Novel Histone Deacetylase Class IIa Selective Substrate Radiotracers for PET Imaging of Epigenetic Regulation in the Brain

Sirtuin 4 Is a Lipoamidase Regulating Pyruvate Dehydrogenase Complex Activity

(2014) Rommel A. Mathias et al.   CELL

In Vivo Imaging of Histone Deacetylases (HDACs) in the Central Nervous System and Major Peripheral Organs

(2014) Changning Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Radionuclide labeling and evaluation of candidate radioligands for PET imaging of histone deacetylase in the brain

(2013) Young Jun Seo et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Histone deacetylase class II and acetylated core histone immunohistochemistry in human brains with Huntington’s disease

(2013) Hsin Hsien Yeh et al.   BRAIN RESEARCH

Unique functional roles for class I and class II histone deacetylases in central nervous system development and function

(2013) Michael J. Morris et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Novel 64Cu-Labeled CUDC-101 for in Vivo PET Imaging of Histone Deacetylases

(2013) Qingqing Meng et al.   ACS Medicinal Chemistry Letters

A consistent description of HYdrogen bond and DEhydration energies in protein–ligand complexes: methods behind the HYDE scoring function

(2012) Nadine Schneider et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Conditional deletion of histone deacetylase-4 in the central nervous system has no major effect on brain architecture or neuronal viability

(2012) Valerie Price et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Imaging epigenetic regulation by histone deacetylases in the brain using PET/MRI with 18F-FAHA

(2012) Hsin-Hsien Yeh et al.   NEUROIMAGE

In Vivo PET Imaging of Histone Deacetylases by18F-Suberoylanilide Hydroxamic Acid (18F-SAHA)

(2011) J. Adam Hendricks et al.   JOURNAL OF MEDICINAL CHEMISTRY

The synthesis and evaluation of N1-(4-(2-[18F]-fluoroethyl)phenyl)-N8-hydroxyoctanediamide ([18F]-FESAHA), A PET radiotracer designed for the delineation of histone deacetylase expression in cancer

(2011) Brian M. Zeglis et al.   NUCLEAR MEDICINE AND BIOLOGY

Histone Deacetylase Inhibitor MS-275 Exhibits Poor Brain Penetration: Pharmacokinetic Studies of [11C]MS-275 using Positron Emission Tomography

(2009) Jacob M. Hooker et al.   ACS Chemical Neuroscience

Focal Nature of Neurological Disorders Necessitates Isotype-Selective Histone Deacetylase (HDAC) Inhibitors

(2009) Elizabeth A. Thomas   MOLECULAR NEUROBIOLOGY

Evaluation of 6-([18F]fluoroacetamido)-1-hexanoicanilide for PET imaging of histone deacetylase in the baboon brain

(2009) Alicia E. Reid et al.   NUCLEAR MEDICINE AND BIOLOGY

KING (Kinemage, Next Generation): A versatile interactive molecular and scientific visualization program

(2009) Vincent B. Chen et al.   PROTEIN SCIENCE

HDAC4 Regulates Neuronal Survival in Normal and Diseased Retinas

(2009) B. Chen et al.   SCIENCE

Probing the elusive catalytic activity of vertebrate class IIa histone deacetylases

(2008) Philip Jones et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Structural and Functional Analysis of the Human HDAC4 Catalytic Domain Reveals a Regulatory Structural Zinc-binding Domain

(2008) Matthew J. Bottomley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The many roles of histone deacetylases in development and physiology: implications for disease and therapy

(2008) Michael Haberland et al.   NATURE REVIEWS GENETICS

Quantification of HDAC inhibition by F-SAHA in rhesus monkey brain using the PET tracer [18F]FAHA

(2008) Sandra M. Sanabria et al.   NEUROIMAGE

Class IIA HDACs in the regulation of neurodegeneration

(2007) Nazanin Majdzadeh   Frontiers in Bioscience-Landmark