Identification of Tetraazacyclic Compounds as Novel Potent Inhibitors Antagonizing RORγt Activity and Suppressing Th17 Cell Differentiation

Identification of benzenesulfonamide quinoline derivatives as potent HIV-1 replication inhibitors targeting Rev protein

(2015) Fudi Zhong et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Interleukin 7 Up-regulates CD95 Protein on CD4+T Cells by Affecting mRNA Alternative Splicing

(2014) Yue Yin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stabilized  -Catenin Potentiates Fas-Mediated T Cell Apoptosis

(2014) Z. Huang et al.   JOURNAL OF IMMUNOLOGY

Discovery of Tertiary Amine and Indole Derivatives as Potent RORγt Inverse Agonists

(2013) Ting Yang et al.   ACS Medicinal Chemistry Letters

Identification of a Selective RORγ Ligand That Suppresses TH17 Cells and Stimulates T Regulatory Cells

(2012) Laura A. Solt et al.   ACS Chemical Biology

Small molecule inhibitors of RORγt: Targeting Th17 cells and other applications

(2012) Jun R. Huh et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Transcription of Il17 and Il17f Is Controlled by Conserved Noncoding Sequence 2

(2012) Xiaohu Wang et al.   IMMUNITY

Protein Kinase C-  Promotes Th17 Differentiation via Upregulation of Stat3

(2012) M.-J. Kwon et al.   JOURNAL OF IMMUNOLOGY

Differential and day-time dependent expression of nuclear receptors RORα, RORβ, RORγ and RXRα in the rodent pancreas and islet

(2012) Eckhard Mühlbauer et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Ursolic Acid Suppresses Interleukin-17 (IL-17) Production by Selectively Antagonizing the Function of RORγt Protein

(2011) Tao Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Basis of Digoxin That Antagonizes RORγt Receptor Activity and Suppresses Th17 Cell Differentiation and Interleukin (IL)-17 Production

(2011) Saori Fujita-Sato et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORγt activity

(2011) Jun R. Huh et al.   NATURE

Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand

(2011) Laura A. Solt et al.   NATURE

Methotrexate attenuates the Th17/IL-17 levels in peripheral blood mononuclear cells from healthy individuals and RA patients

(2011) Yanshan Li et al.   RHEUMATOLOGY INTERNATIONAL

Identification of SR3335 (ML-176): A Synthetic RORα Selective Inverse Agonist

(2010) Naresh Kumar et al.   ACS Chemical Biology

The IL-17 Family Cytokines in Immunity and Disease

(2010) Rajita Pappu et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology

(2010) Sofia Buonocore et al.   NATURE

Ursolic Acid Triggers Apoptosis and Bcl-2 Downregulation in MCF-7 Breast Cancer Cells

(2009) E. Kassi et al.   CANCER INVESTIGATION

Identification of Human CYP2C8 as a Retinoid-Related Orphan Nuclear Receptor Target Gene

(2009) Y. Chen et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

IL-17 and Th17 cells in human inflammatory diseases

(2009) Pierre Miossec   MICROBES AND INFECTION

RORγ-Expressing Th17 Cells Induce Murine Chronic Intestinal Inflammation via Redundant Effects of IL-17A and IL-17F

(2008) Moritz Leppkes et al.   GASTROENTEROLOGY

Clock-dependent and independent transcriptional control of the two isoforms from the mouseRorγgene

(2008) Valérie Mongrain et al.   GENES TO CELLS

Th17 Cell Differentiation: The Long and Winding Road

(2008) Mandy J. McGeachy et al.   IMMUNITY

Regulation of inflammatory responses by IL-17F

(2008) Xuexian O. Yang et al.   JOURNAL OF EXPERIMENTAL MEDICINE