Article
Immunology
Linghui Liang, Wei Xia, Liangyu Yao, Qikai Wu, Lixin Hua, Gong Cheng, Zengjun Wang, Ruizhe Zhao
Summary: This study identified a five immune-related lncRNAs signature that can accurately predict the prognosis of prostate adenocarcinoma patients. Further analysis showed that the signature can stratify patients into high-risk and low-risk groups, and gene expression analysis indicated significant up-regulation of four lncRNAs in tumor tissues. These findings suggest the clinical significance of the signature in prognosis prediction and immunotherapy for prostate adenocarcinoma patients.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Oncology
Ying Liu, Xiang Ao, Yu Wang, Xiaoge Li, Jianxun Wang
Summary: Gastric cancer is the third leading cause of cancer-related deaths worldwide, and chemotherapy is an important treatment method. However, most patients develop resistance to chemotherapy drugs. Recent studies have found that lncRNAs are involved in gastric cancer drug resistance and they regulate drug resistance through various mechanisms. Some lncRNAs have potential clinical applications.
FRONTIERS IN ONCOLOGY
(2022)
Article
Genetics & Heredity
Xiaodong Xie, Jingjing Jin, Chen Wang, Peng Lu, Zefeng Li, Jiemeng Tao, Peijian Cao, Yalong Xu
Summary: In this study, researchers identified a large number of lncRNAs in tobacco, which play important roles in the nicotine biosynthesis pathway. These lncRNAs showed distinct features compared to protein-coding genes in terms of exon number, sequence length, A/U content, and tissue-specific expression pattern. The study also predicted the potential regulatory effects of lncRNAs on protein-coding genes and discovered their involvement in the nicotine pathway.
FRONTIERS IN GENETICS
(2023)
Article
Biochemistry & Molecular Biology
Yongqu Lu, Wendong Wang, Zhenzhen Liu, Junren Ma, Xin Zhou, Wei Fu
Summary: Our study established a metabolism-related lncRNA signature for predicting outcomes of CRC patients, which may contribute to individualized prevention and treatment.
MOLECULAR MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Yifan Li, Lan Lu, Xu Wu, Qianxiu Li, Yueshui Zhao, Fukuan Du, Yu Chen, Jing Shen, Zhangang Xiao, Zhigui Wu, Wei Hu, Chi Hin Cho, Mingxing Li
Summary: This review summarizes the research progress on the roles of long non-coding RNAs (lncRNAs) in gastric cancer (GC), focusing on their involvement in Helicobacter pylori infection, GC metastasis, tumor microenvironment regulation, drug resistance, and associated signaling pathways. LncRNAs may serve as novel biomarkers for diagnosis and prognosis of GC and potential therapeutic targets.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Review
Biotechnology & Applied Microbiology
Zonglin Li, Muhan Lu, Yejiang Zhou, Linxia Xu, Yifan Jiang, Yi Liu, Xin Li, Min Song
Summary: Accumulating evidence suggests that lncRNAs play a crucial role in the chemoresistance of gastric cancer. This systematic review highlights the significance of lncRNAs as potential therapeutic targets for overcoming drug resistance in GC.
ONCOTARGETS AND THERAPY
(2021)
Review
Cell Biology
Yanping Yue, Xinrong Lin, Xinyue Qiu, Lei Yang, Rui Wang
Summary: This paper summarizes the significant role of non-coding RNAs in gastric cancer, including regulating cell activities and influencing therapeutic resistance. In addition, the potential applications of ncRNAs in clinical trials and diagnosis of gastric cancer are discussed.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Medicine, Research & Experimental
Hongxu Li, Jie Gao, Long Liu, Shuijun Zhang
Summary: LINC00958, a long non-coding RNA highly expressed in various malignancies, plays a role in enhancing tumor cells' resistance to radiotherapy and chemotherapy, inducing lymphangiogenesis, and facilitating tumor glycolytic metabolism. Additionally, LINC00958 acts as a ceRNA and regulates the malignant behavior of tumor cells through the miRNA-mRNA axis, showcasing potential as a novel biomarker and therapeutic target in cancer diagnosis and treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biotechnology & Applied Microbiology
Yan Zhang, Lin Chen, Xuanting Ye, Zhixiong Wu, Zeyu Zhang, Biaofeng Sun, Hong Fu, Chuangang Fu, Xiaofei Liang, Hong Jiang
Summary: The study revealed that FRLnc1 in exosomes plays a role in promoting the growth and metastasis of gastric cancer by enhancing cell proliferation and migration. This suggests that FRLnc1 may serve as a potential biomarker for the diagnosis and treatment of gastric cancer, providing a new avenue for therapy.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Xubin Zheng, Kwong-Sak Leung, Man-Hon Wong, Lixin Cheng
Summary: This study proposed a novel diagnostic strategy using relative expressions of lncRNA pairs to identify a sepsis diagnostic signature. The signature showed better predictive performance across different ages and normalization methods compared to common machine learning models and existing signatures. Functional analysis revealed that the lncRNA pairs in the signature are functionally similar.
