Article
Endocrinology & Metabolism
Filippo Luca Gurgoglione, Dario Pitocco, Rocco A. Montone, Riccardo Rinaldi, Riccardo C. Bonadonna, Giulia Magnani, Camilla Calvieri, Emilia Solinas, Alessandro Rizzi, Linda Tartaglione, Andrea Flex, Luca Viti, Carlo Trani, Diego Ardissino, Filippo Crea, Giampaolo Niccoli
Summary: The study aimed to investigate the influence of diabetic microvascular complications (DMC) on coronary collateral (CC) vessel development in patients with coronary chronic total occlusion (CTO). Results showed that patients with DMC had a higher prevalence of CC and high-grade CC compared with those without DMC. Furthermore, there was a positive association between the number of DMC in each patient and the prevalence of high-grade CC.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Anandakumar Amutha, Unnikrishnan Ranjit, Ranjit Mohan Anjana, Coimbatore Subramaniam R. Shanthi, Ramachandran Rajalakshmi, Ulagamathesan Venkatesan, Subramaniapillai Muthukumar, Routray Philips, Sengottuvel Kayalvizhi, Prasanna Kumar Gupta, Nadiminty Ganapathi Sastry, Viswanathan Mohan
Summary: The study found a high incidence of microvascular complications among childhood and adolescent-onset type 1 and type 2 diabetes patients, calling for more aggressive diabetes control strategies.
PEDIATRIC DIABETES
(2021)
Article
Endocrinology & Metabolism
Afnan Mansour, Mira Mousa, Dima Abdelmannan, Guan Tay, Ahmed Hassoun, Habiba Alsafar
Summary: This study conducted an Exome-Wide Association Study (EWAS) on Emirati individuals with type 2 diabetes mellitus (T2DM) to identify susceptibility loci associated with T2DM-related complications. The results showed associations between various genes and each complication category. The study also highlighted the limitations of the current genotyping arrays in representing diverse populations, emphasizing the need for better representation in future studies.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Multidisciplinary Sciences
Joonyub Lee, Seung-Hwan Lee, Kun-Ho Yoon, Jae Hyoung Cho, Kyungdo Han, Yeoree Yang
Summary: The study found that patients with young-onset type 2 diabetes (diagnosed before the age of 40) have a higher risk of developing chronic kidney disease (CKD). A total of 84,384 patients aged 20-64 who started anti-diabetic medication between 2010 and 2011 were included in the study, and those with type 1 diabetes or a history of CKD were excluded. Multivariate logistic regression analysis revealed that patients with young-onset diabetes had a higher incidence of CKD compared to those with late-onset diabetes.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, General & Internal
Naba Al-Sari, Svetlana Kutuzova, Tommi Suvitaival, Peter Henriksen, Flemming Pociot, Peter Rossing, Douglas McCloskey, Cristina Legido-Quigley
Summary: Using blood small molecule profiling and machine learning, the risk of developing complications, such as kidney disease and retinopathy, in diabetes patients can be predicted. This precision diagnostic approach has the potential to be implemented in clinical settings to screen patients early and prevent complications.
Review
Endocrinology & Metabolism
Bilal Bashir, Zohaib Iqbal, Safwaan Adam, Maryam Ferdousi, William Chick, Heleen A. Hussein, Akheel A. Syed, Carel W. Le Roux, Ricardo V. Cohen, Rayaz A. Malik, Handrean Soran
Summary: Bariatric surgery in people with obesity can lead to long-term remission of type 2 diabetes mellitus (T2DM) and a reduction in the incidence of macrovascular complications. However, the impact of bariatric surgery on microvascular complications is less clear.
Review
Endocrinology & Metabolism
William B. Horton, Eugene J. Barrett
Summary: This review discusses the microvascular dysfunction in diabetes mellitus and cardiometabolic disease, suggesting that dysfunction can be an early marker of change. The study also found that familiar complications of diabetes can be late-stage manifestations of microvascular injury that begins years earlier. Advances in understanding normal microvascular function and early dysfunction are leading to novel preventative interventions at early stages of microvascular injury.
