Article
Oncology
Siye Liu, Xiaoping Yu, Songhua Yang, Pingsheng Hu, Yingbin Hu, Xiaoyan Chen, Yilin Li, Zhe Zhang, Cheng Li, Qiang Lu
Summary: A radiomics nomogram based on primary tumor features was established and validated to predict preoperative pathological extramural venous invasion (EMVI) in rectal cancer using machine learning. The nomogram showed high efficiency in predicting EMVI, helping patients choose optimal treatment strategies.
FRONTIERS IN ONCOLOGY
(2021)
Article
Gastroenterology & Hepatology
Taru M. Lehtonen, Laura E. Koskenvuo, Toni T. Seppala, Anna H. Lepisto
Summary: This study found that extramural venous invasion observed in preoperative MRI is a significant prognostic factor for poorer survival and recurrences in rectal cancer patients. A circumferential margin <= 1 mm is associated with local recurrence, but this risk can be controlled with chemoradiotherapy and extended surgery.
COLORECTAL DISEASE
(2022)
Review
Surgery
Francois Rouleau Fournier, Mohammad Ali K. Motamedi, Carl J. Brown, Terry Phang, Manoj J. Raval, Cameron J. Hague, Ahmer A. Karimuddin
Summary: This review aimed to demonstrate the significance of pre- and post-treatment MRI-detected EMVI as independent prognostic factors in patients undergoing neoadjuvant therapy followed by total mesorectal excision.
Article
Medicine, Research & Experimental
Hao Yang, Xinyi Gou, Caizhen Feng, Yinli Zhang, Fan Chai, Nan Hong, Yingjiang Ye, Yi Wang, Bo Gao, Jin Cheng
Summary: This study investigates the association between CT-detected EMVI-related genes and immunotherapy resistance and immune escape in gastric cancer patients. The findings suggest that the EMVI gene signature detected by CT could serve as a potential negative biomarker for ICIs treatment, as it is negatively correlated with TMB and MSI, resulting in poorer prognosis. Furthermore, the expression of CXCL12 and SOX17 genes is significantly higher in CT-detected EMVI-positive samples.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Oncology
Philip D. Mc Entee, Poorya Shokuhi, Ailin C. Rogers, Brian J. Mehigan, Paul H. McCormick, Charles M. Gillham, M. John Kennedy, David J. Gallagher, Ciara E. Ryan, Cian B. Muldoon, John O. Larkin
Summary: Extramural venous invasion (EMVI) is associated with poor prognosis in colorectal cancer (CRC), with increased risk of recurrence and death. This study found that the presence of EMVI is associated with worse oncological outcomes, and suggests considering it as an indication for adjuvant therapy.
Review
Oncology
Jessica Juliana Tan, Rachel V. Carten, Amna Babiker, Muti Abulafi, Amy C. Lord, Gina Brown
Summary: mrEMVI is significantly associated with worsened survival outcomes in rectal cancer, both at baseline and after neoadjuvant treatment. Regression of mrEMVI after neoadjuvant treatment is associated with improved survival outcomes. Accurate and consistent reporting of mrEMVI status is essential.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Medicine, General & Internal
Mohammed S. Alshuhri, Abdulaziz Alduhyyim, Haitham Al-Mubarak, Ahmad A. Alhulail, Othman I. Alomair, Yahia Madkhali, Rakan A. Alghuraybi, Abdullah M. Alotaibi, Abdullalh G. M. Alqahtani
Summary: Machine learning models using MRI radiomics can accurately predict the KRAS mutation status and tumor grading in colorectal cancer patients. This has the potential to guide personalized treatment decisions and improve patients' outcomes.
Article
Oncology
Bo Gao, Caizhen Feng, Fan Chai, Shengcai Wei, Nan Hong, Yingjiang Ye, Yi Wang, Jin Cheng
Summary: CT-detected EMVI-related gene model was established to predict the prognosis in GC patients through radiogenomics approach, providing potential insights for therapeutic strategy and medical decision-making. The seven-gene signature mainly involves pathways related to cell proliferation, cell adhesion, regulation of metal ion transport, and epithelial to mesenchymal transition. The risk stratification model using the signature showed significantly reduced OS in high-risk patients and was identified as an independent predictor of OS in multivariate Cox regression analyses.