Article
Biochemistry & Molecular Biology
Angela L. Riffo-Campos, Javier Perez-Hernandez, Olga Martinez-Arroyo, Ana Ortega, Ana Flores-Chova, Josep Redon, Raquel Cortes
Summary: This study identified different expression profiles of long non-coding RNAs (lncRNAs) associated with hypertension in plasma and plasma exosomes using next-generation sequencing. Analysis of gene ontology and KEGG pathways showed enrichment in biological functions related to albuminuria, providing insights into the mechanisms of albuminuria and cardiovascular damage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Toshihiko Takeiwa, Kazuhiro Ikeda, Kuniko Horie-Inoue, Satoshi Inoue
Summary: Ovarian cancer is a health-threatening malignancy of the ovary in the female reproductive system, often diagnosed at advanced stages with poor prognosis. Recent studies have shown that some lncRNAs play roles in apoptosis of ovarian cancer cells, potentially serving as promising new targets in therapy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xiaocong Lin, Guodan Li, Xiuwen Yan, Weiyu Fu, Jie Ruan, Hang Ding, Huajun Yu, Xiaoyi Chen, Liubo Lan, Yong Dai, Kai Pan, Xinguang Liu, Haitao Zhang
Summary: This study identifies lncRNA BC002811 as a critical regulator in the development and progression of gastric cancer. BC002811 is upregulated in GC tissues and cell lines and its high expression is associated with reduced overall survival in GC patients. BC002811 promotes GC cell proliferation, migration, invasion, and inhibits apoptosis in vitro, and accelerates tumor growth and metastasis in vivo. It upregulates MMP2 and MMP9 and promotes GC cell metastasis by downregulating PTEN expression and blocking SOX2 binding to the PTEN promoter.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Genetics & Heredity
Xianhui Zhang, Changjing Wang, Zhongxin Liu, Yuan Si
Summary: A risk model based on 11 MRlncRNAs was developed as an independent predictor of gastric cancer (GC) prognosis and may be useful in developing personalized treatment strategies for patients.
FRONTIERS IN GENETICS
(2022)
Review
Biochemistry & Molecular Biology
Yeonsoo Chae, Jungwook Roh, Wanyeon Kim
Summary: Gliomas originate in the central nervous system and are categorized based on both histological and molecular genetic characteristics. Long non-coding RNAs (lncRNAs) play a crucial role in regulating tumorigenesis, tumor progression, and therapeutic resistance in glioma cells. Oncogenic lncRNAs and tumor-suppressive lncRNAs orchestrate signaling pathways that influence the pathogenesis and progression of gliomas, as well as the sensitivity to existing anticancer therapies. This review aims to enhance understanding of the impact of lncRNAs on signaling pathways in gliomas and their role in therapeutic resistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Shaopeng Liu, Tao Dong, Yupeng Shi, Hui Luo, Xianmin Xue, Yijin Zhu, Xiangping Wang, Biaoluo Wang, Shuhui Liang, Yanglin Pan, Xuegang Guo, Kaichun Wu
Summary: The water exchange method improved the total enteroscopy rate and increased the intubation depth during SBE. The use of water exchange did not increase the complications of enteroscopy.
Review
Clinical Neurology
Xuan Wang, Jian Wan, Min Wang, Yujie Zhang, Kaichun Wu, Fang Yang
Summary: This study demonstrates an association between multiple sclerosis (MS) and inflammatory bowel disease (IBD), with patients with MS having a higher risk of developing IBD and patients with IBD having a higher risk of developing MS.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xueli Chen, Xinyu Wang, Tianyu Yan, Yun Zheng, Honghao Cao, Feng Ren, Xu Cao, Xiangfeng Meng, Xiaojian Lu, Shuhui Liang, Kaichun Wu
Summary: By optimizing the structural parameters of fiber endoscope and imaging parameters for data acquisition, we developed a CLE system with a sensitivity at submicrocurie level. These results support the possibility that this technology can clinically detect early tumors within 1 minute.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2022)
Article
Cell Biology
Min Deng, Christian F. Guerrero-Juarez, Xiaole Sheng, Jiuzhi Xu, Xi Wu, Kai Yao, Mengzhen Li, Xu Yang, Guilin Li, Jintao Xiao, Xiaowei Liu, Kaichun Wu, Fazheng Ren, Qing Nie, Maksim Plikus, Zhengquan Yu, Cong Lv
Summary: This study reveals that mesenchymal cells (MCs) surrounding the intestine can sense diet changes and modulate the function of intestinal stem cells (ISCs) through the secretion of IGF1. MCs play a critical role in maintaining the proliferation of ISC and progenitor cells, and these findings may provide a novel therapeutic target for gut diseases.