Article
Cardiac & Cardiovascular Systems
Klaudia Bogusz-Gorna, Adriana Polanska, Aleksandra Danczak-Pazdrowska, Ryszard Zaba, Marta Suminska, Piotr Fichna, Andrzej Kedzia
Summary: Capillaroscopy and photoplethysmography are non-invasive, painless, fast, inexpensive methods for studying microcirculation in diabetic patients. This study found that patients with type 1 diabetes had a higher prevalence of abnormal capillaroscopic findings, such as abnormal morphology, enlarged capillaries, and more meandering capillaries, compared to healthy controls. In addition, patients with diagnosed neuropathy had a higher percentage of flow disturbance curves in photoplethysmography.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Endocrinology & Metabolism
Yuxia Wei, Katharina Herzog, Emma Ahlqvist, Tomas Andersson, Thomas Nystrom, Yiqiang Zhan, Tiinamaija Tuomi, Sofia Carlsson
Summary: Despite having fewer metabolic risk factors than type 2 diabetes, latent autoimmune diabetes in adults (LADA) has equal to higher risks of death, cardiovascular diseases (CVDs), and retinopathy. Poorer glycemic control, particularly in LADAhigh, highlights the need for improved LADA management.
Article
Endocrinology & Metabolism
Emilia N. De Melo, Antoine B. M. Clarke, Charlotte McDonald, Fred Saibil, Heather A. Lochnan, Zubin Punthakee, Esther Assor, Margaret A. Marcon, Farid H. Mahmud
Summary: The study found that adults with type 1 diabetes reported higher rates of GI symptoms compared to children. Patients with GI symptoms tended to have higher levels of hemoglobin A1c and microvascular complications.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Emir Muzurovic, Lvana Kraljevic, Mirsala Solak, Sinisa Dragnic, Dimitri P. Mikhailidis
Summary: Homocysteine’s role in the development of vascular complications in diabetes mellitus is still unclear, with conflicting results from studies. While lowering therapies can effectively reduce homocysteine levels, their impact on reducing cardiovascular disease risk remains uncertain, requiring further investigation, especially in diabetic patients.
JOURNAL OF DIABETES AND ITS COMPLICATIONS
(2021)
Article
Endocrinology & Metabolism
Jens Christian Laursen, Hatice Isik Mizrak, Huda Kufaishi, Sofie Korsgaard Hecquet, Elisabeth Buur Stougaard, Ninna Hahn Tougaard, Marie Frimodt-Moller, Tine Willum Hansen, Christian Stevns Hansen, Peter Rossing
Summary: The study found that hypoxemia is associated with increased prevalence of albuminuria, retinopathy, and neuropathy in type 1 diabetes, but not with cardiovascular disease.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Geriatrics & Gerontology
Dominic D. Quintana, Yamini Anantula, Jorge A. Garcia, Elizabeth B. Engler-Chiurazzi, Saumyendra N. Sarkar, Deborah R. Corbin, Candice M. Brown, James W. Simpkins
Summary: The study established a time-course for the structural changes and degeneration of the angioarchitecture in AD, showing early morphological abnormalities and degeneration of microvascular networks in 3xTg AD mice. Analysis of the hippocampus and cortical subregions revealed subregion-dependent microvascular degeneration with onset and progression.
NEUROBIOLOGY OF AGING
(2021)
Review
Oncology
Jan Bures, Darina Kohoutova, Jan Skrha, Bohus Bunganic, Ondrej Ngo, Stepan Suchanek, Pavel Skrha, Miroslav Zavoral
Summary: Pancreatic ductal adenocarcinoma is a serious malignancy and a leading cause of cancer-related deaths worldwide. There are no effective screening methods available so far. Impaired glucose metabolism is present in about 3/4 of patients. This paper proposed a distinct approach to older subjects with new-onset diabetes mellitus with possible pancreatic cancer, aiming to improve the current unsatisfactory situation in diagnostics and subsequent poor outcomes of treatment.
