolone and Prednisone in Solid Organ Transplantation

(2012) Troels K. Bergmann et al.   CLINICAL PHARMACOKINETICS

Megalin mediates the influence of sonic hedgehog on oligodendrocyte precursor cell migration and proliferation during development

(2012) María Cristina Ortega et al.   GLIA

Myelin Gene Regulatory Factor Is Required for Maintenance of Myelin and Mature Oligodendrocyte Identity in the Adult CNS

(2012) M. Koenning et al.   JOURNAL OF NEUROSCIENCE

Therapy of Pelizaeus-Merzbacher disease in mice by feeding a cholesterol-enriched diet

(2012) Gesine Saher et al.   NATURE MEDICINE

Remyelination Therapy for Multiple Sclerosis

(2012) Michael B. Keough et al.   Neurotherapeutics

Oligodendrocyte-protection and remyelination post-spinal cord injuries: A review

(2012) Mina Mekhail et al.   PROGRESS IN NEUROBIOLOGY

Enhancing remyelination in disease--can we wrap it up?

(2011) M. R. Kotter et al.   BRAIN

Pharmacogenomics and Multiple Sclerosis: Moving Toward Individualized Medicine

(2011) Manuel Comabella et al.   Current Neurology and Neuroscience Reports

Regulation of remyelination in multiple sclerosis

(2011) Khalid A. Hanafy et al.   FEBS LETTERS

Axon-glial interaction in the CNS: what we have learned from mouse models of Pelizaeus-Merzbacher disease

(2011) Fredrik I. Gruenenfelder et al.   JOURNAL OF ANATOMY

Transport of the Major Myelin Proteolipid Protein Is Directed by VAMP3 and VAMP7

(2011) A. Feldmann et al.   JOURNAL OF NEUROSCIENCE

Endogenous stem cell proliferation induced by intravenous hedgehog agonist administration after contusion in the adult rat spinal cord

(2011) Nicholas C. Bambakidis et al.   JOURNAL OF NEUROSURGERY-SPINE

Neurotoxicity induced by dexamethasone in the human neuroblastoma SH-SY5Y cell line can be prevented by folic acid

(2011) J. Budni et al.   NEUROSCIENCE

Towards resolving the transcription factor network controlling myelin gene expression

(2011) Debra L. Fulton et al.   NUCLEIC ACIDS RESEARCH

Cells of the oligodendroglial lineage, myelination, and remyelination

(2010) Veronique E. Miron et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Itraconazole, a Commonly Used Antifungal that Inhibits Hedgehog Pathway Activity and Cancer Growth

(2010) James Kim et al.   CANCER CELL

CNS-Resident Glial Progenitor/Stem Cells Produce Schwann Cells as well as Oligodendrocytes during Repair of CNS Demyelination

(2010) Malgorzata Zawadzka et al.   Cell Stem Cell

A yeast-based genomic strategy highlights the cell protein networks altered by FTase inhibitor peptidomimetics

(2010) Giampiero Porcu et al.   Molecular Cancer

Retinoid X receptor gamma signaling accelerates CNS remyelination

(2010) Jeffrey K Huang et al.   NATURE NEUROSCIENCE

Glial Cell Lines: An Overview

(2010) George H. De Vries et al.   NEUROCHEMICAL RESEARCH

Drug reprofiling using zebrafish identifies novel compounds with potential pro-myelination effects

(2010) Clare E. Buckley et al.   NEUROPHARMACOLOGY

Identification of select glucocorticoids as Smoothened agonists: Potential utility for regenerative medicine

(2010) J. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Specific and Strain-Independent Effects of Dexamethasone in the Prevention and Treatment of Experimental Autoimmune Encephalomyelitis in Rodents

(2010) M. Donia et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Evaluating Smoothened as a G-protein-coupled receptor for Hedgehog signalling

(2010) Katie L. Ayers et al.   TRENDS IN CELL BIOLOGY

Myelin Gene Regulatory Factor Is a Critical Transcriptional Regulator Required for CNS Myelination

(2009) Ben Emery et al.   CELL

Vitamins E and D3 Attenuate Demyelination and Potentiate Remyelination Processes of Hippocampal Formation of Rats Following Local Injection of Ethidium Bromide

(2009) Mahdi Goudarzvand et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Hedgehog signalling: Emerging evidence for non-canonical pathways

(2009) Dagan Jenkins   CELLULAR SIGNALLING

The value of drug repositioning in the current pharmaceutical market

(2009) E.L. Tobinick   DRUG NEWS & PERSPECTIVES

Convergent Functional Genomics of Oligodendrocyte Differentiation Identifies Multiple Autoinhibitory Signaling Circuits

(2009) R. Pescini Gobert et al.   MOLECULAR AND CELLULAR BIOLOGY

Caring for Children With Autism Spectrum Disorder, Part II: Screening, Diagnosis, and Management

(2009) Melissa Dodd Inglese   Journal of Pediatric Nursing-Nursing Care of Children & Families

Acute neonatal glucocorticoid exposure produces selective and rapid cerebellar neural progenitor cell apoptotic death

(2008) K K Noguchi et al.   CELL DEATH AND DIFFERENTIATION

Distinct endocytic recycling of myelin proteins promotes oligodendroglial membrane remodeling

(2008) C. Winterstein et al.   JOURNAL OF CELL SCIENCE

The biology of CNS remyelination

(2008) Robin J. M. Franklin et al.   JOURNAL OF NEUROLOGY

Chemoattractive Activity of Sonic Hedgehog in the Adult Subventricular Zone Modulates the Number of Neural Precursors Reaching the Olfactory Bulb

(2008) Elodie Angot et al.   STEM CELLS