Article
Gastroenterology & Hepatology
Qian Cao, Chunxiao Chen, Xiang Gao, Yan Chen, Naizhong Hu, Jie Liang, Kaichun Wu
Summary: Research shows that ustekinumab is more effective in treating Crohn's disease than anti-tumor necrosis factor treatment for patients who did not respond to previous treatment. The remission rates of ustekinumab are superior to those in the UNITI-1 study.
INFLAMMATORY BOWEL DISEASES
(2022)
Article
Microbiology
Jian Wan, Yujie Zhang, Wenfang He, Zuhong Tian, Junchao Lin, Zhenzhen Liu, Yani Li, Min Chen, Shuang Han, Jie Liang, Yongquan Shi, Xuan Wang, Lei Zhou, Ying Cao, Jiayun Liu, Kaichun Wu
Summary: Patients with ulcerative colitis (UC) are at a higher risk of developing Clostridioides difficile infection (CDI), but the gut microbial structure and metabolites in UC and CDI patients have been poorly studied. This study identifies significant differences in gut microbiota and metabolites between UC and CDI patients compared to those with UC alone.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Oncology
Hong Yang, Huimin Zhang, Wei Liu, Bei Tan, Tao Guo, Xiang Gao, Rui Feng, Kaichun Wu, Qian Cao, Zhihua Ran, Zhanju Liu, Naizhong Hu, Liangru Zhu, Yamin Lai, Congling Wang, Wei Han, Jiaming Qian
Summary: This study established a scoring model for differentiating CD and UPIL based on clinical symptoms, endoscopic and imaging features, which showed high accuracy and discriminative ability.
FRONTIERS IN ONCOLOGY
(2022)
Article
Gastroenterology & Hepatology
Chenwen Cai, Juntao Lu, Lijie Lai, Dongjuan Song, Jun Shen, Jinlu Tong, Qing Zheng, Kaichun Wu, Jiaming Qian, Zhihua Ran
Summary: The current status of drug therapy and monitoring for inflammatory bowel disease (IBD) in Asia shows both similarities and differences. Improvements in IBD management in Asia require Asian recommendations, IBD specialist teams, and the practice of therapeutic drug monitoring.
INTESTINAL RESEARCH
(2022)
Article
Gastroenterology & Hepatology
Joseph J. Y. Sung, Han-Mo Chiu, David Lieberman, Ernst J. Kuipers, Matthew D. Rutter, Finlay Macrae, Khay-Guan Yeoh, Tiing Leong Ang, Vui Heng Chong, Sneha John, Jingnan Li, Kaichun Wu, Simon S. M. Ng, Govind K. Makharia, Murdani Abdullah, Nozomu Kobayashi, Masau Sekiguchi, Jeong-Sik Byeon, Hyun-Soo Kim, Susan Parry, Patricia Anne Cabral-Prodigalidad, Deng-Chyang Wu, Suparkij Khomvilai, Rashid N. Lui, Sunny Wong, Yu-Min Lin, E. Dekker
Summary: The Asia-Pacific Working Group on Colorectal Cancer Screening has updated their recommendations on screening methods, age for screening, and surveillance for individuals with a family history of CRC or advanced adenoma based on the most recent studies in the region.
Article
Immunology
Ruqi Chang, Jieteng Chen, Zhaopeng Zhong, Yiyuan Li, Kaichun Wu, Hao Zheng, Yunsheng Yang
Summary: Patients with inflammatory bowel disease often experience cognitive impairment, but the underlying mechanism is unclear. In this study, researchers exposed honeybees to two different strains of E.coli and observed that the IBD-associated strain induced enteritis-like manifestations, cognitive behavioral modifications, increased gut permeability, and shortened lifespan in honeybees. The strain also altered the levels of certain substances in the honeybee gut and affected gene expression in the honeybee brain. This study suggests that honeybees can serve as a potential model for studying the microbiota-gut-brain interaction in IBD.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Medicine, General & Internal
Hong Yang, Huimin Zhang, Wei Liu, Wei Han, Tao Guo, Yamin Lai, Bei Tan, Congling Wang, Minhu Chen, Xiang Gao, Zhihua Ran, Zhanju Liu, Kaichun Wu, Qian Cao, Jiaming Qian
Summary: This study aimed to evaluate the diagnostic value of CT enterography (CTE) in distinguishing CD from intestinal BD and establish differential diagnosis models. The results showed that clinical symptoms and CTE increased the ability of endoscopy to differentiate CD from intestinal BD.