Review
Oncology
Jean-Francois Delattre, Ayse Selcen Oguz Erdogan, Romain Cohen, Qian Shi, Jean-Francois Emile, Julien Taieb, Josep Tabernero, Thierry Andre, Jeffrey A. Meyerhardt, Iris D. Nagtegaal, Magali Svrcek
Summary: The significance of TDs in the management of colorectal cancer has sparked widespread debate in the medical and academic communities, with the integration of TDs in pathologic staging remaining a controversial topic. Neglecting TDs in the presence of lymph node metastasis can lead to prognostic underestimation and incorrect therapeutic decisions.
CANCER TREATMENT REVIEWS
(2022)
Article
Oncology
Mo Chen, Yan Ma, Yi-wen Song, Jinhua Huang, Yuan-hong Gao, Jian Zheng, Fang He
Summary: In this retrospective study, we found that most LARC patients with mrEMVI converted to EMVI-negative after neoadjuvant treatment, resulting in improved overall survival and disease-free survival. Patients receiving neoadjuvant chemoradiotherapy had better survival outcomes compared to those receiving neoadjuvant chemotherapy alone, suggesting the importance of including radiotherapy in the treatment. Patients receiving neoadjuvant chemotherapy in addition to chemoradiotherapy had higher rates of pathological complete response and downstaging, but their survival rates were not improved.
Article
Radiology, Nuclear Medicine & Medical Imaging
Weiqun Ao, Xian Zhang, Xiuzhen Yao, Xiandi Zhu, Shuitang Deng, Jianju Feng
Summary: This study explored the value of quantitative dynamic contrast-enhanced magnetic resonance imaging and diffusion-weighted imaging parameters in assessing extramural venous invasion in rectal cancer. The results showed that Ktrans and Kep values were associated with mrEMVI positivity, while ADC values were associated with mrEMVI negativity. The combined model based on quantitative DCE parameters and ADC values had good prediction efficiency for pathologic EMVI in rectal cancer.
BMC MEDICAL IMAGING
(2022)
Review
Radiology, Nuclear Medicine & Medical Imaging
Akitoshi Inoue, Shannon P. Sheedy, Jay P. Heiken, Payam Mohammadinejad, Rondell P. Graham, Hee Eun Lee, Scott R. Kelley, Stephanie L. Hansel, David H. Bruining, Jeff L. Fidler, Joel G. Fletcher
Summary: MRI is commonly used for staging rectal cancer and detecting EMVI, a predictor for worse prognosis. T2-weighted and diffusion-weighted images can help identify EMVI, while contrast enhanced T1-weighted images show tumor signal intensity.
INSIGHTS INTO IMAGING
(2021)
Article
Cell Biology
Kai Duan, Brian Chow, William Tsui, Colin Elliot, Aysegul Sari, Sameer Shivji, Richard Kirsch, James R. Conner
Summary: This study aims to determine the optimal number of tumor blocks required for venous invasion (VI) detection in colorectal cancer resections. The results demonstrate that the sensitivity of VI detection increases with the number of tumor blocks submitted.
Article
Pathology
Zhen Lin, John T. M. Plukker, Dong-ping Tian, Shao-bin Chen, Gursah Kats-Ugurlu, Min Su
Summary: The study aimed to identify extramural venous invasion (EMVI) in esophageal squamous cell carcinoma (ESCC) and assess its impact on survival and recurrences. EMVI was found in 30.6% of the ESCC patients and was associated with lymph-vascular invasion and poor differentiation grade. EMVI has an independent adverse prognostic effect on survival after surgery.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2023)
Article
Gastroenterology & Hepatology
Sang Sik Cho, Ji Won Park, Gyeong Hoon Kang, Jung Ho Kim, Jeong Mo Bae, Sae-Won Han, Tae-You Kim, Min Jung Kim, Seung-Bum Ryoo, Seung-Yong Jeong, Kyu Joo Park
Summary: This study aimed to determine whether the location of lymphatic invasion, vascular invasion, and perineural invasion could affect the survival of patients with stage II colon cancer. The results showed that extramural invasion was associated with a worse prognosis, while intramural invasion was not. Therefore, pathologic reports about the location of invasion may be helpful for predicting prognosis and determining the need for adjuvant chemotherapy in stage II colon cancers.
DISEASES OF THE COLON & RECTUM
(2023)