Article
Endocrinology & Metabolism
Oana P. Zaharia, Stefanie Lanzinger, Joachim Rosenbauer, Wolfram Karges, Karsten Muessig, Sebastian M. Meyhoefer, Volker Burkart, Michael Hummel, Dirk Raddatz, Michael Roden, Julia Szendroedi, Reinhard W. Holl
Summary: By comparing two differently designed German cohorts, this study assessed the prevalence of cardiovascular risk factors and diabetes-related complications in recent-onset adult type 1 diabetes. Diabetic nephropathy and retinopathy are the most frequent complications in type 1 diabetes, affecting up to every 10th patient within the first year after diagnosis, underlining the need for more stringent risk factor management already at the time of diagnosis of type 1 diabetes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Pharmacology & Pharmacy
Raman Puri, Vimal Mehta, P. Barton Duell, S. K. Wangnoo, Ashu Rastogi, V. Mohan, Abdul Hamid Zargar, Sanjay Kalra, Abhay Kumar Sahoo, S. S. Iyengar, Jamal Yusuf, Saibal Mukhopadhyay, Mani Kant Singla, Altamash Shaikh, Sunil Kohli, Sandeep Mathur, Sachin Jain, S. N. Narasingan, Vipul Gupta, Rajeev Agarwala, Vinod Mittal, Amit Varma, Jayant Kumar Panda, Sadanand Shetty, Madhur Yadav, A. Muruganathan, Pradeep Dabla, K. K. Pareek, P. C. Manoria, Rashmi Nanda, G. B. Sattur, A. K. Pancholia, Nathan D. Wong
Summary: According to the National Lipid Association's report in 2022, an estimated 74 million people in India had diabetes in 2021, mostly type 2 diabetes. Over 50% of diabetes patients were undiagnosed, and over 90% had dyslipidemia associated with accelerated development of atherosclerotic cardiovascular disease (ASCVD). Indian individuals with diabetes have distinct characteristics compared to Western populations, including earlier onset, higher prevalence of metabolic syndrome features, more prevalent ASCVD risk factors, and a more aggressive course of ASCVD complications. In response to the unique features of diabetes and diabetic dyslipidemia in Indian individuals, the Lipid Association of India developed an expert consensus statement to guide the management of diabetic dyslipidemia in this high-risk population. The recommendations were based on a series of 165 webinars conducted by the Lipid Association of India from May 2020 to July 2021, involving 155 experts in endocrinology and cardiology and an additional 2880 physicians.
JOURNAL OF CLINICAL LIPIDOLOGY
(2023)
Article
Health Care Sciences & Services
Kara Suvada, Mohammed K. Ali, Lydia Chwastiak, Subramani Poongothai, Karl M. F. Emmert-Fees, Ranjit Mohan Anjana, Rajesh Sagar, Radha Shankar, Gumpeny R. Sridhar, Madhu Kasuri, Aravind R. Sosale, Bhavana Sosale, Deepa Rao, Nikhil Tandon, K. M. Venkat Narayan, Viswanathan Mohan, Shivani A. Patel
Summary: This study investigated the effects of collaborative care on patients with depression and diabetes over a period of 36 months. The results showed that there were no differences in improvements in multiple or single risk factors at 36 months between the collaborative care and usual care groups. However, patients who had achieved improvements in depressive symptoms and glucose levels at 12 months were more likely to maintain these improvements at 36 months.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Charlotte Steenblock, Nicole Toepfner, Felix Beuschlein, Nikolaos Perakakis, Ranjit Mohan Anjana, Viswanathan Mohan, Nitish R. Mahapatra, Stefan R. Bornstein
Summary: The SARS-CoV-2 virus can infect various tissues including endocrine organs, leading to organ damage or dysfunction. The main receptor ACE2 is expressed in cells of the endocrine system, and the virus has been found in post-mortem samples from COVID-19 patients. The exact mechanisms are not fully understood and further research is needed. Additionally, endocrine diseases may impact the severity of COVID-19, highlighting the importance of reducing their prevalence or improving treatment in the future.
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Natarajan Lakshmi, Rajendra Pradeepa, Ranjit Mohan Anjana, Hari Rakesh, Radhakrishnan Subashini, Ulagamathesan Venkatesan, Mohan Deepa, Nora Vigasini, Moneeza Kalhan Siddiqui, Ewan R. Pearson, Colin N. A. Palmer, Viswanathan Mohan
Summary: This study aimed to assess the secular trends in the prevalence of diabetes and pre-diabetes from two cross-sectional studies done 11 years apart, in rural Tamil Nadu. The study found that the prevalence of diabetes among adults in rural south India has dramatically increased while that of prediabetes has decreased, over an 11-year period.