FRONTIERS IN MEDICINE
(2022)
Review
Gastroenterology & Hepatology
Yue Yin, Jian Wan, Jingmin Yu, Kaichun Wu
Summary: This review summarizes the molecular pathogenesis of colitis-associated colorectal cancer (CAC) from the aspects of immunity, genetics, and intestinal microecology, and it points out the potential mechanisms worthy of further study. It highlights the complexity of the inflammation process to cancer and the dual effects of inflammatory mediators in order to provide inspiration for finding effective biomarkers or targets to make CAC more predictable and treatable.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Gastroenterology & Hepatology
Jian Wan, Xuan Wang, Yujie Zhang, Xianmin Xue, Hui Jia, Min Wang, Jie Liang, Kaichun Wu
Summary: This study aimed to assess the association between cumulative inflammatory burden (CIB) and disease extension in distal UC patients and develop a quantified indicator of CIB. The study found that TA-MES is a good indicator of CIB and is independently associated with increased disease extension in distal UC patients.
GASTROENTEROLOGY REPORT
(2022)
Article
Medicine, Research & Experimental
Tianyu Cao, Yuanyuan Lu, Qi Wang, Hongqiang Qin, Hongwei Li, Hao Guo, Minghui Ge, Sarah E. Glass, Bhuminder Singh, Wenyao Zhang, Jiaqiang Dong, Feng Du, Airong Qian, Ye Tian, Xin Wang, Cunxi Li, Kaichun Wu, Daiming Fan, Yongzhan Nie, Robert J. Coffey, Xiaodi Zhao
Summary: De novo and acquired resistance are major impediments to cancer therapy. A study identified CGA as a prognostic biomarker and therapeutic target in chemoresistant gastric cancer (GC). High levels of CGA were found in chemoresistant GC cells and tissues, and elevated plasma CGA levels were correlated with reduced chemotherapy responsiveness and poor survival. CGA promoted survival and activated EGFR signaling in GC cells. Targeting CGA with anti-EGFR therapies or microRNAs restored chemotherapy sensitivity.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Gastroenterology & Hepatology
Song-Ze Ding, Yi-Qi Du, Hong Lu, Wei-Hong Wang, Hong Cheng, Shi-Yao Chen, Min-Hu Chen, Wei-Chang Chen, Ye Chen, Jing-Yuan Fang, Heng-Jun Gao, Ming-Zhou Guo, Ying Han, Xiao-Hua Hou, Fu-Lian Hu, Bo Jiang, Hai-Xing Jiang, Chun-Hui Lan, Jing-Nan Li, Yan Li, Yan-Qing Li, Jie Liu, You-Ming Li, Bin Lyu, You-Yong Lu, Ying-Lei Miao, Yong-Zhan Nie, Jia-Ming Qian, Jian-Qiu Sheng, Cheng-Wei Tang, Fen Wang, Hua-Hong Wang, Jiang-Bin Wang, Jing-Tong Wang, Jun-Ping Wang, Xue-Hong Wang, Kai-Chun Wu, Xing-Zhou Xia, Wei-Fen Xie, Yong Xie, Jian-Ming Xu, Chang-Qing Yang, Gui-Bin Yang, Yuan Yuan, Zhi-Rong Zeng, Bing-Yong Zhang, Gui-Ying Zhang, Guo-Xin Zhang, Jian-Zhong Zhang, Zhen-Yu Zhang, Peng-Yuan Zheng, Yin Zhu, Xiu-Li Zuo, Li-Ya Zhou, Nong-Hua Lyu, Yun-Sheng Yang, Zhao-Shen Li
Summary: Experts discussed and modified 23 original statements on family-based H. pylori infection transmission, control and management, and reached consensus on 16 statements. The final report consists of three parts: H. pylori infection and transmission among family members, prevention and management of H. pylori infection in children and elderly people within households, and strategies for prevention and management of H. pylori infection for family members. In addition to the 'test-and-treat' and 'screen-and-treat' strategies, this consensus also introduced a novel third 'family-based H. pylori infection control and management' strategy to prevent its intrafamilial transmission and development of related diseases.
