Design of a Selective Substrate and Activity Based Probe for Human Neutrophil Serine Protease 4

Unnatural amino acids increase sensitivity and provide for the design of highly selective caspase substrates

(2014) M Poreba et al.   CELL DEATH AND DIFFERENTIATION

Design of ultrasensitive probes for human neutrophil elastase through hybrid combinatorial substrate library profiling

(2014) P. Kasperkiewicz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structures of Neutrophil Serine Protease 4 Reveal an Unusual Mechanism of Substrate Recognition by a Trypsin-Fold Protease

(2014) S. Jack Lin et al.   STRUCTURE

NSP4 Is Stored in Azurophil Granules and Released by Activated Neutrophils as Active Endoprotease with Restricted Specificity

(2013) N. C. Perera et al.   JOURNAL OF IMMUNOLOGY

Synthesis and Structure–Activity Relationships of Phosphonic Arginine Mimetics as Inhibitors of the M1 and M17 Aminopeptidases from Plasmodium falciparum

(2013) Komagal Kannan Sivaraman et al.   JOURNAL OF MEDICINAL CHEMISTRY

Global Substrate Profiling of Proteases in Human Neutrophil Extracellular Traps Reveals Consensus Motif Predominantly Contributed by Elastase

(2013) Anthony J. O’Donoghue et al.   PLoS One

Perspectives and potential roles for the newly discovered NSP4 in the immune system

(2012) Natascha C Perera et al.   Expert Review of Clinical Immunology

NSP4, an elastase-related protease in human neutrophils with arginine specificity

(2012) N. C. Perera et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Non-combinatorial library screening reveals subsite cooperativity and identifies new high-efficiency substrates for kallikrein-related peptidase 14

(2011) Simon J. de Veer et al.   BIOLOGICAL CHEMISTRY

Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps

(2010) Venizelos Papayannopoulos et al.   JOURNAL OF CELL BIOLOGY

Neutrophil Elastase, Proteinase 3, and Cathepsin G as Therapeutic Targets in Human Diseases

(2010) B. Korkmaz et al.   PHARMACOLOGICAL REVIEWS

Irreversible Inhibition of Serine Proteases – Design and In Vivo Activity of Diaryl α-Aminophosphonate Derivatives

(2009) M. Sienczyk et al.   CURRENT MEDICINAL CHEMISTRY

Neutrophil Extracellular Traps Contain Calprotectin, a Cytosolic Protein Complex Involved in Host Defense against Candida albicans

(2009) Constantin F. Urban et al.   PLoS Pathogens

Proteome-derived, database-searchable peptide libraries for identifying protease cleavage sites

(2008) Oliver Schilling et al.   NATURE BIOTECHNOLOGY

Neutrophil elastase, proteinase 3 and cathepsin G: Physicochemical properties, activity and physiopathological functions

(2007) Brice Korkmaz et al.   BIOCHIMIE