INTERNATIONAL JOURNAL OF DIABETES IN DEVELOPING COUNTRIES
(2023)
Review
Medicine, General & Internal
Garudam Raveendiran Aarthi, Thaharullah Shah Mehreen Begum, Suzana Al Moosawi, Dian Kusuma, Harish Ranjani, Rajendra Paradeepa, Venkatasubramanian Padma, Viswanathan Mohan, Ranjit Mohan Anjana, Daniela Fecht
Summary: Our study systematically reviewed the literature on the associations between built environment characteristics and type 2 diabetes (T2D) in Asia. The findings showed that several built environment attributes, such as urban green space, walkability, food environment, and air pollution, were significantly related to T2D in Asia. Additionally, particulate matter, nitrogen dioxide, and sulfur dioxide were strongly associated with T2D risk. This highlights the importance of considering the built environment in relation to T2D prevention and public health planning.
Article
Medicine, General & Internal
Aastha Aggarwal, Ranganathan Rama, Preet K. Dhillon, Mohan Deepa, Dimple Kondal, Naveen Kaushik, Dipika Bumb, Ravi Mehrotra, Betsy A. Kohler, Viswanathan Mohan, Theresa W. Gillespie, Alpa Patel, Swaminathan Rajaraman, Dorairaj Prabhakaran, Kevin C. Ward, Michael Goodman
Summary: To test a systematic alternative approach, a population-based cohort in Chennai, India was linked with a local population-based cancer registry, and the study found a high level of agreement between self-reported diagnoses and registry-based diagnoses. These findings provide important insights for future cancer surveillance and research in low-income and middle-income countries.
Article
Endocrinology & Metabolism
Ramasamy Aarthy, Kathryn Aston-Mourney, Anandakumar Amutha, Antonina Mikocka-Walus, Ranjit Mohan Anjana, Ranjit Unnikrishnan, Saravanan Jebarani, Ulagamathesan Venkatesan, Sundaramoorthy Gopi, Venkatesan Radha, Viswanathan Mohan
Summary: This study investigates the prevalence, clinical features, and complications of MODY in a tertiary diabetes center in South India and compares them with T1D and T2D. The results show a high prevalence of retinopathy and nephropathy in MODY patients, highlighting the importance of early diagnosis and better diabetes control for individuals with MODY.
PRIMARY CARE DIABETES
(2023)
Editorial Material
Endocrinology & Metabolism
Michael Bergman, Martin Buysschaert, Antonio Ceriello, Akhtar Hussain, Viswanathan Mohan, Giorgio Sesti, Jaakko Tuomilehto
LANCET DIABETES & ENDOCRINOLOGY
(2023)
Review
Multidisciplinary Sciences
Jothydev Kesavadev, Viswanathan Mohan
Summary: The increasing diabetes population has resulted in escalated costs and overburdened physicians. Patient-friendly technologies, such as telemedicine and mobile apps, can significantly reduce complications and improve healthcare outcomes. Remote monitoring and wearable devices also play a vital role in preventing long-term complications and improving patients' quality of life.
JOURNAL OF THE INDIAN INSTITUTE OF SCIENCE
(2023)
Review
Endocrinology & Metabolism
Stephen Twigg, Soo Lim, Seung-Hyun Yoo, Liming Chen, Yuqian Bao, Alice Kong, Ester Yeoh, Siew Pheng Chan, Jeremyjones Robles, Viswanathan Mohan, Neale Cohen, Margaret McGill, Linong Ji
Summary: Diabetes is highly prevalent worldwide and in the APAC region, and glucose monitoring is crucial for optimizing diabetes management. The APAC Diabetes Care Advisory Board conducted a survey and expert panel meeting to explore glucose monitoring patterns, patient profiles, benefits, challenges, and potential solutions in the region. The results will guide the formulation of APAC-specific consensus guidelines for continuous glucose monitoring in people with diabetes.
JOURNAL OF DIABETES SCIENCE AND TECHNOLOGY
(2023)
Article
Genetics & Heredity
Idrees A. Shah, Rabiya Rashid, Abid Bhat, Haroon Rashid, Rohina Bashir, Mir M. Asrar, Imtiyaz A. Wani, Bashir Ahmad Charoo, Venkatesan Radha, V. Mohan, Mohd Ashraf Ganie
Summary: The hypoglycemia caused by excessive insulin secretion in congenital hyperinsulinemia (CHI) can lead to irreversible brain damage. Mutations in several genes, including ABCC8 and KCNJ11, have been identified as causal. A 3-month-old male infant with seizures and hyperinsulinemia was found to have a novel homozygous missense mutation in the KCNJ11 gene. The identification of such mutations is critical for future therapeutic interventions.
Review
Multidisciplinary Sciences
Venkatesan Radha, Sekar Kanthimathi, Anandakumar Amutha, Balaji Bhavadharini, Ranjit Mohan Anjana, Ranjit Unnikrishnan, Viswanathan Mohan
Summary: Monogenic diabetes refers to single gene disorders that cause impairment of insulin secretion and result in diabetes. This study focused on the prevalence of two common forms of monogenic diabetes, maturity onset of diabetes of the young (MODY) and neonatal diabetes mellitus (NDM), in South Asians. The aim was to identify the number of reported cases of monogenic diabetes in South Asian countries.
JOURNAL OF THE INDIAN INSTITUTE OF SCIENCE
(2023)
Review
Multidisciplinary Sciences
Viswanathan Mohan, Kuzhandhaivelu Abirami, Valangaiman Sriram Manasa, Anandakumar Amutha, Balaji Bhavadharini, Rinky Rajput, Nagarajan Lakshmipriya, Chowdary Sruthi, Ranjit Mohan Anjana, Ranjit Unnikrishnan, Sudha Vasudevan, Kamala Krishnaswamy
Summary: A systematic review and meta-analysis found that total and fermented dairy products, especially plain yogurt, are inversely associated with new onset type 2 diabetes, while milk, cheese, and other dairy products have a neutral effect. Subgroup analysis by ethnicity showed that total dairy products and milk have protective effects on diabetes in Asian populations, while fermented dairy products are protective in Western populations. The analysis by age demonstrated that the consumption of high-fat dairy products predisposes younger adults to type 2 diabetes.
JOURNAL OF THE INDIAN INSTITUTE OF SCIENCE
(2023)
Article
Geriatrics & Gerontology
Patricio Lopez-Jaramillo, Diego Gomez-Arbelaez, Daniel Martinez-Bello, Marc Evans M. Abat, Khalid F. Alhabib, Alvaro Avezum, Olga Barbarash, Jephat Chifamba, Maria L. Diaz, Sadi Gulec, Noorhassim Ismail, Romaina Iqbal, Roya Kelishadi, Rasha Khatib, Fernando Lanas, Naomi S. Levitt, Yang Li, Viswanathan Mohan, Prem K. Mony, Paul Poirier, Annika Rosengren, Biju Soman, Chuangshi Wang, Yang Wang, Karen Yeates, Rita Yusuf, Afzalhussein Yusufali, Katarzyna Zatonska, Sumathy Rangarajan, Salim Yusuf
Summary: The TyG index is associated with cardiovascular diseases and mortality, especially in Asia. It is significantly related to the risk of cardiovascular diseases, myocardial infarction, stroke, and type 2 diabetes, indicating that insulin resistance plays a promoting role in the development of these diseases.
LANCET HEALTHY LONGEVITY
(2023)
Article
Endocrinology & Metabolism
Viswanathan Mohan, Ganesan Uma Sankari, Anandakumar Amutha, Ranjit Mohan Anjana, Saravanan Jeba Rani, Ranjit Unnikrishnan, Ulagamathesan Venkatesan, Coimbatore Subramanian Shanthi Rani
Summary: This study aimed to compare the clinical and biochemical profile, as well as the prevalence of complications, between childhood/adolescent-onset and adult-onset type 1 diabetes (T1D) at a diabetes center in south India. The data of 5,578 individuals diagnosed with T1D and treated at the center between 1991 and 2021 were analyzed. The results showed that individuals with adult-onset T1D had a higher prevalence of microvascular complications than those with childhood/adolescent-onset T1D, and GAD-negative individuals in the adult-onset group had a higher percentage of retinopathy and chronic kidney disease.
ACTA DIABETOLOGICA
(2023)
